Omics and Cardiometabolic Disease Risk Prediction.

Abstract:

:Risk assessments are integral for the prevention and management of cardiometabolic disease (CMD). However, individuals may develop CMD without traditional risk factors, necessitating the development of novel biomarkers to aid risk prediction. The emergence of omic technologies, including genomics, proteomics, and metabolomics, has allowed for assessment of orthogonal measures of cardiometabolic risk, potentially improving the ability for novel biomarkers to refine disease risk assessments. While omics has shed light on novel mechanisms for the development of CMD, its adoption in clinical practice faces significant challenges. We review select omic technologies and cardiometabolic investigations for risk prediction, while highlighting challenges and opportunities for translating findings to clinical practice.

journal_name

Annu Rev Med

authors

Tahir UA,Gerszten RE

doi

10.1146/annurev-med-042418-010924

subject

Has Abstract

pub_date

2020-01-27 00:00:00

pages

163-175

eissn

0066-4219

issn

1545-326X

journal_volume

71

pub_type

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