Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis.


:The goal of nonrestorative or non- and microinvasive caries treatment (fluoride- and nonfluoride-based interventions) is to manage the caries disease process at a lesion level and minimize the loss of sound tooth structure. The purpose of this systematic review and network meta-analysis was to summarize the available evidence on nonrestorative treatments for the outcomes of 1) arrest or reversal of noncavitated and cavitated carious lesions on primary and permanent teeth and 2) adverse events. We included parallel and split-mouth randomized controlled trials where patients were followed for any length of time. Studies were identified with MEDLINE and Embase via Ovid, Cochrane CENTRAL, and Cochrane Database of Systematic Reviews. Pairs of reviewers independently conducted the selection of studies, data extraction, risk-of-bias assessments, and assessment of the certainty in the evidence with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Data were synthesized with a random effects model and a frequentist approach. Forty-four trials (48 reports) were eligible, which included 7,378 participants and assessed the effect of 22 interventions in arresting or reversing noncavitated or cavitated carious lesions. Four network meta-analyses suggested that sealants + 5% sodium fluoride (NaF) varnish, resin infiltration + 5% NaF varnish, and 5,000-ppm F (1.1% NaF) toothpaste or gel were the most effective for arresting or reversing noncavitated occlusal, approximal, and noncavitated and cavitated root carious lesions on primary and/or permanent teeth, respectively (low- to moderate-certainty evidence). Study-level data indicated that 5% NaF varnish was the most effective for arresting or reversing noncavitated facial/lingual carious lesions (low certainty) and that 38% silver diamine fluoride solution applied biannually was the most effective for arresting advanced cavitated carious lesions on any coronal surface (moderate to high certainty). Preventing the onset of caries is the ultimate goal of a caries management plan. However, if the disease is present, there is a variety of effective interventions to treat carious lesions nonrestoratively.


J Dent Res


Urquhart O,Tampi MP,Pilcher L,Slayton RL,Araujo MWB,Fontana M,Guzmán-Armstrong S,Nascimento MM,Nový BB,Tinanoff N,Weyant RJ,Wolff MS,Young DA,Zero DT,Brignardello-Petersen R,Banfield L,Parikh A,Joshi G,Carrasco-Labra




Has Abstract


2019-01-01 00:00:00












  • Protective effect of the dental pellicle against erosive challenges in situ.

    abstract::The acquired dental pellicle helps prevent erosion, but the protection level is unknown. This in situ study tested whether a two-hour pellicle protects against different erosive challenges by orange juice. Subjects wore palatal appliances loaded with either enamel or dentin specimens. Pellicle was allowed to form, or ...

    journal_title:Journal of dental research

    pub_type: 杂志文章,随机对照试验


    authors: Hara AT,Ando M,González-Cabezas C,Cury JA,Serra MC,Zero DT

    更新日期:2006-07-01 00:00:00

  • Prevalence and need for replacement of amalgam and composite restorations in Dutch adults.

    abstract::In 1986, the first nationwide epidemiological survey of adult oral health and attitudes to oral health care was carried out in The Netherlands. One of the aims of this study was to evaluate the prevalence and the quality (in terms of need for replacement) of amalgam and composite restorations in the Dutch adult popula...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Kroeze HJ,Plasschaert AJ,van 't Hof MA,Truin GJ

    更新日期:1990-06-01 00:00:00

  • Analysis of multiple 2x2 tables with site-specific periodontal data.

    abstract::Periodontal data typically consist of observations made at multiple sites within each patient. Observations within a patient tend to be positively correlated; hence, standard statistical techniques that assume independence are invalid. Regression techniques for correlated data have been proposed; communicating results...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Panageas KS,Begg MD,Grbic JT,Lamster IB

    更新日期:2003-07-01 00:00:00

  • The influence of various attachment types in mandibular implant-retained overdentures on maximum bite force and EMG.

    abstract::The type of attachment that is used in oral rehabilitation by means of implant-retained mandibular overdentures may influence the retention and the stability of the denture. In this study, we examined the hypothesis that a better retention and stability of the denture improve the oral function. Eighteen edentulous sub...

    journal_title:Journal of dental research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: van Kampen FM,van der Bilt A,Cune MS,Bosman F

    更新日期:2002-03-01 00:00:00

  • A novel missense mutation in Van der Woude syndrome: usefulness of fingernail DNA for genetic analysis.

    abstract::Van der Woude syndrome (VWS) is an autosomal-dominant oral facial disorder. To find a gene mutation in a Japanese family using fingernail DNA samples, we performed this study. We hypothesized that a gene mutation in IRF6 might be involved in VWS, and that fingernail DNA samples may be valuable for detecting such mutat...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Matsuzawa N,Shimozato K,Natsume N,Niikawa N,Yoshiura K

    更新日期:2006-12-01 00:00:00

  • The extent of the odontoblast process in human dentin.

    abstract::Impacted human third molar teeth were examined, both with the light and electron microscope, to determine the extent of the odontoblast process. The odontoblast process was found to be limited to the inner third of coronal dentin and inner half of mid-root dentin. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Thomas HF

    更新日期:1979-11-01 00:00:00

  • Induced hypoxia in rat pulp and periapex demonstrated by 3H-misonidazole retention.

    abstract::Cellular hypoxia may be a useful indication of tissue distress in the dental pulp that could be used to investigate the early stages of pulpal responses. Tritiated misonidazole (3H-MISO) is a marker which preferentially labels cells with decreased oxygen tension (hypoxia). The experiments reported here were carried ou...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Baumgardner KR,Walton RE,Osborne JW,Born JL

    更新日期:1996-10-01 00:00:00

  • The relationship between serum IgG levels to subgingival gram-negative bacteria and degree of periodontal destruction.

    abstract::The relationship between the serum IgG antibody titer against seven species of Gram-negative periodontopathic bacteria and clinical parameters (including plaque index, gingival index, periodontal pocket depth, and alveolar bone loss) was studied in 38 subjects. IgG antibody titer against the sonicated antigens was det...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Naito Y,Okuda K,Takazoe I,Watanabe H,Ishikawa I

    更新日期:1985-11-01 00:00:00

  • Effects of implant healing time on crestal bone loss of a controlled-load dental implant.

    abstract::The universally accepted concept of delay-loaded dental implants has recently been challenged. This study hypothesizes that early loading (decreased implant healing time) leads to increased bone formation and decreased crestal bone loss. We used 17 minipigs to study implants under a controlled load, with non-loaded im...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Ko CC,Douglas WH,DeLong R,Rohrer MD,Swift JQ,Hodges JS,An KN,Ritman EL

    更新日期:2003-08-01 00:00:00

  • Bone regeneration at dental implant sites with suspended stem cells.

    abstract::During the maintenance of bone marrow-derived mesenchymal stem cells (BMMSCs), suspended cells are discarded normally. We noted the osteogenic potential of these cells to be like that of anchorage-dependent BMMSCs. Therefore, we characterized suspended BMMSCs from rabbit bone marrow by bioengineering and applied the s...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Zheng RC,Park YK,Cho JJ,Kim SK,Heo SJ,Koak JY,Lee JH

    更新日期:2014-10-01 00:00:00

  • In vivo remineralization using a sustained topical fluoride delivery system.

    abstract::The efficacy of a new remineralization system was determined in vivo by maintaining a low concentration of approximately 1 ppm fluoride for 48 hrs against a demineralized human tooth. Human subjects were selected who wore removable partial dentures containing two or more of the demineralized teeth with film system. Th...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Abrahams LJ,Yonese M,Higuchi WI,Fox JL,Charbeneau GT

    更新日期:1980-03-01 00:00:00

  • Establishment of an improved implantation technique for hamster mucous membrane irritation testing.

    abstract::Biological evaluation procedures for the acceptance of new dental materials include testing for mucous membrane irritation and inflammation, with the hamster cheek pouch used as a model system. Previous reports have indicated both a low 14-day implant retention rate and poor differentiation between positive and negati...

    journal_title:Journal of dental research

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    authors: Roy M,Wishe HI

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  • In vivo bioreactors for mandibular reconstruction.

    abstract::Large mandibular defects are difficult to reconstruct with good functional and aesthetic outcomes because of the complex geometry of craniofacial bone. While the current gold standard is free tissue flap transfer, this treatment is limited in fidelity by the shape of the harvested tissue and can result in significant ...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审


    authors: Tatara AM,Wong ME,Mikos AG

    更新日期:2014-12-01 00:00:00

  • Corrosion behavior of Au and Ag modified Cu-Ni-Mn alloys.

    abstract::The linear electrochemical polarization method was used to provide quantitative in vitro measurements of corrosion rates as a function of exposure time for Cu-Ni-Mn, Cu-Ni-Mn-Au, Cu-Ni-Mn-Ag, and Cu-Ni-Mn-Au-Ag alloys in artificial saliva. Both Au and Ag additives to dental-cast Cu-Ni-Mn alloys lowered the corrosion r...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Wright SR,Cocks FH,Gettleman L

    更新日期:1980-04-01 00:00:00

  • DPP and DSP are Necessary for Maintaining TGF-β1 Activity in Dentin.

    abstract::Porcine dentin sialophosphoprotein (DSPP) is the most abundant non-collagenous protein in dentin. It is processed by proteases into 3 independent proteins: dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP). We fractionated DPP and DSP along with TGF-β activity by ion exchange (IE) c...

    journal_title:Journal of dental research

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    authors: Yamakoshi Y,Kinoshita S,Izuhara L,Karakida T,Fukae M,Oida S

    更新日期:2014-07-01 00:00:00

  • Clinical effectiveness of orthodontic miniscrew implants: a meta-analysis.

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    journal_title:Journal of dental research

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    authors: Papadopoulos MA,Papageorgiou SN,Zogakis IP

    更新日期:2011-08-01 00:00:00

  • Effects of rinses with an acidic calcium phosphate solution on fluoride uptake, caries, and in situ plaque pH in rats.

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    journal_title:Journal of dental research

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    authors: Schreiber CT,Shern RJ,Chow LC,Kingman A

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  • The influence of tonic muscle activation on human jaw displacement tremor.

    abstract::Jaw displacement tremor was investigated. Both tremor amplitude and tremor frequency were found to increase with increasing muscle activation. Co-contraction of jaw elevator and jaw depressor muscles was employed in order to vary muscle activation levels without the teeth being in occlusion. Reproducibility of tremor ...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: McCarroll RS,De Vries JH

    更新日期:1988-08-01 00:00:00

  • Apoptotic effects of LPS on fibroblasts are indirectly mediated through TNFR1.

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    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Alikhani M,Alikhani Z,Graves DT

    更新日期:2004-09-01 00:00:00

  • Liposomes as drug carriers for oral ulcers.

    abstract::The aim of this study was to test the potential of liposomes as drug carriers to the ulcerated oral mucosa. Radioactive triamcinolone acetonide palmitate (3H-TRMAp) was encapsulated in large multilamellar lipid vesicles and served as the test lotion. 3H-TRMAp in solution served as control. Forty-six hamsters were divi...

    journal_title:Journal of dental research

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    authors: Harsanyi BB,Hilchie JC,Mezei M

    更新日期:1986-09-01 00:00:00

  • Antibodies against mycobacterial antigens in the synovial fluid of patients with temporomandibular disorders.

    abstract::In the absence of active pulmonary disease, mycobacterial infection frequently causes arthritis and can be considered to initiate autoimmune diseases such as rheumatoid arthritis. Temporomandibular disorder (TMD) is a disease in which pain and impaired mandibular movement appear to arise directly from degenerative or ...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Adachi N,Matsumoto S,Tokuhisa M,Kobayashi K,Yamada T

    更新日期:2000-10-01 00:00:00

  • MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis.

    abstract::Periodontitis is characterized by periodontal tissue destruction. Since interleukin-17 (IL-17) has been reported to up-regulate IL-1beta and tumor necrosis factor-alpha (TNF-alpha), it was hypothesized that it is increased in periodontitis and up-regulates these cytokines and tissue-destructive matrix metalloproteinas...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Beklen A,Ainola M,Hukkanen M,Gürgan C,Sorsa T,Konttinen YT

    更新日期:2007-04-01 00:00:00

  • Selection of an experimental unit in rat caries studies.

    abstract::In two separate experiments, none of the 14 subunits examined consistently ranked dentifrices similarly to the ranking obtained when the individual rat was used as the experimental unit. Arbitrarily dividing the rat into subunits and then comparing results among these subunits may lead to false conclusions since the r...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Briner WW

    更新日期:1976-05-01 00:00:00

  • Magnification--an interesting optical property of dentin.

    abstract::Disks of dentin taken from extracted human teeth demonstrated the optical property of the magnification/reduction effect. When images were transmitted from a pulpal-to-occlusal direction, the images were magnified. When the disks were inverted, the images were reduced in size. The images were slightly distorted but cl...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Walton RE,Outhwaite WC,Pashley DF

    更新日期:1976-07-01 00:00:00

  • Effect of filler content and size on properties of composites.

    abstract::Two series of dental composites, along with the unfilled resin matrix, were examined to determine the effects of filler level and size on selected properties. Both series were prepared by incorporating a silanated barium borosilicate filler into a visible-light-activated polyphenylene polymethacrylate resin matrix. On...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Li Y,Swartz ML,Phillips RW,Moore BK,Roberts TA

    更新日期:1985-12-01 00:00:00

  • Triazine monomers and their adhesion to dentin.

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    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Lee CH,Liu XQ,Gong XQ

    更新日期:1986-12-01 00:00:00

  • Posteruptive tooth age in children with Down's syndrome and their sibs.

    abstract::The accumulated posteruptive tooth age was calculated for 212 children with Down's syndrome and 124 of their unaffected sibs. Posteruptive tooth age was shown to vary widely with different morphological permanent tooth types at the same chronological age. Girls in both groups had greater accumulated posteruptive tooth...

    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Orner G

    更新日期:1975-05-01 00:00:00

  • Experimental ridge augmentation with porous hydroxyapatite implants.

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    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Piecuch JF,Topazian RG,Skoly S,Wolfe S

    更新日期:1983-02-01 00:00:00

  • Functional adaptability of jaw-muscle spindles after bite-raising.

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    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Yabushita T,Zeredo JL,Fujita K,Toda K,Soma K

    更新日期:2006-09-01 00:00:00

  • Degradation of starch and its hydrolytic products by oral bacteria.

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    journal_title:Journal of dental research

    pub_type: 杂志文章


    authors: Glor EB,Miller CH,Spandau DF

    更新日期:1988-01-01 00:00:00