Susceptibility of some plaque microorganisms to chemotherapeutic agents.

Abstract:

:Investigators have used chemotherapeutic agents topically for plaque control without knowing the drug concentration necessary to inhibit the growth of odontopathic microorganisms. S mutans, S sanguis, A viscosus and A naeslundii are important components of the plaque flora. The minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC) of niddamycin, vancomycin, bacitracin, and kanamycin were determined for each organism in liquid culture. These antibiotics were selected because of their low absorption from the gastrointestinal tract. Niddamycin, vancomycin, and bacitracin had the lowest MIC, from 0.2 to 10 units/ml. Kanamycin was inhibitory only at much higher concentrations (130 to 500 units/ml). The corresponding MBC was generally higher than the MIC. A viscosus was the most resistant organism tested. These data are important in designing controlled release devices for delivering a suitable antibiotic on a continuous basis intraorally.

journal_name

J Dent Res

authors

Newbrun E,Felton RA,Bulkacz J

doi

10.1177/00220345760550040401

keywords:

subject

Has Abstract

pub_date

1976-07-01 00:00:00

pages

574-9

issue

4

eissn

0022-0345

issn

1544-0591

journal_volume

55

pub_type

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