Abstract：
:Over the last hundred years, groundbreaking research in oral microbiology has provided a broad and deep understanding about the oral microbiome, its interactions with our body, and how the community can affect our health, be protective, or lead to the development of dental diseases. During this exciting journey, hypotheses were proposed, and concepts were established, discarded, and later revisited from updated perspectives. Dental plaque, previously considered a polymicrobial community of unspecific pathogenicity, is recognized as microbial biofilms with healthy, cariogenic, or periodontopathogenic profiles, resulting from specific ecologic determinants and host factors. The "one pathogen, one disease" paradigm of oral infections has been replaced by a holistic concept of a microbial community as the entity of pathogenicity. Cutting-edge technology can now explore large microbial communities related to different clinical conditions, which has led to finding several novel disease-associated species and potential pathobionts and pathobiomes. This vast amount of data generated over time has widened our view of the etiology of caries and periodontal and peri-implant diseases and has promoted updated strategies to treat and prevent the oral diseases.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Colombo APV,Tanner ACRdoi
10.1177/0022034519830686subject
Has Abstractpub_date
2019-04-01 00:00:00pages
373-385issue
4eissn
0022-0345issn
1544-0591journal_volume
98pub_type
杂志文章abstract：:Human saliva contains a number of phosphorylated acidic proline-rich proteins (APRP). Monkey parotid saliva contains a similar protein with the same phosphorylated sequences as the human proteins. A crude protein kinase was prepared from Macaca fascicularis parotid glands which phosphorylated human APRP. The enzyme wa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650030601
更新日期：1986-03-01 00:00:00
abstract：:Although systemic bone loss accompanying estrogen deficiency has been proposed as a risk factor for periodontal disease in post-menopausal women, the mechanisms involved remain unclear. The objective of this study was to elucidate the potential bone-sparing effect of estrogen (17beta-estradiol, E(2)) via modulation of...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700214
更新日期：2008-02-01 00:00:00
abstract：:The limited durability of resin-dentin bonds severely compromises the lifetime of tooth-colored restorations. Bond degradation occurs via hydrolysis of suboptimally polymerized hydrophilic resin components and degradation of water-rich, resin-sparse collagen matrices by matrix metalloproteinases (MMPs) and cysteine ca...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034510391799
更新日期：2011-08-01 00:00:00
abstract：:The effect of chronic fluoride (F) exposure from the drinking water on parameters related to glucose homeostasis was investigated. Wistar rats were randomly distributed into 2 groups (diabetic [D] and nondiabetic [ND]; n = 54 each). In D, diabetes was induced with streptozotocin. Each group was further divided into 3 ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515581186
更新日期：2015-07-01 00:00:00
abstract：:Samples of plaque and surface enamel were collected from 80 boys aged 14 years living in five communities in Ohio (USA). Mean (+/- SE) strontium concentrations in plaque were 1.43 +/- 0.18 micrograms/g (wet) and 12.34 +/- 1.63 micrograms/g (dry). For surface enamel, the mean concentration was 421 +/- 31 micrograms Sr/...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640121201
更新日期：1985-12-01 00:00:00
abstract：:As a major intracellular degradation and recycling machinery, autophagy plays an important role in maintaining cellular homeostasis and remodeling during normal development. Our previous study showed that fluorapatite (FA) crystal-coated electrospun polycaprolactone (PCL) was capable of inducing differentiation and mi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516636852
更新日期：2016-06-01 00:00:00
abstract：:Purinergic signaling is involved in pain generation and modulation in the nociceptive sensory nervous system. Adenosine triphosphate (ATP) induces pain via activation of ionotropic P2X receptors while adenosine mediates analgesia via activation of metabotropic P1 receptors. These purinergic signaling are determined by...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517692953
更新日期：2017-06-01 00:00:00
abstract：:The biogenetic formation of mineral crystals, one aspect of biomineralization, is a multistep process of apatite formation throughout the growth of dentin tissue. An important step is the transformation of the non-mineralized predentin matrix to mineralizing dentin matrix and its biological control. In this study, the...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770081401
更新日期：1998-08-01 00:00:00
abstract：:During periods of periodontal attachment loss, one of the most significant cellular changes is a decrease in the number of fibroblasts. We previously demonstrated that LPS induces apoptosis of fibroblastic cells in vivo, largely through TNF-alpha. We conducted in vivo experiments by subcutaneous inoculation of LPS in ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300903
更新日期：2004-09-01 00:00:00
abstract：:Pieces of fresh rat incisor enamel were extracted with various buffer solutions and prepared for electron microscopy. I observed partial or complete removal of organic constituents, shrinkage of rods and interrods, separation of stippled material from the enamel, and partial decalcification. The results modify the con...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：
更新日期：1982-12-01 00:00:00
abstract：:A number of studies have been made investigating the properties of dental prosthodontic soft polymer materials. In such materials, which are used as short-term denture soft liners, the polymer component is complexed with one or more plasticizers. This lowers the glass transition temperature, Tg, of the polymer by allo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700050201
更新日期：1991-05-01 00:00:00
abstract：:The development of predictive and rapid methods for the assessment of the anticaries activity of topical fluorides has been a long-standing objective of caries researchers. These methods can provide useful benefits in a number of applications, ranging from the identification of novel agents to progress into clinical t...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/002203459207100S19
更新日期：1992-04-01 00:00:00
abstract：:In this study, we sought to determine the association between tooth agenesis and DNA sequence variation in the genes MSX1 and PAX9 in an ethnically diverse human population. Since cleft lip/palate is also associated with both tooth agenesis and the gene TGFA, we included TGFA in the analysis as well. Cheek swab sample...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300913
更新日期：2004-09-01 00:00:00
abstract：:The role of Streptococcus mutans in the initiation of dental caries has been recognized and attributed, at least in part, to its ability to colonize the tooth surface. Therefore, factors which prevent S. mutans attachment to hydroxyapatite (HA) are of considerable interest for the prophylaxis of this infectious diseas...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760020701
更新日期：1997-02-01 00:00:00
abstract：:Contact angle measurements on layers of bacteria were used to determine the bacterial surface free energy (gamma b) of a variety of oral streptococcal strains, both without and after being coated with human whole saliva. At least four isolates of each species, either freshly isolated or laboratory strains, were used. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640100501
更新日期：1985-10-01 00:00:00
abstract：:Acute or chronic inflammation comprises a highly prevalent type of orofacial pain and is mediated by the generation of endogenous agonists that activate numerous receptors expressed on terminals of trigeminal (TG) nociceptive afferent neurons. One such studied receptor is transient receptor potential vanilloid subtype...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034516653751
更新日期：2016-09-01 00:00:00
abstract：:The work described considers the effects on calcified tissues of those concentrations of fluoride which are not overtly cyto-toxic, i.e., in the general region of up to 1-2 mumol/L. Plasma fluoride concentrations or those of the cellular environment are considered rather than dietary levels. The effect of fluoride ion...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/00220345900690S134
更新日期：1990-02-01 00:00:00
abstract：:Dental porcelains rely on the high-thermal-expansion mineral leucite to elevate their bulk thermal expansion to levels compatible with dental PFM alloys. The microcracks that form around these leucite particles when cooled during porcelain manufacture are a potential source of change in bulk porcelain thermal expansio...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750070801
更新日期：1996-07-01 00:00:00
abstract：:The range of substrates transported by the sugar-binding protein-dependent msm (multiple sugar metabolism) system of S. mutans was investigated. By determining the ability of unlabeled sugar to compete with radiolabeled melibiose transport, we have demonstrated that the transported sugars included a number of carbohyd...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720100701
更新日期：1993-10-01 00:00:00
abstract：:In this study, the differences in lesion remineralization and fluoride uptake after brushing with a 300 ppm F or a 1000 ppm F dentifrice (as NaF) were investigated. Twenty volunteers with partial dentures in their lower jaws were divided into two groups. Bovine enamel slabs with artificial lesions were mounted in the ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650120601
更新日期：1986-12-01 00:00:00
abstract：:Evaluation of long-term mechanical behavior of new types of restorations in clinical trials is time-consuming. A partial alternative can be found in experimental fatigue-testing, which simulates accelerated mechanical deterioration. The aim of this study was to determine the feasibility of using fatigue-testing of a c...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/00220345920710050301
更新日期：1992-05-01 00:00:00
abstract：:The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors and tyrosine kinases. DDRs regulate cell functions, and their extracellular domains affect collagen fibrillogenesis and mineralization. Based on the collagenous nature of dentoalveolar tissues, we hypothesized that DDR1 plays an importan...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519881136
更新日期：2019-12-01 00:00:00
abstract：:The incisor dentin of hypophosphatemic (Hyp) mice was examined histopathologically to determine whether the multiple occurrences of interglobular dentin would be influenced by the serum phosphate level. Both normal and Hyp mice (12 weeks of age) were divided into two groups. The mice in one group were given a control ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345920710031101
更新日期：1992-03-01 00:00:00
abstract：:Different types of storage media have been studied for use in the replantation of exarticulated teeth. It was found that human periodontal ligament cells survived well in milk. Fifty percent of the cells were viable after 12 hours' storage in milk, while no cells were viable after three hours' storage in saliva. Brief...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600111301
更新日期：1981-11-01 00:00:00
abstract：:The efficacy of a new remineralization system was determined in vivo by maintaining a low concentration of approximately 1 ppm fluoride for 48 hrs against a demineralized human tooth. Human subjects were selected who wore removable partial dentures containing two or more of the demineralized teeth with film system. Th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590030501
更新日期：1980-03-01 00:00:00
abstract：:The goal of the present investigation was to study whether periodic use of fluoride-gel treatments resulted in an increased prevalence of dental fluorosis. 269 children, from 14 to 16 years of age, who had received semi-annual or quarterly fluoride-gel treatments were examined for possible fluoride-induced enamel chan...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640081101
更新日期：1985-08-01 00:00:00
abstract：:The effect of pH on the growth and proteolytic activity of the type strain and fresh isolates of Porphyromonas gingivalis and Bacteroides intermedius was investigated. B. intermedius strains grew with and without glucose at a pH as low as 5.0. These bacteria grew almost as well as Streptococcus mutans at pH 5.0 and be...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690060801
更新日期：1990-06-01 00:00:00
abstract：:The effect of toothbrushes on soft tissue abrasion was measured using hamster cheek pouch tissue brushed mechanically for various intervals. The detection of protein removed during brushing was used as an index of tissue abrasion. The method was found to be sensitive in detecting the effects of brush load, number of s...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560070301
更新日期：1977-07-01 00:00:00
abstract：:Dimensional alterations of the facial bone wall following tooth extractions in the esthetic zone have a profound effect on treatment outcomes. This prospective study in 39 patients is the first to investigate three-dimensional (3D) alterations of facial bone in the esthetic zone during the initial 8 wks following flap...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/0022034513506713
更新日期：2013-12-01 00:00:00
abstract：:Little is known about the oral health of the frail and home-living elderly. The effects of dentogenic infections on the general condition of the elderly are also unknown. We therefore set out to investigate 191 elderly patients referred to an acute geriatric hospital due to sudden worsening of their general health. Th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760060601
更新日期：1997-06-01 00:00:00
