Abstract：
:Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Chen H,Wang F,Zhang P,Zhang Y,Chen Y,Fan X,Cao X,Liu J,Yang Y,Wang B,Lei B,Gu L,Bai J,Wei L,Zhang R,Zhuang Q,Zhang W,Zhao W,He Adoi
10.1007/s11684-019-0714-8subject
Has Abstractpub_date
2019-10-01 00:00:00pages
610-617issue
5eissn
2095-0217issn
2095-0225pii
10.1007/s11684-019-0714-8journal_volume
13pub_type
杂志文章abstract：:We observed the effect of Dianxianning, which was used as additive treatment to treat 206 epilepsy patients, on the epilepsy seizure rate. Based on a multicenter, prospective, randomized, and controlled clinical trial design, we used the seizure rate of epilepsy as the main index. For the treatment group comprising 13...
journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章,meta分析
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
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