Abstract：
:Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpatients with liver dysfunction and 147 literature-reported cases of Heshouwu DILI were screened. A general algorithm indicated that only 22.5% (9/40) and 30.6% (45/147) of all hospitalization and literature case reports, respectively, demonstrate the high probability of DILI causality of Heshouwu. By contrast, 95% (19/20) of all cases prospectively investigated by pharmacognosy, phytochemistry, and metabolomic tests exhibited highly probable causality, including a patient who was previously incorrectly attributed and a case that was excluded from Heshouwu causality by pharmacognostic evidence. Toxin (heavy metals, pesticides, and mycotoxins) contamination was also excluded from Heshouwu DILI causality. The objectivity of these screening methods for Heshouwu DILI diagnosis addresses safety concerns regarding stilbene-containing herbal medicines and dietary supplements.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Wang J,Ma Z,Niu M,Zhu Y,Liang Q,Zhao Y,Song J,Bai Z,Zhang Y,Zhang P,Li N,Meng Y,Li Q,Qin L,Teng G,Cao J,Li B,Chen S,Li Y,Zou Z,Zhou H,Xiao Xdoi
10.1007/s11684-015-0417-8subject
Has Abstractpub_date
2015-12-01 00:00:00pages
457-67issue
4eissn
2095-0217issn
2095-0225pii
10.1007/s11684-015-0417-8journal_volume
9pub_type
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