Abstract:
:Proteinuric chronic kidney disease (CKD), once a rare affliction believed to be mainly caused by genetic mutations, has become a global pandemic that severely diminishes the quality of life for millions. Despite the changing face of CKD, treatment options and resources remain woefully antiquated and have failed to arrest or reverse the effects of kidney-related diseases. Histological and genetic data strongly implicate one promising target: the podocyte. Podocytes are terminally differentiated cells of the kidney glomerulus that are essential for the integrity of the kidney filter. Their function is primarily based on their intricate structure, which includes foot processes. Loss of these actin-driven membrane extensions is tightly connected to the presence of protein in the urine, podocyte loss, development of CKD, and ultimately renal failure.
journal_name
Annu Rev Medjournal_title
Annual review of medicineauthors
Reiser J,Sever Sdoi
10.1146/annurev-med-050311-163340subject
Has Abstractpub_date
2013-01-01 00:00:00pages
357-66eissn
0066-4219issn
1545-326Xjournal_volume
64pub_type
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