Abstract：
:As a promising method in artificial intelligence, deep learning has been proven successful in several domains ranging from acoustics and images to natural language processing. With medical imaging becoming an important part of disease screening and diagnosis, deep learning-based approaches have emerged as powerful techniques in medical image areas. In this process, feature representations are learned directly and automatically from data, leading to remarkable breakthroughs in the medical field. Deep learning has been widely applied in medical imaging for improved image analysis. This paper reviews the major deep learning techniques in this time of rapid evolution and summarizes some of its key contributions and state-of-the-art outcomes. The topics include classification, detection, and segmentation tasks on medical image analysis with respect to pulmonary medical images, datasets, and benchmarks. A comprehensive overview of these methods implemented on various lung diseases consisting of pulmonary nodule diseases, pulmonary embolism, pneumonia, and interstitial lung disease is also provided. Lastly, the application of deep learning techniques to the medical image and an analysis of their future challenges and potential directions are discussed.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Ma J,Song Y,Tian X,Hua Y,Zhang R,Wu Jdoi
10.1007/s11684-019-0726-4subject
Has Abstractpub_date
2020-08-01 00:00:00pages
450-469issue
4eissn
2095-0217issn
2095-0225pii
10.1007/s11684-019-0726-4journal_volume
14pub_type
杂志文章,评审abstract：:This study aimed to explore the association of maternal depression with nutrient intake, growth, and development of preterm infants. A cohort study of 201 infants was conducted in Beijing. Based on the gestational age of an infant and status of the mother, the infants were divided into four groups: non-depression-full...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0591-y
更新日期：2018-10-01 00:00:00
abstract：:Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release sy...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-019-0714-8
更新日期：2019-10-01 00:00:00
abstract：:Persistent vegetative state (PVS) is a clinical condition wherein the cerebral cortex loses its function although brain stem function remains relatively intact. It has high mortality and disability rates. Although treatment for PVS is extensively studied in developed countries, little breakthrough has been made. In Ch...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0539-2
更新日期：2018-06-01 00:00:00
abstract：:Laparoscopic liver surgery has been increasingly used for the treatment of pediatric liver diseases over the past decade due to the development of special laparoscopic instruments and improvements in the technique. A number of factors are considered when electing to undergo the surgical process, including age, type of...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-011-0165-3
更新日期：2011-12-01 00:00:00
abstract：:Assisted reproduction provides a wide spectrum of treatments and strategies addressing infertility. However, distinct groups of infertile patients with unexplained infertility, congenital disorders, and other complex cases pose a challenge in in vitro fertilization (IVF) practices. This special cohort of patients is a...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-019-0697-5
更新日期：2019-12-01 00:00:00
abstract：:γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit li...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-017-0584-x
更新日期：2018-06-01 00:00:00
abstract：:Zinc (Zn) is an essential mineral that is required for various cellular functions. Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome, diabetes and diabetic complications. The associations of Zn with metabolic syndrome, diabetes and diabetic complications, thus, stem from the multiple ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-013-0251-9
更新日期：2013-03-01 00:00:00
abstract：:Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man's sedentary lifestyle, low-physical activity, obesity, and some nonmodifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at h...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0669-1
更新日期：2018-12-01 00:00:00
abstract：:Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also de...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0530-y
更新日期：2017-06-01 00:00:00
abstract：:Pulmonary hypertension (PH), as a complication of bronchiectasis, is associated with increased mortality. However, hemodynamic characteristics and the efficacy of pulmonary arterial hypertension (PAH) therapies in patients with bronchiectasis and PH remain unknown. Patients with bilateral bronchiectasis and concurrent...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-016-0461-z
更新日期：2016-09-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide. In the last few years, treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs. However,...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-017-0546-3
更新日期：2017-12-01 00:00:00
abstract：:The teeth are highly differentiated chewing organs formed by the development of tooth germ tissue located in the jaw and consist of the enamel, dentin, cementum, pulp, and periodontal tissue. Moreover, the teeth have a complicated regulatory mechanism, special histologic origin, diverse structure, and important functi...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0628-x
更新日期：2019-04-01 00:00:00
abstract：:Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of components involved in the cell cycle machinery. Here, we report that cyclin-dependent kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemo...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-016-0478-3
更新日期：2016-12-01 00:00:00
abstract：:Orbital venous malformation (OVM) is a congenital vascular disease. As a common type of vascular malformation in the orbit, OVM may result in vision deterioration and cosmetic defect. Classification of orbital vascular malformations, especially OVMs, is carried out on the basis of different categories, such as angioge...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0623-2
更新日期：2019-10-01 00:00:00
abstract：:This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute....
journal_title：Frontiers of medicine
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11684-016-0480-9
更新日期：2016-12-01 00:00:00
abstract：:Swallowing multiple magnets is not uncommon worldwide and it frequently leads to serious consequences. However, most patients fail to receive timely and correct diagnosis and treatment. A literature search was performed to establish an algorithm for these accidents by the authors to identify relevant articles publishe...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-012-0207-5
更新日期：2012-09-01 00:00:00
abstract：:This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirus disease 2019 (COVID-19). In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVI...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0813-6
更新日期：2020-12-01 00:00:00
abstract：:At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-014-0343-1
更新日期：2015-03-01 00:00:00
abstract：:A high level of social support can improve long-term diabetes self-management. Support from a single source has been evaluated. This study aims to analyze support from multiple and multilevel sources for diabetic patients by using the Chronic Illness Resources Survey (CIRS). Factors influencing the utilization of the ...
journal_title：Frontiers of medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s11684-016-0441-3
更新日期：2016-06-01 00:00:00
abstract：:Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively stud...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0646-8
更新日期：2018-08-01 00:00:00
abstract：:The ability of tumor cells to sustain continuous proliferation is one of the major characteristics of cancer. The activation of oncogenes and the mutation or inactivation of tumor suppressor genes ensure the rapid proliferation of tumor cells. The PI3K-Akt-mTOR axis is one of the most frequently modified signaling pat...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-020-0805-6
更新日期：2020-12-01 00:00:00
abstract：:Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothel...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-011-0118-x
更新日期：2011-03-01 00:00:00
abstract：:A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively analyzed to investigate the long-term outcomes and prognostic factors of these patients, particularly those who underwent primary debulking surgery followed by platinum-based chemotherapy. Clinicopathological...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-014-0305-7
更新日期：2014-03-01 00:00:00
abstract：:Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a major cause of morbidity and mortality with limited treatment options. Lung transplantation (LTX) has been rarely reported as a treatment option for selected HSCT recipients with this problem. In the present study, we rep...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-017-0538-3
更新日期：2018-04-01 00:00:00
abstract：:At present, clinical pathway has become one of the most important health care reform measures in many countries. In this study, the authors introduced basic concepts and explored the application of the clinical pathway of evidence-based Chinese medicine incorporated with the methodology from the concepts of management...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-011-0128-8
更新日期：2011-06-01 00:00:00
abstract：:This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson's disease (PD) reflected by fractional anisotropy (FA), addressing clinical profiles and methodology-related heterogeneity. Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusio...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-019-0725-5
更新日期：2020-05-26 00:00:00
abstract：:Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpat...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-015-0417-8
更新日期：2015-12-01 00:00:00
abstract：:The inhibitory environment that surrounds the lesion site and the lack of intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) impede the regrowth of injured axons and thereby the reestablishment of neural circuits required for functional recovery after spinal cord injuries (SCI). To cir...
journal_title：Frontiers of medicine
pub_type： 杂志文章,评审
doi：10.1007/s11684-018-0642-z
更新日期：2019-04-01 00:00:00
abstract：:Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies a...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-018-0647-7
更新日期：2018-08-01 00:00:00
abstract：:Recent evidences suggested that cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5) inhibitor represents an important therapeutic target for cardiovascular diseases. Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failure, is unknown. The purpose of this...
journal_title：Frontiers of medicine
pub_type： 杂志文章
doi：10.1007/s11684-014-0378-3
更新日期：2014-12-01 00:00:00
