Abstract:
:Life expectancy has increased dramatically in the United States and in much of the world in recent years and decades. The factors underlying this increase are incompletely understood and are undoubtedly complex. A question that drives current research is whether life expectancy can be further extended using current knowledge of modifiable risk factors. A still more challenging research focus is on the possibility that life expectancy might be further increased through knowledge gained from studies of the basic biology of aging and its genetic and environmental modifiers.
journal_name
Annu Rev Medjournal_title
Annual review of medicineauthors
Sierra F,Hadley E,Suzman R,Hodes Rdoi
10.1146/annurev.med.60.061607.220533subject
Has Abstractpub_date
2009-01-01 00:00:00pages
457-69eissn
0066-4219issn
1545-326Xjournal_volume
60pub_type
杂志文章,评审abstract::Natural killer (NK) cells are a subpopulation of lymphocytes, with azurophilic granules in their cytoplasm, that have spontaneous cytotoxicity against a variety of tumor cells, virus-infected cells, and some normal cells in the bone marrow and thymus. When lymphocytes are cultured in the presence of interleukin 2 (IL ...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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abstract::Pharmacogenetics deals with inherited differences in the response to drugs. The best-recognized examples are genetic polymorphisms of drug-metabolizing enzymes, which affect about 30% of all drugs. Loss of function of thiopurine S-methyltransferase (TPMT) results in severe and life-threatening hematopoietic toxicity i...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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abstract::Clostridium difficile infection is associated with broad-spectrum antibiotic therapy and is the most common cause of infectious diarrhea in hospital patients. Pathogenic strains of C. difficile produce two protein exotoxins, toxin A and toxin B, which cause colonic mucosal injury and inflammation. Infection may be asy...
journal_title:Annual review of medicine
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更新日期:1998-01-01 00:00:00
abstract::In the practice of internal medicine, the value of genetic testing in common (mono)genetic diseases such as familial hemochromatosis, hypercholesterolemia, Mediterranean fever, and thrombophilia is limited. The genotype insufficiently predicts the phenotype because of the powerful effects of other modifying genes, env...
journal_title:Annual review of medicine
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
abstract::The familial nature of multiple endocrine neoplasia syndromes (FMEN) has been recognized for some time but little is known about their cause. Recent application of new molecular techniques has mapped FMEN syndromes to specific chromosomes and provided evidence for the mechanism through which neoplasia occurs. In this ...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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abstract::Graft-versus-host disease (GVHD) is a syndrome observed after allogeneic marrow transplantation and presumably mediated by donor T lymphocytes reactive against the tissues of the recipient. Clinically relevant acute GVHD develops in 35-50% of patients given HLA-identical marrow grafts within the first 100 days of tran...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1984-01-01 00:00:00
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journal_title:Annual review of medicine
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更新日期:2002-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1992-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1990-01-01 00:00:00
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journal_title:Annual review of medicine
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更新日期:2020-01-27 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章
doi:10.1146/annurev.me.38.020187.001135
更新日期:1987-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章
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更新日期:1977-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
abstract::An effective host response to infection or tissue damage requires focal accumulation of leukocytes. Leukocyte adhesion to the vessel wall, a key step in this process, depends on the ordered expression of specific endothelial cell surface molecules. The endothelial molecules that support adhesion include selectins that...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1994-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1994-01-01 00:00:00
abstract::Caffeine is the most widely consumed stimulant drug in the world. This chapter reviews the human pharmacology of caffeine; the evidence for its role in causing human disease, including addiction; and its potential usefulness as a therapeutic agent. ...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1990-01-01 00:00:00
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journal_title:Annual review of medicine
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journal_title:Annual review of medicine
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更新日期:1975-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1985-01-01 00:00:00
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journal_title:Annual review of medicine
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更新日期:2002-01-01 00:00:00
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更新日期:1989-01-01 00:00:00
abstract::Proteinuric chronic kidney disease (CKD), once a rare affliction believed to be mainly caused by genetic mutations, has become a global pandemic that severely diminishes the quality of life for millions. Despite the changing face of CKD, treatment options and resources remain woefully antiquated and have failed to arr...
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更新日期:2013-01-01 00:00:00
abstract::The application of sensitive metabolic tests, such as the deoxyuridine suppression test and measurement of homocysteine and methylmalonic acid, to cobalamin status has identified the entity of mild, preclinical cobalamin deficiency. This state, common in the elderly, responds to cobalamin therapy. Preclinical deficien...
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journal_title:Annual review of medicine
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更新日期:2014-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00