Acetylsalicylic acid treatment improves differentiation and immunomodulation of SHED.

Abstract:

:Stem cells from exfoliated deciduous teeth (SHED) possess multipotent differentiation and immunomodulatory properties. They have been used for orofacial bone regeneration and autoimmune disease treatment. In this study, we show that acetylsalicylic acid (ASA) treatment is able to significantly improve SHED-mediated osteogenic differentiation and immunomodulation. Mechanistically, ASA treatment upregulates the telomerase reverse transcriptase (TERT)/Wnt/β-catenin cascade, leading to improvement of SHED-mediated bone regeneration, and also upregulates TERT/FASL signaling, leading to improvement of SHED-mediated T-cell apoptosis and ameliorating disease phenotypes in dextran sodium sulfate-induced colitis mice. These data indicate that ASA treatment is a practical approach to improving SHED-based cell therapy.

journal_name

J Dent Res

authors

Liu Y,Chen C,Liu S,Liu D,Xu X,Chen X,Shi S

doi

10.1177/0022034514557672

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

209-18

issue

1

eissn

0022-0345

issn

1544-0591

pii

0022034514557672

journal_volume

94

pub_type

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