Abstract：
Purpose:To compare the detection of retinal pigment epithelium (RPE) atrophy in short-wavelength (SW-AF) and near-infrared autofluorescence (NIR-AF) images in Stargardt disease (STGD1) patients. Methods:SW-AF and NIR-AF images (115 eyes from 115 patients) were analyzed by two independent graders. Hypoautofluorescent (hypoAF) areas, indicative of RPE atrophy, were measured, and the two modalities were compared. Results:Patients were segregated into four groups: nascent (6 [5%]), widespread (21 [18%]), discrete (55 [48%]), and chorioretinal atrophy (33 [29%]). The areas of hypoAF were larger in NIR-AF compared to SW-AF images in discrete (3.9 vs. 2.2 mm2, P < 0.001) and chorioretinal atrophy (12.7 vs. 11.4 mm2, P = 0.015). Similar findings were observed qualitatively in nascent and widespread atrophy patients. Using the area linear model (ALM), lesion area increased at similar rates in SW-AF and NIR-AF images of discrete atrophy (0.20 vs. 0.32 mm2/y, P = 0.275) and chorioretinal atrophy (1.30 vs. 1.74 mm2/y, P = 0.671). Using the radius linear model (RLM), the lesion effective radius also increased similarly in SW-AF and NIR-AF images in discrete (0.03 vs. 0.05 mm2/y, P = 0.221) and chorioretinal atrophy (0.08 vs. 0.10 mm2/y, P = 0.754) patients. Conclusions:NIR-AF reveals a larger area of RPE atrophy in STGD1 patients compared to SW-AF images, but rates of lesion enlargement in the two modalities are similar. Translational Relevance:Measurements of RPE atrophy by AF imaging are crucial for monitoring STGD1 disease progression and given our findings we advocate greater use of NIR-AF for patients.
journal_name
Transl Vis Sci Technoljournal_title
Translational vision science & technologyauthors
Jauregui R,Nuzbrokh Y,Su PY,Zernant J,Allikmets R,Tsang SH,Sparrow JRdoi
10.1167/tvst.10.1.3subject
Has Abstractpub_date
2021-01-05 00:00:00pages
3issue
1issn
2164-2591pii
TVST-20-2575journal_volume
10pub_type
杂志文章abstract：Purpose:To determine whether multicolor scanning laser ophthalmoscopy (MC-SLO) was better than color fundus photography (CFP) to enhance residents and specialists' preoperative decision-making and intraoperative performance on the epiretinal membrane (ERM). Methods:Consecutive patients with idiopathic ERM were recruit...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.9.13.36
更新日期：2020-12-18 00:00:00
abstract：:Especially since the incorporation of swept laser sources, optical coherence tomography angiography (OCTA) has enabled quantification of choriocapillaris perfusion. A critical step in this process is binarization, which makes angiographic images quantifiable in terms of perfusion metrics. It remains challenging to hav...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.9.8.44
更新日期：2020-07-29 00:00:00
abstract：Purpose:To evaluate the relationships between refractive error, axial length (AL), and retinal vascular oxygen saturation in an adult population. Methods:This was a hospital-based, prospective observational study. The left eyes of phakic adult subjects without media opacity were analyzed. Subjective undilated manifest...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.8.4.22
更新日期：2019-08-07 00:00:00
abstract：Purpose:To develop an artificial intelligence (AI)-based structure-function (SF) map relating retinal nerve fiber layer (RNFL) damage on spectral domain optical coherence tomography (SDOCT) to functional loss on standard automated perimetry (SAP). Methods:The study included 26,499 pairs of SAP and SDOCT from 15,173 ey...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.9.2.19
更新日期：2020-03-30 00:00:00
abstract：Purpose:To compare the diagnostic ability of the vessel parameters in macular and peripapillary regions measured using spectral-domain optical coherence tomography angiography (SD-OCTA) in differentiating primary open-angle glaucoma (POAG) from healthy eyes. Methods:POAG patients and healthy subjects underwent 6 × 6-m...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.7.6.21
更新日期：2018-12-06 00:00:00
abstract：Purpose:Semiautomated software applications derive quantitative retinal vascular parameters from fundus camera images. However, the extent of agreement between measurements from different applications is unclear. We evaluate the agreement between retinal measures from two software applications, the Singapore "I" Vessel...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.7.2.12
更新日期：2018-03-23 00:00:00
abstract：Purpose:To explore the contribution of crystalline lens fluorescence to fluorescence lifetimes measured with fluorescence lifetime imaging ophthalmoscopy (FLIO) and to propose a computational model to reduce the lens influence. Methods:FLIO, which detects autofluorescence decay over time in a short-wavelength spectral...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.9.8.13
更新日期：2020-07-09 00:00:00
abstract：PURPOSE:To explore the performance of patient-specific prior information, for example, from structural imaging, in improving perimetric procedures. METHODS:Computer simulation was used to determine the error distribution and presentation count for Structure-Zippy Estimation by Sequential Testing (ZEST), a Bayesian pro...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.2.4.3
更新日期：2013-05-01 00:00:00
abstract：PURPOSE:The photopic negative response (PhNR) may be useful as a tool to monitor longitudinal change in retinal ganglion cell (RGC) function. The goal was to assess PhNR test-retest reliability, and to estimate the amount of change between tests that is likely to be statistically significant for an individual test subj...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.3.6.1
更新日期：2014-11-03 00:00:00
abstract：PURPOSE:We directly demonstrated the revascularization in a free retinal pigment epithelium (RPE)-choroid graft with direct blood flow detection by experimental phase-resolved Doppler optical coherence tomography (PRD-OCT). METHODS:Seven patients with age-related macular degeneration underwent an RPE-choroid graft tra...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.4.1.2
更新日期：2015-01-13 00:00:00
abstract：Purpose:To investigate the molecular components of the vitreous in order to better understand retinal physiology and disease. Methods:Vitreous was acquired from patients undergoing vitrectomy for macular hole and/or epiretinal membrane, postmortem donors, and C57BL/6J mice. Unbiased proteomic analysis was performed vi...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.7.3.6
更新日期：2018-05-14 00:00:00
abstract：PURPOSE:To validate Gaussian mixture-model with expectation maximization (GEM) and variational Bayesian independent component analysis mixture-models (VIM) for detecting glaucomatous progression along visual field (VF) defect patterns (GEM-progression of patterns (POP) and VIM-POP). To compare GEM-POP and VIM-POP with ...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.5.3.2
更新日期：2016-05-03 00:00:00
abstract：Purpose:To assess the repeatability and agreement of ocular biometric parameters measured using the Tomey CASIA SS-1000 and Heidelberg ANTERION anterior segment optical coherence tomography (AS-OCT) devices. Methods:Both eyes of subjects 18 years of age or older were scanned three times with the CASIA and ANTERION und...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.9.9.14
更新日期：2020-08-07 00:00:00
abstract：PURPOSE:To determine the active ingredient in tea tree oil (TTO) responsible for its reported killing effect on Demodex mites, the most common ectoparasite found in the human skin extending to the eye. METHODS:Using a reported in vitro killing assay to measure the survival time of adult Demodex folliculorum up to 150 ...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.2.7.2
更新日期：2013-11-01 00:00:00
abstract：Purpose:To evaluate the safety and tolerability of a microsphere thermo-responsive hydrogel drug delivery system (DDS) loaded with aflibercept in a nonhuman primate model. Methods:A sterile 50 µL of aflibercept-loaded microsphere thermo-responsive hydrogel-DDS (aflibercept-DDS) was injected intravitreally into the rig...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.9.3.30
更新日期：2020-02-27 00:00:00
abstract：PURPOSE:Crowdsourcing is based on outsourcing computationally intensive tasks to numerous individuals in the online community who have no formal training. Our aim was to develop a novel online tool designed to facilitate large-scale annotation of digital retinal images, and to assess the accuracy of crowdsource grading...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.5.5.6
更新日期：2016-09-21 00:00:00
abstract：Purpose:Glaucoma drainage device (GDD) implantation can lead to corneal decompensation. We evaluated changes over time in oxygen tension and in the metabolic environment of the aqueous humor after GDD implantation in the rabbit eye. Methods:Ahmed Glaucoma Valves were implanted in the left eyes of eight male New Zealan...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.7.1.14
更新日期：2018-02-02 00:00:00
abstract：Purpose:To evaluate the effects of vascular endothelial growth factor-A (VEGF-A) gene editing in human retinal pigment epithelial (RPE) cells and human Muller cells, which are the main VEGF-A producing cells in the eye. Methods:CRISPR-Cas9 ribonucleoprotein was used to target exon 1 in VEGF-A gene. Lipofectamine CRISP...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.9.8.23
更新日期：2020-07-14 00:00:00
abstract：Purpose:To determine whether artifacts in optical coherence tomography (OCT) images are associated with the success or failure of adaptive optics scanning light ophthalmoscopy (AOSLO) imaging in subjects with achromatopsia (ACHM). Methods:Previously acquired OCT and non-confocal, split-detector AOSLO images from one e...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.10.1.11
更新日期：2021-01-07 00:00:00
abstract：Purpose:To present an overview of current machine learning methods and their use in medical research, focusing on select machine learning techniques, best practices, and deep learning. Methods:A systematic literature search in PubMed was performed for articles pertinent to the topic of artificial intelligence methods ...
journal_title：Translational vision science & technology
pub_type： 杂志文章,评审
doi：10.1167/tvst.9.2.14
更新日期：2020-02-27 00:00:00
abstract：PURPOSE:To determine the efficacy and safety of repeated intravitreal and subconjunctival administrations of sirolimus in patients with noninfectious uveitis at 1 year in the Sirolimus as a Therapeutic Approach UVEitis (SAVE) Study. METHODS:Open-label, prospective, and randomized interventional clinical trial in which...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.4.2.4
更新日期：2015-03-10 00:00:00
abstract：PURPOSE:We performed video-oculography to evaluate vergence eye movement abnormalities in students diagnosed clinically with vergence disorders. We tested the efficiency of a novel rehabilitation method and evaluated its benefits with video-oculography cross-correlated with clinical tests and symptomatology. METHODS:A...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.5.2.8
更新日期：2016-03-11 00:00:00
abstract：Purpose:This study aims to develop a fully automated algorithm for artery-vein (A-V) and arteriole-venule classification and to quantify the effect of hypertension on A-V caliber and tortuosity ratios of nonproliferative diabetic retinopathy (NPDR) patients. Methods:We combine an optical density ratio (ODR) analysis a...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.7.2.23
更新日期：2018-04-18 00:00:00
abstract：Purpose:Noninvasive keratograph break up times (NIKBUTs) are preferred to dye-based methods to evaluate tear stability in translational medicine. We analyzed the NIKBUTs in different regions of the precorneal tear by using a common imaging technology and explored potential correlations with clinical parameters. Method...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.8.5.30
更新日期：2019-10-17 00:00:00
abstract：Purpose:To investigate whether plasma rich in growth factors (PRGF) eye drops maintain their biological potential after a freeze drying process. The addition of a lyoprotectant like trehalose was also evaluated. Methods:Blood from three healthy donors was collected to obtain eye drops by PRGF technology. The resultant...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.9.7.35
更新日期：2020-06-25 00:00:00
abstract：Purpose:Clinical intensity-based optical coherence tomographic retinal imaging is unable to resolve some of the earliest changes to Alzheimer's disease (AD) neurons. The aim of this pilot study was to demonstrate that scattering-angle-resolved optical coherence tomography (SAR-OCT), which is sensitive to changes in lig...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.9.5.18
更新日期：2020-04-24 00:00:00
abstract：PURPOSE:To investigate whether tear hyperosmolarity, a feature of dry eye disease (DED), affects central corneal thickness (CCT), corneal light reflectivity, and/or tear film reflectivity. METHODS:This prospective, cross-sectional study involved 48 participants (38 with hyperosmolar tears and 10 controls with normo-os...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.6.3.6
更新日期：2017-05-22 00:00:00
abstract：Purpose:To compare the repeatability and reproducibility of axial and lateral retinal measurements using handheld optical coherence tomography (OCT) systems and a tabletop OCT system. Methods:Graders measured central foveal thickness (CFT), optic nerve-to-fovea distance (OFD), and retinal nerve fiber layer (RNFL) thic...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.9.11.25
更新日期：2020-10-21 00:00:00
abstract：:[This corrects the article DOI: 10.1167/tvst.8.2.3.]. ...
journal_title：Translational vision science & technology
pub_type： 杂志文章,已发布勘误
doi：10.1167/tvst.8.3.9
更新日期：2019-05-02 00:00:00
abstract：Purpose:To develop an eye model with a physiological blink mechanism. Methods:All parts of the eye model were designed using computer-aided design software. The eyelid consisted of a unique 3D printed structure containing teeth to physically secure a flexible membrane. Both the eyeball and eyelid membrane were synthes...
journal_title：Translational vision science & technology
pub_type： 杂志文章
doi：10.1167/tvst.8.5.1
更新日期：2019-09-03 00:00:00
