Abstract:
:Therapeutic strategies designed to target cancer metabolism are an area of intense research. Antimetabolites, first used to treat patients in the early twentieth century, served as an early proof of concept for such therapies. We highlight strategies that attempt to improve on the anti-metabolite approach as well as new metabolic drug targets. Some of these targets have the advantage of a strong genetic anchor to drive patient selection (isocitrate dehydrogenase 1/2, Enolase 2). Additional approaches described here derive from hypothesis-driven and systems biology efforts designed to exploit tumor cell metabolic dependencies (fatty acid oxidation, nicotinamide adenine dinucleotide synthesis, glutamine biology).
journal_name
Annu Rev Medjournal_title
Annual review of medicineauthors
Bobrovnikova-Marjon E,Hurov JBdoi
10.1146/annurev-med-092012-112344subject
Has Abstractpub_date
2014-01-01 00:00:00pages
157-70eissn
0066-4219issn
1545-326Xjournal_volume
65pub_type
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