Abstract:
:γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit liver-specific features. Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholic fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regeneration. In this study, we review the properties of hepatic γδ T cells and summarize the roles of γδ T cells in liver diseases. We believe that determining the properties and functions of γδ T cells in liver diseases enhances our understanding of the pathogenesis of liver diseases and is useful for the design of novel γδ T cell-based therapeutic regimens for liver diseases.
journal_name
Front Medjournal_title
Frontiers of medicineauthors
Wang X,Tian Zdoi
10.1007/s11684-017-0584-xsubject
Has Abstractpub_date
2018-06-01 00:00:00pages
262-268issue
3eissn
2095-0217issn
2095-0225pii
10.1007/s11684-017-0584-xjournal_volume
12pub_type
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pub_type: 杂志文章,多中心研究,随机对照试验
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