Abstract:
:Calorie restriction (CR) is the most effective and reproducible intervention for increasing lifespan in a variety of animal species, including mammals. CR is also the most potent, broadly acting cancer-prevention regimen in experimental carcinogenesis models. Translation of the knowledge gained from CR research to human chronic disease prevention and the promotion of healthy aging is critical, especially because obesity, which is an important risk factor for several chronic diseases, including many cancers, is alarmingly increasing in the Western world. This review synthesizes the key biological mechanisms underlying many of the beneficial effects of CR, with a particular focus on the insulin-like growth factor-1 pathway. We also describe some of the opportunities now available for investigations, including gene expression profiling studies, the development of pharmacological mimetics of CR, and the integration of CR regimens with targeted, mechanism-based interventions. These approaches will facilitate the translation of CR research into strategies for effective human chronic disease prevention.
journal_name
Annu Rev Medjournal_title
Annual review of medicineauthors
Hursting SD,Lavigne JA,Berrigan D,Perkins SN,Barrett JCdoi
10.1146/annurev.med.54.101601.152156subject
Has Abstractpub_date
2003-01-01 00:00:00pages
131-52eissn
0066-4219issn
1545-326Xpii
101601.152156journal_volume
54pub_type
杂志文章,评审abstract::Hepatitis E has a worldwide distribution and causes substantial morbidity and mortality in some developing countries, particularly among pregnant women. Hepatitis E virus (HEV) has recently been cloned and sequenced and new diagnostic tests have been developed; these tests have been used to begin to characterize the n...
journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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journal_title:Annual review of medicine
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pub_type: 杂志文章,评审
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journal_title:Annual review of medicine
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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journal_title:Annual review of medicine
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pub_type: 杂志文章
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更新日期:1977-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
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journal_title:Annual review of medicine
pub_type: 临床试验,杂志文章,评审
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journal_title:Annual review of medicine
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journal_title:Annual review of medicine
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更新日期:2009-01-01 00:00:00
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journal_title:Annual review of medicine
pub_type: 杂志文章,评审
doi:10.1146/annurev.me.44.020193.000505
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journal_title:Annual review of medicine
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journal_title:Annual review of medicine
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journal_title:Annual review of medicine
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journal_title:Annual review of medicine
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abstract::Growing concern regarding costs of care and health outcomes in the United States has led to widespread calls to address the issue of health care spending. Today, providers across the country are working both to improve the quality and to reduce the cost of health care. These activities span multiple care delivery sett...
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journal_title:Annual review of medicine
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更新日期:1992-01-01 00:00:00
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