Abstract：
:The prevalence of the risk factors and the risk of cardiac failure are both increasing in China. This might be the consequence of the changes of the life conditions (emigration to the urban areas, changes in the diet and life style, lack of physical exercise, etc.). The wide range of clinical presentations of cardiac failure (acute or chronic) and of therapeutic approaches (medical or surgical) makes necessary the integration within the same structure of the various experts involved in the diagnosis and the treatment of cardiac diseases. Technologic and human resources required to offer all the options represent a multifaceted commitment which should be focused optimally in dedicated centers. In these centers, collaboration should replace competition between the medical and the surgical cardiac specialists. Development of team work should permit to optimize the cost efficacy of the treatments. Most of all, such a structure will facilitate the translation of innovative therapies between the research centers and clinical facilities.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Loisance Ddoi
10.1007/s11684-011-0106-1subject
Has Abstractpub_date
2011-03-01 00:00:00pages
20-5issue
1eissn
2095-0217issn
2095-0225journal_volume
5pub_type
杂志文章,评审abstract：:Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and p...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-015-0421-z
更新日期：2015-12-01 00:00:00
abstract：:Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of components involved in the cell cycle machinery. Here, we report that cyclin-dependent kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemo...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-016-0478-3
更新日期：2016-12-01 00:00:00
abstract：:China recently instituted a two-child policy in response to its aging population, declining workforce and demographic dividend, and the need to develop asocial economy. Additionally, women generally delay having a second child because of the overwhelming pressure in their lives. With the improvements in assisted ferti...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0552-5
更新日期：2017-12-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However,...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-017-0546-3
更新日期：2017-12-01 00:00:00
abstract：:Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular ...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0522-y
更新日期：2017-09-01 00:00:00
abstract：:The mammalian MOF (male absent on the first), a member of the MYST (MOZ, YBF2, SAS2, and Tip60) family of histone acetyltransferases (HATs), is the major enzyme that catalyzes the acetylation of histone H4 on lysine 16. Acetylation of K16 is a prevalent mark associated with chromatin decondensation. MOF has recently b...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-014-0314-6
更新日期：2014-03-01 00:00:00
abstract：:Swallowing multiple magnets is not uncommon worldwide and it frequently leads to serious consequences. However, most patients fail to receive timely and correct diagnosis and treatment. A literature search was performed to establish an algorithm for these accidents by the authors to identify relevant articles publishe...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0207-5
更新日期：2012-09-01 00:00:00
abstract：:Our preliminary studies demonstrated that Metacavir has potential to become a new anti-HBV agent. The main targets of the toxic effects of Metacavir, in rhesus monkeys, were gastrointestinal tracts, liver, blood, and kidneys, which were not related to mitochondrial effects. In this study, the maternal toxicity, embryo...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-015-0376-0
更新日期：2015-03-01 00:00:00
abstract：:Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafis...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-017-0507-x
更新日期：2017-06-01 00:00:00
abstract：:γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit li...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-017-0584-x
更新日期：2018-06-01 00:00:00
abstract：:Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. T...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-014-0318-2
更新日期：2014-03-01 00:00:00
abstract：:Single incision laparoscopic surgery (SILS) is a novel minimally invasive surgical technique that is gaining popularity around the world. One of the most commonly performed procedures is single incision laparoscopic cholecystectomy (SILC). Most reported techniques utilize special purpose-made access port and articulat...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-011-0151-9
更新日期：2011-09-01 00:00:00
abstract：:Laparoscopic liver surgery has been increasingly used for the treatment of pediatric liver diseases over the past decade due to the development of special laparoscopic instruments and improvements in the technique. A number of factors are considered when electing to undergo the surgical process, including age, type of...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-011-0165-3
更新日期：2011-12-01 00:00:00
abstract：:Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%-60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April ...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0603-y
更新日期：2019-02-01 00:00:00
abstract：:Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomical regions of the upper aerodigestive tract (UADT), including the oral cavity, salivary glands, upper and lower jaw bones and facial skin; the nasal cavity, paranasal sinuses, pharynx, larynx and thyroid gland (although th...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0213-7
更新日期：2012-12-01 00:00:00
abstract：:Pulmonary hypertension (PH), as a complication of bronchiectasis, is associated with increased mortality. However, hemodynamic characteristics and the efficacy of pulmonary arterial hypertension (PAH) therapies in patients with bronchiectasis and PH remain unknown. Patients with bilateral bronchiectasis and concurrent...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-016-0461-z
更新日期：2016-09-01 00:00:00
abstract：:Congenital heart disease (CHD) is the most common birth defect worldwide. Long non-coding RNAs (lncRNAs) have been implicated in many diseases. However, their involvement in CHD is not well understood. This study aimed to investigate the role of dysregulated lncRNAs in CHD. We used Gene Expression Omnibus data mining,...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0778-5
更新日期：2020-08-19 00:00:00
abstract：:This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirus disease 2019 (COVID-19). In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVI...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0813-6
更新日期：2020-12-01 00:00:00
abstract：:Recent evidences suggested that cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5) inhibitor represents an important therapeutic target for cardiovascular diseases. Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failure, is unknown. The purpose of this...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-014-0378-3
更新日期：2014-12-01 00:00:00
abstract：:S100A9, a calcium-binding protein, participates in the inflammatory process and development of various tumors, thus attracting much attention in the field of cancer biology. This study aimed to investigate the regulatory mechanism of S100A9 and its function involvement in APL. We used real-time quantitative PCR to det...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-016-0469-4
更新日期：2017-03-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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更新日期：2014-09-01 00:00:00
abstract：:Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0533-8
更新日期：2018-04-01 00:00:00
abstract：:Autoimmune diseases (ADs) increase the risk of non-Hodgkin's lymphoma and contribute to poor prognosis of patients. However, the association between immunologic markers and clinical outcome has rarely been investigated. This study aims to analyze the prognostic value of pretreatment immunologic markers in newly diagno...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-019-0680-1
更新日期：2019-02-01 00:00:00
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journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0537-4
更新日期：2017-12-01 00:00:00
abstract：:It is well documented that patients can show significant heterogeneous responses to treatments so the best treatment strategies may require adaptation over individuals and time. Recently, a number of new statistical methods have been developed to tackle the important problem of estimating personalized treatment rules ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-013-0245-7
更新日期：2013-03-01 00:00:00
abstract：:The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determination of a protein's half-life is dependent on its N-terminal residue. The N-terminal residue serves as the degradation signal of a protein and thus called N-degron. N-degron can be recognized and modifed by several steps...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-016-0458-7
更新日期：2016-09-01 00:00:00
abstract：:Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively stud...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0646-8
更新日期：2018-08-01 00:00:00
abstract：:Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies a...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-018-0647-7
更新日期：2018-08-01 00:00:00
abstract：:The ability of tumor cells to sustain continuous proliferation is one of the major characteristics of cancer. The activation of oncogenes and the mutation or inactivation of tumor suppressor genes ensure the rapid proliferation of tumor cells. The PI3K-Akt-mTOR axis is one of the most frequently modified signaling pat...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0805-6
更新日期：2020-12-01 00:00:00
