Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection.

abstract：:It is well documented that patients can show significant heterogeneous responses to treatments so the best treatment strategies may require adaptation over individuals and time. Recently, a number of new statistical methods have been developed to tackle the important problem of estimating personalized treatment rules ...

journal_title：Frontiers of medicine

authors： Zhao Y,Zeng D

更新日期：2013-03-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post...

journal_title：Frontiers of medicine

authors： Liu F,Liu L,Zheng F,Tang X,Bao Y,Zuo Y

更新日期：2018-04-01 00:00:00

abstract：:Growing evidence suggests that somatic hypermutational status and programmed cell death-1 overexpression are potential predictive biomarkers indicating treatment benefits from immunotherapy using immune checkpoint inhibitors. However, biomarker-matched trials are still limited, and many of the genomic alterations rema...

journal_title：Frontiers of medicine

authors： Chen A,Zhang S,Li J,Ji C,Chen J,Li C

更新日期：2020-02-01 00:00:00

abstract：:Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%-60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April ...

journal_title：Frontiers of medicine

authors： Alfaraj SH,Al-Tawfiq JA,Altuwaijri TA,Memish ZA

更新日期：2019-02-01 00:00:00

abstract：:As a promising method in artificial intelligence, deep learning has been proven successful in several domains ranging from acoustics and images to natural language processing. With medical imaging becoming an important part of disease screening and diagnosis, deep learning-based approaches have emerged as powerful tec...

journal_title：Frontiers of medicine

authors： Ma J,Song Y,Tian X,Hua Y,Zhang R,Wu J

更新日期：2020-08-01 00:00:00

abstract：:Disorders of sex development (DSD) are a group of rare complex clinical syndromes with multiple etiologies. Distinguishing the various causes of DSD is quite difficult in clinical practice, even for senior general physicians because of the similar and atypical clinical manifestations of these conditions. In addition, ...

journal_title：Frontiers of medicine

authors： Ning D,Zhang Z,Qiu K,Lu L,Zhang Q,Zhu Y,Wang R

更新日期：2020-08-01 00:00:00

abstract：:Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, rece...

journal_title：Frontiers of medicine

authors： Shang B,Cao Z,Zhou Q

更新日期：2012-03-01 00:00:00

abstract：:Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease. ...

journal_title：Frontiers of medicine

authors： Liao E

更新日期：2013-03-01 00:00:00

abstract：:NUP98 fuses with approximately 34 different partner genes via translocation in hematological malignancies. Transgenic or retrovirus-mediated bone marrow transplanted mouse models reveal the leukemogenesis of some NUP98-related fusion genes. We previously reported the fusion protein NUP98-IQ motif containing G (IQCG) i...

journal_title：Frontiers of medicine

authors： Pan M,Zhang Q,Liu P,Huang J,Wang Y,Chen S

更新日期：2016-12-01 00:00:00

abstract：:A high level of social support can improve long-term diabetes self-management. Support from a single source has been evaluated. This study aims to analyze support from multiple and multilevel sources for diabetic patients by using the Chronic Illness Resources Survey (CIRS). Factors influencing the utilization of the ...

journal_title：Frontiers of medicine

authors： Zhong H,Shao Y,Fan L,Zhong T,Ren L,Wang Y

更新日期：2016-06-01 00:00:00

abstract：:Although many drugs and therapeutic strategies have been developed for rheumatoid arthritis (RA) treatment, numerous patients with RA fail to respond to currently available agents. In this review, we provide an overview of the complexity of this autoimmune disease by showing the rapidly increasing number of genes asso...

journal_title：Frontiers of medicine

authors： Wu X,Sheng X,Sheng R,Lu H,Xu H

更新日期：2019-08-01 00:00:00

abstract：:Assisted reproduction provides a wide spectrum of treatments and strategies addressing infertility. However, distinct groups of infertile patients with unexplained infertility, congenital disorders, and other complex cases pose a challenge in in vitro fertilization (IVF) practices. This special cohort of patients is a...

journal_title：Frontiers of medicine

authors： Simopoulou M,Sfakianoudis K,Tsioulou P,Rapani A,Giannelou P,Kiriakopoulos N,Pantou A,Vlahos N,Anifandis G,Bolaris S,Pantos K,Koutsilieris M

更新日期：2019-12-01 00:00:00

abstract：:This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson's disease (PD) reflected by fractional anisotropy (FA), addressing clinical profiles and methodology-related heterogeneity. Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusio...

journal_title：Frontiers of medicine

authors： Suo X,Lei D,Li W,Li L,Dai J,Wang S,Li N,Cheng L,Peng R,Kemp GJ,Gong Q

更新日期：2020-05-26 00:00:00

abstract：:At present, clinical pathway has become one of the most important health care reform measures in many countries. In this study, the authors introduced basic concepts and explored the application of the clinical pathway of evidence-based Chinese medicine incorporated with the methodology from the concepts of management...

journal_title：Frontiers of medicine

authors： Wang S,Yu H,Liu J,Liu B

更新日期：2011-06-01 00:00:00

abstract：:This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute....

journal_title：Frontiers of medicine

authors： Ma Y,Zhang N,Wu S,Huang H,Cao Y

更新日期：2016-12-01 00:00:00

abstract：:A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinicopathological...

journal_title：Frontiers of medicine

authors： Fu Y,Wang X,Pan Z,Xie X

更新日期：2014-03-01 00:00:00

abstract：:Zinc (Zn) is an essential mineral that is required for various cellular functions. Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome, diabetes and diabetic complications. The associations of Zn with metabolic syndrome, diabetes and diabetic complications, thus, stem from the multiple ...

journal_title：Frontiers of medicine

authors： Miao X,Sun W,Fu Y,Miao L,Cai L

更新日期：2013-03-01 00:00:00

abstract：:Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, th...

journal_title：Frontiers of medicine

authors： Wang JH

更新日期：2012-09-01 00:00:00

abstract：:Cleft lip and palate (CLP) is the most common craniofacial congenital deformity. The etiology of CLP is multifactorial and involves complex interactions between environmental and genetic factors. Millard's rotation advancement technique has long been considered as state-of-the-art for unilateral cleft lip repair. Howe...

journal_title：Frontiers of medicine

authors： Xu Y,Li J,Shi B

更新日期：2013-12-01 00:00:00

abstract：:γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit li...

journal_title：Frontiers of medicine

authors： Wang X,Tian Z

更新日期：2018-06-01 00:00:00

abstract：:This study aimed to evaluate the efficacy of comprehensive therapy based on traditional Chinese medicine (TCM) patterns on older patients with chronic obstructive pulmonary disease (COPD) through a fourcenter, open-label, randomized controlled trial. Patients were divided into the trial group treated using conventiona...

journal_title：Frontiers of medicine

authors： Wang M,Li J,Li S,Xie Y

更新日期：2014-09-01 00:00:00

abstract：:Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and p...

journal_title：Frontiers of medicine

authors： Gitau SC,Li X,Zhao D,Guo Z,Liang H,Qian M,Lv L,Li T,Xu B,Wang Z,Zhang Y,Xu C,Lu Y,Du Z,Shan H,Yang B

更新日期：2015-12-01 00:00:00

abstract：:Swallowing multiple magnets is not uncommon worldwide and it frequently leads to serious consequences. However, most patients fail to receive timely and correct diagnosis and treatment. A literature search was performed to establish an algorithm for these accidents by the authors to identify relevant articles publishe...

journal_title：Frontiers of medicine

authors： Liu S,Li J,Lv Y

更新日期：2012-09-01 00:00:00

abstract：:Orbital venous malformation (OVM) is a congenital vascular disease. As a common type of vascular malformation in the orbit, OVM may result in vision deterioration and cosmetic defect. Classification of orbital vascular malformations, especially OVMs, is carried out on the basis of different categories, such as angioge...

journal_title：Frontiers of medicine

authors： Li T,Jia R,Fan X

更新日期：2019-10-01 00:00:00

abstract：:The mammalian MOF (male absent on the first), a member of the MYST (MOZ, YBF2, SAS2, and Tip60) family of histone acetyltransferases (HATs), is the major enzyme that catalyzes the acetylation of histone H4 on lysine 16. Acetylation of K16 is a prevalent mark associated with chromatin decondensation. MOF has recently b...

journal_title：Frontiers of medicine

authors： Yang Y,Han X,Guan J,Li X

更新日期：2014-03-01 00:00:00

abstract：:Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man's sedentary lifestyle, low-physical activity, obesity, and some nonmodifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at h...

journal_title：Frontiers of medicine

authors： Pan J,Jia W

更新日期：2018-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the mol...

journal_title：Frontiers of medicine

authors： Gao Q,Shi Y,Wang X,Zhou J,Qiu S,Fan J

更新日期：2012-06-01 00:00:00

abstract：:The teeth are highly differentiated chewing organs formed by the development of tooth germ tissue located in the jaw and consist of the enamel, dentin, cementum, pulp, and periodontal tissue. Moreover, the teeth have a complicated regulatory mechanism, special histologic origin, diverse structure, and important functi...

journal_title：Frontiers of medicine

authors： Zhai Q,Dong Z,Wang W,Li B,Jin Y

更新日期：2019-04-01 00:00:00

abstract：:The rationale for the antibiotic treatment of viral community-acquired pneumonia (CAP) in adults was analyzed to develop a clinical reference standard for this condition. Clinical data from 166 patients diagnosed with viral pneumonia across 14 hospitals in Beijing from November 2010 to December 2017 were collected. Th...

journal_title：Frontiers of medicine

authors： Jiang R,Han B,Dou C,Zhou F,Cao B,Li X

更新日期：2020-06-13 00:00:00

abstract：:Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively stud...

journal_title：Frontiers of medicine

authors： Miyazono K,Katsuno Y,Koinuma D,Ehata S,Morikawa M

更新日期：2018-08-01 00:00:00