听力与言语-语言病理学

行为科学

医学伦理学

  • A new paraprobiotic-based treatment for control of Haemonchus contortus in sheep.

    abstract::Haemonchus contortus is a critical parasite of goats and sheep. Infection by this blood-feeding gastrointestinal nematode (GIN) parasite has significant health consequences, especially in lambs and kids. The parasite has developed resistance to virtually all known classes of small molecule anthelmintics used to treat ...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2020.11.004

    authors: Sanders J,Xie Y,Gazzola D,Li H,Abraham A,Flanagan K,Rus F,Miller M,Hu Y,Guynn S,Draper A,Vakalapudi S,Petersson KH,Zarlenga D,Li RW,Urban JF Jr,Ostroff GR,Zajac A,Aroian RV

    更新日期:2020-12-01 00:00:00

  • Nullscript inhibits Cryptosporidium and Toxoplasma growth.

    abstract::Cryptosporidium and Toxoplasma are parasites that have caused problems worldwide. Cryptosporidium causes severe watery diarrhoea and may be fatal in immunocompromised patients and in infants. Nitazoxanide is the only agent currently approved by the FDA, but its efficacy is limited. Toxoplasmosis is also a problem in t...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2020.10.004

    authors: Murakoshi F,Bando H,Sugi T,Adeyemi OS,Nonaka M,Nakaya T,Kato K

    更新日期:2020-12-01 00:00:00

  • Novel acyl carbamates and acyl / diacyl ureas show in vitro efficacy against Toxoplasma gondii and Cryptosporidium parvum.

    abstract::Toxoplasma gondii and Cryptosporidium parvum are protozoan parasites that are highly prevalent and opportunistically infect humans worldwide, but for which completely effective and safe medications are lacking. Herein, we synthesized a series of novel small molecules bearing the diacyl urea scaffold and related struct...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2020.08.006

    authors: Li K,Grooms GM,Khan SM,Hernandez AG,Witola WH,Stec J

    更新日期:2020-12-01 00:00:00

  • Antileishmanial activity of a new chloroquine analog in an animal model of Leishmania panamensis infection.

    abstract::Leishmania panamensis is a relevant causative agent of tegumentary leishmaniasis in several Latin American countries. Available antileishmanial drugs have several limitations including relatively high toxicity, difficult administration, high production costs and the emergence of resistance in circulating strains. Ther...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2020.08.002

    authors: Herrera L,Llanes A,Álvarez J,Degracia K,Restrepo CM,Rivera R,Stephens DE,Dang HT,Larionov OV,Lleonart R,Fernández PL

    更新日期:2020-12-01 00:00:00

  • Detection of target-site and metabolic resistance to pyrethroids in the bed bug Cimex lectularius in Berlin, Germany.

    abstract::Knockdown-resistance (kdr) against pyrethroids in bed bugs (Cimex lectularis) is associated with the presence of several point mutations in the voltage-sensitive sodium channel α-subunit gene and/or an increased metabolic detoxification by cytochrome P450 monooxygenases (CYPs). In the present study, pyrosequencing ass...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2020.11.003

    authors: Vander Pan A,Kuhn C,Schmolz E,von Samson-Himmelstjerna G,Krücken J

    更新日期:2020-12-01 00:00:00

  • Impact of clinically acquired miltefosine resistance by Leishmania infantum on mouse and sand fly infection.

    abstract:OBJECTIVES:This study evaluated the implications of clinically acquired miltefosine resistance (MIL-R) by assessing virulence in mice and sand flies to reveal the potential of MIL-R strains to circulate. METHODS:Experimental infections with the MIL-R clinical Leishmania infantum isolate MHOM/FR/2005/LEM5159, having a ...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2020.04.004

    authors: Van Bockstal L,Bulté D,Hendrickx S,Sadlova J,Volf P,Maes L,Caljon G

    更新日期:2020-08-01 00:00:00

  • Identification of annotated bioactive molecules that impair motility of the blood fluke Schistosoma mansoni.

    abstract::Neglected tropical diseases are of growing worldwide concern and schistosomiasis, caused by parasitic flatworms, continues to be a major threat with more than 200 million people requiring preventive treatment. As praziquantel (PZQ) remains the treatment of choice, an urgent need for alternative treatments motivates re...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2020.05.002

    authors: Duguet TB,Glebov A,Hussain A,Kulkarni S,Mochalkin I,Geary TG,Rashid M,Spangenberg T,Ribeiro P

    更新日期:2020-08-01 00:00:00

  • In vitro activity of Camellia sinensis (green tea) against trophozoites and cysts of Acanthamoeba castellanii.

    abstract::The effect of Camellia sinensis (green tea) on the growth of Acanthamoeba castellanii trophozoites was examined using a microplate based-Sulforhodamine B (SRB) assay. C. sinensis hot and cold brews at 75% and 100% concentrations significantly inhibited the growth of trophozoites. We also examined the structural altera...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2020.05.001

    authors: Fakae LB,Stevenson CW,Zhu XQ,Elsheikha HM

    更新日期:2020-08-01 00:00:00

  • Mode of action of a formulation containing hydrazones and saponins against leishmania spp. Role in mitochondria, proteases and reinfection process.

    abstract::Toxicity and poor adherence to treatment that favors the generation of resistance in the Leishmania parasites highlight the need to develop better alternatives. Here, we evaluated the in vitro effectiveness of hydrazone derived from chromanes 2-(2,3-dihydro-4H-1-benzothiopyran-4-ylidene) hydrazide (TC1) and 2-(2,3-dih...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2020.06.004

    authors: Upegui Zapata YA,Echeverri F,Quiñones W,Torres F,Nacher M,Rivas LI,Meira CDS,Gedamu L,Escobar G,Archbold R,Vélez ID,Robledo SM

    更新日期:2020-08-01 00:00:00

  • Development of amplicon sequencing for the analysis of benzimidazole resistance allele frequencies in field populations of gastrointestinal nematodes.

    abstract::Anthelmintic resistant gastrointestinal helminths have become a major cause of poor health in sheep and goats. Sensitive and specific molecular markers are needed to monitor the genotypic frequency of resistance in field parasite populations. Gastrointestinal nematode resistance to benzimidazole is caused by a mutatio...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2019.08.003

    authors: Sargison ND,MacLeay M,Morrison AA,Bartley DJ,Evans M,Chaudhry U

    更新日期:2019-08-01 00:00:00

  • Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance.

    abstract::Macrocyclic lactone (ML) anthelmintics are the most important class of anthelmintics because of our high dependence on them for the control of nematode parasites and some ectoparasites in livestock, companion animals and in humans. However, resistance to MLs is of increasing concern. Resistance is commonplace througho...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijpddr.2019.06.002

    authors: Prichard RK,Geary TG

    更新日期:2019-08-01 00:00:00

  • A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing.

    abstract::Infections with parasitic nematodes are among the most significant of the neglected tropical diseases affecting about a billion people living mainly in tropical regions with low economic activity. The most effective current strategy to control nematode infections involves large scale treatment programs with anthelmint...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2019.04.001

    authors: Pandarakalam GC,Speake M,McElroy S,Alturkistani A,Philippe L,Pettitt J,Müller B,Connolly B

    更新日期:2019-08-01 00:00:00

  • The individual components of commercial isometamidium do not possess stronger trypanocidal activity than the mixture, nor bypass isometamidium resistance.

    abstract::The four components present in the trypanocidal treatment Samorin, the commercially available formulation of isometamidium, were separated and purified by column chromatography. These compounds as well as the Samorin mixture and the other phenanthridine trypanocide, homidium, were tested on Trypanosoma congolense and ...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2019.01.003

    authors: Eze AA,Igoli J,Gray AI,Skellern GG,De Koning HP

    更新日期:2019-04-01 00:00:00

  • Transient temperature fluctuations severely decrease P. falciparum susceptibility to artemisinin in vitro.

    abstract::Clinical studies suggest that outcomes for hospitalised malaria patients can be improved by managed hypothermia during treatment. We examined the impact of short pulses of low temperature on ring-stage susceptibility of Plasmodium falciparum to artemisinin in vitro. The usually artemisinin-sensitive clone 3D7 exhibite...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2018.12.003

    authors: Henrici RC,van Schalkwyk DA,Sutherland CJ

    更新日期:2019-04-01 00:00:00

  • Molecular and pharmacological characterization of an acetylcholine-gated chloride channel (ACC-2) from the parasitic nematode Haemonchus contortus.

    abstract::Nematode cys-loop ligand-gated ion channels (LGICs) have been shown to be attractive targets for the development of novel anti-parasitic drugs. The ACC-1 family of receptors are a unique group of acetylcholine-gated chloride channels present only in invertebrates, and sequence analysis suggests that they contain a nov...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2018.09.004

    authors: Habibi SA,Callanan M,Forrester SG

    更新日期:2018-12-01 00:00:00

  • Nicotine-sensitive acetylcholine receptors are relevant pharmacological targets for the control of multidrug resistant parasitic nematodes.

    abstract::The control of parasitic nematodes impacting animal health relies on the use of broad spectrum anthelmintics. However, intensive use of these drugs has led to the selection of resistant parasites in livestock industry. In that respect, there is currently an urgent need for novel compounds able to control resistant par...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2018.11.003

    authors: Charvet CL,Guégnard F,Courtot E,Cortet J,Neveu C

    更新日期:2018-12-01 00:00:00

  • Licochalcone A: An effective and low-toxicity compound against Toxoplasma gondii in vitro and in vivo.

    abstract::Toxoplasma gondii, an obligate intracellular protozoan, is the causative agent of toxoplasmosis, which can cause serious public health problems. The current drugs used to treat toxoplasmosis have many limitations. This study evaluated the anti-T. gondii activity and potential mechanism of Licochalcone A (Lico A) in vi...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2018.02.006

    authors: Si H,Xu C,Zhang J,Zhang X,Li B,Zhou X,Zhang J

    更新日期:2018-08-01 00:00:00

  • Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target.

    abstract::The Coenzyme A (CoA), as a cofactor involved in >100 metabolic reactions, is essential to the basic biochemistry of life. Here, we investigated the CoA biosynthetic pathway of Entamoeba histolytica (E. histolytica), an enteric protozoan parasite responsible for human amebiasis. We identified four key enzymes involved ...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2018.02.004

    authors: Nurkanto A,Jeelani G,Yamamoto T,Naito Y,Hishiki T,Mori M,Suematsu M,Shiomi K,Hashimoto T,Nozaki T

    更新日期:2018-04-01 00:00:00

  • High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth.

    abstract::The apicomplexan parasite Sarcocystis neurona is the primary etiologic agent of equine protozoal myeloencephalitis (EPM), a serious neurologic disease of horses. Many horses in the U.S. are at risk of developing EPM; approximately 50% of all horses in the U.S. have been exposed to S. neurona and treatments for EPM are...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2018.02.002

    authors: Bowden GD,Land KM,O'Connor RM,Fritz HM

    更新日期:2018-04-01 00:00:00

  • Genomic analysis of Isometamidium Chloride resistance in Trypanosoma congolense.

    abstract::Isometamidium Chloride (ISM) is one of the principal drugs used to counteract Trypanosoma congolense infection in livestock, both as a prophylactic as well as a curative treatment. However, numerous cases of ISM resistance have been reported in different African regions, representing a significant constraint in the ba...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2017.10.002

    authors: Tihon E,Imamura H,Van den Broeck F,Vermeiren L,Dujardin JC,Van Den Abbeele J

    更新日期:2017-12-01 00:00:00

  • Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in vitro and in vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes.

    abstract::Millions of people are treated with anthelmintics to control soil-transmitted helminth infections; yet, drug distribution in the plasma and gastrointestinal tract compartments and the pathway of drug uptake into gastrointestinal nematodes responsible for the pharmacological effect are unknown. We assessed the distribu...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2017.03.005

    authors: Cowan N,Meier C,Neodo A,Keiser J

    更新日期:2017-08-01 00:00:00

  • Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth.

    abstract::Malaria, schistosomiasis and leishmaniases are among the most prevalent tropical parasitic diseases and each requires new innovative treatments. Targeting essential parasite pathways, such as those that regulate gene expression and cell cycle progression, is a key strategy for discovering new drug leads. In this study...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2016.12.005

    authors: Chua MJ,Arnold MS,Xu W,Lancelot J,Lamotte S,Späth GF,Prina E,Pierce RJ,Fairlie DP,Skinner-Adams TS,Andrews KT

    更新日期:2017-04-01 00:00:00

  • Assessment of flukicide efficacy against Fasciola hepatica in sheep in Sweden in the absence of a standardised test.

    abstract::Anthelmintic resistance (AR) to Fasciola hepatica is emerging worldwide. Recently, AR to the adulticide compound albendazole (ABZ) was shown in Argentina and Spain. In Sweden, ABZ treatment failure against F. hepatica was first reported in sheep in 2012. The present study tested the efficacy of ABZ and triclabendazole...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2016.06.004

    authors: Novobilský A,Amaya Solis N,Skarin M,Höglund J

    更新日期:2016-12-01 00:00:00

  • The effect of the disulfideisomerase domain containing protein in the defense against polyhexamethylene biguanide of highly tolerant Acanthamoeba at the trophozoite stage.

    abstract::Acanthamoeba castellanii is a free-living protozoan pathogen capable of causing a blinding keratitis and fatal granulomatous encephalitis. Current treatment generally involves an hourly application of polyhexamethylene biguanide (PHMB) over a period of several days but this is not entirely effective against all strain...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2016.11.001

    authors: Huang FC,Liu TS,Li SC,Shih MH,Shin JW,Lin WC

    更新日期:2016-12-01 00:00:00

  • ABC-B transporter genes in Dirofilaria immitis.

    abstract::Dirofilaria immitis is a filarial nematode causing infection and heartworm disease in dogs and other canids, cats, and occasionally in humans. Prevention with macrocyclic lactones (ML) is recommended during the mosquito transmission season. Recently, ML resistance has been reported. ABC-B transporter genes are thought...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2016.04.001

    authors: Bourguinat C,Che H,Mani T,Keller K,Prichard RK

    更新日期:2016-08-01 00:00:00

  • Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites.

    abstract::Histone deacetylase (HDAC) enzymes work together with histone acetyltransferases (HATs) to reversibly acetylate both histone and non-histone proteins. As a result, these enzymes are involved in regulating chromatin structure and gene expression as well as other important cellular processes. HDACs are validated drug ta...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2015.05.004

    authors: Engel JA,Jones AJ,Avery VM,Sumanadasa SD,Ng SS,Fairlie DP,Skinner-Adams T,Andrews KT

    更新日期:2015-06-20 00:00:00

  • Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production.

    abstract::Drug resistance is a problem wherever livestock are raised under intensive conditions and drugs are used to combat parasitic infections. This is particularly true for the anticoccidial agents used for the prevention of coccidiosis caused by protozoa of the apicomplexan genus Eimeria in poultry. Resistance has been doc...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2014.10.002

    authors: Chapman HD,Jeffers TK

    更新日期:2014-10-25 00:00:00

  • Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug.

    abstract::Schistosomiasis is a neglected tropical disease caused by blood-dwelling flukes of the genus Schistosoma. While the disease may affect as many as 249 million people, treatment largely relies on a single drug, praziquantel. The near exclusive use of this drug for such a prevalent disease has led to concerns regarding t...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2014.09.006

    authors: Mwangi IN,Sanchez MC,Mkoji GM,Agola LE,Runo SM,Cupit PM,Cunningham C

    更新日期:2014-09-26 00:00:00

  • Uptake of benzimidazoles by Trichuris suis in vivo in pigs.

    abstract::It is recognized that the clinical efficacy of single dose benzimidazoles (BZs) against the nematode, Trichuris suis of pigs and the closely related Trichuris trichiura in humans is only poor to moderate. Recent in vitro studies have indicated that a low uptake of fenbendazole (FBZ) in T. suis may be responsible for i...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2014.03.003

    authors: Hansen TV,Friis C,Nejsum P,Olsen A,Thamsborg SM

    更新日期:2014-04-08 00:00:00

  • Application of a Poisson distribution quality control measure to the analysis of two human hookworm drug treatment studies in Ghana.

    abstract::We examined faecal egg count reduction tests (FECRTs) conducted with hookworm-infected humans in Ghana in 2007 (study 1) and 2010 (study 2) in order to explore aspects of the test analysis. Some subjects showed increased FEC following drug treatment. This occurred mostly in <150 epg pre-treatment FEC subjects. We soug...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2014.01.001

    authors: Kotze AC,Dobson RJ,Humphries D,Wilson M,Cappello M

    更新日期:2014-01-31 00:00:00

  • The in vitro assay profile of macrocyclic lactone resistance in three species of sheep trichostrongyloids.

    abstract::Anthelmintic resistance has emerged as an important problem in animal industries. Understanding resistance mechanisms, especially against macrocyclic lactones (MLs), is the first step in developing better diagnostic tools. Effects of several MLs including ivermectins and milbemycins were tested using two well establis...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2013.04.002

    authors: Demeler J,Gill JH,von Samson-Himmelstjerna G,Sangster NC

    更新日期:2013-05-24 00:00:00

  • Comparative tissue pharmacokinetics and efficacy of moxidectin, abamectin and ivermectin in lambs infected with resistant nematodes: Impact of drug treatments on parasite P-glycoprotein expression.

    abstract::The high level of resistance to the macrocyclic lactones has encouraged the search for strategies to optimize their potential as antiparasitic agents. There is a need for pharmaco-parasitological studies addressing the kinetic-dynamic differences between various macrocyclic lactones under standardized in vivo conditio...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2012.11.001

    authors: Lloberas M,Alvarez L,Entrocasso C,Virkel G,Ballent M,Mate L,Lanusse C,Lifschitz A

    更新日期:2012-12-03 00:00:00

  • In silico prediction of antimalarial drug target candidates.

    abstract::The need for new antimalarials is persistent due to the emergence of drug resistant parasites. Here we aim to identify new drug targets in Plasmodium falciparum by phylogenomics among the Plasmodium spp. and comparative genomics to Homo sapiens. The proposed target discovery pipeline is largely independent of experime...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2012.07.002

    authors: Ludin P,Woodcroft B,Ralph SA,Mäser P

    更新日期:2012-07-17 00:00:00

  • Nitazoxanide: In vitro and in vivo drug effects against Trichuris muris and Ancylostoma ceylanicum, alone or in combination.

    abstract::Soil-transmitted helminths cause more than 1 billion human infections globally, mostly in the poorest regions of the world. Control relies essentially on a limited panel of four drugs, and drug resistance might be inescapable. Nitazoxanide, an anti-infective drug, has been shown to exert anthelmintic activity in human...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章

    doi:10.1016/j.ijpddr.2012.02.004

    authors: Tritten L,Silbereisen A,Keiser J

    更新日期:2012-03-10 00:00:00

  • Is anthelmintic resistance a concern for the control of human soil-transmitted helminths?

    abstract::The major human soil-transmitted helminths (STH), Ascaris lumbricoides, hookworms (Necator americanus and Ancylostoma duodenale) and Trichuris trichiura have a marked impact on human health in many parts of the world. Current efforts to control these parasites rely predominantly on periodic mass administration of anth...

    journal_title:International journal for parasitology. Drugs and drug resistance

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijpddr.2011.09.002

    authors: Vercruysse J,Albonico M,Behnke JM,Kotze AC,Prichard RK,McCarthy JS,Montresor A,Levecke B

    更新日期:2011-10-14 00:00:00