Abstract：
:Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the molecular stratification of HCCs for diagnosis, prognosis, and therapeutic decision-making. To date, the molecular classification of HCCs has been carried out through transcriptomic, genetic and epigenetic profiling of tumors. Such research has led to identification of several potential molecular targets in HCC, and subsequently, development of novel systemic agents for the treatment of HCC has begun in earnest. In this article, we review the current knowledge of the molecular pathogenesis of HCC and outline potential areas for application of this knowledge in a clinical setting. As a typical virus and inflammation-associated cancer, both host immune response and tumor microenvironment have crucial roles in HCC pathogenesis. In addition, we examine the potential of immunotherapy and strategies targeting various components of the tumor microenvironment, as well as novel molecular and cellular targets in HCC such as cancer stem cells.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Gao Q,Shi Y,Wang X,Zhou J,Qiu S,Fan Jdoi
10.1007/s11684-012-0193-7subject
Has Abstractpub_date
2012-06-01 00:00:00pages
122-33issue
2eissn
2095-0217issn
2095-0225journal_volume
6pub_type
杂志文章,评审abstract：:Although many drugs and therapeutic strategies have been developed for rheumatoid arthritis (RA) treatment, numerous patients with RA fail to respond to currently available agents. In this review, we provide an overview of the complexity of this autoimmune disease by showing the rapidly increasing number of genes asso...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0659-3
更新日期：2019-08-01 00:00:00
abstract：:To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide. The prognosis of GC is not always satisfactory because of late diagnosis. Scholars are keen on discovering novel accurate and economical biomarkers in body liquids for GC screening to detect and evaluate the lesion before ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-016-0493-4
更新日期：2017-03-01 00:00:00
abstract：:The prevalence of the risk factors and the risk of cardiac failure are both increasing in China. This might be the consequence of the changes of the life conditions (emigration to the urban areas, changes in the diet and life style, lack of physical exercise, etc.). The wide range of clinical presentations of cardiac ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-011-0106-1
更新日期：2011-03-01 00:00:00
abstract：:The ability of tumor cells to sustain continuous proliferation is one of the major characteristics of cancer. The activation of oncogenes and the mutation or inactivation of tumor suppressor genes ensure the rapid proliferation of tumor cells. The PI3K-Akt-mTOR axis is one of the most frequently modified signaling pat...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0805-6
更新日期：2020-12-01 00:00:00
abstract：:Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also de...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0530-y
更新日期：2017-06-01 00:00:00
abstract：:Orbital venous malformation (OVM) is a congenital vascular disease. As a common type of vascular malformation in the orbit, OVM may result in vision deterioration and cosmetic defect. Classification of orbital vascular malformations, especially OVMs, is carried out on the basis of different categories, such as angioge...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0623-2
更新日期：2019-10-01 00:00:00
abstract：:Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively stud...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0646-8
更新日期：2018-08-01 00:00:00
abstract：:Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, rece...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0176-8
更新日期：2012-03-01 00:00:00
abstract：:Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothel...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-011-0118-x
更新日期：2011-03-01 00:00:00
abstract：:Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, th...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0215-5
更新日期：2012-09-01 00:00:00
abstract：:Laparoscopic liver surgery has been increasingly used for the treatment of pediatric liver diseases over the past decade due to the development of special laparoscopic instruments and improvements in the technique. A number of factors are considered when electing to undergo the surgical process, including age, type of...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-011-0165-3
更新日期：2011-12-01 00:00:00
abstract：:This study aimed to evaluate the efficacy of comprehensive therapy based on traditional Chinese medicine (TCM) patterns on older patients with chronic obstructive pulmonary disease (COPD) through a fourcenter, open-label, randomized controlled trial. Patients were divided into the trial group treated using conventiona...
journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s11684-014-0360-0
更新日期：2014-09-01 00:00:00
abstract：:The inhibitory environment that surrounds the lesion site and the lack of intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) impede the regrowth of injured axons and thereby the reestablishment of neural circuits required for functional recovery after spinal cord injuries (SCI). To cir...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0642-z
更新日期：2019-04-01 00:00:00
abstract：:Single incision laparoscopic surgery (SILS) is a novel minimally invasive surgical technique that is gaining popularity around the world. One of the most commonly performed procedures is single incision laparoscopic cholecystectomy (SILC). Most reported techniques utilize special purpose-made access port and articulat...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-011-0151-9
更新日期：2011-09-01 00:00:00
abstract：:Alternative splicing plays a fundamental role in the development and physiological function of the inner ear. Inner-ear-specific gene splicing is necessary to establish the identity and maintain the function of the inner ear. For example, exon 68 of Cadherin 23 (Cdh23) gene is subject to inner-ear-specific alternative...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-016-0454-y
更新日期：2016-09-01 00:00:00
abstract：:Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decad...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-013-0267-1
更新日期：2013-06-01 00:00:00
abstract：:Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular ...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0522-y
更新日期：2017-09-01 00:00:00
abstract：:As a promising method in artificial intelligence, deep learning has been proven successful in several domains ranging from acoustics and images to natural language processing. With medical imaging becoming an important part of disease screening and diagnosis, deep learning-based approaches have emerged as powerful tec...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-019-0726-4
更新日期：2020-08-01 00:00:00
abstract：:Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpat...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-015-0417-8
更新日期：2015-12-01 00:00:00
abstract：:An effective eradication therapy of Helicobacter pylori (H. pylori) should be used for the first time. In this study, we assessed whether tailored therapy based on antibiotic susceptibility testing is more effective than traditional therapy. We also evaluated the factors that cause treatment failure in high-resistance...
journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0207-5
更新日期：2012-09-01 00:00:00
abstract：:Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of components involved in the cell cycle machinery. Here, we report that cyclin-dependent kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemo...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-016-0478-3
更新日期：2016-12-01 00:00:00
abstract：:γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit li...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-017-0584-x
更新日期：2018-06-01 00:00:00
abstract：:Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknown. By integrating a large-scale genotype data of 15 581 lung adenocarcinoma (AD) cases, 8350 squamous cell car...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0779-4
更新日期：2020-09-05 00:00:00
abstract：:A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinicopathological...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-014-0305-7
更新日期：2014-03-01 00:00:00
abstract：:This study aimed to explore the association of maternal depression with nutrient intake, growth, and development of preterm infants. A cohort study of 201 infants was conducted in Beijing. Based on the gestational age of an infant and status of the mother, the infants were divided into four groups: non-depression-full...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0591-y
更新日期：2018-10-01 00:00:00
abstract：:Hearing impairment is considered as the most prevalent impairment worldwide. Almost 600 million people in the world suffer from mild or moderate hearing impairment, an estimated 10% of the human population. Genetic factors play an important role in the pathogenesis of this disorder. Hereditary hearing loss is divided ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-016-0449-8
更新日期：2016-06-01 00:00:00
abstract：:S100A9, a calcium-binding protein, participates in the inflammatory process and development of various tumors, thus attracting much attention in the field of cancer biology. This study aimed to investigate the regulatory mechanism of S100A9 and its function involvement in APL. We used real-time quantitative PCR to det...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-016-0469-4
更新日期：2017-03-01 00:00:00
abstract：:At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-014-0343-1
更新日期：2015-03-01 00:00:00
abstract：:Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. T...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-014-0318-2
更新日期：2014-03-01 00:00:00
