Abstract:
Purpose:To evaluate high accumulation of coronary artery calcium (CAC) from retinal fundus images with deep learning technologies as an inexpensive and radiation-free screening method. Methods:Individuals who underwent bilateral retinal fundus imaging and CAC score (CACS) evaluation from coronary computed tomography scans on the same day were identified. With this database, performances of deep learning algorithms (inception-v3) to distinguish high CACS from CACS of 0 were evaluated at various thresholds for high CACS. Vessel-inpainted and fovea-inpainted images were also used as input to investigate areas of interest in determining CACS. Results:A total of 44,184 images from 20,130 individuals were included. A deep learning algorithm for discrimination of no CAC from CACS >100 achieved area under receiver operating curve (AUROC) of 82.3% (79.5%-85.0%) and 83.2% (80.2%-86.3%) using unilateral and bilateral fundus images, respectively, under a 5-fold cross validation setting. AUROC increased as the criterion for high CACS was increased, showing a plateau at 100 and losing significant improvement thereafter. AUROC decreased when fovea was inpainted and decreased further when vessels were inpainted, whereas AUROC increased when bilateral images were used as input. Conclusions:Visual patterns of retinal fundus images in subjects with CACS > 100 could be recognized by deep learning algorithms compared with those with no CAC. Exploiting bilateral images improves discrimination performance, and ablation studies removing retinal vasculature or fovea suggest that recognizable patterns reside mainly in these areas. Translational Relevance:Retinal fundus images can be used by deep learning algorithms for prediction of high CACS.
journal_name
Transl Vis Sci Technoljournal_title
Translational vision science & technologyauthors
Son J,Shin JY,Chun EJ,Jung KH,Park KH,Park SJdoi
10.1167/tvst.9.2.28subject
Has Abstractpub_date
2020-11-11 00:00:00pages
28issue
6issn
2164-2591pii
TVST-19-1853journal_volume
9pub_type
杂志文章abstract::Canaloplasty, a recently developed non-penetrating glaucoma surgical approach, may restore physiological outflow routes in primary open-angle glaucoma with less risk of severe postoperative complications than trabeculectomy. Since the inner wall of Schlemm's canal (SC) is directly in contact with the trabecular meshwo...
journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.2.1.2
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.8.6.26
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journal_title:Translational vision science & technology
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journal_title:Translational vision science & technology
pub_type: 杂志文章
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更新日期:2020-03-30 00:00:00
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.8.6.39
更新日期:2019-12-18 00:00:00
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.5.4.13
更新日期:2016-08-31 00:00:00
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journal_title:Translational vision science & technology
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abstract:Purpose:The Bayesian adaptive quick contrast sensitivity function (qCSF) method with a 10-letter identification task provides an efficient CSF assessment. However, large populations are unfamiliar with letters and cannot benefit from this test. To overcome the barrier, we conducted this study. Method:A new font for di...
journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.7.6.9
更新日期:2018-11-14 00:00:00
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journal_title:Translational vision science & technology
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journal_title:Translational vision science & technology
pub_type: 杂志文章
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更新日期:2016-05-03 00:00:00
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journal_title:Translational vision science & technology
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更新日期:2018-10-11 00:00:00
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journal_title:Translational vision science & technology
pub_type: 杂志文章
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更新日期:2021-01-12 00:00:00
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journal_title:Translational vision science & technology
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.7.1.4
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journal_title:Translational vision science & technology
pub_type: 杂志文章
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更新日期:2019-08-07 00:00:00
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.3.5.1
更新日期:2014-09-03 00:00:00
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.9.7.45
更新日期:2020-06-30 00:00:00
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.9.4.2
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journal_title:Translational vision science & technology
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doi:10.1167/tvst.10.1.3
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.5.6.10
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abstract::[This corrects the article on p. 4 in vol. 7.]. ...
journal_title:Translational vision science & technology
pub_type: 杂志文章,已发布勘误
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journal_title:Translational vision science & technology
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.4.3.14
更新日期:2015-06-30 00:00:00
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.5.2.4
更新日期:2016-03-04 00:00:00
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.8.6.6
更新日期:2019-11-12 00:00:00
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.9.5.8
更新日期:2020-04-15 00:00:00
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journal_title:Translational vision science & technology
pub_type: 杂志文章
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更新日期:2020-05-16 00:00:00
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.9.8.13
更新日期:2020-07-09 00:00:00
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journal_title:Translational vision science & technology
pub_type: 杂志文章
doi:10.1167/tvst.8.4.1
更新日期:2019-07-01 00:00:00
abstract:Purpose:Electronic retinal prostheses restore vision in people with outer retinal degeneration by electrically stimulating the inner retina. We characterized visual cortex electrophysiologic response elicited by electrical stimulation of retina in normally sighted and retinal degenerate rats. Methods:Nine normally sig...
journal_title:Translational vision science & technology
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doi:10.1167/tvst.7.5.33
更新日期:2018-10-31 00:00:00