Abstract:
:Cleft lip and palate (CLP) is the most common craniofacial congenital deformity. The etiology of CLP is multifactorial and involves complex interactions between environmental and genetic factors. Millard's rotation advancement technique has long been considered as state-of-the-art for unilateral cleft lip repair. However, this method may leave the christa philtri on the cleft side insufficiently downward rotated, especially in wide complete clefts. In this study, we introduce a modified technique to better rotate the christa philtri on the cleft side down. The skin, muscle, and mucosa in the deformed region were dissected and separately maneuvered. Sixty patients with unilateral complete cleft lip and palate were operated with this technique. The lip height, lip length, and relative height of the christa philtri were measured for symmetry evaluation. No significant difference was observed between the relative height of the christa philtri on both sides, either immediate (P = 0.214) or 10 months after surgery (P = 0.344). The difference observed in the lip height and lip length immediately after surgery became statistically insignificant after 10 months (P = 0.104 for lip height and 0.121 for lip length). These results suggested that sufficient and stable downward rotation of the christa philtri on the cleft side can be achieved using our technique.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Xu Y,Li J,Shi Bdoi
10.1007/s11684-013-0299-6subject
Has Abstractpub_date
2013-12-01 00:00:00pages
510-16issue
4eissn
2095-0217issn
2095-0225journal_volume
7pub_type
杂志文章abstract::Alternative splicing plays a fundamental role in the development and physiological function of the inner ear. Inner-ear-specific gene splicing is necessary to establish the identity and maintain the function of the inner ear. For example, exon 68 of Cadherin 23 (Cdh23) gene is subject to inner-ear-specific alternative...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-016-0454-y
更新日期:2016-09-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the mol...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-012-0193-7
更新日期:2012-06-01 00:00:00
abstract::This study aims to investigate the effect of non-transecting anastomotic urethroplasty for treatment of posterior urethral stricture. A total of 23 patients with traumatic posterior urethral stricture were enrolled and then divided into two groups. In one group, 12 patients underwent non-transecting anastomotic urethr...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-017-0515-x
更新日期:2017-06-01 00:00:00
abstract::The prevalence of the risk factors and the risk of cardiac failure are both increasing in China. This might be the consequence of the changes of the life conditions (emigration to the urban areas, changes in the diet and life style, lack of physical exercise, etc.). The wide range of clinical presentations of cardiac ...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-011-0106-1
更新日期:2011-03-01 00:00:00
abstract::Laparoscopic liver surgery has been increasingly used for the treatment of pediatric liver diseases over the past decade due to the development of special laparoscopic instruments and improvements in the technique. A number of factors are considered when electing to undergo the surgical process, including age, type of...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-011-0165-3
更新日期:2011-12-01 00:00:00
abstract::The inhibitory environment that surrounds the lesion site and the lack of intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) impede the regrowth of injured axons and thereby the reestablishment of neural circuits required for functional recovery after spinal cord injuries (SCI). To cir...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-018-0642-z
更新日期:2019-04-01 00:00:00
abstract::Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothel...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-011-0118-x
更新日期:2011-03-01 00:00:00
abstract::Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpat...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-015-0417-8
更新日期:2015-12-01 00:00:00
abstract::NUP98 fuses with approximately 34 different partner genes via translocation in hematological malignancies. Transgenic or retrovirus-mediated bone marrow transplanted mouse models reveal the leukemogenesis of some NUP98-related fusion genes. We previously reported the fusion protein NUP98-IQ motif containing G (IQCG) i...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-016-0489-0
更新日期:2016-12-01 00:00:00
abstract::Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively stud...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-018-0646-8
更新日期:2018-08-01 00:00:00
abstract::China recently instituted a two-child policy in response to its aging population, declining workforce and demographic dividend, and the need to develop asocial economy. Additionally, women generally delay having a second child because of the overwhelming pressure in their lives. With the improvements in assisted ferti...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-017-0552-5
更新日期:2017-12-01 00:00:00
abstract::At present, clinical pathway has become one of the most important health care reform measures in many countries. In this study, the authors introduced basic concepts and explored the application of the clinical pathway of evidence-based Chinese medicine incorporated with the methodology from the concepts of management...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-011-0128-8
更新日期:2011-06-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) is an idiopathic group of reactive proliferative diseases linked to aberrant immunity, pathologically characterized by clonal proliferation of Langerhans cells. LCH rarely involves the thymus. We report a case of thymic LCH with diabetes insipidus as the first presentation, without ...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-013-0238-6
更新日期:2013-03-01 00:00:00
abstract::Real world study (RWS) has become a hotspot for clinical research. Data quality plays a vital role in research achievement and other clinical research fields. In this paper, the common quality problems in the RWS of traditional Chinese medicine are discussed, and a countermeasure is proposed. ...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-014-0351-1
更新日期:2014-09-01 00:00:00
abstract::Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomical regions of the upper aerodigestive tract (UADT), including the oral cavity, salivary glands, upper and lower jaw bones and facial skin; the nasal cavity, paranasal sinuses, pharynx, larynx and thyroid gland (although th...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-012-0213-7
更新日期:2012-12-01 00:00:00
abstract::This study aimed to evaluate the therapeutic effect of traditional Chinese medicine (TCM) by observing the changes in CD4 T-lymphocyte cell count of 110 cases with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) treated continuously with TCM for 84 months. Information of 110 HIV/AIDS patie...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-014-0363-x
更新日期:2014-09-01 00:00:00
abstract::This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute....
journal_title:Frontiers of medicine
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11684-016-0480-9
更新日期:2016-12-01 00:00:00
abstract::Assisted reproduction provides a wide spectrum of treatments and strategies addressing infertility. However, distinct groups of infertile patients with unexplained infertility, congenital disorders, and other complex cases pose a challenge in in vitro fertilization (IVF) practices. This special cohort of patients is a...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-019-0697-5
更新日期:2019-12-01 00:00:00
abstract::Traditional Chinese medicine (TCM) investigates the clinical diagnosis and treatment regularities in a typical schema of personalized medicine, which means that individualized patients with same diseases would obtain distinct diagnosis and optimal treatment from different TCM physicians. This principle has been recogn...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-014-0349-8
更新日期:2014-09-01 00:00:00
abstract::Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. T...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-014-0318-2
更新日期:2014-03-01 00:00:00
abstract::A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinicopathological...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-014-0305-7
更新日期:2014-03-01 00:00:00
abstract::This study evaluated the immunogenicity and protective immunity of a Hemophilus influenzae b (Hib) polysaccharide conjugate vaccine with the pneumococcal surface adhesin A (PsaA) protein carrier in young mice. The Hib polysaccharide was conjugated with the rPsaA protein carrier, which was produced using recombinant DN...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-016-0470-y
更新日期:2016-12-01 00:00:00
abstract::Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decad...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-013-0267-1
更新日期:2013-06-01 00:00:00
abstract::It is well documented that patients can show significant heterogeneous responses to treatments so the best treatment strategies may require adaptation over individuals and time. Recently, a number of new statistical methods have been developed to tackle the important problem of estimating personalized treatment rules ...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-013-0245-7
更新日期:2013-03-01 00:00:00
abstract::Orbital venous malformation (OVM) is a congenital vascular disease. As a common type of vascular malformation in the orbit, OVM may result in vision deterioration and cosmetic defect. Classification of orbital vascular malformations, especially OVMs, is carried out on the basis of different categories, such as angioge...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-018-0623-2
更新日期:2019-10-01 00:00:00
abstract::Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not only results in hemolysis and vasoocclusion but also precipitates inflammation, oxidative stress and chronic organ dysfunction. Oxidative stress is ...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-015-0375-1
更新日期:2015-03-01 00:00:00
abstract::Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release sy...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-019-0714-8
更新日期:2019-10-01 00:00:00
abstract::Foodborne disease is one of the most important public health issues worldwide. China faces various and unprecedented challenges in all aspects of the food chain. Data from laboratory-based foodborne disease surveillance systems from 2013 to 2016, as well as different regions and ages, can be found along with differenc...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-017-0608-6
更新日期:2018-02-01 00:00:00
abstract::This study aimed to explore the association of maternal depression with nutrient intake, growth, and development of preterm infants. A cohort study of 201 infants was conducted in Beijing. Based on the gestational age of an infant and status of the mother, the infants were divided into four groups: non-depression-full...
journal_title:Frontiers of medicine
pub_type: 杂志文章
doi:10.1007/s11684-017-0591-y
更新日期:2018-10-01 00:00:00
abstract::Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease. ...
journal_title:Frontiers of medicine
pub_type: 杂志文章,评审
doi:10.1007/s11684-013-0254-6
更新日期:2013-03-01 00:00:00