Podocyte biology and pathogenesis of kidney disease.

Abstract:

:Proteinuric chronic kidney disease (CKD), once a rare affliction believed to be mainly caused by genetic mutations, has become a global pandemic that severely diminishes the quality of life for millions. Despite the changing face of CKD, treatment options and resources remain woefully antiquated and have failed to arrest or reverse the effects of kidney-related diseases. Histological and genetic data strongly implicate one promising target: the podocyte. Podocytes are terminally differentiated cells of the kidney glomerulus that are essential for the integrity of the kidney filter. Their function is primarily based on their intricate structure, which includes foot processes. Loss of these actin-driven membrane extensions is tightly connected to the presence of protein in the urine, podocyte loss, development of CKD, and ultimately renal failure.

journal_name

Annu Rev Med

authors

Reiser J,Sever S

doi

10.1146/annurev-med-050311-163340

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

357-66

eissn

0066-4219

issn

1545-326X

journal_volume

64

pub_type

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