Abstract：
:An effective eradication therapy of Helicobacter pylori (H. pylori) should be used for the first time. In this study, we assessed whether tailored therapy based on antibiotic susceptibility testing is more effective than traditional therapy. We also evaluated the factors that cause treatment failure in high-resistance areas. For this multicenter trial, we recruited 467 H. pylori-positive patients. The patients were randomly assigned to receive tailored triple therapy (TATT), tailored bismuth-containing quadruple therapy (TABQT), or traditional bismuth-containing quadruple therapy (TRBQT). For the TATT and TABQT groups, antibiotic selection proceeded via susceptibility testing using an agar-dilution test. The patients in the TRBQT group were given amoxicillin, clarithromycin, esomeprazole, and bismuth. Successful eradication was defined as a negative 13C-urea breath test at least eight weeks after the treatment ended. Susceptibility testing was conducted using an agar-dilution test. The eradication rate was examined via intention-to-treat (ITT) and per-protocol (PP) analyses. The clarithromycin, levofloxacin, and metronidazole resistance rates were 26.12%, 28.69%, and 96.79%, respectively. Resistance against amoxicillin and furazolidone was rare. The eradication rates for TATT, TRBQT, and TABQT were 67.32%, 63.69%, and 85.99% in the ITT analysis (P 0.001) and 74.64%, 68.49%, and 91.22% in the PP analysis (P 0.001), respectively. The efficacy of TABQT was affected by clarithromycin resistance, and bismuth exerted a direct influence on TATT failure. TABQT was the most efficacious regimen for use in high-resistance regions, especially among clarithromycin-susceptible patients.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Pan J,Shi Z,Lin D,Yang N,Meng F,Lin L,Jin Z,Zhou Q,Wu J,Zhang J,Li Ydoi
10.1007/s11684-019-0706-8subject
Has Abstractpub_date
2020-02-01 00:00:00pages
43-50issue
1eissn
2095-0217issn
2095-0225pii
10.1007/s11684-019-0706-8journal_volume
14pub_type
杂志文章,多中心研究,随机对照试验abstract：:This study aimed to evaluate the therapeutic effect of traditional Chinese medicine (TCM) by observing the changes in CD4 T-lymphocyte cell count of 110 cases with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) treated continuously with TCM for 84 months. Information of 110 HIV/AIDS patie...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-014-0363-x
更新日期：2014-09-01 00:00:00
abstract：:Swallowing multiple magnets is not uncommon worldwide and it frequently leads to serious consequences. However, most patients fail to receive timely and correct diagnosis and treatment. A literature search was performed to establish an algorithm for these accidents by the authors to identify relevant articles publishe...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0207-5
更新日期：2012-09-01 00:00:00
abstract：:The mammalian MOF (male absent on the first), a member of the MYST (MOZ, YBF2, SAS2, and Tip60) family of histone acetyltransferases (HATs), is the major enzyme that catalyzes the acetylation of histone H4 on lysine 16. Acetylation of K16 is a prevalent mark associated with chromatin decondensation. MOF has recently b...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-014-0314-6
更新日期：2014-03-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However,...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-017-0546-3
更新日期：2017-12-01 00:00:00
abstract：:Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomical regions of the upper aerodigestive tract (UADT), including the oral cavity, salivary glands, upper and lower jaw bones and facial skin; the nasal cavity, paranasal sinuses, pharynx, larynx and thyroid gland (although th...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0213-7
更新日期：2012-12-01 00:00:00
abstract：:Although many drugs and therapeutic strategies have been developed for rheumatoid arthritis (RA) treatment, numerous patients with RA fail to respond to currently available agents. In this review, we provide an overview of the complexity of this autoimmune disease by showing the rapidly increasing number of genes asso...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0659-3
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abstract：:This study evaluated the immunogenicity and protective immunity of a Hemophilus influenzae b (Hib) polysaccharide conjugate vaccine with the pneumococcal surface adhesin A (PsaA) protein carrier in young mice. The Hib polysaccharide was conjugated with the rPsaA protein carrier, which was produced using recombinant DN...
journal_title：Frontiers of medicine
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
abstract：:Foodborne disease is one of the most important public health issues worldwide. China faces various and unprecedented challenges in all aspects of the food chain. Data from laboratory-based foodborne disease surveillance systems from 2013 to 2016, as well as different regions and ages, can be found along with differenc...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-017-0608-6
更新日期：2018-02-01 00:00:00
abstract：:Hearing impairment is considered as the most prevalent impairment worldwide. Almost 600 million people in the world suffer from mild or moderate hearing impairment, an estimated 10% of the human population. Genetic factors play an important role in the pathogenesis of this disorder. Hereditary hearing loss is divided ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-016-0449-8
更新日期：2016-06-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-013-0254-6
更新日期：2013-03-01 00:00:00
abstract：:Congenital heart disease (CHD) is the most common birth defect worldwide. Long non-coding RNAs (lncRNAs) have been implicated in many diseases. However, their involvement in CHD is not well understood. This study aimed to investigate the role of dysregulated lncRNAs in CHD. We used Gene Expression Omnibus data mining,...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0778-5
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-016-0458-7
更新日期：2016-09-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-015-0421-z
更新日期：2015-12-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0805-6
更新日期：2020-12-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-013-0267-1
更新日期：2013-06-01 00:00:00
abstract：:Langerhans cell histiocytosis (LCH) is an idiopathic group of reactive proliferative diseases linked to aberrant immunity, pathologically characterized by clonal proliferation of Langerhans cells. LCH rarely involves the thymus. We report a case of thymic LCH with diabetes insipidus as the first presentation, without ...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-013-0238-6
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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journal_title：Frontiers of medicine
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-015-0417-8
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