听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING期刊下所有文献
  • In Vitro Antifungal Screening of Argentine Native or Naturalized Plants against the Phytopathogen Monilinia fructicola.

    abstract:BACKGROUND:One of the main problems that fruit health has gone through in recent years is the difficult eradication of their fungal pathogens during crops or the post-harvest stage. This concerns the whole world because it represents huge production losses, fruit export restrictions and consumer distrust. Consequently,...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207324666210121113648

    authors: Stegmayer MI,Fernández LN,Álvarez NH,Seimandi GM,Reutemann AG,Derita MG

    更新日期:2021-01-20 00:00:00

  • Potential of MurA Enzyme and GBAP in Fsr Quorum Sensing System as Antibacterial Drugs Target: In vitro and In silico Study of Antibacterial Compounds from Myrmecodia pendans.

    abstract:BACKGROUND:Increasing the resistance issue has become the reason for the development of new antibacterial in crucial condition. Many ways are tracked to determine the most effective antibacterial agent. Some proteins that are a key role in bacteria metabolism are targeted, including MurA in cell wall biosynthesis and g...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666200628111348

    authors: Apriyanti E,Satari MH,Kurnia D

    更新日期:2021-01-01 00:00:00

  • Exploration of the Potential Mechanism of Calculus Bovis in Treatment of Primary Liver Cancer by Network Pharmacology.

    abstract:AIM AND OBJECTIVE:Calculus Bovis (CB) has been employed to treat diseases for a long time. It has been identified to play significant anti-inflammatory and anti-tumor roles. However, the mechanism of treating primary liver cancer (PLC) remains to be revealed. This study aims to clarify the molecules and mechanisms of C...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666200808172051

    authors: Zhang Z,Zeng P,Gao W,Wu R,Deng T,Chen S,Tian X

    更新日期:2021-01-01 00:00:00

  • Host-directed Therapy: A New Arsenal to Come.

    abstract::The emergence of drug-resistant strains among the variety of pathogens worsens the situation in today's scenario. In such a situation, a very heavy demand for developing the new antibiotics has arisen, but unfortunately, very limited success has been achieved in this arena till now. Infectious diseases usually make th...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323999200728115857

    authors: Mohan M,Bhattacharya D

    更新日期:2021-01-01 00:00:00

  • On Extremal Graphs of Degree Distance Index by Using Edge-Grafting Transformations Method.

    abstract:BACKGROUND:Topological indices have numerous implementations in chemistry, biology and in lot of other areas. It is a real number associated to a graph, which provides information about its physical and chemical properties and their correlations. For a connected graph H, the degree distance defined as DD(H)=∑_(\{h_1,h_...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666201224123643

    authors: Imran M,Akhtar S,Ahmad U,Ahmad S,Bilal A

    更新日期:2020-12-24 00:00:00

  • Design, Synthesis and Biological Evaluation of New Cycloalkyl Fused Quinolines Tethered to Isatin Schiff Bases as Cholinesterase Inhibitors.

    abstract:AIMS AND OBJECTIVE:Alzheimer's disease is now a most prevalent neuro degenerative disease of central nervous system leading to dementia in elderly aged population. Numerous pathological changes have been associated in the progression of Alzheimer's disease. One of such pathological hypothesis is declined cholinergic ac...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666201211092138

    authors: Macha B,Kulkarni R,Garige AK,Palabindala R,Akkinepally R,Garlapati A

    更新日期:2020-12-10 00:00:00

  • Scutellaria barbata flavonoids improve the composited Aβ-induced abnormal changes of glial cells in rats' brain.

    abstract:AIM:It has been reported that glial cells are involved in Alzheimer's disease (AD). According to our previous research, Scutellaria barbata flavonoids (SBFs) can protect the neuronal disorder and memory impairment for AD-like rats, while the effect of SBFs on the glial cells disorder in AD-like rats has been less well ...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666201209092358

    authors: Cheng JJ,Guo Q,Wu XG,Ma S,Gao Y,Ya-Zhen S

    更新日期:2020-12-08 00:00:00

  • Validation of an UPLC-DAD method for the quantification of phenolic acids, verbascoside and 6-epi-aububin in Crescentia cujete fruit.

    abstract:BACKGROUND:The fruit pulp decoction of Crescentia cujete, commonly known as calabash, is traditionally used for the treatment of several respiratory diseases and is available as syrup formulations. Unfortunately, there is no detailed investigation on analytical methods for warranting the quality of these products. AIM...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666201207114302

    authors: Rivera-Mondragón A,Caballero-George C,Pieters L,Foubert K

    更新日期:2020-12-06 00:00:00

  • A Pilot Study for Investigation of Plasma Amino Acid Profile in Neurofibromatosis Type 1 Patients.

    abstract:BACKGROUND:Neurofibromatosis, also known as Von Recklinghausen disease, is a systemic and progressive genetic disease that primarily affects the skin, eyes, nervous system and bones. The disease can occur in a variety of ways and can vary from individuals. Metabolomic-based research using blood samples has enabled new ...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666201204143206

    authors: Oz O,Koyuncu I,Gonel A

    更新日期:2020-12-04 00:00:00

  • Receptor dynamics in molecular recognition by Cryo-EM and molecular simulation.

    abstract::The appropriate selection of initial receptor structure has been the 'cornerstone' or foundation of successful structure-based virtual screening (SBVS), and plagued the structure-based design with a significantly practical problem to determine the major physiological states or important transition states of receptors ...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666201110150140

    authors: Zhao Y,Wang H,Zang Y,Zhu X,Zhang S,Zhang L

    更新日期:2020-11-10 00:00:00

  • Functional characterization and structural modelling of peptidoglycan degrading β-N-acetyl-glucosaminidase from a dental isolate of Serratia marcescens.

    abstract:INTRODUCTION:Enzymatic degradation of peptidoglycan, a structural cell wall component of Gram-positive bacteria, has attracted considerable attention being a specific target for many known antibiotics. METHODS:Peptidoglycan hydrolases are involved in bacterial lysis through peptidoglycan degradation. β-N-acetylglucosa...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323999201103204234

    authors: Rathee A,Panwar A,Kumari S,Chhibber S,Kumar A

    更新日期:2020-11-03 00:00:00

  • Mechanistic Insights to the Binding of Antibody CR3022 Against RBD from SARS-CoV and HCoV-19/SARS-CoV-2: A Computational Study.

    abstract:Aims & Objective:Corona Virus Disease 2019 (COVID-19) caused by the human coronavirus 2019 (HCoV-19, also known as SARS-CoV-2) infection is currently in a global outbreak. COVID-19 has posed a huge threat to public health and economic stability worldwide. CR3022, a human monoclonal neutralizing antibody isolated from a...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666201026160500

    authors: Yu W,Wu X,Ren J,Zhang X,Wang Y,Li C,Xu W,Li J,Li G,Zheng W,Liao H,Yuan X

    更新日期:2020-10-26 00:00:00

  • Correlative Study of Bone-Related Biochemicals and Endocrine Changes in Perimenopausal Women in Enugu, Nigeria.

    abstract:BACKGROUND AND OBJECTIVE:Perimenopause is a physiological occurrence in women, and is characterized by endocrine and biochemical changes. During perimenopause phase, many derangements or abnormal health conditions start developing as a result of hormonal changes. These derangements in health conditions and biochemical ...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666201023120212

    authors: Ikegwuonu CI,Uchendu IK,Maduka CI

    更新日期:2020-10-23 00:00:00

  • The influence of diabetes mellitus on rotator cuff repair: A systematic review and meta-analysis.

    abstract:BACKGROUND:Clinical outcomes after rotator cuff repair associated with diabetes mellitus(DM) are generally favorable, but no study has attempted to establish the influence of DM on outcomes after rotator cuff repair. PURPOSE:To conduct a meta-analysis of clinical studies evaluating patient outcomes between people with...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: meta分析

    doi:10.2174/1386207323666201020114034

    authors: Lu X,Sun H,Xu Y,Cao X

    更新日期:2020-10-20 00:00:00

  • Moringa oleifera leaf extract attenuates Pb acetate-induced testicular damage in rats.

    abstract:BACKGROUND:Lead (Pb) remains a common contaminant in the environment in many parts of the world. Pb exposure adversely affects many human organs, including the gonads, via oxidant and inflammatory marker propagation in affected tissues. Moringa oleifera leaf extract (MOE) is a rich source of antioxidants reported to ha...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666200923142831

    authors: Albasher G,Alrajhi R,Alshammry E,Almeer R

    更新日期:2020-09-23 00:00:00

  • Systematic evaluation of the mechanisms of Mulberry leaf (Morus alba Linne) acting on diabetes based on network pharmacology and molecular docking.

    abstract:BACKGROUND:Diabetes mellitus is one of the most common endocrine metabolic disorder diseases. The application of herbal medicine to control glucose levels and improve insulin action might be a useful approach in the treatment of diabetes. Mulberry leaves (ML) has been reported to exert important activities of anti-diab...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666200914103719

    authors: Wu Q,Hu Y

    更新日期:2020-09-13 00:00:00

  • Osteopontin is a prognostic factor in patients with advanced gastric cancer.

    abstract:OBJECTIVE:Osteopontin (OPN), a phosphorylated sialoprotein, has been shown to overexpress in a variety of cancers and to contribute tumor progression and metastasis by increasing cell migration and adhesion. In the current study, we aimed to investigate the prognostic and predictive role of OPN in patients with advance...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666200902135349

    authors: Yazici O,Dogan M,Ozal G,Aktas SH,Demirkazik A,Utkan G,Senler FC,Icli F,Akbulut H

    更新日期:2020-09-02 00:00:00

  • Antidepressant Drug Design on TCAs and Phenoxyphenylpropylamines utilizing QSAR and Pharmacophore Modeling.

    abstract:BACKGROUND:Depression is a mental illness caused by the imbalance of important neurotransmitters such as serotonin (5-HT) and norepinephrine (NE). It is a serious neurological disorder that could be treated by antidepressant drugs. OBJECTIVE:There are two major classes such as TCAs and phenoxyphenylpropylamines which ...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666200901104222

    authors: Kumar A,Nandi S,Saxena AK

    更新日期:2020-08-31 00:00:00

  • Study on the active ingredients and potential targets of rice bran petroleum ether extracts for treating diabetes based on network pharmacology.

    abstract:AIM AND OBJECTIVE:In ancient China, rice bran was used to treat diabetes and hyperlipidemia. The aim of this paper is to explore the active compounds and underlying mechanism of rice bran petroleum ether extracts (RBPE) against diabetes using network pharmacology. MATERIALS AND METHODS:Gas chromatography-mass spectrom...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323999200821162307

    authors: Huang X,Zhang M,Wu H,Wang X,Xu F

    更新日期:2020-08-21 00:00:00

  • Discovery of Potent SARS-CoV-2 Inhibitors from Approved Antiviral Drugs via Docking Screening.

    abstract:BACKGROUND:Corona Virus Disease 2019 (COVID-19) pandemic threatens patients, societies and healthcare systems around the world. There is an emergent need to search for possible medications. OBJECTIVE:This article intends to use virtual screening and molecular docking methods to find potential inhibitors that can respo...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323999200730205447

    authors: Chtita S,Belhassan A,Aouidate A,Belaidi S,Bouachrine M,Lakhlifi T

    更新日期:2020-07-30 00:00:00

  • Moxifloxacin Hydrochloride-Loaded Eudragit® RL 100 and Kollidon® SR Based Nanoparticles: Formulation, In vitro Characterization and Cytotoxicity.

    abstract:BACKGROUND:Considering the low ocular bioavailability of conventional formulations used for ocular bacterial infection treatment, there's a need for designing efficient novel drug delivery systems that may enhance of precorneal retention time and corneal permeability. AIM AND OBJECTIVE:The current research focuses on ...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666200428091945

    authors: Kırımlıoğlu GY,Özer S,Büyükköroğlu G,Yazan Y

    更新日期:2020-04-27 00:00:00

  • Expression Levels of A Disintegrin-like Metalloproteinase with Thrombospondin Motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in Inflamed and Healthy Gingival Tissues.

    abstract:BACKGROUND:ADAMTS (A disintegrin-like metalloproteinase with thrombospondin motifs) is a group of 19 zinc-dependent metalloproteases known to function in many pathological and physiological processes, such as adhesion, cell fusion, signaling, proteolysis and ECM degradation. OBJECTIVES:The aim of this study was to dem...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666200218113000

    authors: Tayman MA,Koyuncu İ,Köklü NÖ

    更新日期:2020-01-01 00:00:00

  • Network Pharmacology-based Investigation of the Underlying Mechanism of Panax notoginseng Treatment of Diabetic Retinopathy.

    abstract:BACKGROUND:Panax notoginseng, a Chinese herbal medicine, has been widely used to treat vascular diseases. Diabetic retinopathy (DR) is one of the complications of diabetic microangiopathy. According to recent studies, the application of Panax notoginseng extract and related Chinese patent medicine preparations can sign...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666200305093709

    authors: Piao C,Sun Z,Jin,Wang H,Wu X,Zhang N,Lian F,Tong X

    更新日期:2020-01-01 00:00:00

  • Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives.

    abstract:AIM AND OBJECTIVE:In the last decades, cancer has become a major problem in public health all around the globe. Chimeric chemical structures have been established as an important trend on medicinal chemistry in the last years. Thiazacridines are hybrid molecules composed of a thiazolidine and acridine nucleus, both pha...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666200319105239

    authors: Almeida ML,Viana DCF,da Costa VCM,Dos Santos FA,Pereira MC,Pitta MGR,de Melo Rêgo MJB,Pitta IR,Pitta MGR

    更新日期:2020-01-01 00:00:00

  • Dendrobium officinalis Flower Improves Learning and Reduces Memory Impairment by Mediating Antioxidant Effect and Balancing the Release of Neurotransmitters in Senescent Rats.

    abstract:AIM AND OBJECTIVE:The Dendrobium officinalis flower (DOF) is popular in China due to common belief in its anti-aging properties and positive effects on "nourish yin". However, there have been relatively few confirmatory pharmacological experiments conducted to date. The aim of this work was to evaluate whether DOF has ...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666200407080352

    authors: Li LZ,Lei SS,Li B,Zhou FC,Chen YH,Su J,Lv GY,Chen SH

    更新日期:2020-01-01 00:00:00

  • Novel Thiazole-Based Thiazolidinones as Potent Anti-infective Agents: In silico PASS and Toxicity Prediction, Synthesis, Biological Evaluation and Molecular Modelling.

    abstract:AIMS AND OBJECTIVE:The infectious disease treatment remains a challenging concern owing to the increasing number of pathogenic microorganisms associated with resistance to multiple drugs. A promising approach for combating microbial infection is to combine two or more known bioactive heterocyclic pharmacophores in one ...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666200127115238

    authors: Tratrat C

    更新日期:2020-01-01 00:00:00

  • Identification of Three Differentially Expressed miRNAs as Potential Biomarkers for Lung Adenocarcinoma Prognosis.

    abstract:OBJECTIVE:The aim of this study areto screen MicroRNAs (miRNAs) related to the prognosis of lung adenocarcinoma (LUAD) and to explore the possible molecular mechanisms. METHODS:The data for a total of 535 patients with LUAD data were downloaded from The Cancer Genome Atlas (TCGA) database. The miRNAs for LUAD prognosi...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207323666200124123103

    authors: Wang W,Liu B,Duan X,Feng X,Wang T,Wang P,Ding M,Zhang Q,Feng F,Wu Y,Yao W,Wang Q,Yang Y

    更新日期:2020-01-01 00:00:00

  • Effect of the Phragmitis Rhizoma Aqueous Extract on the Pharmacokinetics of Docetaxel in Rats.

    abstract:BACKGROUND:Traditionally, Phragmitis rhizoma has been prescribed to relive a fever, vomiting, dysuria, and constipation, and to promote secretion of fluids. In addition, recent studies have reported its efficacy as a diuretic and antiemetic. Our previous study demonstrated that the Phragmitis rhizoma aqueous extract (E...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207322666190419110724

    authors: Shin S,Kim NS,Kim YA,Oh HR,Bang OS

    更新日期:2019-08-08 00:00:00

  • Identification of N-Substituted Triazolo-azetidines as Novel Antibacterials using pDualrep2 HTS Platform.

    abstract:AIM AND OBJECTIVE:Antibiotic resistance is a serious constraint to the development of new effective antibacterials. Therefore, the discovery of the new antibacterials remains one of the main challenges in modern medicinal chemistry. This study was undertaken to identify novel molecules with antibacterial activity. MAT...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207322666190412165316

    authors: Ivanenkov YA,Yamidanov RS,Osterman IA,Sergiev PV,Aladinskiy VA,Aladinskaya AV,Terentiev VA,Veselov MS,Ayginin AA,Skvortsov DA,Komarova KS,Chemeris AV,Baimiev AK,Sofronova AA,Malyshev AS,Machulkin AE,Petrov RA,Bezrukov D

    更新日期:2019-08-08 00:00:00

  • Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development.

    abstract:AIM AND OBJECTIVE:Flap endonuclease-1 (FEN1) plays a central role in DNA replication and DNA damage repair process. In mammals, FEN1 functional sites variation is related to cancer and chronic inflammation, and supports the role of FEN1 as a tumor suppressor. However, FEN1 is overexpressed in multiple types of cancer c...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207322666190704095602

    authors: Liu SB,Qiu XQ,Guo WQ,Li JL,Su Q,Du JH,Hu HJ,Wang XX,Song YH,Lou X,Xu XB

    更新日期:2019-01-01 00:00:00

  • Identification of Genes Associated with Lung Adenocarcinoma Prognosis.

    abstract:OBJECTIVE:Lung cancer is the most prevalent cancer in the world, and lung adenocarcinoma is the most common lung cancer subtype. Identification and determination of relevant prognostic markers are the key steps to personalized cancer management. METHODS:We collected the gene expression profiles from 265 tumor tissues ...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207322666190404152140

    authors: He ZH,Lv W,Wang LM,Wang YQ,Hu J

    更新日期:2019-01-01 00:00:00

  • Plasma-Free Amino Acid Profiling of Nasal Polyposis Patients.

    abstract:AIM AND OBJECTIVE:To determine the mechanisms present in the etiopathogenesis of nasal polyposis. It is not clear whether amino acids contribute in a causal way to the development of the disease. Therefore, the aim of this study was to determine the plasma-free amino acid profile in patients with nasal polyposis and to...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207322666190920110324

    authors: Celik M,Şen A,Koyuncu İ,Gönel A

    更新日期:2019-01-01 00:00:00

  • Constructing a Risk Prediction Model for Lung Cancer Recurrence by Using Gene Function Clustering and Machine Learning.

    abstract:OBJECTIVE:A significant proportion of patients with early non-small cell lung cancer (NSCLC) can be cured by surgery. The distant metastasis of tumors is the most common cause of treatment failure. Precisely predicting the likelihood that a patient develops distant metastatic risk will help identify patients who can fu...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207322666190129111749

    authors: Zhong J,Chen JM,Chen SL,Yi YF

    更新日期:2019-01-01 00:00:00

  • The Application of High-Throughput Technologies in Precision Diagnosis and Personalized Therapy (Pt III).

    abstract:: ...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 社论

    doi:10.2174/138620732204190724103437

    authors: Huang T

    更新日期:2019-01-01 00:00:00

  • Identification of the Active Constituents and Significant Pathways of Guizhi-Shaoyao-Zhimu Decoction for the Treatment of Diabetes Mellitus Based on Molecular Docking and Network Pharmacology.

    abstract:AIM AND OBJECTIVE:This study was designed to explore the active compounds and significant pathways of Guizhi-Shaoyao-Zhimu decoction (GSZD) for treating diabetes mellitus using molecular docking combined with network pharmacology. MATERIALS AND METHODS:Chemical constituents of GSZD and diabetes-related target proteins...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207322666191022101613

    authors: Zhang Q,Li R,Peng W,Zhang M,Liu J,Wei S,Wang J,Wu C,Gao Y,Pu X

    更新日期:2019-01-01 00:00:00

  • Exploration of the Hepatoprotective Effect and Mechanism of Swertia mussotii Franch in an Acute Liver Injury Rat Model.

    abstract:BACKGROUND AND OBJECTIVE:Swertia mussotii Franch, also known as "Zangyinchen", is one of a Tibetan traditional herb used for treatment of liver diseases over thousands of years at Qinghai-Tibet Plateau, has been confirmed to be hepatoprotective. However, the underlying mechanism is largely unknown. MATERIALS AND METHO...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207322666191106105725

    authors: Yun H,Duan X,Xiong W,Ding Y,Wu X,Kang J,Pu X,Yang Y,Chen Z

    更新日期:2019-01-01 00:00:00

  • Network Pharmacology and Reverse Molecular Docking-Based Prediction of the Molecular Targets and Pathways for Avicularin Against Cancer.

    abstract:AIM AND OBJECTIVE:Avicularin has been found to inhibit the proliferation of HepG-2 cells in vitro in the screening of our laboratory. We intended to explain the molecular mechanism of this effect. Therefore, the combined methods of reverse molecular docking and network pharmacology were used in order to illuminate the ...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207322666190206163409

    authors: Duan C,Li Y,Dong X,Xu W,Ma Y

    更新日期:2019-01-01 00:00:00

  • Virtual Combinatorial Library Design, Synthesis and In vitro Anticancer Assessment of -2-Amino-3-Cyanopyridine Derivatives.

    abstract:AIM AND OBJECTIVE:For the development of new class of anticancer agents, a series of novel 2-amino-3-cyanopyridine derivatives were designed from virtual screening with Glide program by setting Topoisomerase II as the target. MATERIALS AND METHODS:The top ranked ten molecules from the virtual screening were synthesize...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207321666180228113925

    authors: Dev S,Dhaneshwar SR,Mathew B

    更新日期:2018-01-01 00:00:00

  • DABCO Catalyzed Green and Efficient Synthesis of 2-Amino-4H-Pyrans and Their Biological Evaluation as Antimicrobial and Anticancer Agents.

    abstract:AIM AND OBJECTIVE:The present method is simple, green and highly efficient for the synthesis of 2-amino-4H-pyran derivatives which are achieved by a one pot three component cyclocondensation of aldehyde, malanonitrile and ethyl acetoacetate or methyl acetoacetate using DABCO under solvent free with grinding conditions ...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207321666180315095422

    authors: Waghmare AS,Pandit SS,Suryawanshi DM

    更新日期:2018-01-01 00:00:00

  • Using Naïve Bayes Algorithm to Estimate the Response to Drug in Lung Cancer Patients.

    abstract:AIM AND OBJECTIVE:Lung cancer is a highly heterogeneous cancer, due to the significant differences in molecular levels, resulting in different clinical manifestations of lung cancer patients there is a big difference. Including disease characterization, drug response, the risk of recurrence, survival, etc. Method:Clin...

    journal_title:Combinatorial chemistry & high throughput screening

    pub_type: 杂志文章

    doi:10.2174/1386207322666190125151624

    authors: Guo B,Zheng Q

    更新日期:2018-01-01 00:00:00

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