Abstract：
OBJECTIVES:This study aimed to characterise insertional mutations disturbing themgrB gene in carbapenem-resistant Klebsiella pneumoniae (CRKp). METHODS:A total of 118 clinical CRKp isolates were surveyed for polymyxin resistance and insertion sequence (IS) elements disruptingmgrB. RESULTS:Of the 118 isolates, 78 (66.1%) displayed polymyxin resistance, of which 54% (42/78) hadmgrB::IS inserts. Sequencing analyses showed 13 insertion sites in mgrB. mgrB::ISSen4(IS3) was observed for the first time in CRKp. CONCLUSIONS:Ten different IS elements disruptedmgrB, with a predominance (76%) of IS5 sequences.
journal_name
J Glob Antimicrob Resistjournal_title
Journal of global antimicrobial resistanceauthors
Silva DMD,Faria-Junior C,Nery DR,Oliveira PM,Silva LOR,Alves EG,Lima GRCEC,Pereira ALdoi
10.1016/j.jgar.2020.11.003subject
Has Abstractpub_date
2020-11-24 00:00:00pages
53-57eissn
2213-7165issn
2213-7173pii
S2213-7165(20)30289-7journal_volume
24pub_type
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