Reduced Expression of VEGF-A in Human Retinal Pigment Epithelial Cells and Human Muller Cells Following CRISPR-Cas9 Ribonucleoprotein-Mediated Gene Disruption.

abstract：PURPOSE:To validate the performance of a new perimetric algorithm (Gradient-Oriented Automated Natural Neighbor Approach; GOANNA) in humans using a novel combination of computer simulation and human testing, which we call Artificial Scotoma Generation (ASG). METHODS:Fifteen healthy observers were recruited. Baseline c...

journal_title：Translational vision science & technology

authors： Chong LX,Turpin A,McKendrick AM

更新日期：2016-09-01 00:00:00

abstract：Purpose:We quantified the interrelationship between retinal blood vessel (BV) anatomical variation, spherical equivalent (SE) of refractive error, and functional diagnostic parameters in glaucoma to identify optimal parameters for the improvement of optical coherence tomography (OCT) retinal nerve fiber layer thickness...

journal_title：Translational vision science & technology

authors： Wang M,Jin Q,Wang H,Li D,Baniasadi N,Elze T

更新日期：2018-01-18 00:00:00

abstract：Purpose:To assess the repeatability and agreement of ocular biometric parameters measured using the Tomey CASIA SS-1000 and Heidelberg ANTERION anterior segment optical coherence tomography (AS-OCT) devices. Methods:Both eyes of subjects 18 years of age or older were scanned three times with the CASIA and ANTERION und...

journal_title：Translational vision science & technology

authors： Pardeshi AA,Song AE,Lazkani N,Xie X,Huang A,Xu BY

更新日期：2020-08-07 00:00:00

abstract：:Canaloplasty, a recently developed non-penetrating glaucoma surgical approach, may restore physiological outflow routes in primary open-angle glaucoma with less risk of severe postoperative complications than trabeculectomy. Since the inner wall of Schlemm's canal (SC) is directly in contact with the trabecular meshwo...

journal_title：Translational vision science & technology

authors： Tian B,Kaufman PL

更新日期：2013-01-31 00:00:00

abstract：PURPOSE:We evaluated the efficacy of column scatter plots to describe genotype-phenotype correlations in a Japanese cohort with retinitis pigmentosa (RP). METHODS:Clinical records of 121 patients with RP with identified causative mutations were reviewed. Visual acuity, central and peripheral visual fields, electroreti...

journal_title：Translational vision science & technology

authors： Ogino K,Oishi A,Oishi M,Gotoh N,Morooka S,Sugahara M,Hasegawa T,Miyata M,Yoshimura N

更新日期：2016-03-04 00:00:00

abstract：Purpose:Gelatinous drop-like corneal dystrophy (GDLD) is a rare autosomal recessive corneal dystrophy that causes severe vision loss. Because of its poor prognosis, there is a demand for novel treatments for GDLD. Here, we establish a new in vitro disease model of GDLD based on immortalized human corneal epithelial (HC...

journal_title：Translational vision science & technology

authors： Xu P,Kai C,Kawasaki S,Kobayashi Y,Yamamoto K,Tsujikawa M,Hayashi R,Nishida K

更新日期：2018-12-21 00:00:00

abstract：PURPOSE:To evaluate the safety, tolerability, and intraocular pressure (IOP)-lowering effect of Latrunculin-B (Lat-B), a marine macrolide that disrupts the actin cytoskeleton, in patients with ocular hypertension (OHT) or early primary open-angle glaucoma (POAG). METHODS:In this Phase I, multicenter, double-masked, ra...

journal_title：Translational vision science & technology

authors： Rasmussen CA,Kaufman PL,Ritch R,Haque R,Brazzell RK,Vittitow JL

更新日期：2014-09-03 00:00:00

abstract：Purpose:Electronic retinal prostheses restore vision in people with outer retinal degeneration by electrically stimulating the inner retina. We characterized visual cortex electrophysiologic response elicited by electrical stimulation of retina in normally sighted and retinal degenerate rats. Methods:Nine normally sig...

journal_title：Translational vision science & technology

authors： Nimmagadda K,Weiland JD

更新日期：2018-10-31 00:00:00

abstract：PURPOSE:A novel glaucoma drainage device (GDD) with local drug delivery (LDD) system was created and characterized for safety and effectiveness after implantation into the suprachoroidal space (SCS) of rabbit eyes. METHODS:Thin films of two different polymers, Poly(3-hydroxybutyrate) (P(3HB)) and Poly(4-hydroxybutyrat...

journal_title：Translational vision science & technology

authors： Hovakimyan M,Siewert S,Schmidt W,Sternberg K,Reske T,Stachs O,Guthoff R,Wree A,Witt M,Schmitz KP,Allemann R

更新日期：2015-06-30 00:00:00

abstract：Purpose:Evaluate efficiency, precision, and validity of RetCAT, which comprises ten diabetic retinopathy (DR) quality of life (QoL) computerized adaptive tests (CATs). Methods:In this cross-sectional clinical study, 183 English and/or Mandarin-speaking participants with DR (mean age ± standard deviation [SD] 56.4 ± 11...

journal_title：Translational vision science & technology

authors： Fenwick EK,Barnard J,Gan A,Loe BS,Khadka J,Pesudovs K,Man R,Lee SY,Tan G,Wong TY,Lamoureux EL

更新日期：2020-06-03 00:00:00

abstract：Purpose:Progressive calcification of Bruch's membrane (BM) causes considerable visual morbidity in patients with pseudoxanthoma elasticum (PXE). Since calcification is hyperreflective on optical coherence tomography (OCT), our aim was to measure BM calcification with OCT imaging. Methods:Case-control study with 45 pat...

journal_title：Translational vision science & technology

authors： Risseeuw S,Bennink E,Poirot MG,de Jong PA,Spiering W,Imhof SM,van Leeuwen R,Ossewaarde-van Norel J

更新日期：2020-07-23 00:00:00

abstract：Purpose:To evaluate the changes of retinal capillary nonperfusion areas and retinal capillary vessel density of the superficial capillary plexus (SCP) and deep capillary plexus in patients with diabetes with diabetic macular edema treated with an intravitreal dexamethasone implant (IDI). Methods:We enrolled 28 patient...

journal_title：Translational vision science & technology

authors： Toto L,D'Aloisio R,Chiarelli AM,Di Antonio L,Evangelista F,D'Onofrio G,Merla A,Parravano M,Di Marzio G,Mastropasqua R

更新日期：2020-06-11 00:00:00

abstract：:[This corrects the article on p. 4 in vol. 7.]. ...

journal_title：Translational vision science & technology

authors：

更新日期：2018-04-23 00:00:00

abstract：PURPOSE:To determine the active ingredient in tea tree oil (TTO) responsible for its reported killing effect on Demodex mites, the most common ectoparasite found in the human skin extending to the eye. METHODS:Using a reported in vitro killing assay to measure the survival time of adult Demodex folliculorum up to 150 ...

journal_title：Translational vision science & technology

authors： Tighe S,Gao YY,Tseng SC

更新日期：2013-11-01 00:00:00

abstract：Purpose:To describe a new technique for mapping parafoveal intercapillary areas (PICAs) using optical coherence tomography angiography (OCTA), and demonstrate its utility for quantifying parafoveal nonperfusion in diabetic retinopathy (DR). Methods:Nineteen controls, 15 diabetics with no retinopathy (noDR), 15 with no...

journal_title：Translational vision science & technology

authors： Krawitz BD,Phillips E,Bavier RD,Mo S,Carroll J,Rosen RB,Chui TYP

更新日期：2018-07-12 00:00:00

abstract：Purpose:To create hybrid three-dimensional (3D) models of the choroidal vasculature from swept-source optical coherence tomography (SS-OCT) angiography images and to evaluate the model's characteristics. Methods:This study used prospective, noncomparative case series, including 21 eyes of 21 healthy individuals. The 6...

journal_title：Translational vision science & technology

authors： Sekiryu T,Sugano Y,Ojima A,Mori T,Furuta M,Okamoto M,Eifuku S

更新日期：2019-10-22 00:00:00

abstract：Purpose:To determine whether artifacts in optical coherence tomography (OCT) images are associated with the success or failure of adaptive optics scanning light ophthalmoscopy (AOSLO) imaging in subjects with achromatopsia (ACHM). Methods:Previously acquired OCT and non-confocal, split-detector AOSLO images from one e...

journal_title：Translational vision science & technology

authors： Litts KM,Woertz EN,Georgiou M,Patterson EJ,Lam BL,Fishman GA,Pennesi ME,Kay CN,Hauswirth WW,Michaelides M,Carroll J

更新日期：2021-01-07 00:00:00

abstract：PURPOSE:No prismatic solution for peripheral field loss (PFL) has gained widespread acceptance. Field extended by prisms has a corresponding optical scotoma at the prism apices. True expansion can be achieved when each eye is given a different view (through visual confusion). We analyze the effects of apical scotomas a...

journal_title：Translational vision science & technology

authors： Apfelbaum H,Peli E

更新日期：2015-12-31 00:00:00

abstract：Purpose:We tested the hypotheses that retinal venule diameter (Dv) is associated with baseline intracranial pressure (ICP) level and that Dv is reduced shortly after ICP lowering. Methods:Dv and arteriole diameter (Da) were extracted from scanning laser ophthalmoscopic images in 40 eyes of 20 adult human subjects (10 ...

journal_title：Translational vision science & technology

authors： Moss HE,Vangipuram G,Shirazi Z,Shahidi M

更新日期：2018-03-19 00:00:00

abstract：Purpose:To investigate the change in cytokine microenvironment of the aqueous humor (AH) after surgery in children with congenital or developmental cataracts. Methods:AH samples were obtained from 59 eyes diagnosed with a congenital or developmental cataract. Thirty-three of these eyes were aphakic following previous ...

journal_title：Translational vision science & technology

authors： Zhao Y,Deng X,Chang P,Hu M,Li Z,Zhang F,Ding X,Zhao Y

更新日期：2020-07-02 00:00:00

abstract：Purpose:Corneal neovascularization (CoNV) is a major risk factor for corneal graft rejection and other corneal conditions. The maturity of CoNV is important to guide treatment. This study investigated associations between clinical and angiographic characteristics of CoNV. Methods:In a prospective cross-sectional study...

journal_title：Translational vision science & technology

authors： Palme C,Romano V,Brunner M,Vinciguerra R,Kaye SB,Steger B

更新日期：2018-10-01 00:00:00

abstract：Purpose:To describe a minimally invasive experimental model of acute ocular hypertension (OHT) with characteristics of acute angle closure (AAC). Methods:Adult C57/Bl6 mice (n = 31) were subjected to OHT in one eye using a modified circumlimbal suture technique that elevated intraocular pressure (IOP) for 30 minutes. ...

journal_title：Translational vision science & technology

authors： Chong RS,Busoy JMF,Tan B,Yeo SW,Lee YS,Barathi AV,Crowston JG,Schmetterer L

更新日期：2020-06-22 00:00:00

abstract：Purpose:The posthatching chicken is a valuable animal model for research, but molecular tools needed for altering its gene expression are not yet available. Our purpose here was to adapt the adeno-associated viral (AAV) vector method, used widely in mammalian studies, for use in investigations of the chicken retina. We...

journal_title：Translational vision science & technology

authors： Waldner DM,Visser F,Fischer AJ,Bech-Hansen NT,Stell WK

更新日期：2019-07-01 00:00:00

abstract：Purpose:We aimed to develop and evaluate the Computerized Glaucoma Visual Function Test (CoGVFT), among a cohort of glaucoma patients, and identify potential new items to optimize the test. Method:A cross-sectional study involving 84 patients with open-angle glaucoma of varying severity and 18 controls without glaucom...

journal_title：Translational vision science & technology

authors： Jong C,Skalicky SE

更新日期：2020-11-03 00:00:00

abstract：Purpose:To study the choroid in uncomplicated pregnant women using advanced optical coherence tomography (OCT) imaging and analysis. Methods:Women with uncomplicated pregnancy in the third trimester (>28 weeks gestational age) and age-matched nonpregnant women were enrolled in this prospective study. All subjects unde...

journal_title：Translational vision science & technology

authors： Su L,Taweebanjongsin W,Gaw SL,Rabina G,Sadda SR,Tsui I

更新日期：2020-08-13 00:00:00

abstract：Purpose:To compare the detection of retinal pigment epithelium (RPE) atrophy in short-wavelength (SW-AF) and near-infrared autofluorescence (NIR-AF) images in Stargardt disease (STGD1) patients. Methods:SW-AF and NIR-AF images (115 eyes from 115 patients) were analyzed by two independent graders. Hypoautofluorescent (...

journal_title：Translational vision science & technology

authors： Jauregui R,Nuzbrokh Y,Su PY,Zernant J,Allikmets R,Tsang SH,Sparrow JR

更新日期：2021-01-05 00:00:00

abstract：PURPOSE:The goal of this analysis was to determine the test-retest variability of functional and structural measures from a cohort of patients with advanced forms of Stargardt Disease (STGD) participating in the SAR422459 (NCT01367444) gene therapy clinical trial. METHODS:Twenty-two participants, aged 24 to 66, diagno...

journal_title：Translational vision science & technology

authors： Parker MA,Choi D,Erker LR,Pennesi ME,Yang P,Chegarnov EN,Steinkamp PN,Schlechter CL,Dhaenens CM,Mohand-Said S,Audo I,Sahel J,Weleber RG,Wilson DJ

更新日期：2016-10-01 00:00:00

abstract：Purpose:The activation of microglia, the primary innate immune cell resident in the retina, produces inflammatory mediators, which underlie changes in diabetic retinopathy including increased vascular permeability. This study evaluates the safety and efficacy of dextromethorphan, a drug capable of inhibiting microglial...

journal_title：Translational vision science & technology

authors： Valent DJ,Wong WT,Chew EY,Cukras CA

更新日期：2018-12-17 00:00:00

abstract：PURPOSE:Endophthalmitis is a rare complication of intravitreal injection (IVI). It is recommended that povidone-iodine be the last agent applied before IVI. Patients have reported povidone-iodine application to be the most bothersome part of IVIs. Topical anesthetics have been demonstrated to have antibacterial effects...

journal_title：Translational vision science & technology

authors： Reynolds MM,Greenwood-Quaintance KE,Patel R,Pulido JS

更新日期：2016-07-05 00:00:00

abstract：Purpose:Determine the repeatability of and optimum stimulus parameters for testing polarization pattern perception in a real-world clinical population, and assess the ability of polarization perception to distinguish normal from abnormal eyes. Methods:Polarization perception was evaluated in staff and patients attendi...

journal_title：Translational vision science & technology

authors： Misson GP,Anderson SJ,Armstrong RA,Gillett M,Reynolds D

更新日期：2020-10-28 00:00:00