Subretinal Fibrosis Detection Using Polarization Sensitive Optical Coherence Tomography.

abstract：PURPOSE:To validate the performance of a new perimetric algorithm (Gradient-Oriented Automated Natural Neighbor Approach; GOANNA) in humans using a novel combination of computer simulation and human testing, which we call Artificial Scotoma Generation (ASG). METHODS:Fifteen healthy observers were recruited. Baseline c...

journal_title：Translational vision science & technology

authors： Chong LX,Turpin A,McKendrick AM

更新日期：2016-09-01 00:00:00

abstract：Purpose:To investigate the change in cytokine microenvironment of the aqueous humor (AH) after surgery in children with congenital or developmental cataracts. Methods:AH samples were obtained from 59 eyes diagnosed with a congenital or developmental cataract. Thirty-three of these eyes were aphakic following previous ...

journal_title：Translational vision science & technology

authors： Zhao Y,Deng X,Chang P,Hu M,Li Z,Zhang F,Ding X,Zhao Y

更新日期：2020-07-02 00:00:00

abstract：Purpose:Genipin has been proposed as a possible neuroprotective therapy in myopia and glaucoma. Here, we aim to determine the effects of prolonged genipin-induced scleral stiffening on visual function. Methods:Eyes from Brown Norway rats were treated in vivo with either a single 15 mM genipin retrobulbar injection or ...

journal_title：Translational vision science & technology

authors： Hannon BG,Luna C,Feola AJ,Ritch MD,Read AT,Stinnett SS,Vo H,Pardue MT,Gonzalez P,Ethier CR

更新日期：2020-09-08 00:00:00

abstract：Purpose:Glaucoma drainage device (GDD) implantation can lead to corneal decompensation. We evaluated changes over time in oxygen tension and in the metabolic environment of the aqueous humor after GDD implantation in the rabbit eye. Methods:Ahmed Glaucoma Valves were implanted in the left eyes of eight male New Zealan...

journal_title：Translational vision science & technology

authors： Williamson BK,Hawkey NM,Blake DA,Frenkel JW,McDaniel KP,Davis JK,Satija C,Beazer A,Dhungana S,Carlson J,McRitchie S,Ayyala RS

更新日期：2018-02-02 00:00:00

abstract：PURPOSE:Endophthalmitis is a rare complication of intravitreal injection (IVI). It is recommended that povidone-iodine be the last agent applied before IVI. Patients have reported povidone-iodine application to be the most bothersome part of IVIs. Topical anesthetics have been demonstrated to have antibacterial effects...

journal_title：Translational vision science & technology

authors： Reynolds MM,Greenwood-Quaintance KE,Patel R,Pulido JS

更新日期：2016-07-05 00:00:00

abstract：Purpose:Factor I (FI) is a serine protease regulator of the complement system. Genetic variants in CFI are associated with advanced age-related macular degeneration (AAMD). However, the clinical and functional impact of these variants is unknown. This study assessed the functional significance of rare CFI variants usin...

journal_title：Translational vision science & technology

authors： Java A,Baciu P,Widjajahakim R,Sung YJ,Yang J,Kavanagh D,Atkinson J,Seddon J

更新日期：2020-08-24 00:00:00

abstract：Purpose:In vivo evaluation of corneal biomechanics holds the potential for improving diagnosis and management of ocular diseases. We aimed to develop an ocular pulse elastography (OPE) technique to quantify corneal strains generated by naturally occurring pulsations of the intraocular pressure (IOP) using high-frequenc...

journal_title：Translational vision science & technology

authors： Clayson K,Pavlatos E,Pan X,Sandwisch T,Ma Y,Liu J

更新日期：2020-01-30 00:00:00

abstract：Purpose:To image the human trabecular meshwork (TM) in vivo using adaptive optics gonioscopy (AOG) with approximately 2-μm lateral resolution. Methods:An existing Indiana University adaptive optics scanning laser ophthalmoscope was altered by adding a 12-mm button lens to a clinical gonioscopic lens allowing high-reso...

journal_title：Translational vision science & technology

authors： King BJ,Burns SA,Sapoznik KA,Luo T,Gast TJ

更新日期：2019-09-11 00:00:00

abstract：Purpose:Corneal neovascularization (CoNV) is a major risk factor for corneal graft rejection and other corneal conditions. The maturity of CoNV is important to guide treatment. This study investigated associations between clinical and angiographic characteristics of CoNV. Methods:In a prospective cross-sectional study...

journal_title：Translational vision science & technology

authors： Palme C,Romano V,Brunner M,Vinciguerra R,Kaye SB,Steger B

更新日期：2018-10-01 00:00:00

abstract：Purpose:To investigate the potential of statistical and machine learning approaches to determine the diabetic status of patients from optical coherence tomography angiography (OCT-A) images. Methods:This was a retrospective cross-sectional observational study based at Manchester Royal Eye Hospital, United Kingdom. OCT...

journal_title：Translational vision science & technology

authors： Aslam TM,Hoyle DC,Puri V,Bento G

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:We evaluate solutions for an applanating surface modification to the Goldmann tonometer prism, which substantially negates the errors due to patient variability in biomechanics. METHODS:A modified Goldmann or correcting applanation tonometry surface (CATS) prism is presented which was optimized to minimize the...

journal_title：Translational vision science & technology

authors： McCafferty S,Lim G,Duncan W,Enikov E,Schwiegerling J

更新日期：2016-09-09 00:00:00

abstract：Purpose:To compare the repeatability and reproducibility of axial and lateral retinal measurements using handheld optical coherence tomography (OCT) systems and a tabletop OCT system. Methods:Graders measured central foveal thickness (CFT), optic nerve-to-fovea distance (OFD), and retinal nerve fiber layer (RNFL) thic...

journal_title：Translational vision science & technology

authors： Chen X,Tai V,McGeehan B,Ying GS,Viehland C,Imperio R,Winter KP,Raynor W,Tran-Viet D,Mangalesh S,Maguire MG,Toth CA,BabySTEPS Group.

更新日期：2020-10-21 00:00:00

abstract：PURPOSE:To investigate whether tear hyperosmolarity, a feature of dry eye disease (DED), affects central corneal thickness (CCT), corneal light reflectivity, and/or tear film reflectivity. METHODS:This prospective, cross-sectional study involved 48 participants (38 with hyperosmolar tears and 10 controls with normo-os...

journal_title：Translational vision science & technology

authors： Deinema LA,Vingrys AJ,Chinnery HR,Downie LE

更新日期：2017-05-22 00:00:00

abstract：Purpose:To assess the influence of an outdoor program on myopia progression in school children. Methods:The prospective interventional school-based study included 373 students aged 6 to 7 years (grade 1 or 2) who were examined annually between 2012 and 2016. Between 2012 and 2013, the children in the study group (n = ...

journal_title：Translational vision science & technology

authors： Guo Y,Liu L,Lv Y,Tang P,Feng Y,Wu M,Xu L,Jonas JB

更新日期：2019-05-02 00:00:00

abstract：Purpose:To compare the diagnostic ability of the vessel parameters in macular and peripapillary regions measured using spectral-domain optical coherence tomography angiography (SD-OCTA) in differentiating primary open-angle glaucoma (POAG) from healthy eyes. Methods:POAG patients and healthy subjects underwent 6 × 6-m...

journal_title：Translational vision science & technology

authors： Richter GM,Chang R,Situ B,Chu Z,Burkemper B,Reznik A,Bedrood S,Kashani AH,Varma R,Wang RK

更新日期：2018-12-06 00:00:00

abstract：Purpose:To determine whether artifacts in optical coherence tomography (OCT) images are associated with the success or failure of adaptive optics scanning light ophthalmoscopy (AOSLO) imaging in subjects with achromatopsia (ACHM). Methods:Previously acquired OCT and non-confocal, split-detector AOSLO images from one e...

journal_title：Translational vision science & technology

authors： Litts KM,Woertz EN,Georgiou M,Patterson EJ,Lam BL,Fishman GA,Pennesi ME,Kay CN,Hauswirth WW,Michaelides M,Carroll J

更新日期：2021-01-07 00:00:00

abstract：Purpose:To compare the detection of retinal pigment epithelium (RPE) atrophy in short-wavelength (SW-AF) and near-infrared autofluorescence (NIR-AF) images in Stargardt disease (STGD1) patients. Methods:SW-AF and NIR-AF images (115 eyes from 115 patients) were analyzed by two independent graders. Hypoautofluorescent (...

journal_title：Translational vision science & technology

authors： Jauregui R,Nuzbrokh Y,Su PY,Zernant J,Allikmets R,Tsang SH,Sparrow JR

更新日期：2021-01-05 00:00:00

abstract：PURPOSE:To evaluate the safety, tolerability, and intraocular pressure (IOP)-lowering effect of Latrunculin-B (Lat-B), a marine macrolide that disrupts the actin cytoskeleton, in patients with ocular hypertension (OHT) or early primary open-angle glaucoma (POAG). METHODS:In this Phase I, multicenter, double-masked, ra...

journal_title：Translational vision science & technology

authors： Rasmussen CA,Kaufman PL,Ritch R,Haque R,Brazzell RK,Vittitow JL

更新日期：2014-09-03 00:00:00

abstract：Purpose:To explore the contribution of crystalline lens fluorescence to fluorescence lifetimes measured with fluorescence lifetime imaging ophthalmoscopy (FLIO) and to propose a computational model to reduce the lens influence. Methods:FLIO, which detects autofluorescence decay over time in a short-wavelength spectral...

journal_title：Translational vision science & technology

authors： Brauer JL,Schultz R,Klemm M,Hammer M

更新日期：2020-07-09 00:00:00

abstract：Purpose:Glaucoma remains a leading cause of irreversible blindness worldwide. Animal glaucoma models replicate high intraocular pressure, a risk factor for glaucoma, to induce retinal ganglion cell (RGC) degeneration. We describe an inducible, magnetic bead model in the Brown Norway rat in which we are able to determin...

journal_title：Translational vision science & technology

authors： Tribble JR,Otmani A,Kokkali E,Lardner E,Morgan JE,Williams PA

更新日期：2021-01-12 00:00:00

abstract：Purpose:Evaluate efficiency, precision, and validity of RetCAT, which comprises ten diabetic retinopathy (DR) quality of life (QoL) computerized adaptive tests (CATs). Methods:In this cross-sectional clinical study, 183 English and/or Mandarin-speaking participants with DR (mean age ± standard deviation [SD] 56.4 ± 11...

journal_title：Translational vision science & technology

authors： Fenwick EK,Barnard J,Gan A,Loe BS,Khadka J,Pesudovs K,Man R,Lee SY,Tan G,Wong TY,Lamoureux EL

更新日期：2020-06-03 00:00:00

abstract：Purpose:To present an overview of current machine learning methods and their use in medical research, focusing on select machine learning techniques, best practices, and deep learning. Methods:A systematic literature search in PubMed was performed for articles pertinent to the topic of artificial intelligence methods ...

journal_title：Translational vision science & technology

authors： Choi RY,Coyner AS,Kalpathy-Cramer J,Chiang MF,Campbell JP

更新日期：2020-02-27 00:00:00

abstract：Purpose:Although the expression of microRNAs (miRNAs) in retinal pigment epithelial (RPE) cells undergoing epithelial-mesenchymal transition (EMT) is involved in the pathogenesis of proliferative vitreoretinopathy (PVR), its expression in the vitreous of patients with primary retinal detachment (RD) and different PVR g...

journal_title：Translational vision science & technology

authors： Toro MD,Reibaldi M,Avitabile T,Bucolo C,Salomone S,Rejdak R,Nowomiejska K,Tripodi S,Posarelli C,Ragusa M,Barbagallo C

更新日期：2020-05-22 00:00:00

abstract：Purpose:To determine whether multicolor scanning laser ophthalmoscopy (MC-SLO) was better than color fundus photography (CFP) to enhance residents and specialists' preoperative decision-making and intraoperative performance on the epiretinal membrane (ERM). Methods:Consecutive patients with idiopathic ERM were recruit...

journal_title：Translational vision science & technology

authors： Zhang Z,Li M,Sun Y,Wei Y,Zhang S

更新日期：2020-12-18 00:00:00

abstract：PURPOSE:To examine the protective effects of antioxidants in cultured trabecular meshwork (TM) cells exposed to oxidative stress. METHODS:Primary porcine TM cells were pretreated with 50 μM resveratrol, 0.2 mM urate, 1 mM ascorbate, 1 mM reduced glutathione (rGSH), or 1 mM ρ-coumarate followed by exposure to hydrogen ...

journal_title：Translational vision science & technology

authors： Ammar DA,Hamweyah KM,Kahook MY

更新日期：2012-05-31 00:00:00

abstract：Purpose:To evaluate the changes of retinal capillary nonperfusion areas and retinal capillary vessel density of the superficial capillary plexus (SCP) and deep capillary plexus in patients with diabetes with diabetic macular edema treated with an intravitreal dexamethasone implant (IDI). Methods:We enrolled 28 patient...

journal_title：Translational vision science & technology

authors： Toto L,D'Aloisio R,Chiarelli AM,Di Antonio L,Evangelista F,D'Onofrio G,Merla A,Parravano M,Di Marzio G,Mastropasqua R

更新日期：2020-06-11 00:00:00

abstract：PURPOSE:To validate Gaussian mixture-model with expectation maximization (GEM) and variational Bayesian independent component analysis mixture-models (VIM) for detecting glaucomatous progression along visual field (VF) defect patterns (GEM-progression of patterns (POP) and VIM-POP). To compare GEM-POP and VIM-POP with ...

journal_title：Translational vision science & technology

authors： Yousefi S,Balasubramanian M,Goldbaum MH,Medeiros FA,Zangwill LM,Weinreb RN,Liebmann JM,Girkin CA,Bowd C

更新日期：2016-05-03 00:00:00

abstract：Purpose:To evaluate the feasibility of using signal detection theory (SDT) in estimating criterion and detectability indices for corneal pneumatic stimuli and test corneal psychophysical data against linking hypotheses from nonprimate physiology using Bayesian analysis. Methods:Corneal pneumatic stimuli were delivered...

journal_title：Translational vision science & technology

authors： Jayakumar V,Simpson TL

更新日期：2020-11-10 00:00:00

abstract：Purpose:We aimed to develop and evaluate the Computerized Glaucoma Visual Function Test (CoGVFT), among a cohort of glaucoma patients, and identify potential new items to optimize the test. Method:A cross-sectional study involving 84 patients with open-angle glaucoma of varying severity and 18 controls without glaucom...

journal_title：Translational vision science & technology

authors： Jong C,Skalicky SE

更新日期：2020-11-03 00:00:00

abstract：Purpose:We quantified the interrelationship between retinal blood vessel (BV) anatomical variation, spherical equivalent (SE) of refractive error, and functional diagnostic parameters in glaucoma to identify optimal parameters for the improvement of optical coherence tomography (OCT) retinal nerve fiber layer thickness...

journal_title：Translational vision science & technology

authors： Wang M,Jin Q,Wang H,Li D,Baniasadi N,Elze T

更新日期：2018-01-18 00:00:00