abstract：:In this paper we report a case of the rare entity epithelial sheath neuroma (ESN). A 66-year-old white female presented with a 1-month history of pruritic, raised, erythematous skin lesion on her upper back. The clinical impression initially led to a differential diagnosis that included lymphoma or inflamed sebaceous ...

journal_title：Clinical neuropathology

authors： Al-Dalahmah O,McEntire C,Niedt GW

更新日期：2020-09-01 00:00:00

abstract：:After a short summary of Arnold Pick's biography, the history of how Pick's disease (PiD) was reported is presented, from its clinical symptoms to its molecular characterization. The macroscopic description of frontotemporal atrophy by Pick is recounted followed by a description of the histological lesions observed by...

journal_title：Clinical neuropathology

authors： Mikol J

更新日期：2020-07-01 00:00:00

abstract：:Hereditary spastic paraparesis (HSP) caused by mutations in the SPAST (SPG4) gene are autosomal-dominant inherited disorders characterized by weakness of lower extremities, spasticity and hyperreflexia. Some cases with cognitive decline have been repored. Herein we present an asymptomatic carrier of a SPAST gene mutat...

journal_title：Clinical neuropathology

authors： Forcén S,Crespo Cuevas AM,Aldecoa I,Ramos O,Ispierto L,Álvarez R,Vilas D

更新日期：2020-07-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is a rare condition affecting children more frequently than adults. LCH can involve any organ in the body and has a wide spectrum of clinical presentation from a single self-healing bone lesion to a multisystemic life-threatening disease. The diagnosis of LCH requires histology with...

journal_title：Clinical neuropathology

authors： El Sissy FN,Lorillon G,Mandonnet E,Polivka M,Addle-Biassette H,Emile JF

更新日期：2020-03-01 00:00:00

abstract：:Myxomas are the commonest type of benign cardiac tumors, however, myxomas of an extracardiac origin are rare. This case report presents the postmortem finding of a myxoma arising in the superior sagittal sinus of a 76-year-old woman in the absence of a cardiac primary tumor. ...

journal_title：Clinical neuropathology

authors： Rekathati N,Englund E

更新日期：2020-03-01 00:00:00

abstract：AIMS:Due to their rarity, the natural history and imaging of myxoid meningiomas are not completely characterized. We analyzed clinical, imaging, and pathologic features of myxoid meningioma seen neurosurgically or in consultation between 1999 and 2018. MATERIALS AND METHODS:Archival material was searched for meningiom...

journal_title：Clinical neuropathology

authors： Johnson MD,Hussain A

更新日期：2019-09-01 00:00:00

abstract：: ...

journal_title：Clinical neuropathology

authors： Das S

更新日期：2019-03-01 00:00:00

abstract：: ...

journal_title：Clinical neuropathology

authors： Hainfellner JA

更新日期：2019-01-01 00:00:00

abstract：:The patient was an 81-year-old woman diagnosed with atypical motor neuron disease who died after a long clinical course (7.5 years without mechanical assistance of ventilation) characterized by lower motor neuron signs and symptoms. Upper motor neuron signs and cognitive impairment were not apparent. Autopsy demonstra...

journal_title：Clinical neuropathology

authors： Shintaku M,Kaneda D,Oyanagi K

更新日期：2018-03-01 00:00:00

abstract：:Pilocytic astrocytoma (PA), featuring activation of the mitogen-activated protein kinase (MAPK) pathway, is the most common tumor of the pediatric central nervous system. However, it remains unknown whether MAPK activation is present in the reactive gliosis of non-neoplastic lesions. Therefore, we investigated the exp...

journal_title：Clinical neuropathology

authors： Takeuchi H,Neishi H,Higashino Y,Kitai R,Kikuta KI,Imamura Y

更新日期：2018-01-01 00:00:00

abstract：:The Brain Tumor Epidemiology Consortium (BTEC) is an international consortium that aims to advance the development of multicenter and interdisciplinary collaborations that focus on research related to the etiology, outcomes, and prevention of brain tumors. The 18^th annual BTEC meeting was held in Banff, AB,...

journal_title：Clinical neuropathology

authors： Johnson KJ,Schwartzbaum J,Kruchko C,Scheurer ME,Lau CC,Woehrer A,Hainfellner JA,Wiemels J

更新日期：2017-11-01 00:00:00

abstract：:Atypical teratoid rhabdoid tumor (AT/RT) is a rare and aggressive tumor usually occurring at younger ages. Pleomorphic xanthoastrocytomas (PXA) on the other hand are quiescent tumors with benign behavior. AT/RTs arising in the setting of PXA are exceptional. We present the case of a 23-year-old female patient, the fou...

journal_title：Clinical neuropathology

authors： Uner M,Saglam A,Meydan BC,Aslan K,Soylemezoglu F

更新日期：2017-09-01 00:00:00

abstract：:Rare forms of autosomal-dominant Charcot-Marie-Tooth disease (AD-CMT) may be associated with mutations in Fibulin-5 (FBLN5) as AD-CMT is genetically heterogeneous. Here, we report the first pathological study of an Asian family. The proband was a 46-year-old man with slowly progressive distal numbness and weakness for...

journal_title：Clinical neuropathology

authors： Cheng S,Lv H,Zhang W,Wang Z,Shi X,Liang W,Yuan Y

更新日期：2017-07-01 00:00:00

abstract：:Metastatic spread of a systemic neoplasm to a central nervous system malignancy is a rare but well-documented phenomenon. Over 100 case reports of tumor-to-tumor spread involving the central nervous system have been described since the first report in 1930. Overwhelmingly, intracranial meningioma represents the most c...

journal_title：Clinical neuropathology

authors： Richter B,Harinath L,Pu C,Stabingas K

更新日期：2017-03-01 00:00:00

abstract：:Melanocytic lesions in the central nervous system (CNS) may be primary to the site but are more commonly metastases from cutaneous primaries. In fact, melanomas are one of the most common malignancies that can metastasize to the brain, and some patients may not have a diagnosis of melanoma prior to the discovery of th...

journal_title：Clinical neuropathology

authors： Gamsizkan M,Yilmaz I,Simsek HA,Onguru O,Griffin A,Tihan T

更新日期：2016-07-01 00:00:00

abstract：:A 29-year-old pregnant woman developed progressively worsening encephalopathy, left hemiparesis, and hemodynamic instability over a 6-week period. Initial brain MRI and work-up for infectious and autoimmune causes were normal, although elevated IgG and oligoclonal bands were seen on analysis of the cerebrospinal fluid...

journal_title：Clinical neuropathology

authors： Reis GF,Ritter JM,Bellini WJ,Rota PA,Bollen AW

更新日期：2015-09-01 00:00:00

abstract：MATERIALS AND METHODS:The present paper examines the brains and spinal cords in 7 patients with amyotrophic lateral sclerosis (ALS) receiving artificial respirator support in a totally locked-in state (TLS) neuropathologically in order to clarify whether any anatomical structures in the central nervous system are prese...

journal_title：Clinical neuropathology

authors： Oyanagi K,Mochizuki Y,Nakayama Y,Hayashi K,Shimizu T,Nagao M,Hashimoto T,Yamazaki M,Matsubara S,Komori T

更新日期：2015-09-01 00:00:00

abstract：:Glutamine synthetase is an enzyme involved in the clearance of glutamate, the most potent excitatory neurotransmitter. We studied the immunohistochemical expression of glutamine synthetase in neocortical samples from 5 children who underwent surgery for pharmacoresistant epilepsy and a histological diagnosis of focal ...

journal_title：Clinical neuropathology

authors： Buccoliero AM,Barba C,Giordano F,Baroni G,Genitori L,Guerrini R,Taddei GL

更新日期：2015-03-01 00:00:00

abstract：:Meningioangiomatosis is a rare, benign, developmental, or hamartomatous lesion which may involve the leptomeninges and underlying brain parenchyma. Histologically, meningioangiomatosis is marked by a proliferation of blood vessels in the parenchyma, rimmed by collars of spindled meningothelial cells. There are anecdot...

journal_title：Clinical neuropathology

authors： Grabowski MM,Prayson RA

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:We report the incidence of spontaneous infarction of a falcine meningioma without preceding hemorrhage and shed light on the relation between intratumoral necrosis and hemorrhage. CLINICAL PRESENTATION:A 50 year-old woman presented with recurrent headaches and was found to harbor a falcine meningioma. The pa...

journal_title：Clinical neuropathology

authors： Jain A,Hoeprich M,Mittal M,Kupsky WJ,Mittal S

更新日期：2014-11-01 00:00:00

abstract：:Hemangiopericytoma (HPC) is a rare tumor of the central nervous system, most commonly found in the cranial cavity. HPCs in the spine are rare, and very few of them are primary osseous HPC. The aims of this study were to describe a rare case of primary osseous HPC in the thoracic spine and review the literature. A 54-y...

journal_title：Clinical neuropathology

authors： Ren K,Zhou X,Wu S,Sun X

更新日期：2014-09-01 00:00:00

abstract：:We describe an autopsied case of a Japanese woman with Gerstmann-Straeussler-Scheinker disease (GSS) presenting with a rapidly progressive clinical course. Disease onset occurred at the age of 54 with dementia and gait disturbance. Her clinical course progressively deteriorated until she reached a bedridden state with...

journal_title：Clinical neuropathology

authors： Iwasaki Y,Mori K,Ito M,Nokura K,Tatsumi S,Mimuro M,Kitamoto T,Yoshida M

更新日期：2014-09-01 00:00:00

abstract：:We present an unusual medulloblastoma in a 3.9-year-old boy who had a 2-week history of nausea and vertigo. MRI revealed a 5×5.5×5 cm sized tumor located in the fourth ventricle and spinal leptomeningeal dissemination. The patient was treated according to the MET-HIT 2000-BIS4 protocol but showed tumor progression aft...

journal_title：Clinical neuropathology

authors： Stefanits H,Ebetsberger-Dachs G,Weis S,Haberler C

更新日期：2014-03-01 00:00:00

abstract：AIMS:To quantify white matter pathology in progressive supranuclear palsy (PSP). MATERIAL:Histological sections of white matter of 8 PSP and 8 control cases. METHOD:Densities and spatial patterns of vacuolation, glial cell nuclei, and glial inclusions (GI) were measured in 8 cortical and subcortical fiber tracts. RE...

journal_title：Clinical neuropathology

authors： Armstrong RA

更新日期：2013-09-01 00:00:00

abstract：:Gangliocytic lesions of the pituitary gland producing Cushing's disease are extremely rare entities that may exist with or without a pituitary adenoma. The latter have been designated mixed pituitary adenoma-gangliocytomas, the majority of which produce growth hormone, not adrenocorticotropin (ACTH), and are localized...

journal_title：Clinical neuropathology

authors： Bridenstine M,Kerr JM,Lillehei KO,Kleinschmidt-DeMasters BK

更新日期：2013-09-01 00:00:00

abstract：:Cortical ependymomas are rare gliomas with classic ependymal features but are unusual in primarily involving the cerebral cortex. Here, we present a 19-year old woman with new-onset seizures who was found to have a large, cortically based non-enhancing lesion with scalloping of the overlying calvarium. Abundant ependy...

journal_title：Clinical neuropathology

authors： Hiniker A,Lee HS,Chang S,Berger M,Perry A

更新日期：2013-07-01 00:00:00

abstract：:Classic herpes simplex virus encephalitis (HSVE) is an acute viral infection that usually follows a monophasic disease course; however some patients, mainly children, experience a relapse within weeks or months after the initial event. In a subset of these patients a viral reactivation is unlikely because the CSF PCR ...

journal_title：Clinical neuropathology

authors： Höftberger R,Armangue T,Leypoldt F,Graus F,Dalmau J

更新日期：2013-07-01 00:00:00

abstract：:Pilocytic astrocytoma (PA) is the most common pediatric tumor, with the vast majority being benign (WHO Grade I). Herein, we present a rare sporadic (not radiation- or NF1-associated) anaplastic PA arising from the cerebellum of an adult patient. The diagnosis was based on the coexistence of classic PA and more cellul...

journal_title：Clinical neuropathology

authors： Yeo YH,Byrne NP,Counelis GJ,Perry A

更新日期：2013-05-01 00:00:00

abstract：:Gliosarcoma, a biphasic tumor with both mesenchymal and glial elements, is typically considered a variant of astrocytoma (glioblastoma), WHO Grade IV. A 57-year-old man presented with altered mental status and was found to have a large right frontal mass. Biopsy and subsequent subtotal resection revealed a WHO Grade I...

journal_title：Clinical neuropathology

authors： Hiniker A,Hagenkord JM,Powers MP,Aghi MK,Prados MD,Perry A

更新日期：2013-05-01 00:00:00

abstract：:Klippel-Feil syndrome is an uncommon congenital anomaly that is characterized by abnormal fusion of the cervical vertebrae and occasionally accompanied by various anomalies of other bones and internal organs. We report the autopsy case of a 5-year-old girl with this syndrome ssociated with congenital cervical dislocat...

journal_title：Clinical neuropathology

authors： Shintaku M,Wada K,Koyama T,Kohno H,Sakamoto T,Hida S

更新日期：2013-01-01 00:00:00

abstract：:Both cavernous angiomas and focal cortical dysplasia (FCD) are well recognized causes of pharmacoresistant epilepsy. Anecdotal cases of FCD adjacent to cavernous angiomas have been documented in the literature. This study systematically reviews a series of cavernous angiomas in epilepsy patients, looking for evidence ...

journal_title：Clinical neuropathology

authors： Chen DJ,Severson E,Prayson RA

更新日期：2013-01-01 00:00:00

abstract：:In 2005, a seminal paper showed that glioblastoma patients aged 18 to 70, whose tumors have a methylated MGMT promoter have a better prognosis than patients with tumors carrying an unmethylated MGMT promoter. As a consequence of this and several confirmatory studies, routine MGMT testing in the clinical setting was pr...

journal_title：Clinical neuropathology

authors： Berghoff AS,Preusser M

更新日期：2012-11-01 00:00:00

abstract：:Intracranial occurrence of a chloroma (myeloid sarcoma, MS) in the absence of a preceding hematological malignancy is unusual. We report the case of a 20-year-old man who presented with Garcin's syndrome of short duration. MRI revealed multiple extra-axial contrast enhancing lesions: two mirror lesions on the skull ba...

journal_title：Clinical neuropathology

authors： Thakar S,Dadlani R,Ghosal N,Jethwani D,Mahadevan A,Hegde AS

更新日期：2012-09-01 00:00:00

abstract：:A retrospective study of the essential general pathology and neuropathological features in 100 nondemented individuals aged 65 years or older (mean 81.23 ± 5.47 y) was performed using semiquantitative methods. 91% of the patients had a history of hypertension, 31% malignancies, 24% COPD, 18% myocardial infarction, and...

journal_title：Clinical neuropathology

authors： Jellinger KA,Attems J

更新日期：2012-03-01 00:00:00

abstract：:Nerve biopsy is a valuable tool in the diagnostic work-up of peripheral neuropathies. Currently, major indications include interstitial pathologies such as suspected vasculitis and amyloidosis, atypical cases of inflammatory neuropathy and the differential diagnosis of hereditary neuropathies that cannot be specified ...

journal_title：Clinical neuropathology

authors： Weis J,Brandner S,Lammens M,Sommer C,Vallat JM

更新日期：2012-01-01 00:00:00

abstract：AIMS:The stereotactic brain biopsy is an essential diagnostic procedure in modern neurologic patient management. A side-cutting biopsy needle is one of the most widely used needle types. Recently we found a characteristic tissue artifact named "peripheral compressing artifact" in the brain tissues biopsied using a side...

journal_title：Clinical neuropathology

authors： Kim SH,Chang WS,Kim JP,Minn YK,Choi J,Chang JW,Kim TS,Park YG,Chang JH

更新日期：2011-11-01 00:00:00

abstract：:Focal and symmetric necrotic lesions of the brainstem are thought to result from fetal hypotension or cardiac arrest in the perinatal period and thus occur in the course of postnatal intensive care rather than in utero. Here, we report for the first time on brainstem necrosis in a preterm stillborn demonstrating that ...

journal_title：Clinical neuropathology

authors： Szekessy DP,Bamberg C,Blechschmidt C,Kaindl AM,Stoltenburg-Didinger G

更新日期：2010-11-01 00:00:00

abstract：:Definitive diagnosis of neurodegenerative diseases (NDDs) relies on the neuropathological evaluation. NDDs are defined as disorders with progressive loss of neurons showing distinct anatomical distribution, and accordingly different clinical phenotypes. Recent research has identified a spectrum of immunohistochemicall...

journal_title：Clinical neuropathology

authors： Kovacs GG,Budka H

更新日期：2010-09-01 00:00:00

abstract：:After the interruption of the international multicenter Phase 2 clinical trial with active immunotherapy based on synthetic Abeta42 (AN1792), few reports about the neuropathological findings in those patients and those from the Phase 1 clinical trial were published. These reports described some pathological similariti...

journal_title：Clinical neuropathology

authors： Uro-Coste E,Russano de Paiva G,Guilbeau-Frugier C,Sastre N,Ousset PJ,da Silva NA,Lavialle-Guillotreau V,Vellas B,Delisle MB

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:Isolated neurosarcoidosis without evidence of extracranial manifestation continues to be a rare phenomenon. This case report and others in the literature demonstrate the difficulty in making the diagnosis of isolated neurosarcoidosis, as it may be indistinguishable from other pathologies on radiographic and l...

journal_title：Clinical neuropathology

authors： Kimball MM,Wind JJ,Codispoti KE,Jones RV,Leiphart JW

更新日期：2010-05-01 00:00:00