Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis.


:The goal of nonrestorative or non- and microinvasive caries treatment (fluoride- and nonfluoride-based interventions) is to manage the caries disease process at a lesion level and minimize the loss of sound tooth structure. The purpose of this systematic review and network meta-analysis was to summarize the available evidence on nonrestorative treatments for the outcomes of 1) arrest or reversal of noncavitated and cavitated carious lesions on primary and permanent teeth and 2) adverse events. We included parallel and split-mouth randomized controlled trials where patients were followed for any length of time. Studies were identified with MEDLINE and Embase via Ovid, Cochrane CENTRAL, and Cochrane Database of Systematic Reviews. Pairs of reviewers independently conducted the selection of studies, data extraction, risk-of-bias assessments, and assessment of the certainty in the evidence with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Data were synthesized with a random effects model and a frequentist approach. Forty-four trials (48 reports) were eligible, which included 7,378 participants and assessed the effect of 22 interventions in arresting or reversing noncavitated or cavitated carious lesions. Four network meta-analyses suggested that sealants + 5% sodium fluoride (NaF) varnish, resin infiltration + 5% NaF varnish, and 5,000-ppm F (1.1% NaF) toothpaste or gel were the most effective for arresting or reversing noncavitated occlusal, approximal, and noncavitated and cavitated root carious lesions on primary and/or permanent teeth, respectively (low- to moderate-certainty evidence). Study-level data indicated that 5% NaF varnish was the most effective for arresting or reversing noncavitated facial/lingual carious lesions (low certainty) and that 38% silver diamine fluoride solution applied biannually was the most effective for arresting advanced cavitated carious lesions on any coronal surface (moderate to high certainty). Preventing the onset of caries is the ultimate goal of a caries management plan. However, if the disease is present, there is a variety of effective interventions to treat carious lesions nonrestoratively.


J Dent Res


Urquhart O,Tampi MP,Pilcher L,Slayton RL,Araujo MWB,Fontana M,Guzmán-Armstrong S,Nascimento MM,Nový BB,Tinanoff N,Weyant RJ,Wolff MS,Young DA,Zero DT,Brignardello-Petersen R,Banfield L,Parikh A,Joshi G,Carrasco-Labra




Has Abstract


2019-01-01 00:00:00












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    abstract::The mechanism of formation of nodular material on the surface of a Pd-Ag-based alloy for porcelain during pre-porcelainization heat treatment was investigated using scanning electron microscopy, x-ray diffraction, quantitative metallography, and Auger electron spectroscopy. The nodules were found to form by a Nabarro-...

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    authors: Byrd KE,Milberg DJ,Luschei ES

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    abstract::Recent studies have shown that the extent of hydrolysis by plaque of the trypsin substrate, N-benzoyl-DL-arginine-2-naphthylamide (BANA), correlates with the numbers and proportions of spirochetes in subgingival plaque samples, and appears to be an indicator of clinical disease. In this study, BANA hydrolysis by subgi...

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    authors: Schmidt EF,Bretz WA,Hutchinson RA,Loesche WJ

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    abstract::The effect of chronic fluoride (F) exposure from the drinking water on parameters related to glucose homeostasis was investigated. Wistar rats were randomly distributed into 2 groups (diabetic [D] and nondiabetic [ND]; n = 54 each). In D, diabetes was induced with streptozotocin. Each group was further divided into 3 ...

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    authors: Lobo JG,Leite AL,Pereira HA,Fernandes MS,Peres-Buzalaf C,Sumida DH,Rigalli A,Buzalaf MA

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    pub_type: 杂志文章


    authors: Bartold PM

    更新日期:1992-09-01 00:00:00

  • Porphyromonas gingivalis Outer Membrane Vesicles Increase Vascular Permeability.

    abstract::Periodontitis is increasingly associated with increased risk of cardiovascular and other systemic diseases. The Gram-negative anaerobe, Porphyromonas gingivalis, is a key periodontal pathogen, and several lines of evidence link the presence of this bacterium in the circulation with vascular disease. The outer membrane...

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    authors: Farrugia C,Stafford GP,Murdoch C

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    authors: Ikeno T,Nasu J,Kuzuya H

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    authors: Kim JY,Cha YG,Cho SW,Kim EJ,Lee MJ,Lee JM,Cai J,Ohshima H,Jung HS

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    authors: Nasjleti CE,Castelli WA,Caffesse RG

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    authors: Goldenberg M,Das P,Messersmith M,Stockton DW,Patel PI,D'Souza RN

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    abstract::Intracystic fluid pressure is thought to be involved in odontogenic cyst growth. In this study, we investigated the effects of positive pressure on the expression of interleukin-1alpha (IL-1alpha), matrix metalloproteinases (MMPs), and prostaglandin E2 (PGE2) in odontogenic keratocysts to determine whether this pressu...

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    abstract::The ability of human oral bacteria to inhibit Streptococcus mutans was studied under a variety of in vitro conditions using an agar overlay assay. Extensive inherent variability in microbial antagonism by certain organisms was demonstrated. Antagonistic activity was also significantly influenced by changes in the assa...

    journal_title:Journal of dental research

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    authors: Deyloff JL,Sanders CC

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  • Protective effect of the dental pellicle against erosive challenges in situ.

    abstract::The acquired dental pellicle helps prevent erosion, but the protection level is unknown. This in situ study tested whether a two-hour pellicle protects against different erosive challenges by orange juice. Subjects wore palatal appliances loaded with either enamel or dentin specimens. Pellicle was allowed to form, or ...

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    authors: Hara AT,Ando M,González-Cabezas C,Cury JA,Serra MC,Zero DT

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  • Genotoxic evaluation of chronic fluoride exposure: micronucleus and sperm morphology studies.

    abstract::The purpose of this study was to investigate the genotoxic effects of chronic fluoride exposure on mammalian cells in vivo by use of the mouse bone-marrow micronucleus test and the sperm morphology methodology. Mice of genotype B6C3F1 were obtained at weaning and maintained on a low-fluoride diet (less than 0.2 ppm F)...

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    authors: Dunipace AJ,Zhang W,Noblitt TW,Li Y,Stookey GK

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    abstract::Although little is known about the mechanism of action of eugenol, some related compounds have been compared with capsaicin derivatives in terms of the relationship between their chemical structure and activity. To elucidate whether eugenol and capsaicin act via a common mechanism at the neuronal membrane, we investig...

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    authors: Ohkubo T,Kitamura K

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    abstract::Degradation of dentin matrix components within caries dentin has been correlated with the activity of host-derived proteases, such as matrix metalloproteases (MMPs) and cysteine cathepsins (CTs). Since this relationship has not been fully established, we hypothesized that the abundance of MMPs and CTs in caries-affect...

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  • In vivo remineralization using a sustained topical fluoride delivery system.

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    authors: Abrahams LJ,Yonese M,Higuchi WI,Fox JL,Charbeneau GT

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    abstract::The synchronized cyrstal dissolution hypothesis previously proposed to explain the unusual dissolution behavior of human dental enamel and hydroxyapatite in partially saturated acidic media has been critically examined with dissolution-dialysis transport experiments. The findings are in accord with the hypothesis. A m...

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    authors: Fawzi MB,Sonobe T,Higuchi WI,Hefferren JJ

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  • Breastfeeding and Oral Health: Evidence and Methodological Challenges.

    abstract::Breastfeeding is a powerful health-promoting behavior. A 2016 Lancet global collaboration to review the health implications of breastfeeding was among the first to consider oral health outcomes. While a role was suggested for breastfeeding in preventing malocclusion, caries was the only included disease condition unfa...

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    authors: Tanaka T,Nagata K,Takeyama M,Atsuta M,Nakabayashi N,Masuhara E

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  • Fit of porcelain fused-to-metal crown and bridge castings.

    abstract::The dimensional accuracy of porcelain fused to metal crown and bridge castings was determined on truncated cone-shaped steel dies. Ni-Cr castings produced in manufacturers' laboratories were consistently undersize, while precious metal castings were consistently oversize. Ni-Cr castings, produced in NBS laboratories u...

    journal_title:Journal of dental research

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    authors: Eden GT,Franklin OM,Powell JM,Ohta Y,Dickson G

    更新日期:1979-12-01 00:00:00

  • Relationship between growth and the pattern of tooth initiation in alligator embryos.

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    journal_title:Journal of dental research

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    authors: Osborn JW

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    authors: Usui Y,Uematsu T,Uchihashi T,Takahashi M,Takahashi M,Ishizuka M,Doto R,Tanaka H,Komazaki Y,Osawa M,Yamada K,Yamaoka M,Furusawa K

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  • Wear and mechanical properties of nano-silica-fused whisker composites.

    abstract::Resin composites must be improved if they are to overcome the high failure rates in large stress-bearing posterior restorations. This study aimed to improve wear resistance via nano-silica-fused whiskers. It was hypothesized that nano-silica-fused whiskers would significantly improve composite mechanical properties an...

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    authors: Crisp S,Kent BE,Lewis BG,Ferner AJ,Wilson AD

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    authors: van Ruijven LJ,Giesen EB,van Eijden TM

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