abstract：Purpose:Glaucoma remains a leading cause of irreversible blindness worldwide. Animal glaucoma models replicate high intraocular pressure, a risk factor for glaucoma, to induce retinal ganglion cell (RGC) degeneration. We describe an inducible, magnetic bead model in the Brown Norway rat in which we are able to determin...

journal_title：Translational vision science & technology

authors： Tribble JR,Otmani A,Kokkali E,Lardner E,Morgan JE,Williams PA

更新日期：2021-01-12 00:00:00

abstract：Purpose:To determine whether artifacts in optical coherence tomography (OCT) images are associated with the success or failure of adaptive optics scanning light ophthalmoscopy (AOSLO) imaging in subjects with achromatopsia (ACHM). Methods:Previously acquired OCT and non-confocal, split-detector AOSLO images from one e...

journal_title：Translational vision science & technology

authors： Litts KM,Woertz EN,Georgiou M,Patterson EJ,Lam BL,Fishman GA,Pennesi ME,Kay CN,Hauswirth WW,Michaelides M,Carroll J

更新日期：2021-01-07 00:00:00

abstract：Purpose:To compare the detection of retinal pigment epithelium (RPE) atrophy in short-wavelength (SW-AF) and near-infrared autofluorescence (NIR-AF) images in Stargardt disease (STGD1) patients. Methods:SW-AF and NIR-AF images (115 eyes from 115 patients) were analyzed by two independent graders. Hypoautofluorescent (...

journal_title：Translational vision science & technology

authors： Jauregui R,Nuzbrokh Y,Su PY,Zernant J,Allikmets R,Tsang SH,Sparrow JR

更新日期：2021-01-05 00:00:00

abstract：Purpose:To determine whether multicolor scanning laser ophthalmoscopy (MC-SLO) was better than color fundus photography (CFP) to enhance residents and specialists' preoperative decision-making and intraoperative performance on the epiretinal membrane (ERM). Methods:Consecutive patients with idiopathic ERM were recruit...

journal_title：Translational vision science & technology

authors： Zhang Z,Li M,Sun Y,Wei Y,Zhang S

更新日期：2020-12-18 00:00:00

abstract：Purpose:To investigate the retinal vessel density (VD) in healthy and normal-tension glaucoma (NTG) eyes through optical coherence tomography angiography (OCTA) and to determine the correlation between VD and the retinal nerve fiber layer (RNFL) thickness and functional visual field (VF) defects for different locations...

journal_title：Translational vision science & technology

authors： Lin YH,Huang SM,Yeung L,Ku WC,Chen HS,Lai CC,Chuang LH

更新日期：2020-12-17 00:00:00

abstract：Purpose:To automate the segmentation of retinal layers, we propose DeepRetina, a method based on deep neural networks. Methods:DeepRetina uses the improved Xception65 to extract and learn the characteristics of retinal layers. The Xception65-extracted feature maps are inputted to an atrous spatial pyramid pooling modu...

journal_title：Translational vision science & technology

authors： Li Q,Li S,He Z,Guan H,Chen R,Xu Y,Wang T,Qi S,Mei J,Wang W

更新日期：2020-12-09 00:00:00

abstract：Purpose:Corneal neovascularization (CNV) is the invasion of new blood vessels into the avascular cornea, leading to reduced corneal transparency and visual acuity, impaired vision, and even blindness. Current treatment options for CNV are limited. We developed a novel treatment method, termed photo-mediated ultrasound ...

journal_title：Translational vision science & technology

authors： Qin Y,Yu Y,Fu J,Xie X,Wang T,Woodward MA,Paulus YM,Yang X,Wang X

更新日期：2020-12-09 00:00:00

abstract：Purpose:Topical carbonic anhydrase inhibitors (CAIs) can influence retinal fluid distribution, but their role in treating central serous chorioretinopathy (CSCR) has not been studied. We examined the efficacy of a topical CAI (dorzolamide) in treating chronic CSCR. Methods:Prospective, nonrandomized, controlled interv...

journal_title：Translational vision science & technology

authors： Liew G,Ho IV,Ong S,Gopinath B,Mitchell P

更新日期：2020-12-04 00:00:00

abstract：Purpose:To develop a deep learning model for objective evaluation of experimental autoimmune uveitis (EAU), the animal model of posterior uveitis that reveals its essential pathological features via fundus photographs. Methods:We developed a deep learning construct to identify uveitis using reference mouse fundus imag...

journal_title：Translational vision science & technology

authors： Sun J,Huang X,Egwuagu C,Badr Y,Dryden SC,Fowler BT,Yousefi S

更新日期：2020-12-02 00:00:00

abstract：Purpose:To evaluate high accumulation of coronary artery calcium (CAC) from retinal fundus images with deep learning technologies as an inexpensive and radiation-free screening method. Methods:Individuals who underwent bilateral retinal fundus imaging and CAC score (CACS) evaluation from coronary computed tomography s...

journal_title：Translational vision science & technology

authors： Son J,Shin JY,Chun EJ,Jung KH,Park KH,Park SJ

更新日期：2020-11-11 00:00:00

abstract：Purpose:To evaluate the feasibility of using signal detection theory (SDT) in estimating criterion and detectability indices for corneal pneumatic stimuli and test corneal psychophysical data against linking hypotheses from nonprimate physiology using Bayesian analysis. Methods:Corneal pneumatic stimuli were delivered...

journal_title：Translational vision science & technology

authors： Jayakumar V,Simpson TL

更新日期：2020-11-10 00:00:00

abstract：Purpose:We aimed to develop and evaluate the Computerized Glaucoma Visual Function Test (CoGVFT), among a cohort of glaucoma patients, and identify potential new items to optimize the test. Method:A cross-sectional study involving 84 patients with open-angle glaucoma of varying severity and 18 controls without glaucom...

journal_title：Translational vision science & technology

authors： Jong C,Skalicky SE

更新日期：2020-11-03 00:00:00

abstract：Purpose:Determine the repeatability of and optimum stimulus parameters for testing polarization pattern perception in a real-world clinical population, and assess the ability of polarization perception to distinguish normal from abnormal eyes. Methods:Polarization perception was evaluated in staff and patients attendi...

journal_title：Translational vision science & technology

authors： Misson GP,Anderson SJ,Armstrong RA,Gillett M,Reynolds D

更新日期：2020-10-28 00:00:00

abstract：Purpose:To compare the repeatability and reproducibility of axial and lateral retinal measurements using handheld optical coherence tomography (OCT) systems and a tabletop OCT system. Methods:Graders measured central foveal thickness (CFT), optic nerve-to-fovea distance (OFD), and retinal nerve fiber layer (RNFL) thic...

journal_title：Translational vision science & technology

authors： Chen X,Tai V,McGeehan B,Ying GS,Viehland C,Imperio R,Winter KP,Raynor W,Tran-Viet D,Mangalesh S,Maguire MG,Toth CA,BabySTEPS Group.

更新日期：2020-10-21 00:00:00

abstract：Purpose:Congenital stationary night blindness 2A (CSNB2A) is a genetic retinal disorder characterized by poor visual acuity, nystagmus, strabismus, and other signs of retinal dysfunction resulting from mutations in Cacna1f-the gene coding for the pore-forming subunit of the calcium channel CaV1.4. Mouse models of CSNB2...

journal_title：Translational vision science & technology

authors： Waldner DM,Ito K,Chen LL,Nguyen L,Chow RL,Lee A,Rancourt DE,Tremblay F,Stell WK,Bech-Hansen NT

更新日期：2020-10-14 00:00:00

abstract：Purpose:To determine the effectiveness of intravitreal aflibercept (IVA) on the retinal function in eyes with diabetic macular edema (DME). Methods:Twenty-five eyes of 25 patients with DME were treated with three consecutive monthly IVA injections. The retinal sensitivities (RS) within the central 10° were determined ...

journal_title：Translational vision science & technology

authors： Ichio A,Sugimoto M,Matsubara H,Mochida D,Kato K,Kondo M

更新日期：2020-10-06 00:00:00

abstract：Purpose:To investigate the effects of Ripasudil (K-115), a Rho-kinase inhibitor, in a porcine model of pigmentary glaucoma. Methods:In vitro trabecular meshwork (TM) cells and ex vivo perfused eyes were subjected to pigment dispersion followed by K-115 treatment (PK115). PK115 was compared to controls (C) and pigment ...

journal_title：Translational vision science & technology

authors： Wang C,Dang Y,Waxman S,Hong Y,Shah P,Loewen RT,Xia X,Loewen NA

更新日期：2020-09-25 00:00:00

abstract：Purpose:Genipin has been proposed as a possible neuroprotective therapy in myopia and glaucoma. Here, we aim to determine the effects of prolonged genipin-induced scleral stiffening on visual function. Methods:Eyes from Brown Norway rats were treated in vivo with either a single 15 mM genipin retrobulbar injection or ...

journal_title：Translational vision science & technology

authors： Hannon BG,Luna C,Feola AJ,Ritch MD,Read AT,Stinnett SS,Vo H,Pardue MT,Gonzalez P,Ethier CR

更新日期：2020-09-08 00:00:00

abstract：Purpose:Factor I (FI) is a serine protease regulator of the complement system. Genetic variants in CFI are associated with advanced age-related macular degeneration (AAMD). However, the clinical and functional impact of these variants is unknown. This study assessed the functional significance of rare CFI variants usin...

journal_title：Translational vision science & technology

authors： Java A,Baciu P,Widjajahakim R,Sung YJ,Yang J,Kavanagh D,Atkinson J,Seddon J

更新日期：2020-08-24 00:00:00

abstract：Purpose:To study the choroid in uncomplicated pregnant women using advanced optical coherence tomography (OCT) imaging and analysis. Methods:Women with uncomplicated pregnancy in the third trimester (>28 weeks gestational age) and age-matched nonpregnant women were enrolled in this prospective study. All subjects unde...

journal_title：Translational vision science & technology

authors： Su L,Taweebanjongsin W,Gaw SL,Rabina G,Sadda SR,Tsui I

更新日期：2020-08-13 00:00:00

abstract：Purpose:To assess the repeatability and agreement of ocular biometric parameters measured using the Tomey CASIA SS-1000 and Heidelberg ANTERION anterior segment optical coherence tomography (AS-OCT) devices. Methods:Both eyes of subjects 18 years of age or older were scanned three times with the CASIA and ANTERION und...

journal_title：Translational vision science & technology

authors： Pardeshi AA,Song AE,Lazkani N,Xie X,Huang A,Xu BY

更新日期：2020-08-07 00:00:00

abstract：Purpose:Diagnosis of ocular graft-versus-host disease (oGVHD) is hampered by a lack of clinically-validated biomarkers. This study aims to predict disease severity on the basis of tear protein expression in mild oGVHD. Methods:Forty-nine patients with and without chronic oGVHD after AHCT were recruited to a cross-sect...

journal_title：Translational vision science & technology

authors： O'Leary OE,Schoetzau A,Amruthalingam L,Geber-Hollbach N,Plattner K,Jenoe P,Schmidt A,Ullmer C,Drawnel FM,Fauser S,Scholl HPN,Passweg J,Halter JP,Goldblum D

更新日期：2020-08-03 00:00:00

abstract：:Especially since the incorporation of swept laser sources, optical coherence tomography angiography (OCTA) has enabled quantification of choriocapillaris perfusion. A critical step in this process is binarization, which makes angiographic images quantifiable in terms of perfusion metrics. It remains challenging to hav...

journal_title：Translational vision science & technology

authors： Braun PX,Mehta N,Gendelman I,Alibhai AY,Baumal CR,Duker JS,Waheed NK

更新日期：2020-07-29 00:00:00

abstract：Purpose:Progressive calcification of Bruch's membrane (BM) causes considerable visual morbidity in patients with pseudoxanthoma elasticum (PXE). Since calcification is hyperreflective on optical coherence tomography (OCT), our aim was to measure BM calcification with OCT imaging. Methods:Case-control study with 45 pat...

journal_title：Translational vision science & technology

authors： Risseeuw S,Bennink E,Poirot MG,de Jong PA,Spiering W,Imhof SM,van Leeuwen R,Ossewaarde-van Norel J

更新日期：2020-07-23 00:00:00

abstract：Purpose:To evaluate the effects of vascular endothelial growth factor-A (VEGF-A) gene editing in human retinal pigment epithelial (RPE) cells and human Muller cells, which are the main VEGF-A producing cells in the eye. Methods:CRISPR-Cas9 ribonucleoprotein was used to target exon 1 in VEGF-A gene. Lipofectamine CRISP...

journal_title：Translational vision science & technology

authors： Ameri H,Murat C,Arbabi A,Jiang W,Janga SR,Qin PZ,Hamm-Alvarez SF

更新日期：2020-07-14 00:00:00

abstract：Purpose:To explore the contribution of crystalline lens fluorescence to fluorescence lifetimes measured with fluorescence lifetime imaging ophthalmoscopy (FLIO) and to propose a computational model to reduce the lens influence. Methods:FLIO, which detects autofluorescence decay over time in a short-wavelength spectral...

journal_title：Translational vision science & technology

authors： Brauer JL,Schultz R,Klemm M,Hammer M

更新日期：2020-07-09 00:00:00

abstract：Purpose:To investigate the change in cytokine microenvironment of the aqueous humor (AH) after surgery in children with congenital or developmental cataracts. Methods:AH samples were obtained from 59 eyes diagnosed with a congenital or developmental cataract. Thirty-three of these eyes were aphakic following previous ...

journal_title：Translational vision science & technology

authors： Zhao Y,Deng X,Chang P,Hu M,Li Z,Zhang F,Ding X,Zhao Y

更新日期：2020-07-02 00:00:00

abstract：Purpose:The aim of this study was to evaluate and compare the electrical performance and properties of commercially available electroretinography (ERG) electrodes. Methods:A passive ionic model was used to measure impedance, noise, and potential drift in 10 types of ocular surface and skin ERG electrodes. Results:The...

journal_title：Translational vision science & technology

authors： Man TTC,Yip YWY,Cheung FKF,Lee WS,Pang CP,Brelén ME

更新日期：2020-06-30 00:00:00

abstract：Purpose:To investigate whether plasma rich in growth factors (PRGF) eye drops maintain their biological potential after a freeze drying process. The addition of a lyoprotectant like trehalose was also evaluated. Methods:Blood from three healthy donors was collected to obtain eye drops by PRGF technology. The resultant...

journal_title：Translational vision science & technology

authors： Anitua E,de la Fuente M,Alcalde I,Sanchez C,Merayo-Lloves J,Muruzabal F

更新日期：2020-06-25 00:00:00

abstract：Purpose:To describe a minimally invasive experimental model of acute ocular hypertension (OHT) with characteristics of acute angle closure (AAC). Methods:Adult C57/Bl6 mice (n = 31) were subjected to OHT in one eye using a modified circumlimbal suture technique that elevated intraocular pressure (IOP) for 30 minutes. ...

journal_title：Translational vision science & technology

authors： Chong RS,Busoy JMF,Tan B,Yeo SW,Lee YS,Barathi AV,Crowston JG,Schmetterer L

更新日期：2020-06-22 00:00:00

abstract：Purpose:To evaluate the changes of retinal capillary nonperfusion areas and retinal capillary vessel density of the superficial capillary plexus (SCP) and deep capillary plexus in patients with diabetes with diabetic macular edema treated with an intravitreal dexamethasone implant (IDI). Methods:We enrolled 28 patient...

journal_title：Translational vision science & technology

authors： Toto L,D'Aloisio R,Chiarelli AM,Di Antonio L,Evangelista F,D'Onofrio G,Merla A,Parravano M,Di Marzio G,Mastropasqua R

更新日期：2020-06-11 00:00:00

abstract：Purpose:Evaluate efficiency, precision, and validity of RetCAT, which comprises ten diabetic retinopathy (DR) quality of life (QoL) computerized adaptive tests (CATs). Methods:In this cross-sectional clinical study, 183 English and/or Mandarin-speaking participants with DR (mean age ± standard deviation [SD] 56.4 ± 11...

journal_title：Translational vision science & technology

authors： Fenwick EK,Barnard J,Gan A,Loe BS,Khadka J,Pesudovs K,Man R,Lee SY,Tan G,Wong TY,Lamoureux EL

更新日期：2020-06-03 00:00:00

abstract：Purpose:Although the expression of microRNAs (miRNAs) in retinal pigment epithelial (RPE) cells undergoing epithelial-mesenchymal transition (EMT) is involved in the pathogenesis of proliferative vitreoretinopathy (PVR), its expression in the vitreous of patients with primary retinal detachment (RD) and different PVR g...

journal_title：Translational vision science & technology

authors： Toro MD,Reibaldi M,Avitabile T,Bucolo C,Salomone S,Rejdak R,Nowomiejska K,Tripodi S,Posarelli C,Ragusa M,Barbagallo C

更新日期：2020-05-22 00:00:00

abstract：Purpose:While using their amblyopic eye, individuals with strabismic amblyopia count inaccurately and underestimate the number of features. These deficits are attributed to limitations in high-level cortical functions and attention. In the current study, we examined whether feature counting is affected in strabismic an...

journal_title：Translational vision science & technology

authors： Wong-Kee-You AMB,Wei H,Hou C

更新日期：2020-05-16 00:00:00

abstract：Purpose:To quantify the effect of silicone hydrogel crosslink density on the adhesion at corneal epithelial cells/silicone hydrogel contact lens interface. Methods:A custom-built rheometer, referred to as the live cell monolayer rheometer, was used to measure the adhesive strengths between corneal epithelial cell mono...

journal_title：Translational vision science & technology

authors： Liu C,Scales CW,Fuller GG

更新日期：2020-05-11 00:00:00

abstract：Purpose:Clinical intensity-based optical coherence tomographic retinal imaging is unable to resolve some of the earliest changes to Alzheimer's disease (AD) neurons. The aim of this pilot study was to demonstrate that scattering-angle-resolved optical coherence tomography (SAR-OCT), which is sensitive to changes in lig...

journal_title：Translational vision science & technology

authors： Gardner MR,Baruah V,Vargas G,Motamedi M,Milner TE,Rylander HG 3rd

更新日期：2020-04-24 00:00:00

abstract：Purpose:We assessed the ability to detect preperimetric glaucoma (PPG) based on asymmetry in the thickness of the macular inner retinal layers measured by spectral-domain optical coherence tomography. Methods:We studied 45 normal eyes and 50 PPG eyes retrospectively. Three-dimensional optical coherence tomography macu...

journal_title：Translational vision science & technology

authors： Takemoto D,Higashide T,Ohkubo S,Udagawa S,Sugiyama K

更新日期：2020-04-15 00:00:00

abstract：Purpose:To develop an artificial intelligence (AI)-based structure-function (SF) map relating retinal nerve fiber layer (RNFL) damage on spectral domain optical coherence tomography (SDOCT) to functional loss on standard automated perimetry (SAP). Methods:The study included 26,499 pairs of SAP and SDOCT from 15,173 ey...

journal_title：Translational vision science & technology

authors： Mariottoni EB,Datta S,Dov D,Jammal AA,Berchuck SI,Tavares IM,Carin L,Medeiros FA

更新日期：2020-03-30 00:00:00

abstract：Purpose:To culturally and linguistically adapt the Convergence Insufficiency Symptom Survey (CISS) to Spanish and assess the psychometric performance of the new version through Rasch analysis and classical test theory methods. Methods:The Spanish version of the CISS (CISSVE) was completed by 449 subjects (9-30 years o...

journal_title：Translational vision science & technology

authors： González-Pérez M,Pérez-Garmendia C,Barrio AR,García-Montero M,Antona B

更新日期：2020-03-23 00:00:00

abstract：Purpose:Subretinal fibrosis (SRFib) is an important cause of permanent loss-of-vision diseases with submacular neovascularization, but a reliable diagnostic method is currently missing. This study uses polarization-sensitive optical coherence tomography (PS-OCT) to detect SRFib within retinal lesions by measurement of ...

journal_title：Translational vision science & technology

authors： Gräfe MGO,van de Kreeke JA,Willemse J,Braaf B,de Jong Y,Tan HS,Verbraak FD,de Boer JF

更新日期：2020-03-16 00:00:00