Sepsis biomarkers: an omics perspective.

abstract：:Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafis...

journal_title：Frontiers of medicine

authors： Yang Q,Sun P,Chen S,Li H,Chen F

更新日期：2017-06-01 00:00:00

abstract：:It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2). Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infection. However, some patients also exhibit no...

journal_title：Frontiers of medicine

authors： Zou X,Chen K,Zou J,Han P,Hao J,Han Z

更新日期：2020-04-01 00:00:00

abstract：:The rationale for the antibiotic treatment of viral community-acquired pneumonia (CAP) in adults was analyzed to develop a clinical reference standard for this condition. Clinical data from 166 patients diagnosed with viral pneumonia across 14 hospitals in Beijing from November 2010 to December 2017 were collected. Th...

journal_title：Frontiers of medicine

authors： Jiang R,Han B,Dou C,Zhou F,Cao B,Li X

更新日期：2020-06-13 00:00:00

abstract：:An effective eradication therapy of Helicobacter pylori (H. pylori) should be used for the first time. In this study, we assessed whether tailored therapy based on antibiotic susceptibility testing is more effective than traditional therapy. We also evaluated the factors that cause treatment failure in high-resistance...

journal_title：Frontiers of medicine

authors： Pan J,Shi Z,Lin D,Yang N,Meng F,Lin L,Jin Z,Zhou Q,Wu J,Zhang J,Li Y

更新日期：2020-02-01 00:00:00

abstract：:Laparoscopic liver surgery has been increasingly used for the treatment of pediatric liver diseases over the past decade due to the development of special laparoscopic instruments and improvements in the technique. A number of factors are considered when electing to undergo the surgical process, including age, type of...

journal_title：Frontiers of medicine

authors： Wei J,Feng J

更新日期：2011-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the mol...

journal_title：Frontiers of medicine

authors： Gao Q,Shi Y,Wang X,Zhou J,Qiu S,Fan J

更新日期：2012-06-01 00:00:00

abstract：:NUP98 fuses with approximately 34 different partner genes via translocation in hematological malignancies. Transgenic or retrovirus-mediated bone marrow transplanted mouse models reveal the leukemogenesis of some NUP98-related fusion genes. We previously reported the fusion protein NUP98-IQ motif containing G (IQCG) i...

journal_title：Frontiers of medicine

authors： Pan M,Zhang Q,Liu P,Huang J,Wang Y,Chen S

更新日期：2016-12-01 00:00:00

abstract：:The prevalence of the risk factors and the risk of cardiac failure are both increasing in China. This might be the consequence of the changes of the life conditions (emigration to the urban areas, changes in the diet and life style, lack of physical exercise, etc.). The wide range of clinical presentations of cardiac ...

journal_title：Frontiers of medicine

authors： Loisance D

更新日期：2011-03-01 00:00:00

abstract：:Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknown. By integrating a large-scale genotype data of 15 581 lung adenocarcinoma (AD) cases, 8350 squamous cell car...

journal_title：Frontiers of medicine

authors： Qin N,Li Y,Wang C,Zhu M,Dai J,Hong T,Albanes D,Lam S,Tardon A,Chen C,Goodman G,Bojesen SE,Landi MT,Johansson M,Risch A,Wichmann HE,Bickeboller H,Rennert G,Arnold S,Brennan P,Field JK,Shete S,Le Marchand L,Me

更新日期：2020-09-05 00:00:00

abstract：:Orbital venous malformation (OVM) is a congenital vascular disease. As a common type of vascular malformation in the orbit, OVM may result in vision deterioration and cosmetic defect. Classification of orbital vascular malformations, especially OVMs, is carried out on the basis of different categories, such as angioge...

journal_title：Frontiers of medicine

authors： Li T,Jia R,Fan X

更新日期：2019-10-01 00:00:00

abstract：:We observed the effect of Dianxianning, which was used as additive treatment to treat 206 epilepsy patients, on the epilepsy seizure rate. Based on a multicenter, prospective, randomized, and controlled clinical trial design, we used the seizure rate of epilepsy as the main index. For the treatment group comprising 13...

journal_title：Frontiers of medicine

authors： He L,Wen T,Yan S,Li R,Liu Z,Ren H,Liu J,Zhang F,Wu J,Liu J

更新日期：2011-06-01 00:00:00

abstract：:Pulmonary hypertension (PH), as a complication of bronchiectasis, is associated with increased mortality. However, hemodynamic characteristics and the efficacy of pulmonary arterial hypertension (PAH) therapies in patients with bronchiectasis and PH remain unknown. Patients with bilateral bronchiectasis and concurrent...

journal_title：Frontiers of medicine

authors： Wang L,Jiang S,Shi J,Gong S,Zhao Q,Jiang R,Yuan P,Pudasaini B,He J,Jing Z,Liu J

更新日期：2016-09-01 00:00:00

abstract：:This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirus disease 2019 (COVID-19). In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVI...

journal_title：Frontiers of medicine

authors： Chen G,Su W,Yang J,Luo D,Xia P,Jia W,Li X,Wang C,Lang S,Meng Q,Zhang Y,Ke Y,Fan A,Yang S,Zheng Y,Fan X,Qiao J,Lian F,Wei L,Tong X

更新日期：2020-12-01 00:00:00

abstract：:Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%-60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April ...

journal_title：Frontiers of medicine

authors： Alfaraj SH,Al-Tawfiq JA,Altuwaijri TA,Memish ZA

更新日期：2019-02-01 00:00:00

abstract：:As a promising method in artificial intelligence, deep learning has been proven successful in several domains ranging from acoustics and images to natural language processing. With medical imaging becoming an important part of disease screening and diagnosis, deep learning-based approaches have emerged as powerful tec...

journal_title：Frontiers of medicine

authors： Ma J,Song Y,Tian X,Hua Y,Zhang R,Wu J

更新日期：2020-08-01 00:00:00

abstract：:Congenital heart disease (CHD) is the most common birth defect worldwide. Long non-coding RNAs (lncRNAs) have been implicated in many diseases. However, their involvement in CHD is not well understood. This study aimed to investigate the role of dysregulated lncRNAs in CHD. We used Gene Expression Omnibus data mining,...

journal_title：Frontiers of medicine

authors： Ma J,Chen S,Hao L,Sheng W,Chen W,Ma X,Zhang B,Ma D,Huang G

更新日期：2020-08-19 00:00:00

abstract：:Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies a...

journal_title：Frontiers of medicine

authors： Wang L,Bernards R

更新日期：2018-08-01 00:00:00

abstract：:Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man's sedentary lifestyle, low-physical activity, obesity, and some nonmodifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at h...

journal_title：Frontiers of medicine

authors： Pan J,Jia W

更新日期：2018-12-01 00:00:00

abstract：:Assisted reproduction provides a wide spectrum of treatments and strategies addressing infertility. However, distinct groups of infertile patients with unexplained infertility, congenital disorders, and other complex cases pose a challenge in in vitro fertilization (IVF) practices. This special cohort of patients is a...

journal_title：Frontiers of medicine

authors： Simopoulou M,Sfakianoudis K,Tsioulou P,Rapani A,Giannelou P,Kiriakopoulos N,Pantou A,Vlahos N,Anifandis G,Bolaris S,Pantos K,Koutsilieris M

更新日期：2019-12-01 00:00:00

abstract：:Disorders of sex development (DSD) are a group of rare complex clinical syndromes with multiple etiologies. Distinguishing the various causes of DSD is quite difficult in clinical practice, even for senior general physicians because of the similar and atypical clinical manifestations of these conditions. In addition, ...

journal_title：Frontiers of medicine

authors： Ning D,Zhang Z,Qiu K,Lu L,Zhang Q,Zhu Y,Wang R

更新日期：2020-08-01 00:00:00

abstract：:This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute....

journal_title：Frontiers of medicine

authors： Ma Y,Zhang N,Wu S,Huang H,Cao Y

更新日期：2016-12-01 00:00:00

abstract：:Growing evidence suggests that somatic hypermutational status and programmed cell death-1 overexpression are potential predictive biomarkers indicating treatment benefits from immunotherapy using immune checkpoint inhibitors. However, biomarker-matched trials are still limited, and many of the genomic alterations rema...

journal_title：Frontiers of medicine

authors： Chen A,Zhang S,Li J,Ji C,Chen J,Li C

更新日期：2020-02-01 00:00:00

abstract：:Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, rece...

journal_title：Frontiers of medicine

authors： Shang B,Cao Z,Zhou Q

更新日期：2012-03-01 00:00:00

abstract：:Alternative splicing plays a fundamental role in the development and physiological function of the inner ear. Inner-ear-specific gene splicing is necessary to establish the identity and maintain the function of the inner ear. For example, exon 68 of Cadherin 23 (Cdh23) gene is subject to inner-ear-specific alternative...

journal_title：Frontiers of medicine

authors： Wang Y,Liu Y,Nie H,Ma X,Xu Z

更新日期：2016-09-01 00:00:00

abstract：:Autoimmune diseases (ADs) increase the risk of non-Hodgkin's lymphoma and contribute to poor prognosis of patients. However, the association between immunologic markers and clinical outcome has rarely been investigated. This study aims to analyze the prognostic value of pretreatment immunologic markers in newly diagno...

journal_title：Frontiers of medicine

authors： Cao Y,Liu Z,Wu W,Qian Y,Shi Q,Shen R,Ouyang B,Xu P,Cheng S,Ye J,Lu Y,Wang C,Yang C,Wang L,Zhao W

更新日期：2019-02-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post...

journal_title：Frontiers of medicine

authors： Liu F,Liu L,Zheng F,Tang X,Bao Y,Zuo Y

更新日期：2018-04-01 00:00:00

abstract：:This study aimed to explore the association of maternal depression with nutrient intake, growth, and development of preterm infants. A cohort study of 201 infants was conducted in Beijing. Based on the gestational age of an infant and status of the mother, the infants were divided into four groups: non-depression-full...

journal_title：Frontiers of medicine

authors： Wang H,Zhou H,Zhang Y,Wang Y,Sun J

更新日期：2018-10-01 00:00:00

abstract：:Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively stud...

journal_title：Frontiers of medicine

authors： Miyazono K,Katsuno Y,Koinuma D,Ehata S,Morikawa M

更新日期：2018-08-01 00:00:00

abstract：:This study aims to investigate the effect of non-transecting anastomotic urethroplasty for treatment of posterior urethral stricture. A total of 23 patients with traumatic posterior urethral stricture were enrolled and then divided into two groups. In one group, 12 patients underwent non-transecting anastomotic urethr...

journal_title：Frontiers of medicine

authors： Le W,Li C,Zhang J,Wu D,Liu B

更新日期：2017-06-01 00:00:00

abstract：:Zinc (Zn) is an essential mineral that is required for various cellular functions. Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome, diabetes and diabetic complications. The associations of Zn with metabolic syndrome, diabetes and diabetic complications, thus, stem from the multiple ...

journal_title：Frontiers of medicine

authors： Miao X,Sun W,Fu Y,Miao L,Cai L

更新日期：2013-03-01 00:00:00