Abstract:
:Dental epithelial progenitor cells differentiate into various cell types during development of tooth germs. To study this mechanism, we produced immortalized dental epithelial progenitor cells derived from the cervical-loop epithelium of a rat lower incisor. The expression patterns of cytokeratin 14, nerve growth factor receptor p75, amelogenin, Notch2, and alkaline phosphatase were examined by immunohistochemistry in both lower and higher cell densities. The patterns of each were compared in the dental epithelium of rat lower incisors. The results demonstrated that these cells could produce ameloblast lineage cells, stratum intermedium cells, stellate reticulum, and outer enamel epithelium. Furthermore, fibroblast growth factor 10 stimulated proliferation of dental progenitor cells and subsequently increased the number of cells expressing alkaline phosphatase. These results suggest that fibroblast growth factor 10 plays a role in coupling mitogenesis of the cervical-loop cells and the production of stratum intermedium cells in rat incisors.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Kawano S,Saito M,Handa K,Morotomi T,Toyono T,Seta Y,Nakamura N,Uchida T,Toyoshima K,Ohishi M,Harada Hdoi
10.1177/154405910408300209keywords:
subject
Has Abstractpub_date
2004-02-01 00:00:00pages
129-33issue
2eissn
0022-0345issn
1544-0591journal_volume
83pub_type
杂志文章abstract::Growing evidence suggests that individual genetic susceptibility may influence the host's response to infections. The aim of this project was to study whether gene polymorphisms of inflammatory markers are associated with the presence of viable periodontopathogenic bacteria. We extracted genomic DNA from 45 young adul...
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