Abstract:
:Mercury emitted from dental amalgam may select for increased numbers of antibiotic- or mercury-resistant commensal bacteria in patients and increase their risk for bacterial diseases that are resistant to common therapies. We hypothesized that the presence of dental amalgams would increase the level of mercury-, tetracycline-, ampicillin-, erythromycin-, or chloramphenicol-resistant oral and urinary bacteria as compared with levels in children receiving composite fillings. Samples were collected at baseline, 3-6 months after the initial dental treatment, and annually for 7 years of follow-up. There were no statistically significant differences between treatment groups in the numbers of bacteria growing on antibiotic- or mercury-supplemented plates. This study provided no evidence that amalgam fillings on posterior teeth influenced the level of antibiotic- or mercury-resistant oral or urinary bacteria as detected by culture.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Roberts MC,Leroux BG,Sampson J,Luis HS,Bernardo M,Leitão Jdoi
10.1177/154405910808700502subject
Has Abstractpub_date
2008-05-01 00:00:00pages
475-9issue
5eissn
0022-0345issn
1544-0591pii
87/5/475journal_volume
87pub_type
杂志文章,随机对照试验abstract::There are no prospective studies investigating the effects of sugar-related feeding practices on changes in dental caries from early childhood to young adulthood. The aim of this study was to assess whether sugar-related feeding practices affect dental caries between the ages of 6 and 18 y. This birth cohort study was...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515625907
更新日期:2016-04-01 00:00:00
abstract::Using a pin-on-disc sliding-wear test apparatus, the wear behavior of a typical composite restorative vs. styli fashioned from human enamel, sintered alumina, and magnesium fluoride was examined. The rates of restorative wear were found to be identical, within the experimental error of the measurements, for tests usin...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630062501
更新日期:1984-06-01 00:00:00
abstract::The solubilities of extracellular polysaccharide fractions produced by 14 oral streptococcal strains were compared in water, aqueous lithium and guanidine salt solutions, dimethyl sulfoxide (DMSO), and a 9:1 DMSO-water mixture. The best results for solubilizing the fractions were obtained with the DMSO-water mixture p...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345750540042601
更新日期:1975-07-01 00:00:00
abstract::Gingival overgrowth is a common side-effect of the administration of cyclosporin A (CSA), phenytoin, and calcium blockers. To identify the signaling mechanisms possibly involved in the overgrowth, we examined how CSA affects the activities of MAP kinases and transcription factors in human gingival fibroblasts (HGF). T...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910508400609
更新日期:2005-06-01 00:00:00
abstract::The ability of physiological amounts of lysozyme to de-chain two serotype c strains of Streptococcus mutans was determined. Both human and hen lysozymes were equally effective in chain breakage of S. mutans DPR and S. mutans DJR. De-chaining did not affect growth of cultures, but resulted in finely dispersed suspensio...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640010901
更新日期:1985-01-01 00:00:00
abstract::Better understanding of dental caries and other oral conditions has guided new strategies to prevent disease and manage its consequences at individual and public health levels. This article discusses advances in prevention and minimal intervention dentistry over the last century by focusing on some milestones within s...
journal_title:Journal of dental research
pub_type: 历史文章,杂志文章
doi:10.1177/0022034519837252
更新日期:2019-06-01 00:00:00
abstract::A plaque growth chamber was developed for long-term growth of five separate plaques from the same plaque or saliva sample under identical conditions of temperature and gas phase. Reagent addition and growth conditions for each plaque could be independently controlled, and each was accessible for sequential sampling an...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700110301
更新日期:1991-11-01 00:00:00
abstract::Oxygen inhibits polymerization of resin-based materials. We hypothesized that compromised bonding to bleached enamel can be reversed with sodium ascorbate, an anti-oxidant. Sandblasted human enamel specimens were treated with distilled water (control) and 10% carbamide peroxide gel with or without further treatment wi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910208100709
更新日期:2002-07-01 00:00:00
abstract::The purpose of this work was to determine the influence of chemical food-simulating liquids on the wear of various commercial dental composite restoratives. In many cases, pre-conditioning the restoratives in these liquids for one week produced swelling of the polymer matrix and considerable surface damage. The result...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640111601
更新日期:1985-11-01 00:00:00
abstract::The inhibitory activity of 2-phosphono-butane 1,2,4 tricarboxylic acid (PBTA) in the formation of hydroxyapatite (HA) was studied in vitro and in vivo. PBTA, at 4 ppm, inhibited the spontaneous formation of HA in vitro from a supersaturated solution. PBTA, at 2 ppm, completely inhibited the crystal growth of HA; at lo...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640011201
更新日期:1985-01-01 00:00:00
abstract::Autoimmune responses to heat-shock protein 60 (HSP60) contribute to the progression of atherosclerosis, whereas immunization with HSP60 may induce atheroprotective responses. We assessed the capacity of an atheroprotective vaccine that targeted a recombinant HSP60 from Porphyromonas gingivalis (rGroEL) to induce a pro...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514523784
更新日期:2014-04-01 00:00:00
abstract::With clinical oral examinations not always possible in health surveys, researchers may instead be invited to add questions to a wider health survey. In such situations, an item is needed which adequately represents both clinical and self-reported oral health. This study investigated the clinical validity of Locker's g...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512460676
更新日期:2012-11-01 00:00:00
abstract::The use of electric current during the application of etch-and-rinse adhesive systems has been recently claimed to increase bonding of etch-and-rinse adhesives by enhancing substrate impregnation. The null hypothesis tested in this study was that electrically assisted application has no effect on bond strength of self...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608501205
更新日期:2006-12-01 00:00:00
abstract::Amylase activity in various tissues--i.e., submandibular/sublingual and parotid glands, the pancreas, saliva, and serum--in rats was measured after injection of isoproterenol, pilocarpine, and acetylcholine. All agents reduced amylase activity in the parotid gland and increased the enzyme activity in the submandibular...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620011201
更新日期:1983-01-01 00:00:00
abstract::The antimicrobial and cariostatic activities of the dihydrochloride and dihydrofluoride salts of alexidine (1,6-bis-[2-ethylhexylbiguanido]hexane) were compared to those of chlorhexidine acetate and sodium fluoride in rats implanted orally with Streptococcus mutans 6715 and fed a cariogenic diet. Experimental caries w...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580041901
更新日期:1979-04-01 00:00:00
abstract::Three single-composition, high-copper amalgams were analyzed for the composition of their before- and after-reaction phases. The method used was electron probe microanalysis. The results may be summarized as follows: All alloys consist essentially of Ag3Sn (gamma), Cu3Sn (epsilon), and, in some cases, Ag4Sn (beta). Wh...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630062301
更新日期:1984-06-01 00:00:00
abstract::The purpose of this study was to determine the role of saliva-derived biomarkers and periodontal pathogens during periodontal disease progression (PDP). One hundred human participants were recruited into a 12-month investigation. They were seen bi-monthly for saliva and clinical measures and bi-annually for subtractio...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章
doi:10.1177/0022034511399908
更新日期:2011-06-01 00:00:00
abstract::Dental plaque collected from the label aspect of the anterior dentition of children harbored Neisseria that synthesized an extracellular iodophilic polysaccharide (EIP) from sucrose. Gas chromatograms of fully-acetylated EIP derivatives indicated that glucose (97%) and galactose (3%) were the only monosaccharide const...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345820610050101
更新日期:1982-05-01 00:00:00
abstract::The gingival microbiota in beagle dogs was investigated during a period of 42 days after the placement of continuous wire and arch bar splints. The splints were found to induce an increase in helicoidal-shaped micro-organisms and black-pigmented Bacteroides. Two different asaccharolytic Bacteroides types were isolated...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630110601
更新日期:1984-11-01 00:00:00
abstract::Histone deacetylases (HDACs) are important regulators of gene expression that are aberrantly regulated in several inflammatory and infectious diseases. HDAC inhibitors (HDACi) suppress inflammatory activation of various cell types through epigenetic and non-epigenetic mechanisms, and ameliorate pathology in a mouse mo...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034519885088
更新日期:2020-01-01 00:00:00
abstract::The junctional epithelium (JE) is unique with regard to its wide intercellular spaces and sparsely developed intercellular junctions. Thus, knowledge of the molecular mechanisms that regulate the formation of the intercellular junctions of the junctional epithelium may be essential to understand the pathophysiology of...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515619375
更新日期:2016-03-01 00:00:00
abstract::Mutations and common polymorphisms in interferon regulatory factor 6 ( IRF6) are associated with both syndromic and nonsyndromic forms of cleft lip/palate (CLP). To date, much of the focus on this transcription factor has been on identifying its direct targets and the gene regulatory network in which it operates. Nota...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034517723615
更新日期:2017-10-01 00:00:00
abstract::Streptococcus mutans strain JH1005 is a mutant that produces levels of bacteriocin activity three-fold-elevated than those produced by its parent, JH1001. A single infection regimen with JH1005 was found to result in persistent colonization of the teeth of all three adult subjects tested. This is a significant improve...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660060101
更新日期:1987-06-01 00:00:00
abstract::Previous findings from studies utilizing human labial and palatine minor salivary glands are reviewed. These studies took histopathological, biochemical, and ultrastructural approaches, and focused on control and diseased glands. Disease-oriented summarization are used, and control results are discussed in the context...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660s108
更新日期:1987-02-01 00:00:00
abstract::Conservative techniques for improving the appearance of discolored teeth have become popular in the past decade. These include: in-office bleaching with 30% hydrogen peroxide, which is applied on etched enamel with a gauze pad and then exposed to a bleaching light; home bleaching with a mild form of peroxide, such as ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720011001
更新日期:1993-01-01 00:00:00
abstract::The efficacy of a new remineralization system was determined in vivo by maintaining a low concentration of approximately 1 ppm fluoride for 48 hrs against a demineralized human tooth. Human subjects were selected who wore removable partial dentures containing two or more of the demineralized teeth with film system. Th...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345800590030501
更新日期:1980-03-01 00:00:00
abstract::Since edentate subjects have a reduced masticatory function, it can be expected that the morphology of the cancellous bone of their mandibular condyles has changed according to the altered mechanical environment. In the present study, the morphology of cylindrical cancellous bone specimens of the mandibular condyles o...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408300314
更新日期:2004-03-01 00:00:00
abstract::The amount of free water in 50 samples of air-dried enamel from permanent and deciduous teeth was measured by the Karl Fischer method. Samples included both contemporary and burial specimens. The mean values obtained showed that free water constituted about 1% of enamel mass. However, the range of individual values va...
journal_title:Journal of dental research
pub_type: 历史文章,杂志文章
doi:10.1177/00220345880670051701
更新日期:1988-05-01 00:00:00
abstract::This study contains the first part of a research project in which the applicability of fracture mechanics parameters to predict failure of a restored tooth was investigated. Fracture mechanics parameters have been used in dental research before, but were restricted to comparative studies between various brands of comp...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670060601
更新日期:1988-06-01 00:00:00
abstract::The classic stimulus for cellular cytokine production is bacterial lipopolysaccharide (endotoxin). It was therefore hypothesized that tumor necrosis factor-alpha (TNF-alpha) may be responsible for pericoronitis. TNF-alpha and its receptors were detected by immunohistochemical staining in third molar pericoronitis in t...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910508401216
更新日期:2005-12-01 00:00:00