Development and Optimization of Freeze-Dried Eye Drops Derived From Plasma Rich in Growth Factors Technology.

abstract：PURPOSE:To investigate whether tear hyperosmolarity, a feature of dry eye disease (DED), affects central corneal thickness (CCT), corneal light reflectivity, and/or tear film reflectivity. METHODS:This prospective, cross-sectional study involved 48 participants (38 with hyperosmolar tears and 10 controls with normo-os...

journal_title：Translational vision science & technology

authors： Deinema LA,Vingrys AJ,Chinnery HR,Downie LE

更新日期：2017-05-22 00:00:00

abstract：PURPOSE:We performed video-oculography to evaluate vergence eye movement abnormalities in students diagnosed clinically with vergence disorders. We tested the efficiency of a novel rehabilitation method and evaluated its benefits with video-oculography cross-correlated with clinical tests and symptomatology. METHODS:A...

journal_title：Translational vision science & technology

authors： Kapoula Z,Morize A,Daniel F,Jonqua F,Orssaud C,Brémond-Gignac D

更新日期：2016-03-11 00:00:00

abstract：Purpose:To describe a new technique for mapping parafoveal intercapillary areas (PICAs) using optical coherence tomography angiography (OCTA), and demonstrate its utility for quantifying parafoveal nonperfusion in diabetic retinopathy (DR). Methods:Nineteen controls, 15 diabetics with no retinopathy (noDR), 15 with no...

journal_title：Translational vision science & technology

authors： Krawitz BD,Phillips E,Bavier RD,Mo S,Carroll J,Rosen RB,Chui TYP

更新日期：2018-07-12 00:00:00

abstract：Purpose:To image the human trabecular meshwork (TM) in vivo using adaptive optics gonioscopy (AOG) with approximately 2-μm lateral resolution. Methods:An existing Indiana University adaptive optics scanning laser ophthalmoscope was altered by adding a 12-mm button lens to a clinical gonioscopic lens allowing high-reso...

journal_title：Translational vision science & technology

authors： King BJ,Burns SA,Sapoznik KA,Luo T,Gast TJ

更新日期：2019-09-11 00:00:00

abstract：Purpose:Congenital stationary night blindness 2A (CSNB2A) is a genetic retinal disorder characterized by poor visual acuity, nystagmus, strabismus, and other signs of retinal dysfunction resulting from mutations in Cacna1f-the gene coding for the pore-forming subunit of the calcium channel CaV1.4. Mouse models of CSNB2...

journal_title：Translational vision science & technology

authors： Waldner DM,Ito K,Chen LL,Nguyen L,Chow RL,Lee A,Rancourt DE,Tremblay F,Stell WK,Bech-Hansen NT

更新日期：2020-10-14 00:00:00

abstract：PURPOSE:Optical coherence tomography angiography (OCT-A) allows noninvasive visualization of retinal vessels in vivo. OCT-A was used to characterize the vascular network of the mouse retina and was compared with fluorescein angiography (FA) and histology. METHODS:In the present study, OCT-A based on a Heidelberg Engin...

journal_title：Translational vision science & technology

authors： Giannakaki-Zimmermann H,Kokona D,Wolf S,Ebneter A,Zinkernagel MS

更新日期：2016-08-18 00:00:00

abstract：Purpose:To describe a minimally invasive experimental model of acute ocular hypertension (OHT) with characteristics of acute angle closure (AAC). Methods:Adult C57/Bl6 mice (n = 31) were subjected to OHT in one eye using a modified circumlimbal suture technique that elevated intraocular pressure (IOP) for 30 minutes. ...

journal_title：Translational vision science & technology

authors： Chong RS,Busoy JMF,Tan B,Yeo SW,Lee YS,Barathi AV,Crowston JG,Schmetterer L

更新日期：2020-06-22 00:00:00

abstract：Purpose:To explore the contribution of crystalline lens fluorescence to fluorescence lifetimes measured with fluorescence lifetime imaging ophthalmoscopy (FLIO) and to propose a computational model to reduce the lens influence. Methods:FLIO, which detects autofluorescence decay over time in a short-wavelength spectral...

journal_title：Translational vision science & technology

authors： Brauer JL,Schultz R,Klemm M,Hammer M

更新日期：2020-07-09 00:00:00

abstract：PURPOSE:We developed and evaluated a training procedure for marking the endpoints of the ellipsoid zone (EZ), also known as the inner segment/outer segment (IS/OS) border, on frequency domain optical coherence tomography (fdOCT) scans from patients with retinitis pigmentosa (RP). METHODS:A manual for marking EZ endpoi...

journal_title：Translational vision science & technology

authors： Ramachandran R,X Cai C,Lee D,C Epstein B,Locke KG,G Birch D,C Hood D

更新日期：2016-05-17 00:00:00

abstract：PURPOSE:Developing a novel image enhancement method so that nonframe-averaged optical coherence tomography (OCT) images become comparable to active eye-tracking frame-averaged OCT images. METHODS:Twenty-one eyes of 21 healthy volunteers were scanned with noneye-tracking nonframe-averaged OCT device and active eye-trac...

journal_title：Translational vision science & technology

authors： Chen CL,Ishikawa H,Wollstein G,Bilonick RA,Kagemann L,Schuman JS

更新日期：2016-01-11 00:00:00

abstract：PURPOSE:The goal of this analysis was to determine the test-retest variability of functional and structural measures from a cohort of patients with advanced forms of Stargardt Disease (STGD) participating in the SAR422459 (NCT01367444) gene therapy clinical trial. METHODS:Twenty-two participants, aged 24 to 66, diagno...

journal_title：Translational vision science & technology

authors： Parker MA,Choi D,Erker LR,Pennesi ME,Yang P,Chegarnov EN,Steinkamp PN,Schlechter CL,Dhaenens CM,Mohand-Said S,Audo I,Sahel J,Weleber RG,Wilson DJ

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To evaluate the impact of high-speed cut rates (up to 7500 cuts per minute [cpm]) on vitreous flow through various gauge probes. METHODS:An open-sky vitrectomy technique was performed on porcine eyes using the CONSTELLATION Vision System with three different gauges of dual-pneumatic probes (27+-, 25+-, and 23-...

journal_title：Translational vision science & technology

authors： Abulon DJ,Buboltz DC

更新日期：2016-02-22 00:00:00

abstract：Purpose:Glaucoma drainage device (GDD) implantation can lead to corneal decompensation. We evaluated changes over time in oxygen tension and in the metabolic environment of the aqueous humor after GDD implantation in the rabbit eye. Methods:Ahmed Glaucoma Valves were implanted in the left eyes of eight male New Zealan...

journal_title：Translational vision science & technology

authors： Williamson BK,Hawkey NM,Blake DA,Frenkel JW,McDaniel KP,Davis JK,Satija C,Beazer A,Dhungana S,Carlson J,McRitchie S,Ayyala RS

更新日期：2018-02-02 00:00:00

abstract：Purpose:To culturally and linguistically adapt the Convergence Insufficiency Symptom Survey (CISS) to Spanish and assess the psychometric performance of the new version through Rasch analysis and classical test theory methods. Methods:The Spanish version of the CISS (CISSVE) was completed by 449 subjects (9-30 years o...

journal_title：Translational vision science & technology

authors： González-Pérez M,Pérez-Garmendia C,Barrio AR,García-Montero M,Antona B

更新日期：2020-03-23 00:00:00

abstract：PURPOSE:To evaluate the safety, tolerability, and intraocular pressure (IOP)-lowering effect of Latrunculin-B (Lat-B), a marine macrolide that disrupts the actin cytoskeleton, in patients with ocular hypertension (OHT) or early primary open-angle glaucoma (POAG). METHODS:In this Phase I, multicenter, double-masked, ra...

journal_title：Translational vision science & technology

authors： Rasmussen CA,Kaufman PL,Ritch R,Haque R,Brazzell RK,Vittitow JL

更新日期：2014-09-03 00:00:00

abstract：Purpose:Subretinal fibrosis (SRFib) is an important cause of permanent loss-of-vision diseases with submacular neovascularization, but a reliable diagnostic method is currently missing. This study uses polarization-sensitive optical coherence tomography (PS-OCT) to detect SRFib within retinal lesions by measurement of ...

journal_title：Translational vision science & technology

authors： Gräfe MGO,van de Kreeke JA,Willemse J,Braaf B,de Jong Y,Tan HS,Verbraak FD,de Boer JF

更新日期：2020-03-16 00:00:00

abstract：Purpose:Evaluate efficiency, precision, and validity of RetCAT, which comprises ten diabetic retinopathy (DR) quality of life (QoL) computerized adaptive tests (CATs). Methods:In this cross-sectional clinical study, 183 English and/or Mandarin-speaking participants with DR (mean age ± standard deviation [SD] 56.4 ± 11...

journal_title：Translational vision science & technology

authors： Fenwick EK,Barnard J,Gan A,Loe BS,Khadka J,Pesudovs K,Man R,Lee SY,Tan G,Wong TY,Lamoureux EL

更新日期：2020-06-03 00:00:00

abstract：Purpose:We evaluate the antimicrobial effect of toluidine blue O (TBO)-mediated photodynamic antimicrobial chemotherapy (PACT) on Staphylococcus epidermidis and Staphylococcus aureus isolated from ocular surface infection. Methods:We selected 24 strains of bacteria for this study. The antimicrobial effect of different...

journal_title：Translational vision science & technology

authors： Shen J,Liang Q,Su G,Zhang Y,Wang Z,Baudouin C,Labbé A

更新日期：2019-06-21 00:00:00

abstract：Purpose:The purpose of this study is to evaluate whether a single best image can represent central endothelial cell density (ECD) in corneas of differing cell size coefficient of variance (CV). Methods:Four hundred one healthy eyes but with variant CV values were enrolled. For each eye, three nonoverlapping central co...

journal_title：Translational vision science & technology

authors： Shi Y,Huang J,Baghdasaryan E,Huang P,Huang X,Sadda SR,Lee OL

更新日期：2019-05-29 00:00:00

abstract：Purpose:To examine repeatability and reproducibility of ellipsoid zone (EZ) width measurements in patients with retinitis pigmentosa (RP) using a longitudinal reflectivity profile (LRP) analysis. Methods:We examined Bioptigen optical coherence tomography (OCT) scans from 48 subjects with RP or Usher syndrome. Nominal ...

journal_title：Translational vision science & technology

authors： Strampe MR,Huckenpahler AL,Higgins BP,Tarima S,Visotcky A,Stepien KE,Kay CN,Carroll J

更新日期：2018-06-04 00:00:00

abstract：Purpose:To compare the antimicrobial effect of topical anesthetics, antivirals, antibiotics, and biocides on the viability of Acanthamoeba cysts and trophozoites in vitro. Methods:Amoebicidal and cysticidal assays were performed against both trophozoites and cysts of Acanthamoeba castellanii (ATCC 50370) and Acanthamo...

journal_title：Translational vision science & technology

authors： Heaselgrave W,Hamad A,Coles S,Hau S

更新日期：2019-09-25 00:00:00

abstract：Purpose:To investigate the potential of statistical and machine learning approaches to determine the diabetic status of patients from optical coherence tomography angiography (OCT-A) images. Methods:This was a retrospective cross-sectional observational study based at Manchester Royal Eye Hospital, United Kingdom. OCT...

journal_title：Translational vision science & technology

authors： Aslam TM,Hoyle DC,Puri V,Bento G

更新日期：2020-03-09 00:00:00

abstract：Purpose:Semiautomated software applications derive quantitative retinal vascular parameters from fundus camera images. However, the extent of agreement between measurements from different applications is unclear. We evaluate the agreement between retinal measures from two software applications, the Singapore "I" Vessel...

journal_title：Translational vision science & technology

authors： McGrory S,Taylor AM,Pellegrini E,Ballerini L,Kirin M,Doubal FN,Wardlaw JM,Doney ASF,Dhillon B,Starr JM,Trucco E,Deary IJ,MacGillivray TJ

更新日期：2018-03-23 00:00:00

abstract：Purpose:To compare the detection of retinal pigment epithelium (RPE) atrophy in short-wavelength (SW-AF) and near-infrared autofluorescence (NIR-AF) images in Stargardt disease (STGD1) patients. Methods:SW-AF and NIR-AF images (115 eyes from 115 patients) were analyzed by two independent graders. Hypoautofluorescent (...

journal_title：Translational vision science & technology

authors： Jauregui R,Nuzbrokh Y,Su PY,Zernant J,Allikmets R,Tsang SH,Sparrow JR

更新日期：2021-01-05 00:00:00

abstract：PURPOSE:To validate Gaussian mixture-model with expectation maximization (GEM) and variational Bayesian independent component analysis mixture-models (VIM) for detecting glaucomatous progression along visual field (VF) defect patterns (GEM-progression of patterns (POP) and VIM-POP). To compare GEM-POP and VIM-POP with ...

journal_title：Translational vision science & technology

authors： Yousefi S,Balasubramanian M,Goldbaum MH,Medeiros FA,Zangwill LM,Weinreb RN,Liebmann JM,Girkin CA,Bowd C

更新日期：2016-05-03 00:00:00

abstract：Purpose:To determine whether multicolor scanning laser ophthalmoscopy (MC-SLO) was better than color fundus photography (CFP) to enhance residents and specialists' preoperative decision-making and intraoperative performance on the epiretinal membrane (ERM). Methods:Consecutive patients with idiopathic ERM were recruit...

journal_title：Translational vision science & technology

authors： Zhang Z,Li M,Sun Y,Wei Y,Zhang S

更新日期：2020-12-18 00:00:00

abstract：PURPOSE:To develop an automated method for quantifying vitreous signal intensity on optical coherence tomography (OCT), with particular application for use in the assessment of vitreous inflammation. METHODS:This retrospective, observational case-control series comprised 30 patients (30 eyes), with vitreous haze secon...

journal_title：Translational vision science & technology

authors： Keane PA,Balaskas K,Sim DA,Aman K,Denniston AK,Aslam T,And For The Equator Study Group

更新日期：2015-09-16 00:00:00

abstract：Purpose:Genipin has been proposed as a possible neuroprotective therapy in myopia and glaucoma. Here, we aim to determine the effects of prolonged genipin-induced scleral stiffening on visual function. Methods:Eyes from Brown Norway rats were treated in vivo with either a single 15 mM genipin retrobulbar injection or ...

journal_title：Translational vision science & technology

authors： Hannon BG,Luna C,Feola AJ,Ritch MD,Read AT,Stinnett SS,Vo H,Pardue MT,Gonzalez P,Ethier CR

更新日期：2020-09-08 00:00:00

abstract：Purpose:To determine the effectiveness of intravitreal aflibercept (IVA) on the retinal function in eyes with diabetic macular edema (DME). Methods:Twenty-five eyes of 25 patients with DME were treated with three consecutive monthly IVA injections. The retinal sensitivities (RS) within the central 10° were determined ...

journal_title：Translational vision science & technology

authors： Ichio A,Sugimoto M,Matsubara H,Mochida D,Kato K,Kondo M

更新日期：2020-10-06 00:00:00

abstract：Purpose:To compare the diagnostic ability of the vessel parameters in macular and peripapillary regions measured using spectral-domain optical coherence tomography angiography (SD-OCTA) in differentiating primary open-angle glaucoma (POAG) from healthy eyes. Methods:POAG patients and healthy subjects underwent 6 × 6-m...

journal_title：Translational vision science & technology

authors： Richter GM,Chang R,Situ B,Chu Z,Burkemper B,Reznik A,Bedrood S,Kashani AH,Varma R,Wang RK

更新日期：2018-12-06 00:00:00