Transgenic Expression of Cacna1f Rescues Vision and Retinal Morphology in a Mouse Model of Congenital Stationary Night Blindness 2A (CSNB2A).

abstract：PURPOSE:No prismatic solution for peripheral field loss (PFL) has gained widespread acceptance. Field extended by prisms has a corresponding optical scotoma at the prism apices. True expansion can be achieved when each eye is given a different view (through visual confusion). We analyze the effects of apical scotomas a...

journal_title：Translational vision science & technology

authors： Apfelbaum H,Peli E

更新日期：2015-12-31 00:00:00

abstract：PURPOSE:To demonstrate that silent substitution stimuli can be used to generate electroretinograms (ERGs) that effectively isolate rod photoreceptor function in humans without the need for dark adaptation, and that this approach constitutes a viable alternative to current clinical standard testing protocols. METHODS:R...

journal_title：Translational vision science & technology

authors： Maguire J,Parry NR,Kremers J,Kommanapalli D,Murray IJ,McKeefry DJ

更新日期：2016-08-31 00:00:00

abstract：PURPOSE:To evaluate the impact of high-speed cut rates (up to 7500 cuts per minute [cpm]) on vitreous flow through various gauge probes. METHODS:An open-sky vitrectomy technique was performed on porcine eyes using the CONSTELLATION Vision System with three different gauges of dual-pneumatic probes (27+-, 25+-, and 23-...

journal_title：Translational vision science & technology

authors： Abulon DJ,Buboltz DC

更新日期：2016-02-22 00:00:00

abstract：Purpose:While using their amblyopic eye, individuals with strabismic amblyopia count inaccurately and underestimate the number of features. These deficits are attributed to limitations in high-level cortical functions and attention. In the current study, we examined whether feature counting is affected in strabismic an...

journal_title：Translational vision science & technology

authors： Wong-Kee-You AMB,Wei H,Hou C

更新日期：2020-05-16 00:00:00

abstract：Purpose:To evaluate the feasibility of using signal detection theory (SDT) in estimating criterion and detectability indices for corneal pneumatic stimuli and test corneal psychophysical data against linking hypotheses from nonprimate physiology using Bayesian analysis. Methods:Corneal pneumatic stimuli were delivered...

journal_title：Translational vision science & technology

authors： Jayakumar V,Simpson TL

更新日期：2020-11-10 00:00:00

abstract：Purpose:To culturally and linguistically adapt the Convergence Insufficiency Symptom Survey (CISS) to Spanish and assess the psychometric performance of the new version through Rasch analysis and classical test theory methods. Methods:The Spanish version of the CISS (CISSVE) was completed by 449 subjects (9-30 years o...

journal_title：Translational vision science & technology

authors： González-Pérez M,Pérez-Garmendia C,Barrio AR,García-Montero M,Antona B

更新日期：2020-03-23 00:00:00

abstract：PURPOSE:Identifying potential biomarkers for disease progression in retinitis pigmentosa (RP) is highly relevant now that gene therapy and other treatments are in clinical trial. Here we report a novel technique for analysis of short-wavelength autofluorescence (AF) imaging to quantify defined regions of AF in RP patie...

journal_title：Translational vision science & technology

authors： Jolly JK,Wagner SK,Moules J,Gekeler F,Webster AR,Downes SM,MacLaren RE

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Optical coherence tomography angiography (OCT-A) allows noninvasive visualization of retinal vessels in vivo. OCT-A was used to characterize the vascular network of the mouse retina and was compared with fluorescein angiography (FA) and histology. METHODS:In the present study, OCT-A based on a Heidelberg Engin...

journal_title：Translational vision science & technology

authors： Giannakaki-Zimmermann H,Kokona D,Wolf S,Ebneter A,Zinkernagel MS

更新日期：2016-08-18 00:00:00

abstract：Purpose:To investigate the retinal vessel density (VD) in healthy and normal-tension glaucoma (NTG) eyes through optical coherence tomography angiography (OCTA) and to determine the correlation between VD and the retinal nerve fiber layer (RNFL) thickness and functional visual field (VF) defects for different locations...

journal_title：Translational vision science & technology

authors： Lin YH,Huang SM,Yeung L,Ku WC,Chen HS,Lai CC,Chuang LH

更新日期：2020-12-17 00:00:00

abstract：Purpose:Corneal neovascularization (CNV) is the invasion of new blood vessels into the avascular cornea, leading to reduced corneal transparency and visual acuity, impaired vision, and even blindness. Current treatment options for CNV are limited. We developed a novel treatment method, termed photo-mediated ultrasound ...

journal_title：Translational vision science & technology

authors： Qin Y,Yu Y,Fu J,Xie X,Wang T,Woodward MA,Paulus YM,Yang X,Wang X

更新日期：2020-12-09 00:00:00

abstract：Purpose:To explore the contribution of crystalline lens fluorescence to fluorescence lifetimes measured with fluorescence lifetime imaging ophthalmoscopy (FLIO) and to propose a computational model to reduce the lens influence. Methods:FLIO, which detects autofluorescence decay over time in a short-wavelength spectral...

journal_title：Translational vision science & technology

authors： Brauer JL,Schultz R,Klemm M,Hammer M

更新日期：2020-07-09 00:00:00

abstract：Purposes:To investigate the limbal structure using anterior segment optical coherence tomography (AS-OCT) and compare the difference between a Chinese Han population and a Caucasian population. Methods:Sixty healthy Chinese Han subjects (109 eyes, Chinese group) and 32 healthy Caucasian subjects (51 eyes, Caucasian gr...

journal_title：Translational vision science & technology

authors： Le Q,Cordova D,Xu J,Deng SX

更新日期：2018-08-07 00:00:00

abstract：Purpose:Gelatinous drop-like corneal dystrophy (GDLD) is a rare autosomal recessive corneal dystrophy that causes severe vision loss. Because of its poor prognosis, there is a demand for novel treatments for GDLD. Here, we establish a new in vitro disease model of GDLD based on immortalized human corneal epithelial (HC...

journal_title：Translational vision science & technology

authors： Xu P,Kai C,Kawasaki S,Kobayashi Y,Yamamoto K,Tsujikawa M,Hayashi R,Nishida K

更新日期：2018-12-21 00:00:00

abstract：Purpose:Electronic retinal prostheses restore vision in people with outer retinal degeneration by electrically stimulating the inner retina. We characterized visual cortex electrophysiologic response elicited by electrical stimulation of retina in normally sighted and retinal degenerate rats. Methods:Nine normally sig...

journal_title：Translational vision science & technology

authors： Nimmagadda K,Weiland JD

更新日期：2018-10-31 00:00:00

abstract：:Canaloplasty, a recently developed non-penetrating glaucoma surgical approach, may restore physiological outflow routes in primary open-angle glaucoma with less risk of severe postoperative complications than trabeculectomy. Since the inner wall of Schlemm's canal (SC) is directly in contact with the trabecular meshwo...

journal_title：Translational vision science & technology

authors： Tian B,Kaufman PL

更新日期：2013-01-31 00:00:00

abstract：PURPOSE:Human long (L) and middle (M) wavelength cone opsin genes are highly variable due to intermixing. Two L/M cone opsin interchange mutants, designated LIAVA and LVAVA, are associated with clinical diagnoses, including red-green color vision deficiency, blue cone monochromacy, cone degeneration, myopia, and Bornho...

journal_title：Translational vision science & technology

authors： Greenwald SH,Kuchenbecker JA,Rowlan JS,Neitz J,Neitz M

更新日期：2017-05-10 00:00:00

abstract：Purpose:To determine whether multicolor scanning laser ophthalmoscopy (MC-SLO) was better than color fundus photography (CFP) to enhance residents and specialists' preoperative decision-making and intraoperative performance on the epiretinal membrane (ERM). Methods:Consecutive patients with idiopathic ERM were recruit...

journal_title：Translational vision science & technology

authors： Zhang Z,Li M,Sun Y,Wei Y,Zhang S

更新日期：2020-12-18 00:00:00

abstract：Purpose:To assess the influence of an outdoor program on myopia progression in school children. Methods:The prospective interventional school-based study included 373 students aged 6 to 7 years (grade 1 or 2) who were examined annually between 2012 and 2016. Between 2012 and 2013, the children in the study group (n = ...

journal_title：Translational vision science & technology

authors： Guo Y,Liu L,Lv Y,Tang P,Feng Y,Wu M,Xu L,Jonas JB

更新日期：2019-05-02 00:00:00

abstract：Purpose:To evaluate the relationships between refractive error, axial length (AL), and retinal vascular oxygen saturation in an adult population. Methods:This was a hospital-based, prospective observational study. The left eyes of phakic adult subjects without media opacity were analyzed. Subjective undilated manifest...

journal_title：Translational vision science & technology

authors： Lim LS,Lim XH,Tan L

更新日期：2019-08-07 00:00:00

abstract：Purpose:The posthatching chicken is a valuable animal model for research, but molecular tools needed for altering its gene expression are not yet available. Our purpose here was to adapt the adeno-associated viral (AAV) vector method, used widely in mammalian studies, for use in investigations of the chicken retina. We...

journal_title：Translational vision science & technology

authors： Waldner DM,Visser F,Fischer AJ,Bech-Hansen NT,Stell WK

更新日期：2019-07-01 00:00:00

abstract：Purpose:The Bayesian adaptive quick contrast sensitivity function (qCSF) method with a 10-letter identification task provides an efficient CSF assessment. However, large populations are unfamiliar with letters and cannot benefit from this test. To overcome the barrier, we conducted this study. Method:A new font for di...

journal_title：Translational vision science & technology

authors： Zheng H,Wang C,Cui R,He X,Shen M,Lesmes LA,Lu ZL,Qu J,Hou F

更新日期：2018-11-14 00:00:00

abstract：PURPOSE:Developing a novel image enhancement method so that nonframe-averaged optical coherence tomography (OCT) images become comparable to active eye-tracking frame-averaged OCT images. METHODS:Twenty-one eyes of 21 healthy volunteers were scanned with noneye-tracking nonframe-averaged OCT device and active eye-trac...

journal_title：Translational vision science & technology

authors： Chen CL,Ishikawa H,Wollstein G,Bilonick RA,Kagemann L,Schuman JS

更新日期：2016-01-11 00:00:00

abstract：PURPOSE:A novel glaucoma drainage device (GDD) with local drug delivery (LDD) system was created and characterized for safety and effectiveness after implantation into the suprachoroidal space (SCS) of rabbit eyes. METHODS:Thin films of two different polymers, Poly(3-hydroxybutyrate) (P(3HB)) and Poly(4-hydroxybutyrat...

journal_title：Translational vision science & technology

authors： Hovakimyan M,Siewert S,Schmidt W,Sternberg K,Reske T,Stachs O,Guthoff R,Wree A,Witt M,Schmitz KP,Allemann R

更新日期：2015-06-30 00:00:00

abstract：PURPOSE:We evaluate solutions for an applanating surface modification to the Goldmann tonometer prism, which substantially negates the errors due to patient variability in biomechanics. METHODS:A modified Goldmann or correcting applanation tonometry surface (CATS) prism is presented which was optimized to minimize the...

journal_title：Translational vision science & technology

authors： McCafferty S,Lim G,Duncan W,Enikov E,Schwiegerling J

更新日期：2016-09-09 00:00:00

abstract：Purpose:To compare the diagnostic ability of the vessel parameters in macular and peripapillary regions measured using spectral-domain optical coherence tomography angiography (SD-OCTA) in differentiating primary open-angle glaucoma (POAG) from healthy eyes. Methods:POAG patients and healthy subjects underwent 6 × 6-m...

journal_title：Translational vision science & technology

authors： Richter GM,Chang R,Situ B,Chu Z,Burkemper B,Reznik A,Bedrood S,Kashani AH,Varma R,Wang RK

更新日期：2018-12-06 00:00:00

abstract：PURPOSE:We directly demonstrated the revascularization in a free retinal pigment epithelium (RPE)-choroid graft with direct blood flow detection by experimental phase-resolved Doppler optical coherence tomography (PRD-OCT). METHODS:Seven patients with age-related macular degeneration underwent an RPE-choroid graft tra...

journal_title：Translational vision science & technology

authors： van Zeeburg EJ,Braaf B,Cereda MG,van Meurs JC,de Boer JF

更新日期：2015-01-13 00:00:00

abstract：Purpose:Diagnosis of ocular graft-versus-host disease (oGVHD) is hampered by a lack of clinically-validated biomarkers. This study aims to predict disease severity on the basis of tear protein expression in mild oGVHD. Methods:Forty-nine patients with and without chronic oGVHD after AHCT were recruited to a cross-sect...

journal_title：Translational vision science & technology

authors： O'Leary OE,Schoetzau A,Amruthalingam L,Geber-Hollbach N,Plattner K,Jenoe P,Schmidt A,Ullmer C,Drawnel FM,Fauser S,Scholl HPN,Passweg J,Halter JP,Goldblum D

更新日期：2020-08-03 00:00:00

abstract：Purpose:We evaluate the antimicrobial effect of toluidine blue O (TBO)-mediated photodynamic antimicrobial chemotherapy (PACT) on Staphylococcus epidermidis and Staphylococcus aureus isolated from ocular surface infection. Methods:We selected 24 strains of bacteria for this study. The antimicrobial effect of different...

journal_title：Translational vision science & technology

authors： Shen J,Liang Q,Su G,Zhang Y,Wang Z,Baudouin C,Labbé A

更新日期：2019-06-21 00:00:00

abstract：Purpose:To quantify the effect of silicone hydrogel crosslink density on the adhesion at corneal epithelial cells/silicone hydrogel contact lens interface. Methods:A custom-built rheometer, referred to as the live cell monolayer rheometer, was used to measure the adhesive strengths between corneal epithelial cell mono...

journal_title：Translational vision science & technology

authors： Liu C,Scales CW,Fuller GG

更新日期：2020-05-11 00:00:00

abstract：Purpose:To assess the repeatability and agreement of ocular biometric parameters measured using the Tomey CASIA SS-1000 and Heidelberg ANTERION anterior segment optical coherence tomography (AS-OCT) devices. Methods:Both eyes of subjects 18 years of age or older were scanned three times with the CASIA and ANTERION und...

journal_title：Translational vision science & technology

authors： Pardeshi AA,Song AE,Lazkani N,Xie X,Huang A,Xu BY

更新日期：2020-08-07 00:00:00