听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览Annual Review of Medicine期刊下所有文献
  • Novel Targets for Alzheimer's Disease: A View Beyond Amyloid.

    abstract::Genetic studies of autosomal dominant Alzheimer's disease (AD) revealed that β-amyloid is central to disease pathogenesis. However, amyloid-targeted therapies have generally failed to slow progression in patients with symptomatic disease. This result suggests a transition from an early amyloid-dependent phase to a lat...

    journal_title:Annual review of medicine

    pub_type: 杂志文章

    doi:10.1146/annurev-med-052919-120219

    authors: Ray WJ,Buggia-Prevot V

    更新日期:2021-01-27 00:00:00

  • Biological Aspects of Cancer Health Disparities.

    abstract::Racial and ethnic disparities span the continuum of cancer care and are driven by a complex interplay among social, psychosocial, lifestyle, environmental, health system, and biological determinants of health. Research is needed to identify these determinants of cancer health disparities and to develop interventions t...

    journal_title:Annual review of medicine

    pub_type: 杂志文章

    doi:10.1146/annurev-med-070119-120305

    authors: Freedman JA,Al Abo M,Allen TA,Piwarski SA,Wegermann K,Patierno SR

    更新日期:2021-01-27 00:00:00

  • A Crucial Role for Diet in the Relationship Between Gut Microbiota and Cardiometabolic Disease.

    abstract::Cardiometabolic disease (CMD), such as type 2 diabetes mellitus and cardiovascular disease, contributes significantly to morbidity and mortality on a global scale. The gut microbiota has emerged as a potential target to beneficially modulate CMD risk, possibly via dietary interventions. Dietary interventions have been...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-062218-023720

    authors: Attaye I,Pinto-Sietsma SJ,Herrema H,Nieuwdorp M

    更新日期:2020-01-27 00:00:00

  • Prevention of HIV Transmission and the HPTN 052 Study.

    abstract::The HIV Prevention Trials Network 052 study (HPTN 052) was a clinical trial designed to determine whether early treatment for HIV infection prevented transmission of the virus in couples where one partner was infected with HIV and the other was not, referred to as HIV serodiscordant or serodifferent couples. The study...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1146/annurev-med-110918-034551

    authors: Cohen MS,Gamble T,McCauley M

    更新日期:2020-01-27 00:00:00

  • CD40 Agonist Antibodies in Cancer Immunotherapy.

    abstract::CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist CD40 antibodies of varying formulations have been evaluated in the clinic ...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-062518-045435

    authors: Vonderheide RH

    更新日期:2020-01-27 00:00:00

  • Omics and Cardiometabolic Disease Risk Prediction.

    abstract::Risk assessments are integral for the prevention and management of cardiometabolic disease (CMD). However, individuals may develop CMD without traditional risk factors, necessitating the development of novel biomarkers to aid risk prediction. The emergence of omic technologies, including genomics, proteomics, and meta...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-042418-010924

    authors: Tahir UA,Gerszten RE

    更新日期:2020-01-27 00:00:00

  • Arrhythmogenic Right Ventricular Cardiomyopathy: Progress Toward Personalized Management.

    abstract::Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease characterized by fibrofatty replacement of the ventricular myocardium, a high risk of ventricular arrhythmias, and progressive ventricular dysfunction. The clinical course is highly variable, and optimal approaches to management remai...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,meta分析

    doi:10.1146/annurev-med-041217-010932

    authors: James CA,Calkins H

    更新日期:2019-01-27 00:00:00

  • Abbreviated Magnetic Resonance Imaging (MRI) for Breast Cancer Screening: Rationale, Concept, and Transfer to Clinical Practice.

    abstract::Given the increasing understanding of cancer as a heterogeneous group of diseases, detection methods should offer a sensitivity profile that ensures perfect sensitivity for biologically important cancers while screening out self-limiting pseudocancers. However, mammographic screening is biased toward detection of duct...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-121417-100403

    authors: Kuhl CK

    更新日期:2019-01-27 00:00:00

  • Clinical Application and Potential of Fecal Microbiota Transplantation.

    abstract::Fecal microbiota transplantation (FMT) is a well-established treatment for recurrent Clostridioides difficile infection. FMT has become a more readily available and useful new treatment option as a result of stool banks. The current state of knowledge indicates that dysbiosis of the gut microbiota is implicated in sev...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-111717-122956

    authors: Ooijevaar RE,Terveer EM,Verspaget HW,Kuijper EJ,Keller JJ

    更新日期:2019-01-27 00:00:00

  • Innovations in Ventricular Assist Devices for End-Stage Heart Failure.

    abstract::The number of patients with end-stage heart failure (HF) continues to increase over time, but there has been little change in the availability of organs for cardiac transplantation, intensifying the demand for left ventricular assist devices (LVADs) as a bridge to transplantation. There is also a growing number of pat...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-041217-011015

    authors: Miller RJH,Teuteberg JJ,Hunt SA

    更新日期:2019-01-27 00:00:00

  • Basket Studies: Redefining Clinical Trials in the Era of Genome-Driven Oncology.

    abstract::Understanding a tumor's detailed molecular profile has become increasingly necessary to deliver the standard of care for patients with advanced cancer. Innovations in both tumor genomic sequencing technology and the development of drugs that target molecular alterations have fueled recent gains in genome-driven oncolo...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-062016-050343

    authors: Tao JJ,Schram AM,Hyman DM

    更新日期:2018-01-29 00:00:00

  • Computed Tomography Scanning for Early Detection of Lung Cancer.

    abstract::Parallel and often unrelated developments in health care and technology have all been necessary to bring about early detection of lung cancer and the opportunity to decrease mortality from lung cancer through early detection of the disease by computed tomography. Lung cancer screening programs provide education for pa...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-020917-053556

    authors: Jacobson FL,Jaklitsch MT

    更新日期:2018-01-29 00:00:00

  • Precision Medicine: Functional Advancements.

    abstract::Precision medicine was conceptualized on the strength of genomic sequence analysis. High-throughput functional metrics have enhanced sequence interpretation and clinical precision. These technologies include metabolomics, magnetic resonance imaging, and I rhythm (cardiac monitoring), among others. These technologies a...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-041316-090905

    authors: Caskey T

    更新日期:2018-01-29 00:00:00

  • Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus.

    abstract::In 2012, a zoonotic coronavirus was identified as the causative agent of Middle East respiratory syndrome and was named MERS coronavirus (MERS-CoV). As of August 11, 2016, the virus has infected 1,791 patients, with a mortality rate of 35.6%. Although MERS-CoV generally causes subclinical or mild disease, infection ca...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-051215-031152

    authors: Fehr AR,Channappanavar R,Perlman S

    更新日期:2017-01-14 00:00:00

  • Cardiac Pacing and Defibrillation Devices: Cost and Effectiveness.

    abstract::Implantable cardiac pacing and defibrillation devices are effective and commonly used therapies for patients with cardiac rhythm disorders. Because device implantation is not easily reversible, as well as the high healthcare costs inherent in device use, a clear understanding of the clinical benefits relative to costs...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-043015-123540

    authors: Groeneveld PW,Dixit S

    更新日期:2017-01-14 00:00:00

  • Catastrophic Antiphospholipid Syndrome: Candidate Therapies for a Potentially Lethal Disease.

    abstract::Catastrophic antiphospholipid syndrome (CAPS) is a potentially lethal disease that presents with rapidly progressive multiple organ thromboses. Anticoagulation, corticosteroids, intravenous immunoglobulin, and plasma exchange are the most commonly used treatments for CAPS patients. However, the high mortality despite ...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-042915-102529

    authors: Unlu O,Erkan D

    更新日期:2017-01-14 00:00:00

  • Management of Rectal Cancer Without Radical Resection.

    abstract::The basis of the current treatment of rectal cancer is a radical total mesorectal excision of the rectum, and although this provides excellent oncological control, it is associated with morbidity and functional problems in cancer survivors. Organ-preservation alternatives are local excision alone for very early tumors...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-062915-021419

    authors: Beets GL,Figueiredo NF,Beets-Tan RG

    更新日期:2017-01-14 00:00:00

  • Adjuvant Bisphosphonates and Breast Cancer Survival.

    abstract::Randomized trials have studied bisphosphonates in the adjuvant setting of early breast cancer to investigate their ability to prevent treatment-induced bone loss. Trial results have also suggested their potential to prevent disease recurrence and metastases. These trials are summarized in this review. A recent patient...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-053014-103600

    authors: Strobl S,Korkmaz B,Devyatko Y,Schuetz M,Exner R,Dubsky PC,Jakesz R,Gnant M

    更新日期:2016-01-01 00:00:00

  • Cardiovascular Effects of Incretin-Based Therapies.

    abstract::The incretin-based therapies, dipeptidyl peptidase-4 (DPP4) inhibitors and glucagon-like peptide-1 (GLP-1) analogs, are important new classes of therapy for type 2 diabetes mellitus (T2DM). These agents prolong the action of the incretin hormones, GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), by inhibi...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-050214-013431

    authors: White WB,Baker WL

    更新日期:2016-01-01 00:00:00

  • Pathogenesis of macrophage activation syndrome and potential for cytokine- directed therapies.

    abstract::Macrophage activation syndrome (MAS) is an acute episode of overwhelming inflammation characterized by activation and expansion of T lymphocytes and hemophagocytic macrophages. In rheumatology, it occurs most frequently in patients with systemic juvenile idiopathic arthritis (SJIA) and systemic lupus erythematosus. Th...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-061813-012806

    authors: Schulert GS,Grom AA

    更新日期:2015-01-01 00:00:00

  • ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura.

    abstract::Pathogenesis of thrombotic thrombocytopenic purpura (TTP) was a mystery for over half a century until the discovery of ADAMTS13. ADAMTS13 is primarily synthesized in the liver, and its main function is to cleave von Willebrand factor (VWF) anchored on the endothelial surface, in circulation, and at the sites of vascul...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-061813-013241

    authors: Zheng XL

    更新日期:2015-01-01 00:00:00

  • Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics.

    abstract::Ketamine is the prototype for a new generation of glutamate-based antidepressants that rapidly alleviate depression within hours of treatment. Over the past decade, there has been replicated evidence demonstrating the rapid and potent antidepressant effects of ketamine in treatment-resistant depression. Moreover, prec...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-053013-062946

    authors: Abdallah CG,Sanacora G,Duman RS,Krystal JH

    更新日期:2015-01-01 00:00:00

  • Targeting metabolic changes in cancer: novel therapeutic approaches.

    abstract::Therapeutic strategies designed to target cancer metabolism are an area of intense research. Antimetabolites, first used to treat patients in the early twentieth century, served as an early proof of concept for such therapies. We highlight strategies that attempt to improve on the anti-metabolite approach as well as n...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-092012-112344

    authors: Bobrovnikova-Marjon E,Hurov JB

    更新日期:2014-01-01 00:00:00

  • Delivering value: provider efforts to improve the quality and reduce the cost of health care.

    abstract::Growing concern regarding costs of care and health outcomes in the United States has led to widespread calls to address the issue of health care spending. Today, providers across the country are working both to improve the quality and to reduce the cost of health care. These activities span multiple care delivery sett...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-100312-135931

    authors: Gordon JE,Leiman JM,Deland EL,Pardes H

    更新日期:2014-01-01 00:00:00

  • Thyroid cancer.

    abstract::Thyroid cancer is rapidly increasing in incidence, but the mortality rate remains flat. Debate has arisen over the need to detect or treat most thyroid cancers early, given their favorable natural history. The appropriate extent of surgery for thyroid cancer is also controversial: some researchers advocate partial and...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-061512-105739

    authors: Carling T,Udelsman R

    更新日期:2014-01-01 00:00:00

  • Anti-B cell antibody therapies for inflammatory rheumatic diseases.

    abstract::Several monoclonal antibodies targeting B cells have been tested as therapeutics for inflammatory rheumatic diseases. We review important observations from randomized clinical trials regarding the efficacy and safety of anti-B cell antibody-based therapies for rheumatoid arthritis, systemic lupus erythematosus, antine...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-070912-133235

    authors: Faurschou M,Jayne DR

    更新日期:2014-01-01 00:00:00

  • Defective complement inhibitory function predisposes to renal disease.

    abstract::The role of the complement system in mediating human renal disease has long been recognized in immune-complex excess syndromes such as systemic lupus erythematosus and in dense deposit disease in which no immunoglobulin (Ig) is present. Over the past 15 years, mutations in complement regulatory genes have been demonst...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-072211-110606

    authors: Java A,Atkinson J,Salmon J

    更新日期:2013-01-01 00:00:00

  • Update on typical and atypical antipsychotic drugs.

    abstract::Antipsychotic drugs (APDs) are best classified as typical or atypical. The distinction is based solely on their ability to cause extrapyramidal side effects (EPS), including tardive dyskinesia (TD). The two classes differ in mechanism of action, with atypical APDs providing important modulation of serotonergic neurotr...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-050911-161504

    authors: Meltzer HY

    更新日期:2013-01-01 00:00:00

  • Podocyte biology and pathogenesis of kidney disease.

    abstract::Proteinuric chronic kidney disease (CKD), once a rare affliction believed to be mainly caused by genetic mutations, has become a global pandemic that severely diminishes the quality of life for millions. Despite the changing face of CKD, treatment options and resources remain woefully antiquated and have failed to arr...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-050311-163340

    authors: Reiser J,Sever S

    更新日期:2013-01-01 00:00:00

  • Human genome sequencing in health and disease.

    abstract::Following the "finished," euchromatic, haploid human reference genome sequence, the rapid development of novel, faster, and cheaper sequencing technologies is making possible the era of personalized human genomics. Personal diploid human genome sequences have been generated, and each has contributed to our better unde...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-051010-162644

    authors: Gonzaga-Jauregui C,Lupski JR,Gibbs RA

    更新日期:2012-01-01 00:00:00

  • Circulating tumor cells and circulating tumor DNA.

    abstract::Solid tumors derived from epithelial tissues (carcinomas) are responsible for 90% of all new cancers in Europe, and the main four tumor entities are breast, prostate, lung, and colon cancer. Present tumor staging is mainly based on local tumor extension, metastatic lymph node involvement, and evidence of overt distant...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-062310-094219

    authors: Alix-Panabières C,Schwarzenbach H,Pantel K

    更新日期:2012-01-01 00:00:00

  • CCR5 antagonism in HIV infection: current concepts and future opportunities.

    abstract::CCR5 antagonists inhibit HIV-1 entry by blocking the interaction of HIV-1 with the CCR5 cellular receptor. In patients with established HIV-1 infection, some viral strains use an alternative coreceptor for HIV-1 entry, CXCR4; CCR5 antagonists are not effective in patients harboring these viral strains. Coreceptor trop...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-052010-145454

    authors: Wilkin TJ,Gulick RM

    更新日期:2012-01-01 00:00:00

  • Imaging of atherosclerosis.

    abstract::It is now well recognized that the atherosclerotic plaques responsible for thrombus formation are not necessarily those that impinge most on the lumen of the vessel. Nevertheless, clinical investigations for atherosclerosis still focus on quantifying the degree of stenosis caused by plaques. Many of the features assoc...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-041709-133809

    authors: Owen DR,Lindsay AC,Choudhury RP,Fayad ZA

    更新日期:2011-01-01 00:00:00

  • New approaches to the treatment of osteoporosis.

    abstract::Although safe and effective agents are currently available to treat osteoporosis, fragility fractures remain a significant problem worldwide. Recent improvements in the understanding of the cellular, biochemical, and molecular pathways of bone biology have led to the development of newer agents to treat osteoporosis, ...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-061709-145401

    authors: Silva BC,Bilezikian JP

    更新日期:2011-01-01 00:00:00

  • Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapy.

    abstract::The genomic era is changing the understanding of cancer, although translation of the vast amount of data available into decision-making algorithms is far from reality. Molecular profiling of hepatocellular carcinoma (HCC), the most common cause of death among cirrhotic patients and a fast-growing malignancy in Western...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.med.080608.100623

    authors: Villanueva A,Minguez B,Forner A,Reig M,Llovet JM

    更新日期:2010-01-01 00:00:00

  • Emotion recollected in tranquility: lessons learned from the COX-2 saga.

    abstract::Nonsteroidal antinflammatory drugs (NSAIDs) inhibit prostaglandin formation by cyclooxygenases (COX) 1 and 2. NSAIDs selective for inhibition of COX-2 are less likely than traditional drugs to cause serious gastrointestinal adverse effects, but predispose to adverse cardiovascular events, such as heart failure, myocar...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-med-011209-153129

    authors: Grosser T,Yu Y,Fitzgerald GA

    更新日期:2010-01-01 00:00:00

  • Genetic testing in clinical practice.

    abstract::In the practice of internal medicine, the value of genetic testing in common (mono)genetic diseases such as familial hemochromatosis, hypercholesterolemia, Mediterranean fever, and thrombophilia is limited. The genotype insufficiently predicts the phenotype because of the powerful effects of other modifying genes, env...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.med.60.103007.132540

    authors: Lamberts SW,Uitterlinden AG

    更新日期:2009-01-01 00:00:00

  • Goals of inpatient treatment for psychiatric disorders.

    abstract::The purpose of the psychiatric hospital changed dramatically during the twentieth century. Formerly the primary location for psychiatric treatment, the hospital now plays a more circumscribed role within a community-based system of care. Crisis stabilization, safety, and a focus on rapid discharge are the critical com...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.med.60.042607.080257

    authors: Sharfstein SS

    更新日期:2009-01-01 00:00:00

  • Barrett's Esophagus and esophageal adenocarcinoma.

    abstract::The incidence of esophageal adenocarcinoma (EAC) has risen dramatically over the past three decades in western countries. The importance of Barrett's esophagus (BE) derives from its potential to transform to adenocarcinoma. BE is characterized by endoscopically recognized displacement of the squamocolumnar junction pr...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.med.59.061206.112706

    authors: Bresalier RS

    更新日期:2009-01-01 00:00:00

  • Prospects for life span extension.

    abstract::Life expectancy has increased dramatically in the United States and in much of the world in recent years and decades. The factors underlying this increase are incompletely understood and are undoubtedly complex. A question that drives current research is whether life expectancy can be further extended using current kn...

    journal_title:Annual review of medicine

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.med.60.061607.220533

    authors: Sierra F,Hadley E,Suzman R,Hodes R

    更新日期:2009-01-01 00:00:00

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