Using the Pathophysiology of Dry AMD to Guide Binarization of the Choriocapillaris on OCTA: A Model.

abstract：Purpose:Mapping of epithelial thickness (ET) is useful for detection of keratoconus, a disease characterized by corneal thinning and bulging in which epithelial thinning occurs over the apex. In prior clinical studies, optical coherence tomography (OCT) measurements of ET were systematically thinner than those obtained...

journal_title：Translational vision science & technology

authors： Rohrbach D,Silverman RH,Chun D,Lloyd HO,Urs R,Mamou J

更新日期：2018-04-11 00:00:00

abstract：Purpose:To determine the effectiveness of intravitreal aflibercept (IVA) on the retinal function in eyes with diabetic macular edema (DME). Methods:Twenty-five eyes of 25 patients with DME were treated with three consecutive monthly IVA injections. The retinal sensitivities (RS) within the central 10° were determined ...

journal_title：Translational vision science & technology

authors： Ichio A,Sugimoto M,Matsubara H,Mochida D,Kato K,Kondo M

更新日期：2020-10-06 00:00:00

abstract：PURPOSE:A novel glaucoma drainage device (GDD) with local drug delivery (LDD) system was created and characterized for safety and effectiveness after implantation into the suprachoroidal space (SCS) of rabbit eyes. METHODS:Thin films of two different polymers, Poly(3-hydroxybutyrate) (P(3HB)) and Poly(4-hydroxybutyrat...

journal_title：Translational vision science & technology

authors： Hovakimyan M,Siewert S,Schmidt W,Sternberg K,Reske T,Stachs O,Guthoff R,Wree A,Witt M,Schmitz KP,Allemann R

更新日期：2015-06-30 00:00:00

abstract：Purpose:Factor I (FI) is a serine protease regulator of the complement system. Genetic variants in CFI are associated with advanced age-related macular degeneration (AAMD). However, the clinical and functional impact of these variants is unknown. This study assessed the functional significance of rare CFI variants usin...

journal_title：Translational vision science & technology

authors： Java A,Baciu P,Widjajahakim R,Sung YJ,Yang J,Kavanagh D,Atkinson J,Seddon J

更新日期：2020-08-24 00:00:00

abstract：Purpose:Glaucoma remains a leading cause of irreversible blindness worldwide. Animal glaucoma models replicate high intraocular pressure, a risk factor for glaucoma, to induce retinal ganglion cell (RGC) degeneration. We describe an inducible, magnetic bead model in the Brown Norway rat in which we are able to determin...

journal_title：Translational vision science & technology

authors： Tribble JR,Otmani A,Kokkali E,Lardner E,Morgan JE,Williams PA

更新日期：2021-01-12 00:00:00

abstract：Purpose:The purpose of this study is to evaluate whether a single best image can represent central endothelial cell density (ECD) in corneas of differing cell size coefficient of variance (CV). Methods:Four hundred one healthy eyes but with variant CV values were enrolled. For each eye, three nonoverlapping central co...

journal_title：Translational vision science & technology

authors： Shi Y,Huang J,Baghdasaryan E,Huang P,Huang X,Sadda SR,Lee OL

更新日期：2019-05-29 00:00:00

abstract：Purpose:To study the choroid in uncomplicated pregnant women using advanced optical coherence tomography (OCT) imaging and analysis. Methods:Women with uncomplicated pregnancy in the third trimester (>28 weeks gestational age) and age-matched nonpregnant women were enrolled in this prospective study. All subjects unde...

journal_title：Translational vision science & technology

authors： Su L,Taweebanjongsin W,Gaw SL,Rabina G,Sadda SR,Tsui I

更新日期：2020-08-13 00:00:00

abstract：Purpose:To determine whether multicolor scanning laser ophthalmoscopy (MC-SLO) was better than color fundus photography (CFP) to enhance residents and specialists' preoperative decision-making and intraoperative performance on the epiretinal membrane (ERM). Methods:Consecutive patients with idiopathic ERM were recruit...

journal_title：Translational vision science & technology

authors： Zhang Z,Li M,Sun Y,Wei Y,Zhang S

更新日期：2020-12-18 00:00:00

abstract：Purpose:While using their amblyopic eye, individuals with strabismic amblyopia count inaccurately and underestimate the number of features. These deficits are attributed to limitations in high-level cortical functions and attention. In the current study, we examined whether feature counting is affected in strabismic an...

journal_title：Translational vision science & technology

authors： Wong-Kee-You AMB,Wei H,Hou C

更新日期：2020-05-16 00:00:00

abstract：Purpose:To assess the repeatability and agreement of ocular biometric parameters measured using the Tomey CASIA SS-1000 and Heidelberg ANTERION anterior segment optical coherence tomography (AS-OCT) devices. Methods:Both eyes of subjects 18 years of age or older were scanned three times with the CASIA and ANTERION und...

journal_title：Translational vision science & technology

authors： Pardeshi AA,Song AE,Lazkani N,Xie X,Huang A,Xu BY

更新日期：2020-08-07 00:00:00

abstract：Purpose:To develop an artificial intelligence (AI)-based structure-function (SF) map relating retinal nerve fiber layer (RNFL) damage on spectral domain optical coherence tomography (SDOCT) to functional loss on standard automated perimetry (SAP). Methods:The study included 26,499 pairs of SAP and SDOCT from 15,173 ey...

journal_title：Translational vision science & technology

authors： Mariottoni EB,Datta S,Dov D,Jammal AA,Berchuck SI,Tavares IM,Carin L,Medeiros FA

更新日期：2020-03-30 00:00:00

abstract：Purpose:To describe a new technique for mapping parafoveal intercapillary areas (PICAs) using optical coherence tomography angiography (OCTA), and demonstrate its utility for quantifying parafoveal nonperfusion in diabetic retinopathy (DR). Methods:Nineteen controls, 15 diabetics with no retinopathy (noDR), 15 with no...

journal_title：Translational vision science & technology

authors： Krawitz BD,Phillips E,Bavier RD,Mo S,Carroll J,Rosen RB,Chui TYP

更新日期：2018-07-12 00:00:00

abstract：PURPOSE:To evaluate the effect of age on optic nerve axon counts, spectral-domain optical coherence tomography (SDOCT) scan quality, and peripapillary retinal nerve fiber layer thickness (RNFLT) measurements in healthy monkey eyes. METHODS:In total, 83 healthy rhesus monkeys were included in this study (age range: 1.2...

journal_title：Translational vision science & technology

authors： Fortune B,Reynaud J,Cull G,Burgoyne CF,Wang L

更新日期：2014-05-22 00:00:00

abstract：Purpose:To investigate whether plasma rich in growth factors (PRGF) eye drops maintain their biological potential after a freeze drying process. The addition of a lyoprotectant like trehalose was also evaluated. Methods:Blood from three healthy donors was collected to obtain eye drops by PRGF technology. The resultant...

journal_title：Translational vision science & technology

authors： Anitua E,de la Fuente M,Alcalde I,Sanchez C,Merayo-Lloves J,Muruzabal F

更新日期：2020-06-25 00:00:00

abstract：Purpose:To explore the difference of the default mode network (DMN) in patients with retinal detachment (RD) by the study of the resting state functional connectivity (rs-FC). Methods:A total of 30 patients with RD (16 men, 14 women) and 30 similarly matched normal controls (NCs) were examined and recorded with rs-fMR...

journal_title：Translational vision science & technology

authors： Su T,Shu YQ,Liu KC,Ye L,Chen LL,Shi WQ,Min YL,Xu XW,Yuan Q,Zhu PW,Shao Y

更新日期：2018-11-30 00:00:00

abstract：Purpose:The posthatching chicken is a valuable animal model for research, but molecular tools needed for altering its gene expression are not yet available. Our purpose here was to adapt the adeno-associated viral (AAV) vector method, used widely in mammalian studies, for use in investigations of the chicken retina. We...

journal_title：Translational vision science & technology

authors： Waldner DM,Visser F,Fischer AJ,Bech-Hansen NT,Stell WK

更新日期：2019-07-01 00:00:00

abstract：Purpose:Clinical intensity-based optical coherence tomographic retinal imaging is unable to resolve some of the earliest changes to Alzheimer's disease (AD) neurons. The aim of this pilot study was to demonstrate that scattering-angle-resolved optical coherence tomography (SAR-OCT), which is sensitive to changes in lig...

journal_title：Translational vision science & technology

authors： Gardner MR,Baruah V,Vargas G,Motamedi M,Milner TE,Rylander HG 3rd

更新日期：2020-04-24 00:00:00

abstract：Purpose:Diagnosis of ocular graft-versus-host disease (oGVHD) is hampered by a lack of clinically-validated biomarkers. This study aims to predict disease severity on the basis of tear protein expression in mild oGVHD. Methods:Forty-nine patients with and without chronic oGVHD after AHCT were recruited to a cross-sect...

journal_title：Translational vision science & technology

authors： O'Leary OE,Schoetzau A,Amruthalingam L,Geber-Hollbach N,Plattner K,Jenoe P,Schmidt A,Ullmer C,Drawnel FM,Fauser S,Scholl HPN,Passweg J,Halter JP,Goldblum D

更新日期：2020-08-03 00:00:00

abstract：Purpose:To investigate variation and determinants of macular layers, peripapillary retinal nerve fiber layer (pRNFL) and Bruch's membrane opening-minimum rim width (BMO-MRW) in the general population. Methods:In 1306 participants, we performed spectral domain optical coherence tomography (SD-OCT) scans of the macula, ...

journal_title：Translational vision science & technology

authors： Mauschitz MM,Holz FG,Finger RP,Breteler MMB

更新日期：2019-06-04 00:00:00

abstract：PURPOSE:We evaluate solutions for an applanating surface modification to the Goldmann tonometer prism, which substantially negates the errors due to patient variability in biomechanics. METHODS:A modified Goldmann or correcting applanation tonometry surface (CATS) prism is presented which was optimized to minimize the...

journal_title：Translational vision science & technology

authors： McCafferty S,Lim G,Duncan W,Enikov E,Schwiegerling J

更新日期：2016-09-09 00:00:00

abstract：Purpose:The activation of microglia, the primary innate immune cell resident in the retina, produces inflammatory mediators, which underlie changes in diabetic retinopathy including increased vascular permeability. This study evaluates the safety and efficacy of dextromethorphan, a drug capable of inhibiting microglial...

journal_title：Translational vision science & technology

authors： Valent DJ,Wong WT,Chew EY,Cukras CA

更新日期：2018-12-17 00:00:00

abstract：Purpose:To evaluate dysfunction in various ocular surface diseases (OSDs) including primary meibomian gland disease (MGD), perennial allergic conjunctivitis, and primary and secondary Sjögren syndromes. Methods:A retrospective analysis of 146 patients (111 women and 35 men) with symptomatic OSDs was performed. Patient...

journal_title：Translational vision science & technology

authors： Robin M,Liang H,Rabut G,Augstburger E,Baudouin C,Labbé A

更新日期：2019-11-12 00:00:00

abstract：Purpose:To assess the influence of an outdoor program on myopia progression in school children. Methods:The prospective interventional school-based study included 373 students aged 6 to 7 years (grade 1 or 2) who were examined annually between 2012 and 2016. Between 2012 and 2013, the children in the study group (n = ...

journal_title：Translational vision science & technology

authors： Guo Y,Liu L,Lv Y,Tang P,Feng Y,Wu M,Xu L,Jonas JB

更新日期：2019-05-02 00:00:00

abstract：Purpose:To develop an eye model with a physiological blink mechanism. Methods:All parts of the eye model were designed using computer-aided design software. The eyelid consisted of a unique 3D printed structure containing teeth to physically secure a flexible membrane. Both the eyeball and eyelid membrane were synthes...

journal_title：Translational vision science & technology

authors： Phan CM,Walther H,Qiao H,Shinde R,Jones L

更新日期：2019-09-03 00:00:00

abstract：Purpose:To evaluate high accumulation of coronary artery calcium (CAC) from retinal fundus images with deep learning technologies as an inexpensive and radiation-free screening method. Methods:Individuals who underwent bilateral retinal fundus imaging and CAC score (CACS) evaluation from coronary computed tomography s...

journal_title：Translational vision science & technology

authors： Son J,Shin JY,Chun EJ,Jung KH,Park KH,Park SJ

更新日期：2020-11-11 00:00:00

abstract：PURPOSE:Developing a novel image enhancement method so that nonframe-averaged optical coherence tomography (OCT) images become comparable to active eye-tracking frame-averaged OCT images. METHODS:Twenty-one eyes of 21 healthy volunteers were scanned with noneye-tracking nonframe-averaged OCT device and active eye-trac...

journal_title：Translational vision science & technology

authors： Chen CL,Ishikawa H,Wollstein G,Bilonick RA,Kagemann L,Schuman JS

更新日期：2016-01-11 00:00:00

abstract：PURPOSE:No prismatic solution for peripheral field loss (PFL) has gained widespread acceptance. Field extended by prisms has a corresponding optical scotoma at the prism apices. True expansion can be achieved when each eye is given a different view (through visual confusion). We analyze the effects of apical scotomas a...

journal_title：Translational vision science & technology

authors： Apfelbaum H,Peli E

更新日期：2015-12-31 00:00:00

abstract：Purpose:We developed and evaluated an eye dropper bottle sensor system comprising motion sensor with automatic motion waveform analysis using deep learning (DL) to accurately measure adherence of patients with antiglaucoma ophthalmic solution therapy. Methods:We enrolled 20 patients with open-angle glaucoma who were t...

journal_title：Translational vision science & technology

authors： Nishimura K,Tabuchi H,Nakakura S,Nakatani Y,Yorihiro A,Hasegawa S,Tanabe H,Noguchi A,Aoki R,Kiuchi Y

更新日期：2019-06-27 00:00:00

abstract：PURPOSE:Crowdsourcing is based on outsourcing computationally intensive tasks to numerous individuals in the online community who have no formal training. Our aim was to develop a novel online tool designed to facilitate large-scale annotation of digital retinal images, and to assess the accuracy of crowdsource grading...

journal_title：Translational vision science & technology

authors： Mitry D,Zutis K,Dhillon B,Peto T,Hayat S,Khaw KT,Morgan JE,Moncur W,Trucco E,Foster PJ,1 for the UK Biobank Eye and Vision Consortium.

更新日期：2016-09-21 00:00:00

abstract：Purpose:The aim of the present study was to analyze quantitative optical coherence tomography (OCT) and OCT angiography (OCTA) parameters to identify clinically relevant cutoff values able to detect clinically different Stargardt's disease (STGD) subgroups. Methods:Consecutive STGD patients were recruited and underwen...

journal_title：Translational vision science & technology

authors： Arrigo A,Romano F,Aragona E,di Nunzio C,Sperti A,Bandello F,Battaglia Parodi M

更新日期：2019-12-05 00:00:00