abstract：:During orofacial tissue development, the anterior and posterior regions of the Meckel's cartilage undergo mineralization, while the middle region undergoes degeneration. Despite the interesting and particular phenomena, the mechanisms that regulate the different fates of Meckel's cartilage, including the effects of bi...

journal_title：Journal of dental research

authors： Farahat M,Kazi GAS,Hara ES,Matsumoto T

更新日期：2021-02-01 00:00:00

abstract：:The diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection relies on the detection of viral RNA by real-time reverse transcription polymerase chain reaction (rRT-PCR) performed with respiratory specimens, especially nasopharyngeal swabs. However, this procedure requires specialized medical...

journal_title：Journal of dental research

authors： Azzi L,Maurino V,Baj A,Dani M,d'Aiuto A,Fasano M,Lualdi M,Sessa F,Alberio T

更新日期：2021-02-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) plays a crucial role in the modulation of orofacial pain, and we hypothesized that CGRP mediated a neuron-glia crosstalk in orofacial pain. The objective of this study was to elucidate the mechanisms whereby CGRP mediated trigeminal neuron-glia crosstalk in modulating orofacial p...

journal_title：Journal of dental research

authors： Liang H,Hu H,Shan D,Lyu J,Yan X,Wang Y,Jian F,Li X,Lai W,Long H

更新日期：2021-01-01 00:00:00

abstract：:This 24-mo randomized controlled trial was based on a double-blind parallel design, and it compared the effectiveness of 2 fluoride application protocols in arresting dentine caries in primary teeth. Three-year-old children with active dentine caries were recruited and randomly allocated to 2 treatment groups. Childre...

journal_title：Journal of dental research

authors： Chen KJ,Gao SS,Duangthip D,Lo ECM,Chu CH

更新日期：2021-01-01 00:00:00

abstract：:Periodontitis is increasingly associated with increased risk of cardiovascular and other systemic diseases. The Gram-negative anaerobe, Porphyromonas gingivalis, is a key periodontal pathogen, and several lines of evidence link the presence of this bacterium in the circulation with vascular disease. The outer membrane...

journal_title：Journal of dental research

authors： Farrugia C,Stafford GP,Murdoch C

更新日期：2020-12-01 00:00:00

abstract：:Periodontitis is a complex, multifactorial chronic disease involving continuous interactions among bacteria, host immune/inflammatory responses, and modifying genetic and environmental factors. More than any other cytokine family, the interleukin (IL)-1 family includes key signaling molecules that trigger and perpetua...

journal_title：Journal of dental research

authors： Papathanasiou E,Conti P,Carinci F,Lauritano D,Theoharides TC

更新日期：2020-12-01 00:00:00

abstract：:The etiology and pathogenesis of craniofacial birth defects are multifactorial and include both genetic and environmental factors. Despite the identification of numerous genes associated with congenital craniofacial anomalies, our understanding of their etiology remains incomplete, and many affected individuals have a...

journal_title：Journal of dental research

authors： Dash S,Bhatt S,Falcon KT,Sandell LL,Trainor PA

更新日期：2020-11-06 00:00:00

abstract：:Pain and discomfort are common problems for patients undergoing orthodontic treatment. We have demonstrated that cortical excitation propagation in the somatosensory and insular cortices (IC) induced by electrical stimulation of the periodontal ligament (PDL) is facilitated 1 d after experimental tooth movement (ETM)....

journal_title：Journal of dental research

authors： Horinuki E,O'Hashi K,Kobayashi M

更新日期：2020-10-08 00:00:00

abstract：:Insulin resistance is one of the critical pathogeneses of type 2 diabetes mellitus (T2DM). Elevated levels of plasma branched-chain amino acids (BCAAs) are associated with insulin resistance. Recent studies have demonstrated the role of Porphyromonas gingivalis in the development of insulin resistance. However, the me...

journal_title：Journal of dental research

authors： Tian J,Liu C,Zheng X,Jia X,Peng X,Yang R,Zhou X,Xu X

更新日期：2020-07-01 00:00:00

abstract：:Early childhood caries (ECC) is a chronic disease affecting the oral health of children globally. This disease is multifactorial, but a primary factor is cariogenic microorganisms such as Streptococcus mutans. Biosynthetic gene clusters (BGCs) encode small molecules with diverse biological activities that influence th...

journal_title：Journal of dental research

authors： Momeni SS,Beno SM,Baker JL,Edlund A,Ghazal T,Childers NK,Wu H

更新日期：2020-07-01 00:00:00

abstract：:The term "artificial intelligence" (AI) refers to the idea of machines being capable of performing human tasks. A subdomain of AI is machine learning (ML), which "learns" intrinsic statistical patterns in data to eventually cast predictions on unseen data. Deep learning is a ML technique using multi-layer mathematical...

journal_title：Journal of dental research

authors： Schwendicke F,Samek W,Krois J

更新日期：2020-07-01 00:00:00

abstract：:The main goal of peri-implantitis treatment is to control infection and arrest bone loss, which requires the removal of polymicrobial biofilms on the implant surface and the reduction of tissue invasion. Additionally, prognosis can be improved if reosseointegration occurs on previously contaminated implants. To evalua...

journal_title：Journal of dental research

authors： Qin W,Wang C,Jiang C,Sun J,Yu C,Jiao T

更新日期：2020-07-01 00:00:00

abstract：:Severe early childhood caries (S-ECC) is a multifactorial disease that can lead to suffering and reduced oral health-related quality of life in young children. The bacterial and fungal composition of dental plaque and how children's sex is associated with S-ECC are largely unknown. In this study, V4-16S rRNA and ITS1 ...

journal_title：Journal of dental research

authors： de Jesus VC,Shikder R,Oryniak D,Mann K,Alamri A,Mittermuller B,Duan K,Hu P,Schroth RJ,Chelikani P

更新日期：2020-06-01 00:00:00

abstract：:The oral microbiome is one of the most stable ecosystems in the body and yet the reasons for this are still unclear. As well as being stable, it is also highly diverse which can be ascribed to the variety of niches available in the mouth. Previous studies have focused on the microflora in disease-either caries or peri...

journal_title：Journal of dental research

authors： Carpenter GH

更新日期：2020-06-01 00:00:00

abstract：:Extracellular vesicles (EVs), several tens to hundreds of nanometers in size, are vesicles secreted by cells for intercellular communication. EVs released from mesenchymal stem cells (MSC-EVs) have the potential to treat multiple diseases. This study aimed to determine the effects of MSC-EVs on bisphosphonate-related ...

journal_title：Journal of dental research

authors： Watanabe J,Sakai K,Urata Y,Toyama N,Nakamichi E,Hibi H

更新日期：2020-05-01 00:00:00

abstract：:The aim of this systematic review and network meta-analysis was to summarize the direct and indirect clinical evidence on the effectiveness of professionally applied and self-applied topical fluorides in preventing dental root caries. Controlled clinical trials with any follow-up duration were included. MEDLINE, PubMe...

journal_title：Journal of dental research

authors： Zhang J,Sardana D,Li KY,Leung KCM,Lo ECM

更新日期：2020-05-01 00:00:00

abstract：:Cleft palate is among the most common structural birth defects in humans. Previous studies have shown that mutations in FOXF2 are associated with cleft palate in humans and mice and that Foxf2 acts in a Shh-Foxf-Fgf18-Shh molecular network controlling palatal shelf growth. In this study, we combined RNA-seq and ChIP-s...

journal_title：Journal of dental research

authors： Xu J,Liu H,Lan Y,Park JS,Jiang R

更新日期：2020-04-01 00:00:00

abstract：:Histone deacetylases (HDACs) are important regulators of gene expression that are aberrantly regulated in several inflammatory and infectious diseases. HDAC inhibitors (HDACi) suppress inflammatory activation of various cell types through epigenetic and non-epigenetic mechanisms, and ameliorate pathology in a mouse mo...

journal_title：Journal of dental research

authors： Lagosz KB,Bysiek A,Macina JM,Bereta GP,Kantorowicz M,Lipska W,Sochalska M,Gawron K,Kaczmarzyk T,Chomyszyn-Gajewska M,Fossati G,Potempa J,Grabiec AM

更新日期：2020-01-01 00:00:00

abstract：:Cardiovascular disease is a common cause of morbidity and premature mortality. Cardiovascular disease can be prevented when risk factors are identified early. Calcified carotid artery atheromas (CCAAs), detected in panoramic radiographs, and periodontitis have both been associated with increased risk of cardiovascular...

journal_title：Journal of dental research

authors： Gustafsson N,Ahlqvist J,Näslund U,Buhlin K,Gustafsson A,Kjellström B,Klinge B,Rydén L,Levring Jäghagen E

更新日期：2020-01-01 00:00:00

abstract：:The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors and tyrosine kinases. DDRs regulate cell functions, and their extracellular domains affect collagen fibrillogenesis and mineralization. Based on the collagenous nature of dentoalveolar tissues, we hypothesized that DDR1 plays an importan...

journal_title：Journal of dental research

authors： Chavez MB,Kolli TN,Tan MH,Zachariadou C,Wang C,Embree MC,Lira Dos Santos EJ,Nociti FH Jr,Wang Y,Tatakis DN,Agarwal G,Foster BL

更新日期：2019-12-01 00:00:00

abstract：:Fibroblast growth factor receptor 2 (FGFR2) in craniofacial bones mediates osteoprogenitor proliferation, differentiation, and apoptosis. The distortion of proper craniofacial bone growth may cause class II and class III skeletal malocclusion and result in compromised function and aesthetics. Here, we investigated the...

journal_title：Journal of dental research

authors： Jiang Q,Mei L,Zou Y,Ding Q,Cannon RD,Chen H,Li H

更新日期：2019-11-01 00:00:00

abstract：:The discovery of the phenomenon "osseointegration," or functional ankylosis, has led to the development of oral implants with high clinical performance. Consequently, the placement of titanium implants has changed the paradigms of restorative dentistry. Implants are used to prevent placing reconstructions anchored on ...

journal_title：Journal of dental research

authors： Lang NP

更新日期：2019-11-01 00:00:00

abstract：:Each odontoblast is tightly linked to other odontoblasts. They form a line of defense and are capable of withstanding external stimuli, particularly the inflammation caused by caries. Thus, we investigated exosomes derived from odontoblasts as an intercellular mechanism by which inflamed odontoblasts are protected fro...

journal_title：Journal of dental research

authors： Wang HS,Yang FH,Wang YJ,Pei F,Chen Z,Zhang L

更新日期：2019-10-01 00:00:00

abstract：:Breastfeeding is important for health and development. Yet, the interaction between breastfeeding duration and usage of fluoridated water on caries experience has not been investigated. This study examined exposure to fluoridation as an effect modifier of the association between breastfeeding duration and caries. The ...

journal_title：Journal of dental research

authors： Ha DH,Spencer AJ,Peres KG,Rugg-Gunn AJ,Scott JA,Do LG

更新日期：2019-07-01 00:00:00

abstract：:The oral cavity contains a rich consortium of exopolysaccharide-producing microbes. These extracellular polysaccharides comprise a major component of the oral biofilm. Together with extracellular proteins, DNA, and lipids, they form the biofilm matrix, which contributes to bacterial colonization, biofilm formation and...

journal_title：Journal of dental research

authors： Cugini C,Shanmugam M,Landge N,Ramasubbu N

更新日期：2019-07-01 00:00:00

abstract：:The discovery and implementation of fluoride in the prevention of dental caries is often praised as one of the most important achievements in health care. In the early 20th century, it took 30 y to identify fluoride as the cause of enamel mottling but also of reduced caries prevalence in a population drinking water co...

journal_title：Journal of dental research

authors： Ten Cate JM,Buzalaf MAR

更新日期：2019-07-01 00:00:00

abstract：:Better understanding of dental caries and other oral conditions has guided new strategies to prevent disease and manage its consequences at individual and public health levels. This article discusses advances in prevention and minimal intervention dentistry over the last century by focusing on some milestones within s...

journal_title：Journal of dental research

authors： Innes NPT,Chu CH,Fontana M,Lo ECM,Thomson WM,Uribe S,Heiland M,Jepsen S,Schwendicke F

更新日期：2019-06-01 00:00:00

abstract：:Carbamide peroxide (CP) is widely used as a tooth-whitening agent in self-administered tooth-bleaching products. In this study, the effects of 5% and 10% CP on dentinal collagen structure and chemical properties were evaluated in vitro. Thirty-five intact teeth were exposed to 2 whitening protocols (2 or 4 h daily) wi...

journal_title：Journal of dental research

authors： Redha O,Strange A,Maeva A,Sambrook R,Mordan N,McDonald A,Bozec L

更新日期：2019-04-01 00:00:00

abstract：:The present study was conducted to investigate the role of proteolysis by matrix metalloproteinase 20 (MMP20) in regulating the initial formation of the enamel mineral structure during the secretory stage of amelogenesis, utilizing Mmp20-null mice that lack this essential protease. Ultrathin sagittal sections of maxil...

journal_title：Journal of dental research

authors： Yamazaki H,Tran B,Beniash E,Kwak SY,Margolis HC

更新日期：2019-04-01 00:00:00

abstract：:Over the last hundred years, groundbreaking research in oral microbiology has provided a broad and deep understanding about the oral microbiome, its interactions with our body, and how the community can affect our health, be protective, or lead to the development of dental diseases. During this exciting journey, hypot...

journal_title：Journal of dental research

authors： Colombo APV,Tanner ACR

更新日期：2019-04-01 00:00:00

abstract：:The extent of dental tissue destruction during the treatment of white spot lesions (WSLs) increases with the severity of the lesion. If the depth and shape of WSLs can be predicted with a noninvasive diagnostic method before dental caries treatment, more conservative interventions can be planned. Given the superiority...

journal_title：Journal of dental research

authors： Kim J,Shin TJ,Kong HJ,Hwang JY,Hyun HK

更新日期：2019-03-01 00:00:00

abstract：:The field of dental materials has undergone more of a revolution than an evolution over the past 100 y. The development of new products, especially in the past half century, has occurred at a staggering pace, and their introduction to the market has been equally impressive. The movement has mostly come in the area of ...

journal_title：Journal of dental research

authors： Bayne SC,Ferracane JL,Marshall GW,Marshall SJ,van Noort R

更新日期：2019-03-01 00:00:00

abstract：:Periodontal diseases are initiated by bacteria that accumulate in a biofilm on the tooth surface and affect the adjacent periodontal tissue. Systemic diseases such as diabetes, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) increase susceptibility to destructive periodontal diseases. In human studie...

journal_title：Journal of dental research

authors： Graves DT,Corrêa JD,Silva TA

更新日期：2019-02-01 00:00:00

abstract：:We investigated whether oral health, represented by missing teeth, was associated with an increased risk of cardiovascular disease, including myocardial infarction (MI), heart failure (HF), stroke, and all-cause mortality. Subjects who underwent routine dental examinations and health checkups provided by the Korean Na...

journal_title：Journal of dental research

authors： Lee HJ,Choi EK,Park JB,Han KD,Oh S

更新日期：2019-02-01 00:00:00

abstract：:The impact of osteoporosis on implant treatment is still a matter of debate in the scientific community, as it may possibly lead to higher failure rates. As long-term controlled trials are missing, the aim of this study was to verify the long-term outcome of implants placed in patients with systemic osteoporosis. Post...

journal_title：Journal of dental research

authors： Temmerman A,Rasmusson L,Kübler A,Thor A,Merheb J,Quirynen M

更新日期：2019-01-01 00:00:00

abstract：:The goal of nonrestorative or non- and microinvasive caries treatment (fluoride- and nonfluoride-based interventions) is to manage the caries disease process at a lesion level and minimize the loss of sound tooth structure. The purpose of this systematic review and network meta-analysis was to summarize the available ...

journal_title：Journal of dental research

authors： Urquhart O,Tampi MP,Pilcher L,Slayton RL,Araujo MWB,Fontana M,Guzmán-Armstrong S,Nascimento MM,Nový BB,Tinanoff N,Weyant RJ,Wolff MS,Young DA,Zero DT,Brignardello-Petersen R,Banfield L,Parikh A,Joshi G,Carrasco-Labra

更新日期：2019-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV), in addition to its transforming properties, contributes to the pathogenesis of several inflammatory diseases. Here, we investigated its involvement in oral lichen planus (OLP), a common autoimmune-like disease of unknown etiopathogenesis that can display a malignant potential. EBV-infected ce...

journal_title：Journal of dental research

authors： Raybaud H,Olivieri CV,Lupi-Pegurier L,Pagnotta S,Marsault R,Cardot-Leccia N,Doglio A

更新日期：2018-12-01 00:00:00

abstract：:Candida albicans is an opportunistic fungal organism frequently detected in the oral cavity of children with severe early childhood caries (S-ECC). Previous studies suggested the cariogenic potential of C. albicans, in vitro and in vivo, and further demonstrated its synergistic interactions with Streptococcus mutans. ...

journal_title：Journal of dental research

authors： Xiao J,Grier A,Faustoferri RC,Alzoubi S,Gill AL,Feng C,Liu Y,Quivey RG,Kopycka-Kedzierawski DT,Koo H,Gill SR

更新日期：2018-12-01 00:00:00

abstract：:In the current theme of dental pulp regeneration, biological and synthetic scaffolds are becoming a potential therapy for pulp revitalization. The goal is to provide a suitable environment for cellular infiltration, proliferation, and differentiation. The extracellular matrix (ECM) represents a natural scaffold materi...

journal_title：Journal of dental research

authors： Alqahtani Q,Zaky SH,Patil A,Beniash E,Ray H,Sfeir C

更新日期：2018-12-01 00:00:00

abstract：:Dental implants have become an increasingly popular treatment choice for replacing missing teeth. Yet, little is known about the prevalence and sociodemographic distribution of dental implant use in the United States. To address this knowledge gap, we analyzed data from 7 National Health and Nutrition Examination Surv...

journal_title：Journal of dental research

authors： Elani HW,Starr JR,Da Silva JD,Gallucci GO

更新日期：2018-12-01 00:00:00