当前位置： SCI文献检索 > Translational Vision Science & Technology期刊下所有文献 > Detectability and Bias Indices of Pneumatic Corneal Stimuli Using Signal Detection Theory.

Detectability and Bias Indices of Pneumatic Corneal Stimuli Using Signal Detection Theory.

Abstract：

Purpose:To evaluate the feasibility of using signal detection theory (SDT) in estimating criterion and detectability indices for corneal pneumatic stimuli and test corneal psychophysical data against linking hypotheses from nonprimate physiology using Bayesian analysis. Methods:Corneal pneumatic stimuli were delivered using the Waterloo Belmonte esthesiometer. Corneal thresholds were estimated in 30 asymptomatic participants and 1.5× threshold stimuli were used as signals (with 0.4 probability). There were 100-trial mechanical and cold stimulus experiments and 50-trial chemical experiments. Trials were demarcated auditorily and "yes" or "no" recorded after each trial. Cold stimulus experiments were conducted with 0.6 signal probability. Criterion (c), likelihood ratio (lnβ), and d' were calculated from the yes-no responses. Results:Average d' was 0.59 ± 0.1, 1.65 ± 0.37, and 1.14 ± 0.3 units for cold, mechanical, and chemical stimuli, respectively. Bayes factors obtained using Bayesian analysis of variance mildly favored (BF10 = 1.55) differences between d's of the stimulus types, with no support for differences in criteria between stimulus types. Multiple comparisons of d' supported linking hypotheses based on nociception and nerve conductance theories. Conclusions:Our experiments are the first to demonstrate the feasibility of estimating SDT indices and test different hypotheses. The conservative strategy (reporting "no" more often) chosen by participants was anticipated due to relatively large proportion of catch trials. Translational Relevance:SDT when using pneumatic esthesiometry is vital to evaluate bias in responses of participants. Considering the varied forms of inherent noise in the corneal sensory system, SDT is critical to understand the sensory and decisional characteristics.

journal_name

Transl Vis Sci Technol

journal_title

Translational vision science & technology

authors

Jayakumar V,Simpson TL

doi

10.1167/tvst.9.12.17

subject

Has Abstract

pub_date

2020-11-10 00:00:00

pages

17

issue

12

issn

2164-2591

pii

TVST-20-2423

journal_volume

9

pub_type

杂志文章

相关文献

Translational Vision Science & Technology文献大全
  • Validation of the Total Visual Acuity Extraction Algorithm (TOVA) for Automated Extraction of Visual Acuity Data From Free Text, Unstructured Clinical Records.

    abstract：PURPOSE:With increasing volumes of electronic health record data, algorithm-driven extraction may aid manual extraction. Visual acuity often is extracted manually in vision research. The total visual acuity extraction algorithm (TOVA) is presented and validated for automated extraction of visual acuity from free text, ...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.6.2.2

    authors： Baughman DM,Su GL,Tsui I,Lee CS,Lee AY

    更新日期：2017-03-06 00:00:00

  • Effects of Intravitreal Aflibercept on Retinal Function and Improvement of Macular Edema Associated With Diabetic Retinopathy.

    abstract：Purpose:To determine the effectiveness of intravitreal aflibercept (IVA) on the retinal function in eyes with diabetic macular edema (DME). Methods:Twenty-five eyes of 25 patients with DME were treated with three consecutive monthly IVA injections. The retinal sensitivities (RS) within the central 10° were determined ...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.9.11.2

    authors： Ichio A,Sugimoto M,Matsubara H,Mochida D,Kato K,Kondo M

    更新日期：2020-10-06 00:00:00

  • Measuring the Contrast Sensitivity Function Using the qCSF Method With 10 Digits.

    abstract：Purpose:The Bayesian adaptive quick contrast sensitivity function (qCSF) method with a 10-letter identification task provides an efficient CSF assessment. However, large populations are unfamiliar with letters and cannot benefit from this test. To overcome the barrier, we conducted this study. Method:A new font for di...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.7.6.9

    authors： Zheng H,Wang C,Cui R,He X,Shen M,Lesmes LA,Lu ZL,Qu J,Hou F

    更新日期：2018-11-14 00:00:00

  • DeepRetina: Layer Segmentation of Retina in OCT Images Using Deep Learning.

    abstract：Purpose:To automate the segmentation of retinal layers, we propose DeepRetina, a method based on deep neural networks. Methods:DeepRetina uses the improved Xception65 to extract and learn the characteristics of retinal layers. The Xception65-extracted feature maps are inputted to an atrous spatial pyramid pooling modu...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.9.2.61

    authors： Li Q,Li S,He Z,Guan H,Chen R,Xu Y,Wang T,Qi S,Mei J,Wang W

    更新日期：2020-12-09 00:00:00

  • Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT.

    abstract：PURPOSE:We directly demonstrated the revascularization in a free retinal pigment epithelium (RPE)-choroid graft with direct blood flow detection by experimental phase-resolved Doppler optical coherence tomography (PRD-OCT). METHODS:Seven patients with age-related macular degeneration underwent an RPE-choroid graft tra...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.4.1.2

    authors： van Zeeburg EJ,Braaf B,Cereda MG,van Meurs JC,de Boer JF

    更新日期：2015-01-13 00:00:00

  • OCTA-Based Identification of Different Vascular Patterns in Stargardt Disease.

    abstract：Purpose:The aim of the present study was to analyze quantitative optical coherence tomography (OCT) and OCT angiography (OCTA) parameters to identify clinically relevant cutoff values able to detect clinically different Stargardt's disease (STGD) subgroups. Methods:Consecutive STGD patients were recruited and underwen...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.8.6.26

    authors： Arrigo A,Romano F,Aragona E,di Nunzio C,Sperti A,Bandello F,Battaglia Parodi M

    更新日期：2019-12-05 00:00:00

  • Test-Retest Variability of Functional and Structural Parameters in Patients with Stargardt Disease Participating in the SAR422459 Gene Therapy Trial.

    abstract：PURPOSE:The goal of this analysis was to determine the test-retest variability of functional and structural measures from a cohort of patients with advanced forms of Stargardt Disease (STGD) participating in the SAR422459 (NCT01367444) gene therapy clinical trial. METHODS:Twenty-two participants, aged 24 to 66, diagno...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.5.5.10

    authors： Parker MA,Choi D,Erker LR,Pennesi ME,Yang P,Chegarnov EN,Steinkamp PN,Schlechter CL,Dhaenens CM,Mohand-Said S,Audo I,Sahel J,Weleber RG,Wilson DJ

    更新日期：2016-10-01 00:00:00

  • The Effects of Glaucoma Drainage Devices on Oxygen Tension, Glycolytic Metabolites, and Metabolomics Profile of Aqueous Humor in the Rabbit.

    abstract：Purpose:Glaucoma drainage device (GDD) implantation can lead to corneal decompensation. We evaluated changes over time in oxygen tension and in the metabolic environment of the aqueous humor after GDD implantation in the rabbit eye. Methods:Ahmed Glaucoma Valves were implanted in the left eyes of eight male New Zealan...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.7.1.14

    authors： Williamson BK,Hawkey NM,Blake DA,Frenkel JW,McDaniel KP,Davis JK,Satija C,Beazer A,Dhungana S,Carlson J,McRitchie S,Ayyala RS

    更新日期：2018-02-02 00:00:00

  • Selected Antimicrobial Activity of Topical Ophthalmic Anesthetics.

    abstract：PURPOSE:Endophthalmitis is a rare complication of intravitreal injection (IVI). It is recommended that povidone-iodine be the last agent applied before IVI. Patients have reported povidone-iodine application to be the most bothersome part of IVIs. Topical anesthetics have been demonstrated to have antibacterial effects...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.5.4.2

    authors： Reynolds MM,Greenwood-Quaintance KE,Patel R,Pulido JS

    更新日期：2016-07-05 00:00:00

  • Development of an Eye Model With a Physiological Blink Mechanism.

    abstract：Purpose:To develop an eye model with a physiological blink mechanism. Methods:All parts of the eye model were designed using computer-aided design software. The eyelid consisted of a unique 3D printed structure containing teeth to physically secure a flexible membrane. Both the eyeball and eyelid membrane were synthes...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.8.5.1

    authors： Phan CM,Walther H,Qiao H,Shinde R,Jones L

    更新日期：2019-09-03 00:00:00

  • In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection.

    abstract：Purpose:We evaluate the antimicrobial effect of toluidine blue O (TBO)-mediated photodynamic antimicrobial chemotherapy (PACT) on Staphylococcus epidermidis and Staphylococcus aureus isolated from ocular surface infection. Methods:We selected 24 strains of bacteria for this study. The antimicrobial effect of different...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.8.3.45

    authors： Shen J,Liang Q,Su G,Zhang Y,Wang Z,Baudouin C,Labbé A

    更新日期：2019-06-21 00:00:00

  • Functional Connectivity of Paired Default Mode Network Subregions in Retinal Detachment.

    abstract：Purpose:To explore the difference of the default mode network (DMN) in patients with retinal detachment (RD) by the study of the resting state functional connectivity (rs-FC). Methods:A total of 30 patients with RD (16 men, 14 women) and 30 similarly matched normal controls (NCs) were examined and recorded with rs-fMR...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.7.6.15

    authors： Su T,Shu YQ,Liu KC,Ye L,Chen LL,Shi WQ,Min YL,Xu XW,Yuan Q,Zhu PW,Shao Y

    更新日期：2018-11-30 00:00:00

  • Avian Adeno-Associated Viral Transduction of the Postembryonic Chicken Retina.

    abstract：Purpose:The posthatching chicken is a valuable animal model for research, but molecular tools needed for altering its gene expression are not yet available. Our purpose here was to adapt the adeno-associated viral (AAV) vector method, used widely in mammalian studies, for use in investigations of the chicken retina. We...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.8.4.1

    authors： Waldner DM,Visser F,Fischer AJ,Bech-Hansen NT,Stell WK

    更新日期：2019-07-01 00:00:00

  • Multicolor Scanning Laser Ophthalmoscopy Strengthens Surgeons' Preoperative Decision-Making and Intraoperative Performance on Epiretinal Membrane.

    abstract：Purpose:To determine whether multicolor scanning laser ophthalmoscopy (MC-SLO) was better than color fundus photography (CFP) to enhance residents and specialists' preoperative decision-making and intraoperative performance on the epiretinal membrane (ERM). Methods:Consecutive patients with idiopathic ERM were recruit...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.9.13.36

    authors： Zhang Z,Li M,Sun Y,Wei Y,Zhang S

    更新日期：2020-12-18 00:00:00

  • Influence of Lens Fluorescence on Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) Fundus Imaging and Strategies for Its Compensation.

    abstract：Purpose:To explore the contribution of crystalline lens fluorescence to fluorescence lifetimes measured with fluorescence lifetime imaging ophthalmoscopy (FLIO) and to propose a computational model to reduce the lens influence. Methods:FLIO, which detects autofluorescence decay over time in a short-wavelength spectral...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.9.8.13

    authors： Brauer JL,Schultz R,Klemm M,Hammer M

    更新日期：2020-07-09 00:00:00

  • Tunnel Vision Prismatic Field Expansion: Challenges and Requirements.

    abstract：PURPOSE:No prismatic solution for peripheral field loss (PFL) has gained widespread acceptance. Field extended by prisms has a corresponding optical scotoma at the prism apices. True expansion can be achieved when each eye is given a different view (through visual confusion). We analyze the effects of apical scotomas a...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.4.6.8

    authors： Apfelbaum H,Peli E

    更新日期：2015-12-31 00:00:00

  • Terpinen-4-ol is the Most Active Ingredient of Tea Tree Oil to Kill Demodex Mites.

    abstract：PURPOSE:To determine the active ingredient in tea tree oil (TTO) responsible for its reported killing effect on Demodex mites, the most common ectoparasite found in the human skin extending to the eye. METHODS:Using a reported in vitro killing assay to measure the survival time of adult Demodex folliculorum up to 150 ...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.2.7.2

    authors： Tighe S,Gao YY,Tseng SC

    更新日期：2013-11-01 00:00:00

  • Functional Staging of Corneal Neovascularization Using Fluorescein and Indocyanine Green Angiography.

    abstract：Purpose:Corneal neovascularization (CoNV) is a major risk factor for corneal graft rejection and other corneal conditions. The maturity of CoNV is important to guide treatment. This study investigated associations between clinical and angiographic characteristics of CoNV. Methods:In a prospective cross-sectional study...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.7.5.15

    authors： Palme C,Romano V,Brunner M,Vinciguerra R,Kaye SB,Steger B

    更新日期：2018-10-01 00:00:00

  • The Interrelationship between Refractive Error, Blood Vessel Anatomy, and Glaucomatous Visual Field Loss.

    abstract：Purpose:We quantified the interrelationship between retinal blood vessel (BV) anatomical variation, spherical equivalent (SE) of refractive error, and functional diagnostic parameters in glaucoma to identify optimal parameters for the improvement of optical coherence tomography (OCT) retinal nerve fiber layer thickness...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.7.1.4

    authors： Wang M,Jin Q,Wang H,Li D,Baniasadi N,Elze T

    更新日期：2018-01-18 00:00:00

  • A Custom-Made Semiautomatic Analysis of Retinal Nonperfusion Areas After Dexamethasone for Diabetic Macular Edema.

    abstract：Purpose:To evaluate the changes of retinal capillary nonperfusion areas and retinal capillary vessel density of the superficial capillary plexus (SCP) and deep capillary plexus in patients with diabetes with diabetic macular edema treated with an intravitreal dexamethasone implant (IDI). Methods:We enrolled 28 patient...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.9.7.13

    authors： Toto L,D'Aloisio R,Chiarelli AM,Di Antonio L,Evangelista F,D'Onofrio G,Merla A,Parravano M,Di Marzio G,Mastropasqua R

    更新日期：2020-06-11 00:00:00

  • Latrunculin B Reduces Intraocular Pressure in Human Ocular Hypertension and Primary Open-Angle Glaucoma.

    abstract：PURPOSE:To evaluate the safety, tolerability, and intraocular pressure (IOP)-lowering effect of Latrunculin-B (Lat-B), a marine macrolide that disrupts the actin cytoskeleton, in patients with ocular hypertension (OHT) or early primary open-angle glaucoma (POAG). METHODS:In this Phase I, multicenter, double-masked, ra...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.3.5.1

    authors： Rasmussen CA,Kaufman PL,Ritch R,Haque R,Brazzell RK,Vittitow JL

    更新日期：2014-09-03 00:00:00

  • The Clinical Application of Polarization Pattern Perception.

    abstract：Purpose:Determine the repeatability of and optimum stimulus parameters for testing polarization pattern perception in a real-world clinical population, and assess the ability of polarization perception to distinguish normal from abnormal eyes. Methods:Polarization perception was evaluated in staff and patients attendi...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.9.11.31

    authors： Misson GP,Anderson SJ,Armstrong RA,Gillett M,Reynolds D

    更新日期：2020-10-28 00:00:00

  • Tuning corneal epithelial cell adhesive strength with varying crosslinker content in silicone hydrogel materials.

    abstract：Purpose:To quantify the effect of silicone hydrogel crosslink density on the adhesion at corneal epithelial cells/silicone hydrogel contact lens interface. Methods:A custom-built rheometer, referred to as the live cell monolayer rheometer, was used to measure the adhesive strengths between corneal epithelial cell mono...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.9.6.3

    authors： Liu C,Scales CW,Fuller GG

    更新日期：2020-05-11 00:00:00

  • Predicting High Coronary Artery Calcium Score From Retinal Fundus Images With Deep Learning Algorithms.

    abstract：Purpose:To evaluate high accumulation of coronary artery calcium (CAC) from retinal fundus images with deep learning technologies as an inexpensive and radiation-free screening method. Methods:Individuals who underwent bilateral retinal fundus imaging and CAC score (CACS) evaluation from coronary computed tomography s...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.9.2.28

    authors： Son J,Shin JY,Chun EJ,Jung KH,Park KH,Park SJ

    更新日期：2020-11-11 00:00:00

  • A Reflectivity Measure to Quantify Bruch's Membrane Calcification in Patients with Pseudoxanthoma Elasticum Using Optical Coherence Tomography.

    abstract：Purpose:Progressive calcification of Bruch's membrane (BM) causes considerable visual morbidity in patients with pseudoxanthoma elasticum (PXE). Since calcification is hyperreflective on optical coherence tomography (OCT), our aim was to measure BM calcification with OCT imaging. Methods:Case-control study with 45 pat...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.9.8.34

    authors： Risseeuw S,Bennink E,Poirot MG,de Jong PA,Spiering W,Imhof SM,van Leeuwen R,Ossewaarde-van Norel J

    更新日期：2020-07-23 00:00:00

  • Optical Coherence Tomography Reveals Changes to Corneal Reflectivity and Thickness in Individuals with Tear Hyperosmolarity.

    abstract：PURPOSE:To investigate whether tear hyperosmolarity, a feature of dry eye disease (DED), affects central corneal thickness (CCT), corneal light reflectivity, and/or tear film reflectivity. METHODS:This prospective, cross-sectional study involved 48 participants (38 with hyperosmolar tears and 10 controls with normo-os...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.6.3.6

    authors： Deinema LA,Vingrys AJ,Chinnery HR,Downie LE

    更新日期：2017-05-22 00:00:00

  • Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System.

    abstract：Purpose:To compare the repeatability and reproducibility of axial and lateral retinal measurements using handheld optical coherence tomography (OCT) systems and a tabletop OCT system. Methods:Graders measured central foveal thickness (CFT), optic nerve-to-fovea distance (OFD), and retinal nerve fiber layer (RNFL) thic...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.9.11.25

    authors： Chen X,Tai V,McGeehan B,Ying GS,Viehland C,Imperio R,Winter KP,Raynor W,Tran-Viet D,Mangalesh S,Maguire MG,Toth CA,BabySTEPS Group.

    更新日期：2020-10-21 00:00:00

  • Virtual Averaging Making Nonframe-Averaged Optical Coherence Tomography Images Comparable to Frame-Averaged Images.

    abstract：PURPOSE:Developing a novel image enhancement method so that nonframe-averaged optical coherence tomography (OCT) images become comparable to active eye-tracking frame-averaged OCT images. METHODS:Twenty-one eyes of 21 healthy volunteers were scanned with noneye-tracking nonframe-averaged OCT device and active eye-trac...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.5.1.1

    authors： Chen CL,Ishikawa H,Wollstein G,Bilonick RA,Kagemann L,Schuman JS

    更新日期：2016-01-11 00:00:00

  • Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) using a Serum-Based Assay in Advanced Age-related Macular Degeneration.

    abstract：Purpose:Factor I (FI) is a serine protease regulator of the complement system. Genetic variants in CFI are associated with advanced age-related macular degeneration (AAMD). However, the clinical and functional impact of these variants is unknown. This study assessed the functional significance of rare CFI variants usin...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.9.9.37

    authors： Java A,Baciu P,Widjajahakim R,Sung YJ,Yang J,Kavanagh D,Atkinson J,Seddon J

    更新日期：2020-08-24 00:00:00

  • Optical Coherence Tomography Artifacts Are Associated With Adaptive Optics Scanning Light Ophthalmoscopy Success in Achromatopsia.

    abstract：Purpose:To determine whether artifacts in optical coherence tomography (OCT) images are associated with the success or failure of adaptive optics scanning light ophthalmoscopy (AOSLO) imaging in subjects with achromatopsia (ACHM). Methods:Previously acquired OCT and non-confocal, split-detector AOSLO images from one e...

    journal_title：Translational vision science & technology

    pub_type： 杂志文章

    doi：10.1167/tvst.10.1.11

    authors： Litts KM,Woertz EN,Georgiou M,Patterson EJ,Lam BL,Fishman GA,Pennesi ME,Kay CN,Hauswirth WW,Michaelides M,Carroll J

    更新日期：2021-01-07 00:00:00