abstract：OBJECTIVES:Biofilms associated with implantable medical devices and wounds are clinically relevant, often requiring repeated use of antibiotics without success. A search for non-antibiotic antimicrobial and antibiofilm solutions is warranted, in line with antimicrobial stewardship. Our study aimed to evaluate the broad...

journal_title：Journal of global antimicrobial resistance

authors： Sivaranjani M,Liu F,White AP

更新日期：2020-12-28 00:00:00

abstract：OBJECTIVES:The Klebsiella pneumoniae carbapenemase (blaKPC) gene is one of the most widespread carbapenemase genes in the world. However, there are few reports on KPC-producing bacteria in Japan. The aim of this study was therefore to investigate KPC-producing K. pneumoniae in Japan. METHODS:A KPC-2-producingK. pneumo...

journal_title：Journal of global antimicrobial resistance

authors： Eda R,Maehana S,Hirabayashi A,Nakamura M,Furukawa T,Ikeda S,Sakai K,Kojima F,Sei K,Suzuki M,Kitasato H

更新日期：2020-12-26 00:00:00

abstract：OBJECTIVES:Flies have been implicated in the dispersal of medically important bacteria including members of the genus Klebsiella between different environmental compartments. The aim of this study was to retrieve and characterize antibiotic-resistant bacteria from flies collected near to hospitals. METHODS:Flies were ...

journal_title：Journal of global antimicrobial resistance

authors： Carramaschi IN,Dos S B Ferreira V,Chagas TPG,Corrêa LL,Picão RC,de C Queiroz MM,Rangel K,Jardim R,da Mota FF,Zahner V

更新日期：2020-12-07 00:00:00

abstract：OBJECTIVES:Limited data have been reported regarding osteomyelitis due to carbapenemase-producing Enterobacteriaceae (CPE), including co-infections with extended-spectrum β-lactamase (ESBL)-producing micro-organisms. METHODS:We conducted a retrospective study in a reference centre for bone and joint infections from 20...

journal_title：Journal of global antimicrobial resistance

authors： Davido B,Noussair L,Saleh-Mghir A,Salomon E,Bouchand F,Matt M,Lawrence C,Bauer T,Herrmann JL,Perronne C,Gaillard JL,Rottman M,Dinh A

更新日期：2020-12-01 00:00:00

abstract：:Coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses increase oxidative stress in the body leading to cellular and tissue damage. To combat this, administration of high-dose vitamin C (ascorbic acid or ascorbate), in addition to standard conventional supportive treat...

journal_title：Journal of global antimicrobial resistance

authors： Hoang BX,Shaw G,Fang W,Han B

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND AIM:The global rise of antimicrobial resistance among bacterial strains is a rapidly growing challenge and is becoming a major public health concern. This study documents the worldwide spread and genotype distribution of human clinical isolates of New Delhi metallo-β-lactamase-producing Klebsiella pneumo...

journal_title：Journal of global antimicrobial resistance

authors： Safavi M,Bostanshirin N,Hajikhani B,Yaslianifard S,van Belkum A,Goudarzi M,Hashemi A,Darban-Sarokhalil D,Dadashi M

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:Delafloxacin is a broad-spectrum anionic fluoroquinolone with activity against Gram-positive and Gram-negative organisms, including methicillin-resistant Staphylococcus aureus. Both oral and intravenous formulations were approved for use in the treatment of acute bacterial skin and skin-structure infections ...

journal_title：Journal of global antimicrobial resistance

authors： Shortridge D,Pfaller MA,Streit JM,Flamm RK

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:Corynebacterium urealyticum is a non-diphtherial urease-producing clinically relevant corynebacterium associated with urinary tract infections. Most clinical C. urealyticum isolates are multidrug-resistant. Whole-genome sequencing (WGS) of C. urealyticum VH4248 isolated from a clinical urine sample at Hospit...

journal_title：Journal of global antimicrobial resistance

authors： Rocha DJP,Azevedo V,Brenig B,Silva A,Blom J,Ramos RT,Aguiar ERG,Chapartegui-González I,Fernández-Martínez M,Martínez-Martínez L,Pacheco LGC,Navas J

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:Malaria treatment is impeded by increasing resistance to conventional antimalarial drugs. Here we explored the activity of ten novel benzothiophene, thiophene and benzene aminoquinolines. METHODS:In vitro testing was performed by the lactate dehydrogenase assay in chloroquine (CQ)-sensitive Plasmodium falci...

journal_title：Journal of global antimicrobial resistance

authors： Srbljanović J,Bobić B,Štajner T,Uzelac A,Opsenica I,Terzić-Jovanović N,Bauman N,Šolaja BA,Djurković-Djaković O

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:Stenotrophomonas maltophilia is an important multidrug-resistant pathogen that is associated with various serious nosocomial infections. In our study, we investigated the antimicrobial resistance traits of clinical S. maltophilia strain CYZ isolated from the sputum of an immunocompromised patient. METHODS:T...

journal_title：Journal of global antimicrobial resistance

authors： Ma J,Feng J,Shan Y,Zhao Y,Qiao H,Xie L,Lin X,Wang C,Chuai X

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:We analysed the concordance of rectal swab isolates and blood culture for Gram-negative bacteria (GNB) isolates in neonates with a suspicion of neonatal sepsis admitted to a neonatal care unit in Haiti. METHODS:We matched pairs of blood and rectal samples taken on the date of suspected sepsis onset in the s...

journal_title：Journal of global antimicrobial resistance

authors： Lenglet A,Schuurmans J,Ariti C,Borgundvaag E,Charles K,Badjo C,Clezy K,Evens E,Senat-Delva R,Berthet M,Lekkerkerker M,McRae M,Wertheim H,Hopman J

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the presence and genetic environment of the multiresistance gene cfr gene in Pasteurella multocida of avian origin from China. METHODS:A total of 113 P. multocida isolates were collected from sick poultries (ducks, chickens and geese) from 2003 to 2016 in Southern Ch...

journal_title：Journal of global antimicrobial resistance

authors： Chen H,Deng H,Cheng L,Liu R,Fu G,Shi S,Wan C,Fu Q,Huang Y,Huang X

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to explore the genomic content of a blaKPC-2- and mcr-1-harbouring Escherichia coli strain and to clarify the molecular mechanism for the transmission of multidrug resistance. METHODS:Antimicrobial susceptibility testing was conducted by the broth microdilution method to determine ...

journal_title：Journal of global antimicrobial resistance

authors： Wang Y,Liu H,Wang Q,Du X,Yu Y,Jiang Y

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:This meta-analysis was performed to compare polymyxin monotherapy and polymyxin-based combination therapy for carbapenem-resistant Klebsiella pneumoniae (CR-KP) infections. METHODS:We conducted searches on MEDLINE, Embase and Cochrane Collaborative database for both observational studies and randomised cont...

journal_title：Journal of global antimicrobial resistance

authors： Hou SY,Wu D,Feng XH

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:This study aimed to characterise insertional mutations disturbing themgrB gene in carbapenem-resistant Klebsiella pneumoniae (CRKp). METHODS:A total of 118 clinical CRKp isolates were surveyed for polymyxin resistance and insertion sequence (IS) elements disruptingmgrB. RESULTS:Of the 118 isolates, 78 (66....

journal_title：Journal of global antimicrobial resistance

authors： Silva DMD,Faria-Junior C,Nery DR,Oliveira PM,Silva LOR,Alves EG,Lima GRCEC,Pereira AL

更新日期：2020-11-24 00:00:00

abstract：OBJECTIVES:Tuberculosis (TB) poses a serious global threat to humans. New bactericidal agents that can shorten treatment duration and target drug resistance still remain a top priority in the discovery of anti-TB drugs. The objective of this study was to investigate the bactericidal potential of 3-cinnamoyl-4-hydroxy-6...

journal_title：Journal of global antimicrobial resistance

authors： Bhat ZS,Rather MA,Ul Lah H,Hussain A,Maqbool M,Yousuf SK,Jabeen Z,Wani MA,Ahmad Z

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Inappropriate antimicrobial prescribing may harm patients and drive antimicrobial resistance. Junior doctors' knowledge of infectious diseases and antimicrobial prescribing is inadequate. Online spaced case-based learning can improve knowledge. OBJECTIVE:To develop infectious diseases and antimicrobial pres...

journal_title：Journal of global antimicrobial resistance

authors： Menon V,Chubaty A,Clezy K,Su Y,Post JJ,Janssen A,Shaw T,Konecny P

更新日期：2020-09-01 00:00:00

abstract：:According to the World Health Organization (WHO), as of today, there are 2.165.500 confirmed cases of the novel coronavirus disease (COVID-19) and 145.705 deaths in over 185 countries. Unfortunately, despite the tremendous efforts to develop a vaccine initiated by various leading health institutions all over the world...

journal_title：Journal of global antimicrobial resistance

authors： Alkholy UM,Salama ME,Mahmoud H,Taher A 832-863-6551,Elsayes KM

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Recently, a growing resistance to antimalarial drugs such as chloroquine, sulfadoxine-pyrimethamine, artemisinin derivatives and mefloquine has been observed. The pharmacokinetic limitation of the current therapy and multi-drug resistance has resulted in an urgent need to study the new antimalarial combinati...

journal_title：Journal of global antimicrobial resistance

authors： Kathpalia H,Juvekar S,Mohanraj K,Apsingekar M,Shidhaye S

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:There are numerous reported cases of extended-spectrum beta-lactamases (ESBLs) producing Enterobacteriaceae in Nigeria. Yet, there are regions in Nigeria where cases of ESBL were under-reported. The review aims to assess the prevalence of ESBL-producing Gram-negative bacteria in Nigeria and the genes involved...

journal_title：Journal of global antimicrobial resistance

authors： Tanko N,Bolaji RO,Olayinka AT,Olayinka BO

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:The production of β-lactamase enzymes such as AmpC β-lactamases and extended-spectrum β-lactamases (ESBLs) is among the main mechanisms for resistance to expanded-spectrum cephalosporins. The present study was conducted to investigate the prevalence and molecular epidemiology of plasmid-mediated AmpC beta (β)...

journal_title：Journal of global antimicrobial resistance

authors： Rizi KS,Mosavat A,Youssefi M,Jamehdar SA,Ghazvini K,Safdari H,Amini Y,Farsiani H

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:This study was conducted to assess the prevalence of azole resistance in Aspergillus isolates from patients with haematological malignancies or who were undergoing haematopoietic stem cell transplantation and to identify the molecular mechanism of resistance. METHODS:In this 28-month prospective study invol...

journal_title：Journal of global antimicrobial resistance

authors： Prigitano A,Esposto MC,Grancini A,Passera M,Paolucci M,Stanzani M,Sartor A,Candoni A,Pitzurra L,Innocenti P,Micozzi A,Cascio GL,Delia M,Mosca A,Mikulska M,Ossi C,Fontana C,Pizzolante M,Gelmi M,Cavanna C,Lallitto F

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Pharmacokinetic (PK) parameters can change significantly during extracorporeal membrane oxygenation (ECMO) and continuous haemodialysis. This case report describes the pharmacokinetics of a 3-h meropenem infusion in an infantile anuric patient on ECMO with continuous haemodialysis. CASE:A 19-month-old femal...

journal_title：Journal of global antimicrobial resistance

authors： Saito J,Shoji K,Oho Y,Aoki S,Matsumoto S,Yoshida M,Nakamura H,Kaneko Y,Hayashi T,Yamatani A,Capparelli E,Miyairi I

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Multidrug-resistant (MDR) enterococci are found extensively in food samples. This study characterized the phenotypic virulence factors and the ability of horizontal gene transfer of a streptomycin resistance gene among enterococci isolated from fermented pork. METHODS:Thirty-six MDR enterococci were subject...

journal_title：Journal of global antimicrobial resistance

authors： Chotinantakul K,Chansiw N,Okada S

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the molecular mechanisms of imipenem resistance in Enterobacteriaceae and to assess the antimicrobial activities of ceftazidime/avibactam (CAZ/AVI) and aztreonam/avibactam (ATM/AVI) against imipenem-resistant clinical isolates in a tertiary hospital in China. METHODS...

journal_title：Journal of global antimicrobial resistance

authors： Wei J,Zou C,Wang D,Huang A,Niu S

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Multidrug-resistant (MDR) bacteria are a major public-health concern. Bacteriophage endolysins (lysins) can be used as novel antimicrobial agents against bacterial infections. In this study, a novel endolysin (LysSS) containing a lysozyme-like domain was evaluated for its antibacterial activity against vario...

journal_title：Journal of global antimicrobial resistance

authors： Kim S,Lee DW,Jin JS,Kim J

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:The emergence of multidrug-resistance (MDR) in Streptococcus pneumoniae clones and non-vaccine serotypes necessitate the development of novel treatment strategies. This work aimed to determine the efficacy of the Mn complex [Mn(CO)3(tpa-κ3N)]Br against clinically important MDR strains of S. pneumoniae. METH...

journal_title：Journal of global antimicrobial resistance

authors： Liakopoulos A,La Ragione RM,Nagel C,Schatzschneider U,Rozen DE,Betts JW

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Rates of nosocomial infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) have increased. A meta-analysis was conducted to explore risk factors for CRKP infection in order to provide a theoretical basis for reducing the CRKP infection rate and actively preventing CRKP infection. METHODS:Onl...

journal_title：Journal of global antimicrobial resistance

authors： Li J,Li Y,Song N,Chen Y

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:Ralstonia pickettii has been increasingly recognised as an emerging opportunistic pathogen in hospital settings in recent years, especially in patients with prolonged hospital stay. Clinical manifestations associated with R. pickettii infection range from mild infections to severe invasive life-threatening i...

journal_title：Journal of global antimicrobial resistance

authors： Jiang T,Xu J,He F

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to determine the percentage of antimicrobial-resistant isolates and the associated resistance mechanisms in Gram-negative bacteria from South Western Nigeria. METHODS:A total of 306 non-duplicate unbiased Gram-negative isolates were recovered from patients admitted to three teachin...

journal_title：Journal of global antimicrobial resistance

authors： Ogbolu DO,Piddock LJV,Webber MA

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:The first report of a plasmid-borne colistin resistance gene (mcr-1) detected in an Escherichia coli isolate from China heralded the emergence of pandrug-resistant bacteria. Since then, the mcr-1 gene has been detected worldwide, but to date it has not been reported in the Philippines. METHODS:In this study...

journal_title：Journal of global antimicrobial resistance

authors： Velasco JMS,Valderama MTG,Margulieux KR,Diones PCS,Reyes AMB,Leonardia SG,Liao CP,Chua DA Jr,Navarro FCS,Ruekit S,Fernandez S,Macareo LR,Crawford JM,Swierczewski BE

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to forecast the monthly incidence rates of infections [infections/1000 bed-days (IBD)] due to carbapenem-resistant Klebsiella pneumoniae (CRKP), carbapenem-resistant Pseudomonas aeruginosa (CRPA), carbapenem-resistant Acinetobacter baumannii (CRAB) and total carbapenem-resistant Gra...

journal_title：Journal of global antimicrobial resistance

authors： Karampatakis T,Tsergouli K,Iosifidis E,Antachopoulos C,Mouloudi E,Karyoti A,Tsakris A,Roilides E

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:Infections caused by multidrug-resistant Gram-negative bacteria are associated with high mortality. A relevant concern is the efficacy of antibiotic therapy in burn patients in whom pathophysiological changes strongly influence pharmacokinetic (PK) parameters. This study aimed to describe the PK parameters o...

journal_title：Journal of global antimicrobial resistance

authors： Corcione S,D'Avolio A,Loia RC,Pensa A,Segala FV,De Nicolò A,Fatiguso G,Romeo M,Di Perri G,Stella M,De Rosa FG

更新日期：2020-03-01 00:00:00

abstract：:Antibiotics are frequently used in food animal production in developing countries to promote the well-being and growth of animals. This practice provides some economic benefits to producers and consumers at large. Nevertheless, this practice is also associated with a number of concerns. A major concern has been that r...

journal_title：Journal of global antimicrobial resistance

authors： Van TTH,Yidana Z,Smooker PM,Coloe PJ

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:Pseudomonas aeruginosa is the most frequent infectious agent in cystic fibrosis patients. P. aeruginosa resistance to first line antibiotics limits therapeutic options, but the therapeutic potential of older generation antibiotics, such as fosfomycin is under investigation. Fosfomycin does not belong to any ...

journal_title：Journal of global antimicrobial resistance

authors： Bressan A,Rodio DM,Stangherlin F,Puggioni G,Ambrosi C,Arcari G,Carattoli A,Antonelli G,Pietropaolo V,Trancassini M

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the efficacy of pyrimethamine-loaded poloxamer 407 nanomicelles on Plasmodium berghei strain NICD in vivo. METHODS:Pyrimethamine-loaded nanomicelles were prepared and their zeta potential, particle size and polydispersity index were measured. For antiplasmodial assessme...

journal_title：Journal of global antimicrobial resistance

authors： Pestehchian N,Vafaei MR,Nematolahy P,Varshosaz J,Yousefi HA,Bide VZ,Kalani H

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Little is known about the treatment outcomes of HIV-negative drug-resistant tuberculosis (TB) patients in Malaysia. With respect to this issue, this study aimed to determine factors associated with unsuccessful treatment outcomes among drug-resistant TB patients at the Institute of Respiratory Medicine, Kuala...

journal_title：Journal of global antimicrobial resistance

authors： Shariff NM,Shah SA,Kamaludin F

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:To determine the contribution of specific uropathogenic Escherichia coli (UPEC) lineages, drug resistance genes, and plasmid incompatibility/replicon (Inc) groups to the prevalence of β-lactam-resistant urinary tract infections (UTIs) in a university community. METHODS:Urine samples were consecutively colle...

journal_title：Journal of global antimicrobial resistance

authors： Tarlton NJ,Moritz C,Adams-Sapper S,Riley LW

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:This study describes the characterisation of type 2 IncC plasmids pC-Ec20-KPC and pC-Ec2-KPC, carrying theblaKPC-2 gene, from two multiresistant Escherichia coli recovered in University Hospital of Larissa (Greece) in 2018. METHODS:E. coli strains Ec-2Lar and Ec-20Lar were recovered from rectal swabs of two...

journal_title：Journal of global antimicrobial resistance

authors： Papagiannitsis CC,Bitar I,Malli E,Tsilipounidaki K,Hrabak J,Petinaki E

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:Mortality associated with carbapenemase-producing Enterobacteriaceae is high as there are few therapeutic options. Escherichia coli sequence type 410 (ST410) is currently an international high-risk clone and is responsible for a large number of clinical infections. Here we report the draft genome sequence of...

journal_title：Journal of global antimicrobial resistance

authors： Huang J,Ma S,Yu Q,Fu M,Shao L,Shan X,Li X

更新日期：2019-12-01 00:00:00