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Photo-Mediated Ultrasound Therapy for the Treatment of Corneal Neovascularization in Rabbit Eyes.

Abstract：

Purpose:Corneal neovascularization (CNV) is the invasion of new blood vessels into the avascular cornea, leading to reduced corneal transparency and visual acuity, impaired vision, and even blindness. Current treatment options for CNV are limited. We developed a novel treatment method, termed photo-mediated ultrasound therapy (PUT), that combines laser and ultrasound, and we tested its feasibility for treating CNV in a rabbit model. Methods:A suture-induced CNV model was established in New Zealand White rabbits, which were randomly divided into two groups: PUT and control. For the PUT group, the applied light fluence at the corneal surface was estimated to be 27 mJ/cm2 at 1064-nm wavelength with a pulse duration of 5 ns, and the ultrasound pressure applied on the cornea was 0.43 MPa at 0.5 MHz. The control group received no treatment. Red-free photography and fluorescein angiography were utilized to evaluate the efficiency of PUT. Safety was evaluated by histology and immunohistochemistry. For comparison with the PUT safety results, conventional laser photocoagulation (LP) treatment was performed with standard clinical parameters: 532-nm continuous-wave (CW) laser with 0.1-second pulse duration, 450-mW power, and 75-µm spot size. Results:In the PUT group, only 1.8% ± 0.8% of the CNV remained 30 days after treatment. In contrast, 71.4% ± 7.2% of the CNV remained in the control group after 30 days. Safety evaluations showed that PUT did not cause any damage to the surrounding tissue. Conclusions:These results demonstrate that PUT is capable of removing CNV safely and effectively in this rabbit model. Translational Relevance:PUT can remove CNV safely and effectively.

journal_name

Transl Vis Sci Technol

journal_title

Translational vision science & technology

authors

Qin Y,Yu Y,Fu J,Xie X,Wang T,Woodward MA,Paulus YM,Yang X,Wang X

doi

10.1167/tvst.9.13.16

subject

Has Abstract

pub_date

2020-12-09 00:00:00

pages

16

issue

13

issn

2164-2591

pii

TVST-20-2827

journal_volume

9

pub_type

杂志文章

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