Abstract：
:The authors tested the hypothesis that obstructive sleep apnea (OSA) signs/symptoms are associated with the occurrence of temporomandibular disorder (TMD), using the OPPERA prospective cohort study of adults aged 18 to 44 years at enrollment (n = 2,604) and the OPPERA case-control study of chronic TMD (n = 1,716). In both the OPPERA cohort and case-control studies, TMD was examiner determined according to established research diagnostic criteria. People were considered to have high likelihood of OSA if they reported a history of sleep apnea or ≥ 2 hallmarks of OSA: loud snoring, daytime sleepiness, witnessed apnea, and hypertension. Cox proportional hazards regression estimated hazard ratios (HRs) and 95% confidence limits (CL) for first-onset TMD. Logistic regression estimated odds ratios (OR) and 95% CL for chronic TMD. In the cohort, 248 individuals developed first-onset TMD during the median 2.8-year follow-up. High likelihood of OSA was associated with greater incidence of first-onset TMD (adjusted HR = 1.73; 95% CL, 1.14, 2.62). In the case-control study, high likelihood of OSA was associated with higher odds of chronic TMD (adjusted OR = 3.63; 95% CL, 2.03, 6.52). Both studies supported a significant association of OSA symptoms and TMD, with prospective cohort evidence finding that OSA symptoms preceded first-onset TMD.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Sanders AE,Essick GK,Fillingim R,Knott C,Ohrbach R,Greenspan JD,Diatchenko L,Maixner W,Dubner R,Bair E,Miller VE,Slade GDdoi
10.1177/0022034513488140subject
Has Abstractpub_date
2013-07-01 00:00:00pages
70S-7Sissue
7 Suppleissn
0022-0345issn
1544-0591pii
0022034513488140journal_volume
92pub_type
杂志文章abstract：:Periodontal inflammation and alveolar bone remodeling during orthodontic tooth movement are considered regional reactions. However, how systemic immune responses are involved in this regional reaction remains unclear. In this study, we explored the systemic effects of orthodontic force by focusing on the mononuclear p...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515592868
更新日期：2015-09-01 00:00:00
abstract：:We evaluated the histopathological response of the periodontal membrane to intentionally-replanted teeth carrying composite (experimental) and silver amalgam (control) restorations in the middle third of each root. The study revealed that the amalgam produced, in the periodontal tissues, an initial localized inflammat...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620011801
更新日期：1983-01-01 00:00:00
abstract：:Adenoviral vectors effectively transfer genes to rat salivary glands. However, potent immune responses limit their use in vivo. Mice offer more opportunities than rats for the study of these immune processes. We first established conditions for infection of mouse salivary glands, with an adenoviral vector. The effects...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790020201
更新日期：2000-02-01 00:00:00
abstract：:This case-control study evaluated the association of headache and other co-morbid pain with temporomandibular disorder (TMD) pain in adolescents and explored the temporal co-variance of headache and TMD pain. In a population-based sample of 12- to 19-year-olds, 350 patients with self-reported TMD pain and 350 healthy ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513496255
更新日期：2013-09-01 00:00:00
abstract：:The human temporalis and masseter muscles are not activated homogeneously during static bite force tasks. In this study, we studied the possible existence of regional differences in these muscles under dynamic conditions. Electromyographic (EMG) activity was recorded by means of bipolar fine-wire electrodes. Six elect...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345950740061201
更新日期：1995-06-01 00:00:00
abstract：:Wall-to-wall (WTW) polymerization contraction of filled and unfilled chemically and photo-initiated resins was studied in relation to the WTW distance. In an experimental set-up, the resins were bonded to two opposing disks, and the axial (WTW) displacement resulting from the polymerization shrinkage was measured cont...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680010701
更新日期：1989-01-01 00:00:00
abstract：UNLABELLED:We have previously shown that the resin monomer 2-hydroxyethylmethacrylate (HEMA) affects mouse B-lymphocyte activity, leading to increased IgG1 antibody production in vivo. In the present study, we tested, in vitro, the hypothesis that HEMA also affects human B-lymphocyte activity. The in vitro production o...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510378522
更新日期：2010-12-01 00:00:00
abstract：:A method of articulator comparison and a technique demonstrating the effects of three occlusal determinants were demonstrated and proved successful. The techniques used could be used in dental research circumstances and in dental schools as a means to study the determinants of occlusion. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550060601
更新日期：1976-11-01 00:00:00
abstract：:Teeth undergo postnatal organogenesis relatively late in life and only complete full maturation a few years after the crown first erupts in the oral cavity. At this stage, development can be arrested if the tooth organ is damaged by either trauma or caries. Regenerative endodontic procedures (REPs) are a treatment alt...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517693606
更新日期：2017-06-01 00:00:00
abstract：:Inorganic polyphosphate [Poly(P)] is especially prevalent in osteoblasts. We tested the hypothesis that Poly(P) stimulates osteoblastic differentiation and polyphosphate metabolism for bone formation. The osteoblast-like cell line, MC 3T3-E1, was cultured with Poly(P), and gene expression was evaluated by real-time re...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510363096
更新日期：2010-05-01 00:00:00
abstract：:Molar teeth of four groups of Osborne-Mendel rats, kept on a cariogenic diet, were treated once per day for 48 days with either distilled water (solution C), a solution containing 0.05% chlorhexidine gluconate and 0.04% NaF, pH 5.8 (solution CXF), CXF plus 1000 ppm Sr (solution CXFS), or CXFS plus 1000 ppm Zn (solutio...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630100401
更新日期：1984-10-01 00:00:00
abstract：:Defined sets of transcriptional factors can reprogram human somatic cells to induced pluripotent stem (iPS) cells. However, many types of human cells are not easily accessible to minimally invasive procedures. Here we evaluated dental pulp cells (DPCs) as an optimal source of iPS cells, since they are easily obtained ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510366846
更新日期：2010-08-01 00:00:00
abstract：:Changes in stimulated and non-stimulated whole saliva flow rates were measured in 11 Hodgkin's disease patients who received therapeutic doses of radiation to a mantle field at the M. D. Anderson Hospital in Houston, Texas. Salivary flow rates were examined before, during, and after radiotherapy. Mean flow rate reduct...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670021801
更新日期：1988-02-01 00:00:00
abstract：:Lysis of cell wall preparations from strains representing serotypes a - g of Streptococcus mutans has provided a convenient and efficient means of obtaining the typing antigens in a soluble undegraded form, and has demonstrated that, in each case, the antigen is a cell wall component in the strict sense of a component...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620100401
更新日期：1983-10-01 00:00:00
abstract：:Significant differences exist between human and Macaca fascicularis patterns of mandibular movement during mastication. Macaque patterns display less asymmetry, more uniformity, and limited lateral excursions when compared to humans for mastication of the same food. Different anatomical structures between the two spec...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570071301
更新日期：1978-07-01 00:00:00
abstract：:Caregivers' health literacy has emerged as an important determinant of young children's health care and outcomes. We examined the hypothesis that caregivers' health literacy influences children's oral-health-care-related expenditures. This was a prospective cohort study of 1,132 child/caregiver dyads (children's mean ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513484335
更新日期：2013-07-01 00:00:00
abstract：:Laser-Raman spectra of synthetic apatites containing from zero to 12.4 wt% carbonate ions and enamel apatite are reported. Special attention is paid to the correlation between the intensities of the carbonate, phosphate, and hydroxyl modes and the carbonate content in the apatites. The data presented here indicate tha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600031601
更新日期：1981-03-01 00:00:00
abstract：:The regulation of blood flow of the dental pulp was investigated in dogs and rats anesthetized with sodium pentobarbital. Pulpal blood flow was altered by variations of local and systemic hemodynamics. Variation in pulpal hemodynamics was attained by means of close intra-arterial injections of adrenergic agonists (NE ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/002203458506400415
更新日期：1985-04-01 00:00:00
abstract：:During the maintenance of bone marrow-derived mesenchymal stem cells (BMMSCs), suspended cells are discarded normally. We noted the osteogenic potential of these cells to be like that of anchorage-dependent BMMSCs. Therefore, we characterized suspended BMMSCs from rabbit bone marrow by bioengineering and applied the s...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514548706
更新日期：2014-10-01 00:00:00
abstract：:Oral bacteria, including Streptococcus mutans and Streptococcus salivarius, contribute to tooth decay and plaque formation; therefore, it is essential to develop strategies to prevent dental caries and plaque formation. We recently showed that organo-selenium compounds covalently attached to different biomaterials inh...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513482141
更新日期：2013-05-01 00:00:00
abstract：:Data from the actual private practices of two dentists were compared with respective data from the participation of the same two dentists in a laboratory model of private practice conducted in the University of North Carolina Dental Research Center. The findings show that a laboratory model can be established which ac...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540032501
更新日期：1975-05-01 00:00:00
abstract：:A previously reported technique for staining areas of degradation in dental composite restorations was evaluated in 51 removed restorations. The staining reagent was silver nitrate, which penetrated the degraded subsurface as ionic silver and was subsequently developed into colored deposits of metallic silver. Several...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700031201
更新日期：1991-03-01 00:00:00
abstract：:To identify salivary biomarkers of periodontal diseases, we used plaque-resistant and -susceptible rats as animal models. The levels of salivary cystatin S in saliva, salivary glands, and gingiva were tested in Nembutal-anesthetized young and adult plaque-resistant and -susceptible rats of both sexes with and without ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770110801
更新日期：1998-11-01 00:00:00
abstract：:Rat parotid secretory granule membranes were examined for the presence of calcium-dependent protein kinase activities and kinase substrates. Protein kinase C (C-kinase), which is stimulated by certain phospholipids, was present in the membranes, as indicated by its ability to catalyze the phosphorylation of histone. T...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660022901
更新日期：1987-02-01 00:00:00
abstract：:Temporomandibular joint (TMJ) disorders, including degenerative TMJ disease, occur primarily in women of reproductive age. Previous studies showed elevated estrogen levels in subjects with TMJ disorders relative to controls and the presence of estrogen receptors α and β (ERα and ERβ) in TMJ fibrocartilage. Additionall...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518767108
更新日期：2018-08-01 00:00:00
abstract：:Phosphatases are involved in bone and tooth mineralization, but their mechanisms of action are not completely understood. Tissue-nonspecific alkaline phosphatase (TNAP, ALPL) regulates inhibitory extracellular pyrophosphate through its pyrophosphatase activity to control mineral propagation in the matrix; mice without...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513490958
更新日期：2013-08-01 00:00:00
abstract：:The accumulated posteruptive tooth age was calculated for 212 children with Down's syndrome and 124 of their unaffected sibs. Posteruptive tooth age was shown to vary widely with different morphological permanent tooth types at the same chronological age. Girls in both groups had greater accumulated posteruptive tooth...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540033001
更新日期：1975-05-01 00:00:00
abstract：:Periodontal data typically consist of observations made at multiple sites within each patient. Observations within a patient tend to be positively correlated; hence, standard statistical techniques that assume independence are invalid. Regression techniques for correlated data have been proposed; communicating results...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200705
更新日期：2003-07-01 00:00:00
abstract：:Previous findings from studies utilizing human labial and palatine minor salivary glands are reviewed. These studies took histopathological, biochemical, and ultrastructural approaches, and focused on control and diseased glands. Disease-oriented summarization are used, and control results are discussed in the context...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660s108
更新日期：1987-02-01 00:00:00
abstract：:In the past two decades, accumulated evidence has clearly demonstrated the inhibitory effects of laser irradiation on enamel demineralization, but the exact mechanisms of these effects remain unclear. The purpose of this study was to investigate the effects of low-energy CO2 laser irradiation on demineralization of bo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790091401
更新日期：2000-09-01 00:00:00
