Abstract:
:Randomized trials have studied bisphosphonates in the adjuvant setting of early breast cancer to investigate their ability to prevent treatment-induced bone loss. Trial results have also suggested their potential to prevent disease recurrence and metastases. These trials are summarized in this review. A recent patient-level meta-analysis by the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) finds convincing evidence that adjuvant antiresorptive treatments provide persistent benefits to breast cancer patients in low-estrogen situations and should be considered an important part of the treatment algorithm.
journal_name
Annu Rev Medjournal_title
Annual review of medicineauthors
Strobl S,Korkmaz B,Devyatko Y,Schuetz M,Exner R,Dubsky PC,Jakesz R,Gnant Mdoi
10.1146/annurev-med-053014-103600subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1-10eissn
0066-4219issn
1545-326Xjournal_volume
67pub_type
杂志文章,评审abstract::Growing concern regarding costs of care and health outcomes in the United States has led to widespread calls to address the issue of health care spending. Today, providers across the country are working both to improve the quality and to reduce the cost of health care. These activities span multiple care delivery sett...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
doi:10.1146/annurev-med-100312-135931
更新日期:2014-01-01 00:00:00
abstract::Carcinoma of the head of the pancreas can be diagnosed and staged effectively by computed tomography (CT) scan and by visceral angiography. If the tumor appears to be resectable, no further studies such as percutaneous biopsy are required. Pancreaticoduodenectomy is the only potentially curable treatment. This operati...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
doi:10.1146/annurev.med.46.1.361
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abstract::Several monoclonal antibodies targeting B cells have been tested as therapeutics for inflammatory rheumatic diseases. We review important observations from randomized clinical trials regarding the efficacy and safety of anti-B cell antibody-based therapies for rheumatoid arthritis, systemic lupus erythematosus, antine...
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abstract::Cystic fibrosis (CF) lung disease reflects the failure of airways defense against chronic bacterial infection. Studies of CF cultures, transgenic mice, and CF patients suggest that the initiating event in CF airways disease pathogenesis is reduced airway surface liquid (ASL) volume, i.e., dehydration. CF ASL volume re...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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abstract::MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several studies have now sh...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
doi:10.1146/annurev.med.59.053006.104707
更新日期:2009-01-01 00:00:00
abstract::Macrophage activation syndrome (MAS) is an acute episode of overwhelming inflammation characterized by activation and expansion of T lymphocytes and hemophagocytic macrophages. In rheumatology, it occurs most frequently in patients with systemic juvenile idiopathic arthritis (SJIA) and systemic lupus erythematosus. Th...
journal_title:Annual review of medicine
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journal_title:Annual review of medicine
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更新日期:2009-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1989-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
abstract::It is clear from the preceding material that bacterial infection is a significant threat to the newborn infant. The most common gram-negative organism causing meningitis in the neonate is E. coli, and the invasive capacity of this organism is correlated with its polysaccharide antigen, K1. Careful studies of supportiv...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1978-01-01 00:00:00
abstract::Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease characterized by fibrofatty replacement of the ventricular myocardium, a high risk of ventricular arrhythmias, and progressive ventricular dysfunction. The clinical course is highly variable, and optimal approaches to management remai...
journal_title:Annual review of medicine
pub_type: 杂志文章,meta分析
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更新日期:2019-01-27 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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journal_title:Annual review of medicine
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journal_title:Annual review of medicine
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journal_title:Annual review of medicine
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journal_title:Annual review of medicine
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journal_title:Annual review of medicine
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journal_title:Annual review of medicine
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
abstract::Nonsteroidal antinflammatory drugs (NSAIDs) inhibit prostaglandin formation by cyclooxygenases (COX) 1 and 2. NSAIDs selective for inhibition of COX-2 are less likely than traditional drugs to cause serious gastrointestinal adverse effects, but predispose to adverse cardiovascular events, such as heart failure, myocar...
journal_title:Annual review of medicine
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更新日期:2010-01-01 00:00:00
abstract::Racial and ethnic disparities span the continuum of cancer care and are driven by a complex interplay among social, psychosocial, lifestyle, environmental, health system, and biological determinants of health. Research is needed to identify these determinants of cancer health disparities and to develop interventions t...
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更新日期:2021-01-27 00:00:00
abstract::Cardiac resynchronization therapy (CRT) is well established as a treatment for patients with moderate to severe heart failure on optimal medical therapy. Early studies demonstrated improved functional capacity and evidence of reverse remodeling; more recently, CRT has been associated with a survival benefit in advance...
journal_title:Annual review of medicine
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abstract::Brain imaging is increasingly applied in psychiatry, both for clinical evaluation and as a research tool. Computerized tomography (CT) and magnetic resonance imaging (MRI) have documented that structural brain abnormalities occur in some types of psychiatric patients, particularly those who suffer from schizophrenia. ...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1988-01-01 00:00:00
abstract::Alzheimer's disease (AD) is unique in medicine in that millions of people suffer from what appears to be the same form of disease, and unlike most other late-onset diseases, the genetic etiologies have been well identified. Three early onset forms of AD inherited as autosomal dominant traits account for less than 2% o...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1996-01-01 00:00:00
abstract::This chapter reviews the biology of gastroesophageal reflux disease, relating pathophysiology to medical and surgical therapy. Various definitions of the disease are presented and workable criteria are developed to identify patients with the disease. The central importance of the lower esophageal high-pressure zone as...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:Annual review of medicine
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更新日期:1993-01-01 00:00:00
abstract::Acute myocardial infarction is caused by coronary thrombosis on an ulcerated atheroma. We now believe that the predominant cause of this intimal disruption is the rupture of the atheroma through the intimal surface, caused by enzymes released by activated macrophages. The subsequent clinical course following atheroma ...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
doi:10.1146/annurev.me.42.020191.000343
更新日期:1991-01-01 00:00:00