Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness.

abstract：:The COVID-19 caused by a novel strain of coronavirus has been spreading rapidly since its occurrence in December 2019. It is highly communicable through human-to-human transmission. China has been making unprecedented efforts in treating the confirmed cases, identifying and isolating their close contacts and suspected...

journal_title：Frontiers of medicine

authors： Gong F,Xiong Y,Xiao J,Lin L,Liu X,Wang D,Li X

更新日期：2020-04-01 00:00:00

abstract：:This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirus disease 2019 (COVID-19). In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVI...

journal_title：Frontiers of medicine

authors： Chen G,Su W,Yang J,Luo D,Xia P,Jia W,Li X,Wang C,Lang S,Meng Q,Zhang Y,Ke Y,Fan A,Yang S,Zheng Y,Fan X,Qiao J,Lian F,Wei L,Tong X

更新日期：2020-12-01 00:00:00

abstract：:Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, rece...

journal_title：Frontiers of medicine

authors： Shang B,Cao Z,Zhou Q

更新日期：2012-03-01 00:00:00

abstract：:China recently instituted a two-child policy in response to its aging population, declining workforce and demographic dividend, and the need to develop asocial economy. Additionally, women generally delay having a second child because of the overwhelming pressure in their lives. With the improvements in assisted ferti...

journal_title：Frontiers of medicine

authors： Li Q,Deng D

更新日期：2017-12-01 00:00:00

abstract：:A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n = 25) or 20 mg (n = 38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in splee...

journal_title：Frontiers of medicine

authors： Du X,Zhou D

更新日期：2016-12-01 00:00:00

abstract：:Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of components involved in the cell cycle machinery. Here, we report that cyclin-dependent kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemo...

journal_title：Frontiers of medicine

authors： Wang X,Tan Y,Li Y,Li J,Jin W,Wang K

更新日期：2016-12-01 00:00:00

abstract：:Electroacupuncture (EA) at Zhongliao (BL33) can improve the symptoms of overactive bladder (OAB), such as urinary frequency, urgency, and incontinence. However, its performance compared with other acupoints remains unclear. This study investigated the effects of EA at BL33 with deep needling on rats with OAB by detect...

journal_title：Frontiers of medicine

authors： Yang L,Wang Y,Mo Q,Liu Z

更新日期：2017-03-01 00:00:00

abstract：:At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms...

journal_title：Frontiers of medicine

authors： Wang Z,Hu Z,Wu J,Ji F,Wang H,Lai Y,Gao X,Ning Y,Zhang C,Li Z,Liang W,Liu J

更新日期：2015-03-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is an idiopathic group of reactive proliferative diseases linked to aberrant immunity, pathologically characterized by clonal proliferation of Langerhans cells. LCH rarely involves the thymus. We report a case of thymic LCH with diabetes insipidus as the first presentation, without ...

journal_title：Frontiers of medicine

authors： Chen X,Huang X,Qiu Y,Chen H,Fu Y,Li X

更新日期：2013-03-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post...

journal_title：Frontiers of medicine

authors： Liu F,Liu L,Zheng F,Tang X,Bao Y,Zuo Y

更新日期：2018-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However,...

journal_title：Frontiers of medicine

authors： Yu M,Li Z

更新日期：2017-12-01 00:00:00

abstract：:Single incision laparoscopic surgery (SILS) is a novel minimally invasive surgical technique that is gaining popularity around the world. One of the most commonly performed procedures is single incision laparoscopic cholecystectomy (SILC). Most reported techniques utilize special purpose-made access port and articulat...

journal_title：Frontiers of medicine

authors： Cui H

更新日期：2011-09-01 00:00:00

abstract：:We observed the effect of Dianxianning, which was used as additive treatment to treat 206 epilepsy patients, on the epilepsy seizure rate. Based on a multicenter, prospective, randomized, and controlled clinical trial design, we used the seizure rate of epilepsy as the main index. For the treatment group comprising 13...

journal_title：Frontiers of medicine

authors： He L,Wen T,Yan S,Li R,Liu Z,Ren H,Liu J,Zhang F,Wu J,Liu J

更新日期：2011-06-01 00:00:00

abstract：:Persistent vegetative state (PVS) is a clinical condition wherein the cerebral cortex loses its function although brain stem function remains relatively intact. It has high mortality and disability rates. Although treatment for PVS is extensively studied in developed countries, little breakthrough has been made. In Ch...

journal_title：Frontiers of medicine

authors： Song H,Chen X,Yu Y,Zhang L

更新日期：2018-06-01 00:00:00

abstract：:This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson's disease (PD) reflected by fractional anisotropy (FA), addressing clinical profiles and methodology-related heterogeneity. Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusio...

journal_title：Frontiers of medicine

authors： Suo X,Lei D,Li W,Li L,Dai J,Wang S,Li N,Cheng L,Peng R,Kemp GJ,Gong Q

更新日期：2020-05-26 00:00:00

abstract：:The prevalence of the risk factors and the risk of cardiac failure are both increasing in China. This might be the consequence of the changes of the life conditions (emigration to the urban areas, changes in the diet and life style, lack of physical exercise, etc.). The wide range of clinical presentations of cardiac ...

journal_title：Frontiers of medicine

authors： Loisance D

更新日期：2011-03-01 00:00:00

abstract：:Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpat...

journal_title：Frontiers of medicine

authors： Wang J,Ma Z,Niu M,Zhu Y,Liang Q,Zhao Y,Song J,Bai Z,Zhang Y,Zhang P,Li N,Meng Y,Li Q,Qin L,Teng G,Cao J,Li B,Chen S,Li Y,Zou Z,Zhou H,Xiao X

更新日期：2015-12-01 00:00:00

abstract：:Our preliminary studies demonstrated that Metacavir has potential to become a new anti-HBV agent. The main targets of the toxic effects of Metacavir, in rhesus monkeys, were gastrointestinal tracts, liver, blood, and kidneys, which were not related to mitochondrial effects. In this study, the maternal toxicity, embryo...

journal_title：Frontiers of medicine

authors： Luo Q,Chen Z,Cheng A,Wang M,Fang J,Peng X,Tang L

更新日期：2015-03-01 00:00:00

abstract：:Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, th...

journal_title：Frontiers of medicine

authors： Wang JH

更新日期：2012-09-01 00:00:00

abstract：:Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomical regions of the upper aerodigestive tract (UADT), including the oral cavity, salivary glands, upper and lower jaw bones and facial skin; the nasal cavity, paranasal sinuses, pharynx, larynx and thyroid gland (although th...

journal_title：Frontiers of medicine

authors： Gao J,Panizza B,Johnson NW,Coman S,Clough AR

更新日期：2012-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the mol...

journal_title：Frontiers of medicine

authors： Gao Q,Shi Y,Wang X,Zhou J,Qiu S,Fan J

更新日期：2012-06-01 00:00:00

abstract：:The teeth are highly differentiated chewing organs formed by the development of tooth germ tissue located in the jaw and consist of the enamel, dentin, cementum, pulp, and periodontal tissue. Moreover, the teeth have a complicated regulatory mechanism, special histologic origin, diverse structure, and important functi...

journal_title：Frontiers of medicine

authors： Zhai Q,Dong Z,Wang W,Li B,Jin Y

更新日期：2019-04-01 00:00:00

abstract：:Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. T...

journal_title：Frontiers of medicine

authors： Liu X,Ren H,Peng D

更新日期：2014-03-01 00:00:00

abstract：:Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release sy...

journal_title：Frontiers of medicine

authors： Chen H,Wang F,Zhang P,Zhang Y,Chen Y,Fan X,Cao X,Liu J,Yang Y,Wang B,Lei B,Gu L,Bai J,Wei L,Zhang R,Zhuang Q,Zhang W,Zhao W,He A

更新日期：2019-10-01 00:00:00

abstract：:Laparoscopic liver surgery has been increasingly used for the treatment of pediatric liver diseases over the past decade due to the development of special laparoscopic instruments and improvements in the technique. A number of factors are considered when electing to undergo the surgical process, including age, type of...

journal_title：Frontiers of medicine

authors： Wei J,Feng J

更新日期：2011-12-01 00:00:00

abstract：:Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies a...

journal_title：Frontiers of medicine

authors： Wang L,Bernards R

更新日期：2018-08-01 00:00:00

abstract：:Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease. ...

journal_title：Frontiers of medicine

authors： Liao E

更新日期：2013-03-01 00:00:00

abstract：:To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide. The prognosis of GC is not always satisfactory because of late diagnosis. Scholars are keen on discovering novel accurate and economical biomarkers in body liquids for GC screening to detect and evaluate the lesion before ...

journal_title：Frontiers of medicine

authors： Huang L,Xu A

更新日期：2017-03-01 00:00:00

abstract：:Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an important respiratory disease with high fatality rates of 40%-60%. Despite the increased number of cases over subsequent years, the number of pediatric cases remained low. A review of studies conducted from June 2012 to April ...

journal_title：Frontiers of medicine

authors： Alfaraj SH,Al-Tawfiq JA,Altuwaijri TA,Memish ZA

更新日期：2019-02-01 00:00:00

abstract：:Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decad...

journal_title：Frontiers of medicine

authors： Zhang C,Bao Z,Zhang W,Jiang T

更新日期：2013-06-01 00:00:00