Ability of Macular Inner Retinal Layer Thickness Asymmetry Evaluated by Optical Coherence Tomography to Detect Preperimetric Glaucoma.

abstract：Purpose:To explore the contribution of crystalline lens fluorescence to fluorescence lifetimes measured with fluorescence lifetime imaging ophthalmoscopy (FLIO) and to propose a computational model to reduce the lens influence. Methods:FLIO, which detects autofluorescence decay over time in a short-wavelength spectral...

journal_title：Translational vision science & technology

authors： Brauer JL,Schultz R,Klemm M,Hammer M

更新日期：2020-07-09 00:00:00

abstract：Purpose:To evaluate the effects of vascular endothelial growth factor-A (VEGF-A) gene editing in human retinal pigment epithelial (RPE) cells and human Muller cells, which are the main VEGF-A producing cells in the eye. Methods:CRISPR-Cas9 ribonucleoprotein was used to target exon 1 in VEGF-A gene. Lipofectamine CRISP...

journal_title：Translational vision science & technology

authors： Ameri H,Murat C,Arbabi A,Jiang W,Janga SR,Qin PZ,Hamm-Alvarez SF

更新日期：2020-07-14 00:00:00

abstract：Purpose:To develop an artificial intelligence (AI)-based structure-function (SF) map relating retinal nerve fiber layer (RNFL) damage on spectral domain optical coherence tomography (SDOCT) to functional loss on standard automated perimetry (SAP). Methods:The study included 26,499 pairs of SAP and SDOCT from 15,173 ey...

journal_title：Translational vision science & technology

authors： Mariottoni EB,Datta S,Dov D,Jammal AA,Berchuck SI,Tavares IM,Carin L,Medeiros FA

更新日期：2020-03-30 00:00:00

abstract：Purpose:Diagnosis of ocular graft-versus-host disease (oGVHD) is hampered by a lack of clinically-validated biomarkers. This study aims to predict disease severity on the basis of tear protein expression in mild oGVHD. Methods:Forty-nine patients with and without chronic oGVHD after AHCT were recruited to a cross-sect...

journal_title：Translational vision science & technology

authors： O'Leary OE,Schoetzau A,Amruthalingam L,Geber-Hollbach N,Plattner K,Jenoe P,Schmidt A,Ullmer C,Drawnel FM,Fauser S,Scholl HPN,Passweg J,Halter JP,Goldblum D

更新日期：2020-08-03 00:00:00

abstract：PURPOSE:To validate the performance of a new perimetric algorithm (Gradient-Oriented Automated Natural Neighbor Approach; GOANNA) in humans using a novel combination of computer simulation and human testing, which we call Artificial Scotoma Generation (ASG). METHODS:Fifteen healthy observers were recruited. Baseline c...

journal_title：Translational vision science & technology

authors： Chong LX,Turpin A,McKendrick AM

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:We developed a surgical method for localized and atraumatic removal of the retinal pigment epithelium (RPE) with a novel instrument. METHODS:Bleb retinal detachments (bRD) were raised with balanced salt solution (BSS) following vitrectomy in 27 rabbits. The RPE was scraped with 3 loop variants (polypropylene [...

journal_title：Translational vision science & technology

authors： Thieltges F,Liu Z,Brinken R,Braun N,Wongsawad W,Somboonthanakij S,Herwig M,Holz FG,Stanzel BV

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:To determine the active ingredient in tea tree oil (TTO) responsible for its reported killing effect on Demodex mites, the most common ectoparasite found in the human skin extending to the eye. METHODS:Using a reported in vitro killing assay to measure the survival time of adult Demodex folliculorum up to 150 ...

journal_title：Translational vision science & technology

authors： Tighe S,Gao YY,Tseng SC

更新日期：2013-11-01 00:00:00

abstract：Purpose:To automate the segmentation of retinal layers, we propose DeepRetina, a method based on deep neural networks. Methods:DeepRetina uses the improved Xception65 to extract and learn the characteristics of retinal layers. The Xception65-extracted feature maps are inputted to an atrous spatial pyramid pooling modu...

journal_title：Translational vision science & technology

authors： Li Q,Li S,He Z,Guan H,Chen R,Xu Y,Wang T,Qi S,Mei J,Wang W

更新日期：2020-12-09 00:00:00

abstract：Purpose:Progressive calcification of Bruch's membrane (BM) causes considerable visual morbidity in patients with pseudoxanthoma elasticum (PXE). Since calcification is hyperreflective on optical coherence tomography (OCT), our aim was to measure BM calcification with OCT imaging. Methods:Case-control study with 45 pat...

journal_title：Translational vision science & technology

authors： Risseeuw S,Bennink E,Poirot MG,de Jong PA,Spiering W,Imhof SM,van Leeuwen R,Ossewaarde-van Norel J

更新日期：2020-07-23 00:00:00

abstract：Purpose:To evaluate high accumulation of coronary artery calcium (CAC) from retinal fundus images with deep learning technologies as an inexpensive and radiation-free screening method. Methods:Individuals who underwent bilateral retinal fundus imaging and CAC score (CACS) evaluation from coronary computed tomography s...

journal_title：Translational vision science & technology

authors： Son J,Shin JY,Chun EJ,Jung KH,Park KH,Park SJ

更新日期：2020-11-11 00:00:00

abstract：Purpose:Mapping of epithelial thickness (ET) is useful for detection of keratoconus, a disease characterized by corneal thinning and bulging in which epithelial thinning occurs over the apex. In prior clinical studies, optical coherence tomography (OCT) measurements of ET were systematically thinner than those obtained...

journal_title：Translational vision science & technology

authors： Rohrbach D,Silverman RH,Chun D,Lloyd HO,Urs R,Mamou J

更新日期：2018-04-11 00:00:00

abstract：Purpose:Myopia is rising in prevalence in many locations, and there is evidence that outdoor light exposure is a major environmental factor playing a role in myopia development. This study examined the patterns of daily light exposure in similarly aged children from two geographic locations (Australia and Singapore) kn...

journal_title：Translational vision science & technology

authors： Read SA,Vincent SJ,Tan CS,Ngo C,Collins MJ,Saw SM

更新日期：2018-05-29 00:00:00

abstract：Purpose:Genipin has been proposed as a possible neuroprotective therapy in myopia and glaucoma. Here, we aim to determine the effects of prolonged genipin-induced scleral stiffening on visual function. Methods:Eyes from Brown Norway rats were treated in vivo with either a single 15 mM genipin retrobulbar injection or ...

journal_title：Translational vision science & technology

authors： Hannon BG,Luna C,Feola AJ,Ritch MD,Read AT,Stinnett SS,Vo H,Pardue MT,Gonzalez P,Ethier CR

更新日期：2020-09-08 00:00:00

abstract：Purpose:Topical carbonic anhydrase inhibitors (CAIs) can influence retinal fluid distribution, but their role in treating central serous chorioretinopathy (CSCR) has not been studied. We examined the efficacy of a topical CAI (dorzolamide) in treating chronic CSCR. Methods:Prospective, nonrandomized, controlled interv...

journal_title：Translational vision science & technology

authors： Liew G,Ho IV,Ong S,Gopinath B,Mitchell P

更新日期：2020-12-04 00:00:00

abstract：PURPOSE:To validate Gaussian mixture-model with expectation maximization (GEM) and variational Bayesian independent component analysis mixture-models (VIM) for detecting glaucomatous progression along visual field (VF) defect patterns (GEM-progression of patterns (POP) and VIM-POP). To compare GEM-POP and VIM-POP with ...

journal_title：Translational vision science & technology

authors： Yousefi S,Balasubramanian M,Goldbaum MH,Medeiros FA,Zangwill LM,Weinreb RN,Liebmann JM,Girkin CA,Bowd C

更新日期：2016-05-03 00:00:00

abstract：Purpose:To compare the antimicrobial effect of topical anesthetics, antivirals, antibiotics, and biocides on the viability of Acanthamoeba cysts and trophozoites in vitro. Methods:Amoebicidal and cysticidal assays were performed against both trophozoites and cysts of Acanthamoeba castellanii (ATCC 50370) and Acanthamo...

journal_title：Translational vision science & technology

authors： Heaselgrave W,Hamad A,Coles S,Hau S

更新日期：2019-09-25 00:00:00

abstract：Purpose:The aim of this study was to evaluate and compare the electrical performance and properties of commercially available electroretinography (ERG) electrodes. Methods:A passive ionic model was used to measure impedance, noise, and potential drift in 10 types of ocular surface and skin ERG electrodes. Results:The...

journal_title：Translational vision science & technology

authors： Man TTC,Yip YWY,Cheung FKF,Lee WS,Pang CP,Brelén ME

更新日期：2020-06-30 00:00:00

abstract：Purpose:Glaucoma remains a leading cause of irreversible blindness worldwide. Animal glaucoma models replicate high intraocular pressure, a risk factor for glaucoma, to induce retinal ganglion cell (RGC) degeneration. We describe an inducible, magnetic bead model in the Brown Norway rat in which we are able to determin...

journal_title：Translational vision science & technology

authors： Tribble JR,Otmani A,Kokkali E,Lardner E,Morgan JE,Williams PA

更新日期：2021-01-12 00:00:00

abstract：PURPOSE:Human long (L) and middle (M) wavelength cone opsin genes are highly variable due to intermixing. Two L/M cone opsin interchange mutants, designated LIAVA and LVAVA, are associated with clinical diagnoses, including red-green color vision deficiency, blue cone monochromacy, cone degeneration, myopia, and Bornho...

journal_title：Translational vision science & technology

authors： Greenwald SH,Kuchenbecker JA,Rowlan JS,Neitz J,Neitz M

更新日期：2017-05-10 00:00:00

abstract：Purpose:To investigate variation and determinants of macular layers, peripapillary retinal nerve fiber layer (pRNFL) and Bruch's membrane opening-minimum rim width (BMO-MRW) in the general population. Methods:In 1306 participants, we performed spectral domain optical coherence tomography (SD-OCT) scans of the macula, ...

journal_title：Translational vision science & technology

authors： Mauschitz MM,Holz FG,Finger RP,Breteler MMB

更新日期：2019-06-04 00:00:00

abstract：Purpose:Although the expression of microRNAs (miRNAs) in retinal pigment epithelial (RPE) cells undergoing epithelial-mesenchymal transition (EMT) is involved in the pathogenesis of proliferative vitreoretinopathy (PVR), its expression in the vitreous of patients with primary retinal detachment (RD) and different PVR g...

journal_title：Translational vision science & technology

authors： Toro MD,Reibaldi M,Avitabile T,Bucolo C,Salomone S,Rejdak R,Nowomiejska K,Tripodi S,Posarelli C,Ragusa M,Barbagallo C

更新日期：2020-05-22 00:00:00

abstract：PURPOSE:To determine the efficacy and safety of repeated intravitreal and subconjunctival administrations of sirolimus in patients with noninfectious uveitis at 1 year in the Sirolimus as a Therapeutic Approach UVEitis (SAVE) Study. METHODS:Open-label, prospective, and randomized interventional clinical trial in which...

journal_title：Translational vision science & technology

authors： Ibrahim MA,Sepah YJ,Watters A,Bittencourt M,Vigil EM,Do DV,Nguyen QD

更新日期：2015-03-10 00:00:00

abstract：Purpose:To determine whether multicolor scanning laser ophthalmoscopy (MC-SLO) was better than color fundus photography (CFP) to enhance residents and specialists' preoperative decision-making and intraoperative performance on the epiretinal membrane (ERM). Methods:Consecutive patients with idiopathic ERM were recruit...

journal_title：Translational vision science & technology

authors： Zhang Z,Li M,Sun Y,Wei Y,Zhang S

更新日期：2020-12-18 00:00:00

abstract：Purpose:To evaluate the safety and tolerability of a microsphere thermo-responsive hydrogel drug delivery system (DDS) loaded with aflibercept in a nonhuman primate model. Methods:A sterile 50 µL of aflibercept-loaded microsphere thermo-responsive hydrogel-DDS (aflibercept-DDS) was injected intravitreally into the rig...

journal_title：Translational vision science & technology

authors： Kim S,Kang-Mieler JJ,Liu W,Wang Z,Yiu G,Teixeira LBC,Mieler WF,Thomasy SM

更新日期：2020-02-27 00:00:00

abstract：Purpose:This study aims to develop a fully automated algorithm for artery-vein (A-V) and arteriole-venule classification and to quantify the effect of hypertension on A-V caliber and tortuosity ratios of nonproliferative diabetic retinopathy (NPDR) patients. Methods:We combine an optical density ratio (ODR) analysis a...

journal_title：Translational vision science & technology

authors： Alam M,Son T,Toslak D,Lim JI,Yao X

更新日期：2018-04-18 00:00:00

abstract：PURPOSE:We evaluated the efficacy of column scatter plots to describe genotype-phenotype correlations in a Japanese cohort with retinitis pigmentosa (RP). METHODS:Clinical records of 121 patients with RP with identified causative mutations were reviewed. Visual acuity, central and peripheral visual fields, electroreti...

journal_title：Translational vision science & technology

authors： Ogino K,Oishi A,Oishi M,Gotoh N,Morooka S,Sugahara M,Hasegawa T,Miyata M,Yoshimura N

更新日期：2016-03-04 00:00:00

abstract：PURPOSE:Identifying potential biomarkers for disease progression in retinitis pigmentosa (RP) is highly relevant now that gene therapy and other treatments are in clinical trial. Here we report a novel technique for analysis of short-wavelength autofluorescence (AF) imaging to quantify defined regions of AF in RP patie...

journal_title：Translational vision science & technology

authors： Jolly JK,Wagner SK,Moules J,Gekeler F,Webster AR,Downes SM,MacLaren RE

更新日期：2016-12-01 00:00:00

abstract：Purposes:To investigate the limbal structure using anterior segment optical coherence tomography (AS-OCT) and compare the difference between a Chinese Han population and a Caucasian population. Methods:Sixty healthy Chinese Han subjects (109 eyes, Chinese group) and 32 healthy Caucasian subjects (51 eyes, Caucasian gr...

journal_title：Translational vision science & technology

authors： Le Q,Cordova D,Xu J,Deng SX

更新日期：2018-08-07 00:00:00

abstract：:Especially since the incorporation of swept laser sources, optical coherence tomography angiography (OCTA) has enabled quantification of choriocapillaris perfusion. A critical step in this process is binarization, which makes angiographic images quantifiable in terms of perfusion metrics. It remains challenging to hav...

journal_title：Translational vision science & technology

authors： Braun PX,Mehta N,Gendelman I,Alibhai AY,Baumal CR,Duker JS,Waheed NK

更新日期：2020-07-29 00:00:00

abstract：PURPOSE:No prismatic solution for peripheral field loss (PFL) has gained widespread acceptance. Field extended by prisms has a corresponding optical scotoma at the prism apices. True expansion can be achieved when each eye is given a different view (through visual confusion). We analyze the effects of apical scotomas a...

journal_title：Translational vision science & technology

authors： Apfelbaum H,Peli E

更新日期：2015-12-31 00:00:00