Abstract：
:Interleukin (IL)-23 is an essential cytokine involved in expansion of the Th17 lineage, which is associated with many immune-related destructive tissue diseases. We hypothesized that the IL-23-induced Th17 pathway plays a role in periodontal pathology and examined the expression of cytokines, and related molecules, in periodontal lesions and control sites. IL-23 and IL-12 were expressed at significantly higher levels in periodontal lesions than in control sites. However, the relative expression of the IL-23 receptor compared with the IL-12 receptor beta2 was significantly higher in periodontal lesions. Moreover, IL-17 expression was significantly higher in periodontal lesions, especially in the tissue adjacent to bone destruction, than in control sites. There was no significant difference in the expression levels of IFN-gamma, an important cytokine inhibiting differentiation toward the Th17 pathway, between periodontal lesions and control sites. Together, these results suggest that the IL-23-induced Th17 pathway is stimulated in inflammatory periodontal lesions.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Ohyama H,Kato-Kogoe N,Kuhara A,Nishimura F,Nakasho K,Yamanegi K,Yamada N,Hata M,Yamane J,Terada Ndoi
10.1177/0022034509339889subject
Has Abstractpub_date
2009-07-01 00:00:00pages
633-8issue
7eissn
0022-0345issn
1544-0591pii
0022034509339889journal_volume
88pub_type
杂志文章abstract：:Seven oral doses of demethylchlortetracycline were administered to monkeys that received serial injections of lead acetate to intravitally stain calcification sites. Bone growth was greatly inhibited, whereas dentin apposition was spared from the cumulative toxicity of demethylchlortetracycline. Cessation of bone grow...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：
更新日期：1975-03-01 00:00:00
abstract：:The purpose of this work was to determine the influence of chemical food-simulating liquids on the wear of various commercial dental composite restoratives. In many cases, pre-conditioning the restoratives in these liquids for one week produced swelling of the polymer matrix and considerable surface damage. The result...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640111601
更新日期：1985-11-01 00:00:00
abstract：:This study's objective was to identify, in a statistically valid and efficient manner, the risk factors associated with dental implant failure. We hypothesize that factors exist which can be modified by clinicians to enhance outcome. A retrospective cohort study design was used. Cohort members had >or= one implant pla...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910208100814
更新日期：2002-08-01 00:00:00
abstract：:Restriction endonuclease analysis (REA) was performed on the total cellular DNA from each of 396 strains of mutans streptococci (1) to determine its potential usefulness for the study of transmission of the organism and (2) to document the proportions and variety of strains harbored by members of a small group of fami...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680070401
更新日期：1989-07-01 00:00:00
abstract：:An infrared spectroscopic study has been made of the development of crystallinity (hopeite) in dental zinc phosphate cements. Crystallization in the bulk of a cement is prevented only by the incorporation, in the liquid, of aluminum which forms complexes with phosphoric acid. The development of surface crystallinity i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570021801
更新日期：1978-02-01 00:00:00
abstract：:The aim of this study was to compare the effectiveness of dexamethasone administration following arthrocentesis of the temporomandibular joint (TMJ) with a placebo (saline). Twenty-eight participants with TMJ arthralgia were randomly assigned to two groups of a parallel double-blind RCT. In both groups, an arthrocente...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034511431260
更新日期：2012-02-01 00:00:00
abstract：:Mercury emitted from dental amalgam may select for increased numbers of antibiotic- or mercury-resistant commensal bacteria in patients and increase their risk for bacterial diseases that are resistant to common therapies. We hypothesized that the presence of dental amalgams would increase the level of mercury-, tetra...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/154405910808700502
更新日期：2008-05-01 00:00:00
abstract：:Bifidobacteria are aciduric bacteria that might play a role in the caries process. To test the hypothesis that Bifidobacteria behave as caries-associated organisms, as predicted by the ecological plaque hypothesis, we determined salivary levels of Bifidobacteria and caries-associated organisms for 156 older adults. Sa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510369319
更新日期：2010-09-01 00:00:00
abstract：:Stress-induced changes imparted in a 'dentin-bonded-crown' material during sintering, annealing, pre-cementation surface modification, and resin coating have been visualized by profilometry. The hypothesis tested was that operative techniques modify the stressing pattern throughout the material thickness. We polished ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509354049
更新日期：2010-01-01 00:00:00
abstract：:Direct FA staining for S mutans serotypes may be performed on smears made from plaque or strain isolates and on colonies attached to agar plates of black membrane filters. Staining with single conjugates directed to S mutans serotypes (a to e) as well as with polyvalent a-, b-, d-, f-fluorescein label and c-, e-rhodam...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/002203457605500126011
更新日期：1976-01-01 00:00:00
abstract：:Dimensional alterations of the facial bone wall following tooth extractions in the esthetic zone have a profound effect on treatment outcomes. This prospective study in 39 patients is the first to investigate three-dimensional (3D) alterations of facial bone in the esthetic zone during the initial 8 wks following flap...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/0022034513506713
更新日期：2013-12-01 00:00:00
abstract：:Previously, we reported that the rate (R) of hydroxyapatite dissolution in acetic, lactic, and phosphoric acid solutions is a function of the degree of saturation with respect to the dissolving mineral, DS (defined as the ratio of the mean ionic activity product for hydroxyapatite [Ca5OH(PO4)3] in solution to its solu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780070701
更新日期：1999-07-01 00:00:00
abstract：:A new hydroxyapatite ceramic implant material for restoration of atrophic edentulous ridges was tested in a canine animal model. The structure of this material is unique, in that it is produced from the skeleton of a coral, and in that it is penetrated by a uniform network of interconnected pores. Results indicate tha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620021301
更新日期：1983-02-01 00:00:00
abstract：:Autonomic and behavioral responses to seven dental procedures were studied in 21 pedodontic patients aged six to 12. When mean pulse rate, pulse amplitude, absolute skin conductance, and skin-conductance responses were compared over all subjects, the injection of the local anesthetic consistently elicited the greatest...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620060801
更新日期：1983-06-01 00:00:00
abstract：:The effect of enamel matrix proteins on the seeded growth of enamel apatite crystals was studied in stable supersaturated solutions at pH 7.4 and 37 degrees C. Of the two major protein classes in the enamel matrix, the enamelins were considerably more effective than the amelogenins in retarding seeded growth. However,...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630021801
更新日期：1984-02-01 00:00:00
abstract：:Elemental analysis of two precious alloyceramic systems revealed the accumulation of Sn atoms within the interaction zone of couples subjected to a range of metal oxidation time; and varying total firing times. The source of Sn atoms which accumulated within the interaction zone was the opaque porcelain layer which co...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560090301
更新日期：1977-09-01 00:00:00
abstract：:Multiple interactions occur among major determinants of dental caries. We have studied the bacterial flora and pH-lowering capacity of the same dental plaques in relation to caries. The findings on the plaque flora are reported here. The buccal surfaces of upper teeth in each subject were selected for study. A low-car...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790021201
更新日期：2000-02-01 00:00:00
abstract：:This study investigated the association between caries status and sealant need at a prior survey and subsequent sealant use in a Medicaid program. Clinical data from a 1986-87 statewide epidemiological survey (N = 8026) representative of North Carolina (NC) schoolchildren (grades K-12) were linked with all NC Medicaid...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760120901
更新日期：1997-12-01 00:00:00
abstract：:The use of electric current during the application of etch-and-rinse adhesive systems has been recently claimed to increase bonding of etch-and-rinse adhesives by enhancing substrate impregnation. The null hypothesis tested in this study was that electrically assisted application has no effect on bond strength of self...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608501205
更新日期：2006-12-01 00:00:00
abstract：:The relationship between occlusal stimuli and a hypofunctional periodontal ligament (PDL) structure has been reported, though changes in occlusal recovery conditions were still unclear. Nitric oxide (NO) produced by NO synthase (NOS) is considered a factor for vascular and immune system control, and it increases accor...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300413
更新日期：2004-04-01 00:00:00
abstract：:The periodontium contains heterogeneous mesenchymal cell populations with various differentiation potentials. The capacity of these cells for tissue formation as well as the origin of their precursors are still not entirely defined. In this study, cells originating from different periodontal tissues were cultured in v...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345950740051201
更新日期：1995-05-01 00:00:00
abstract：:Bone remodeling is a complex process regulated by several mediators. Recent work has revealed that cytokines and growth factors have significant effects on bone cell metabolism. However, little information is available concerning the production of cytokines during orthodontic tooth movement in human subjects, and ther...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750010801
更新日期：1996-01-01 00:00:00
abstract：:Significant associations between atherosclerosis and both Porphyromonas gingivalis, a major periodontopathogen, and the respiratory pathogen, Chlamydia pneumoniae, have been shown. Many individuals with evidence of atherosclerosis demonstrate seropositivity to these pathogens. The aim of the present study was to exami...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600105
更新日期：2007-01-01 00:00:00
abstract：:In the past two decades, accumulated evidence has clearly demonstrated the inhibitory effects of laser irradiation on enamel demineralization, but the exact mechanisms of these effects remain unclear. The purpose of this study was to investigate the effects of low-energy CO2 laser irradiation on demineralization of bo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790091401
更新日期：2000-09-01 00:00:00
abstract：:The accelerating activity of N,N-substituted aminoethyl methacrylates on the curing of methyl methacrylate and composite resins with benzoyl peroxide is somewhat smaller than that of dimethyl-p-toluidine. Tesins cured with aminoethyl methacrylates containing a p-tolyl and 3,5-xylyl substituent on the nitrogen atom tur...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540041301
更新日期：1975-07-01 00:00:00
abstract：:Local anesthetic agents may be classified according to their intrinsic anesthetic potency and duration of activity. Procaine and chloroprocaine are relatively weak, short-acting drugs. Lidocaine, mepivacaine, and prilocaine represent agents of intermediate potency and duration of action. Tetracaine, bupivacaine, and e...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600080903
更新日期：1981-08-01 00:00:00
abstract：:Resin composites must be improved if they are to overcome the high failure rates in large stress-bearing posterior restorations. This study aimed to improve wear resistance via nano-silica-fused whiskers. It was hypothesized that nano-silica-fused whiskers would significantly improve composite mechanical properties an...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408301208
更新日期：2004-12-01 00:00:00
abstract：:Using glycoproteins and milk oligosaccharides as substrate acceptors, we demonstrated at least two fucosyltransferases in human parotid saliva. One enzyme transferred L-fucose from GDP-fucose to the C-3 position of N-acetylglucosamine or glucose residue of oligosaccharide chains, and the other transferred to the C-4 p...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620070701
更新日期：1983-07-01 00:00:00
abstract：:Previous findings from studies utilizing human labial and palatine minor salivary glands are reviewed. These studies took histopathological, biochemical, and ultrastructural approaches, and focused on control and diseased glands. Disease-oriented summarization are used, and control results are discussed in the context...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660s108
更新日期：1987-02-01 00:00:00
abstract：:The effect of toothbrushes on soft tissue abrasion was measured using hamster cheek pouch tissue brushed mechanically for various intervals. The detection of protein removed during brushing was used as an index of tissue abrasion. The method was found to be sensitive in detecting the effects of brush load, number of s...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560070301
更新日期：1977-07-01 00:00:00
