Abstract:
:Investigators have used chemotherapeutic agents topically for plaque control without knowing the drug concentration necessary to inhibit the growth of odontopathic microorganisms. S mutans, S sanguis, A viscosus and A naeslundii are important components of the plaque flora. The minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC) of niddamycin, vancomycin, bacitracin, and kanamycin were determined for each organism in liquid culture. These antibiotics were selected because of their low absorption from the gastrointestinal tract. Niddamycin, vancomycin, and bacitracin had the lowest MIC, from 0.2 to 10 units/ml. Kanamycin was inhibitory only at much higher concentrations (130 to 500 units/ml). The corresponding MBC was generally higher than the MIC. A viscosus was the most resistant organism tested. These data are important in designing controlled release devices for delivering a suitable antibiotic on a continuous basis intraorally.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Newbrun E,Felton RA,Bulkacz Jdoi
10.1177/00220345760550040401keywords:
subject
Has Abstractpub_date
1976-07-01 00:00:00pages
574-9issue
4eissn
0022-0345issn
1544-0591journal_volume
55pub_type
杂志文章abstract::Dental epithelial progenitor cells differentiate into various cell types during development of tooth germs. To study this mechanism, we produced immortalized dental epithelial progenitor cells derived from the cervical-loop epithelium of a rat lower incisor. The expression patterns of cytokeratin 14, nerve growth fact...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408300209
更新日期:2004-02-01 00:00:00
abstract::Periodontal diseases are initiated by bacteria that accumulate in a biofilm on the tooth surface and affect the adjacent periodontal tissue. Systemic diseases such as diabetes, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) increase susceptibility to destructive periodontal diseases. In human studie...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034518805739
更新日期:2019-02-01 00:00:00
abstract::In this study, environmental stains were removed from maxillofacial elastomers by solvent extraction. Silastic 44210, an RTV silicone with proven color and physical property stability, was stained with lipstick, disclosing solution, and methylene blue. These stains were then removed by solvent extraction with each of ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600100501
更新日期:1981-10-01 00:00:00
abstract::Antigenic alterations to the dentin organic matrix may be detected by an immunohistochemical approach. We hypothesized that alterations in the antigenicity of type I collagen and proteoglycans occur in sclerotic dentin under caries lesions. Transverse sections were prepared from carious teeth in the sclerotic zone and...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608500204
更新日期:2006-02-01 00:00:00
abstract::The tongue exerts crucial functions in our daily life. However, we know very little about the regulatory mechanisms of mammalian tongue development. In this review, we summarize recent findings of the molecular and cellular mechanisms that control tissue-tissue interactions during tongue morphogenesis. Specifically, c...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034511434055
更新日期:2012-06-01 00:00:00
abstract::In cases of pulp exposure due to deep dental caries or severe traumatic injuries, existing pulp-capping materials have a limited ability to reconstruct dentin-pulp complexes and can result in pulpectomy because of their low potentials to accelerate dental pulp cell activities, such as migration, proliferation, and dif...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034516653085
更新日期:2016-10-01 00:00:00
abstract::Mixtures containing two bacterial species were analyzed using flow cytometric techniques. Light scattering characteristics of Streptococcus mutans and Actinomyces viscosus show unique profiles for pure cultures. However, the light scatter analysis of a mixture containing these two species demonstrates overlapping near...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630080501
更新日期:1984-08-01 00:00:00
abstract::In the past two decades, accumulated evidence has clearly demonstrated the inhibitory effects of laser irradiation on enamel demineralization, but the exact mechanisms of these effects remain unclear. The purpose of this study was to investigate the effects of low-energy CO2 laser irradiation on demineralization of bo...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345000790091401
更新日期:2000-09-01 00:00:00
abstract::Interleukin (IL)-23 is an essential cytokine involved in expansion of the Th17 lineage, which is associated with many immune-related destructive tissue diseases. We hypothesized that the IL-23-induced Th17 pathway plays a role in periodontal pathology and examined the expression of cytokines, and related molecules, in...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509339889
更新日期:2009-07-01 00:00:00
abstract::This study demonstrated a correlation between silicon x-ray counts and area fractions of adherent porcelain as determined by point-counting. This correlation has allowed a method to be devised for measuring area fractions of porcelain adherent to porcelain-fused-to-metal (PFM) fracture surfaces. The described method, ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620081801
更新日期:1983-08-01 00:00:00
abstract::Dimensional alterations of the facial bone wall following tooth extractions in the esthetic zone have a profound effect on treatment outcomes. This prospective study in 39 patients is the first to investigate three-dimensional (3D) alterations of facial bone in the esthetic zone during the initial 8 wks following flap...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章
doi:10.1177/0022034513506713
更新日期:2013-12-01 00:00:00
abstract::Urinary catecholamines have been used to measure emotionally stressful states which may affect the development of dental caries. This study investigates the hypothesis that children with and without dental caries do not differ significantly in the mean values of urinary catecholamines such as epinephrine, norepinephri...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345950740100801
更新日期:1995-10-01 00:00:00
abstract::Temporomandibular joint (TMJ) disorders, including degenerative TMJ disease, occur primarily in women of reproductive age. Previous studies showed elevated estrogen levels in subjects with TMJ disorders relative to controls and the presence of estrogen receptors α and β (ERα and ERβ) in TMJ fibrocartilage. Additionall...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034518767108
更新日期:2018-08-01 00:00:00
abstract::The proton probe has been used to map F concentration changes in the enamel of 15 teeth showing clinical evidence of caries. Thin sections through the lesions were microradiographed and measurements made of the surface zone (radiodense) and body (radiolucent) areas. Each section was then scanned with a focused beam of...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345950740111001
更新日期:1995-11-01 00:00:00
abstract::Lingual amylase and lingual lipase, two digestive enzymes that are secreted from lingual serous glands (von Ebner's), were simultaneously purified from rat lingual serous glands with hydrophobic chromatography used as the final step. This method, previously developed for the purification of lingual lipase, includes ho...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680020801
更新日期:1989-02-01 00:00:00
abstract::Dental pulp regeneration therapy for the pulpless tooth has attracted recent attention, and clinical trial studies are underway with the tissue engineering approach. However, there remain many concerns, including the extended period for regenerating the dental pulp. In addition, the use of scaffolds increases the risk...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034518772260
更新日期:2018-09-01 00:00:00
abstract::The cariostatic benefit from water fluoridation is indisputable, but the knowledge of possible adverse effects on bone and fracture risk due to fluoride exposure is ambiguous. The association between long-term (chronic) drinking water fluoride exposure and hip fracture (ICD-7-9: '820' and ICD-10: 'S72.0-S72.2') was as...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513506443
更新日期:2013-11-01 00:00:00
abstract::Adenoviral vectors effectively transfer genes to rat salivary glands. However, potent immune responses limit their use in vivo. Mice offer more opportunities than rats for the study of these immune processes. We first established conditions for infection of mouse salivary glands, with an adenoviral vector. The effects...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345000790020201
更新日期:2000-02-01 00:00:00
abstract::The impact of osteoporosis on implant treatment is still a matter of debate in the scientific community, as it may possibly lead to higher failure rates. As long-term controlled trials are missing, the aim of this study was to verify the long-term outcome of implants placed in patients with systemic osteoporosis. Post...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/0022034518798804
更新日期:2019-01-01 00:00:00
abstract::Molar teeth of four groups of Osborne-Mendel rats, kept on a cariogenic diet, were treated once per day for 48 days with either distilled water (solution C), a solution containing 0.05% chlorhexidine gluconate and 0.04% NaF, pH 5.8 (solution CXF), CXF plus 1000 ppm Sr (solution CXFS), or CXFS plus 1000 ppm Zn (solutio...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630100401
更新日期:1984-10-01 00:00:00
abstract::Patients with restorations cemented with a reinforced zinc oxide-eugenol cement and a zinc phosphate cement were recalled after a four- to seven-year interval. No significant differences in clinical success were observed between restoration luted with the two cements. No significant difference in the incidence of cari...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550022201
更新日期:1976-03-01 00:00:00
abstract:UNLABELLED:Excessive mechanical stress (MS) during hyperocclusion is known to result in disappearance of the alveolar hard line, enlargement of the periodontal ligament (PDL) space, and destruction of alveolar bone, leading to occlusal traumatism. We have recently reported that MS induces predominantly C-C chemokine li...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512467803
更新日期:2013-01-01 00:00:00
abstract::A radiotracer technique was used to study silver and gold diffusion into dental porcelain under experimental conditions close to the real conditions in prosthetic laboratories for porcelain bakes. It was clearly shown that these non-oxidizable elements were able to diffuse into the ceramic as well as oxidizable ones. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660120401
更新日期:1987-12-01 00:00:00
abstract::4-META and new phosphate-methacrylate resins adhere strongly to dental alloys. However, for strengthening the water durability of the adhesive interface, the oxidation of the alloy surface is indispensable. A new oxidation method using ion-sputtering was developed, and the effectiveness of this surface treatment on tw...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670110301
更新日期:1988-11-01 00:00:00
abstract::Biological evaluation procedures for the acceptance of new dental materials include testing for mucous membrane irritation and inflammation, with the hamster cheek pouch used as a model system. Previous reports have indicated both a low 14-day implant retention rate and poor differentiation between positive and negati...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650111801
更新日期:1986-11-01 00:00:00
abstract::To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) status and dental health data obtained from 1,048 children in a 10-year follow-...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514561657
更新日期:2015-02-01 00:00:00
abstract::There is a large variability between and among individuals in the physiology of mastication, but it is not known whether this produces a similar variability in the particle sizes of food boluses at the end of the chewing process. Food boluses obtained just before swallowing were analyzed in ten subjects (aged 36.7 +/-...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章
doi:10.1177/154405910408300713
更新日期:2004-07-01 00:00:00
abstract::Seven oral doses of demethylchlortetracycline were administered to monkeys that received serial injections of lead acetate to intravitally stain calcification sites. Bone growth was greatly inhibited, whereas dentin apposition was spared from the cumulative toxicity of demethylchlortetracycline. Cessation of bone grow...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract::The effects of oral rinses on enamel fluoride uptake, caries, and plaque pH in rats were investigated by use of (1) an acidic calcium phosphate solution (CPS) saturated with dicalcium phosphate dihydrate (DCPD) and (2) a 1% fluoride solution. Osborne-Mendel rats, 19 days of age, were randomly assigned to one of four m...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670061401
更新日期:1988-06-01 00:00:00
abstract::Saliva plays a major role in maintaining oral health. Patients with salivary hypofunction exhibit difficulty in chewing and swallowing foods, tooth decay, periodontal disease, and microbial infections. At this time, treatments for hyposalivation are limited to medications (e.g., muscarinic receptor agonists: pilocarpi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515600157
更新日期:2015-11-01 00:00:00