Flagellin-PAc fusion protein is a high-efficacy anti-caries mucosal vaccine.

abstract：:Insulin resistance is one of the critical pathogeneses of type 2 diabetes mellitus (T2DM). Elevated levels of plasma branched-chain amino acids (BCAAs) are associated with insulin resistance. Recent studies have demonstrated the role of Porphyromonas gingivalis in the development of insulin resistance. However, the me...

journal_title：Journal of dental research

authors： Tian J,Liu C,Zheng X,Jia X,Peng X,Yang R,Zhou X,Xu X

更新日期：2020-07-01 00:00:00

abstract：:Morphogenesis (germ-tube formation) in Candida albicans was induced gratuitously by N-acetylhexosamine derivatives (N-acetyl-glucosamine covalently linked to agarose, N-acetylmannosamine, hyaluronic acid, colloidal chitin, and mucin). These compounds were not taken up by the yeast cells and did not support growth. 2-D...

journal_title：Journal of dental research

authors： Shepherd MG,Sullivan PA

更新日期：1984-03-01 00:00:00

abstract：:A full understanding of the key regulators controlling periodontal development and homeostasis is necessary for the design of improved periodontal regenerative therapies. Small leucine-rich proteoglycans (SLRPs) are extracellular matrix molecules suggested to regulate collagen organization and cell signaling. Mice wit...

journal_title：Journal of dental research

authors： Wang L,Foster BL,Kram V,Nociti FH Jr,Zerfas PM,Tran AB,Young MF,Somerman MJ

更新日期：2014-08-01 00:00:00

abstract：:Recent evidence implicates endothelin in nociception, but it is unclear how endothelin activates trigeminal ganglion (TRG) neurons. In the present study, we investigated the expression of the endothelin receptors ETA and ETB and endothelin-induced responses in rat TRG neurons. Double-immunofluorescence studies demonst...

journal_title：Journal of dental research

authors： Yamamoto T,Ono K,Hitomi S,Harano N,Sago T,Yoshida M,Nunomaki M,Shiiba S,Watanabe S,Nakanishi O,Inenaga K

更新日期：2013-04-01 00:00:00

abstract：:Vitamin D, an anti-inflammatory mediator, has potential benefits for physical and oral health. Although it is produced endogenously, some individuals have a greater need for dietary and supplemental sources. This repeated-measures cross-sectional study assessed associations between total vitamin D intake and periodont...

journal_title：Journal of dental research

authors： Alshouibi EN,Kaye EK,Cabral HJ,Leone CW,Garcia RI

更新日期：2013-08-01 00:00:00

abstract：:The treatment of periodontitis/peri-implantitis involves the reduction/eradication of periopathogens. After therapy, beneficial and pathogenic species recolonize the subgingival area. The dynamics of recolonization and especially the role of the supragingival environment in this process are still not well-understood. ...

journal_title：Journal of dental research

authors： Quirynen M,Vogels R,Pauwels M,Haffajee AD,Socransky SS,Uzel NG,van Steenberghe D

更新日期：2005-04-01 00:00:00

abstract：:Defects in the enamelin gene (ENAM) cause amelogenesis imperfecta (AI). Our objective was to identify the genetic etiology of enamel hypoplasia in a Caucasian proband. Our hypothesis was that ENAM was defective. The proband and his father have an AG insertion (g.13185_13186insAG; p.422FsX448) in ENAM previously identi...

journal_title：Journal of dental research

authors： Chan HC,Mai L,Oikonomopoulou A,Chan HL,Richardson AS,Wang SK,Simmer JP,Hu JC

更新日期：2010-07-01 00:00:00

abstract：:Biological mediators have been used to enhance periodontal regeneration. The aim of this prospective randomized controlled study was to evaluate the safety and effectiveness of 3 doses of fibroblast growth factor 2 (FGF-2) when combined with a β-tricalcium phosphate (β-TCP) scaffold carrier placed in vertical infrabon...

journal_title：Journal of dental research

authors： Cochran DL,Oh TJ,Mills MP,Clem DS,McClain PK,Schallhorn RA,McGuire MK,Scheyer ET,Giannobile WV,Reddy MS,Abou-Arraj RV,Vassilopoulos PJ,Genco RJ,Geurs NC,Takemura A

更新日期：2016-05-01 00:00:00

abstract：:In an attempt to make a dynamic study of the isoelectric point and the chargeability of human dental enamel, an electrochemical approach was utilized. Zeta potential of three kinds of the enamel was measured by a streaming potential method. As a result, these isoelectric points could be decided. ...

journal_title：Journal of dental research

authors： Kambara M,Asai T,Kumasaki M,Konishi K

更新日期：1978-02-01 00:00:00

abstract：:Improved mechanical properties of resin composites have been reported to be a consequence of the addition of aldehyde to the resins. The objective of the present study was to examine whether this improvement could be attributed to an increased degree of conversion of double bonds. For this purpose, propanal was added ...

journal_title：Journal of dental research

authors： Peutzfeldt A

更新日期：1994-10-01 00:00:00

abstract：:A plaque growth chamber was developed for long-term growth of five separate plaques from the same plaque or saliva sample under identical conditions of temperature and gas phase. Reagent addition and growth conditions for each plaque could be independently controlled, and each was accessible for sequential sampling an...

journal_title：Journal of dental research

authors： Sissons CH,Cutress TW,Hoffman MP,Wakefield JS

更新日期：1991-11-01 00:00:00

abstract：:Human tooth wear occurs so slowly that traditionally it has needed months or years to be measurable. This study showed that microscopic changes in wear patterns on human teeth could be detected in a matter of days and could be used as indicators of rates of wear. Thus, daily or weekly changes in rates of wear can be d...

journal_title：Journal of dental research

authors： Teaford MF,Tylenda CA

更新日期：1991-03-01 00:00:00

abstract：:The role of Streptococcus mutans in the initiation of dental caries has been recognized and attributed, at least in part, to its ability to colonize the tooth surface. Therefore, factors which prevent S. mutans attachment to hydroxyapatite (HA) are of considerable interest for the prophylaxis of this infectious diseas...

journal_title：Journal of dental research

authors： Tarsi R,Muzzarelli RA,Guzmán CA,Pruzzo C

更新日期：1997-02-01 00:00:00

abstract：:Stress analyses are presented for a second mandibular premolar with a class 1 amalgam restoration. The effects of amalgam setting and thermal expansions are examined. An axisymmetric representation of the structure is used and the analyses are carried out by the finite element method. Lined and unlined restorations ar...

journal_title：Journal of dental research

authors： Wright KW,Yettram AL

更新日期：1978-05-01 00:00:00

abstract：:The human mandibular condyle has a parasagittal plate-like trabecular structure. We tested the hypothesis that this structure reflects the mechanical loading of the condyle. We developed a finite element model of the condyle to analyze the strains occurring during static compressive loading. The principal strains in t...

journal_title：Journal of dental research

authors： van Ruijven LJ,Giesen EB,van Eijden TM

更新日期：2002-10-01 00:00:00

abstract：:Spontaneously occurring bacteriophage-resistant mutants of Actinomyces viscosus were isolated. The mutants exhibited altered coaggregation patterns with streptococci. From analysis of the data, it appears that a cell surface structure on A. viscosus may function both as a phage receptor and as a binding site for co-ag...

journal_title：Journal of dental research

authors： Tylenda CA,Kolenbrander PE,Delisle AL

更新日期：1983-11-01 00:00:00

abstract：:Smoking is a major risk of periodontal diseases. At the site of first contact, the gingiva is exposed to aromatic amines and polycyclic hydrocarbons. These are metabolized by the N-acetyltransferases (NAT), leading to local detoxification and/or activation reactions contributing to the risk of periodontal destruction ...

journal_title：Journal of dental research

authors： Meisel P,Giebel J,Peters M,Foerster K,Cascorbi I,Wulff K,Fanghaenel J,Kocher T

更新日期：2002-05-01 00:00:00

abstract：:The kinetics of subsurface demineralization of tooth sections has been studied in real-time by scanning microradiography (SMR). Demineralization was carried out: (1) with a large volume of solution buffered to pH = 4 to maintain a constant composition; and (2) in a small constant volume (approximately 3 mL), buffered ...

journal_title：Journal of dental research

authors： Gao XJ,Elliott JC,Anderson P

更新日期：1993-05-01 00:00:00

abstract：:This study describes the formation of a calcium polyacrylate-hydroxyapatite cement. Our hypothesis was that calcium phosphates would rapidly hydrolyze in the presence of polyacrylic acid (PAA) to form a cement. PAA, tetracalcium phosphate (TetCP), and dicalcium phosphate (DCP) were reacted together and formed calcium ...

journal_title：Journal of dental research

authors： TenHuisen KS,Brown PW

更新日期：1994-03-01 00:00:00

abstract：:We report a clinical study that examines whether HIV infection affects Streptococcus mutans colonization in the oral cavity. Whole stimulated saliva samples were collected from 46 HIV-seropositive individuals and 69 HIV-seronegative control individuals. The level of S. mutans colonization was determined by conventiona...

journal_title：Journal of dental research

authors： Liu G,Saxena D,Chen Z,Norman RG,Phelan JA,Laverty M,Fisch GS,Corby PM,Abrams W,Malamud D,Li Y

更新日期：2012-09-01 00:00:00

abstract：:Although proanthocyanidins (PACs) modify dentin, the effectiveness of different PAC sources and the correlation with their specific chemical composition are still unknown. This study describes the chemical profiling of natural PAC-rich extracts from 7 plants using ultra high pressure/performance liquid chromatography ...

journal_title：Journal of dental research

authors： Aguiar TR,Vidal CM,Phansalkar RS,Todorova I,Napolitano JG,McAlpine JB,Chen SN,Pauli GF,Bedran-Russo AK

更新日期：2014-04-01 00:00:00

abstract：:A frameshift mutation recently identified within the paired domain of the transcription factor, PAX9, has been linked to a unique form of oligodontia in a single, multigenerational family (Stockton et al., 2000). We now describe the phenotypic and segregation analyses of this remarkable kindred, the initial approach t...

journal_title：Journal of dental research

authors： Goldenberg M,Das P,Messersmith M,Stockton DW,Patel PI,D'Souza RN

更新日期：2000-07-01 00:00:00

abstract：:Previous studies have indicated that tooth-bleaching agents contain potentially hazardous chemicals. The present study evaluates the acute toxicity of a commercially available tooth-bleaching agent and carbamide peroxide, which is the active bleaching ingredient. Rats were dosed by stomach gavage, i.e., via a stomach ...

journal_title：Journal of dental research

authors： Dahl JE,Becher R

更新日期：1995-02-01 00:00:00

abstract：:Bisphosphonates are a class of agents used to treat osteoporosis and malignant bone metastases. The efficacy of these agents in treating and preventing the significant skeletal complications associated with these conditions has had a major positive impact for patients and is responsible for their widespread use in med...

journal_title：Journal of dental research

authors： Ruggiero SL,Drew SJ

更新日期：2007-11-01 00:00:00

abstract：:The effect of chronic fluoride (F) exposure from the drinking water on parameters related to glucose homeostasis was investigated. Wistar rats were randomly distributed into 2 groups (diabetic [D] and nondiabetic [ND]; n = 54 each). In D, diabetes was induced with streptozotocin. Each group was further divided into 3 ...

journal_title：Journal of dental research

authors： Lobo JG,Leite AL,Pereira HA,Fernandes MS,Peres-Buzalaf C,Sumida DH,Rigalli A,Buzalaf MA

更新日期：2015-07-01 00:00:00

abstract：:Streptococcus mutans strain JH1005 is a mutant that produces levels of bacteriocin activity three-fold-elevated than those produced by its parent, JH1001. A single infection regimen with JH1005 was found to result in persistent colonization of the teeth of all three adult subjects tested. This is a significant improve...

journal_title：Journal of dental research

authors： Hillman JD,Dzuback AL,Andrews SW

更新日期：1987-06-01 00:00:00

abstract：:Amelogenin and ameloblastin, the major enamel matrix proteins, are important for enamel mineralization. To identify their synergistic roles in enamel development, we generated Amel X(-/-)/Ambn(-/-) mice. These mice showed additional enamel defects in comparison with Amel X(-/-) or Ambn(-/-) mice. In 7-day-old Amel X(-...

journal_title：Journal of dental research

authors： Hatakeyama J,Fukumoto S,Nakamura T,Haruyama N,Suzuki S,Hatakeyama Y,Shum L,Gibson CW,Yamada Y,Kulkarni AB

更新日期：2009-04-01 00:00:00

abstract：:Conventional analyses of the cost-effectiveness of preventive regimens fail to account for the impact of attrition on reported costs. Using an economic model in which costs are allocated to fixed and variable components, and data from a recently completed clinical field trial, costs per participant are shown to vary w...

journal_title：Journal of dental research

authors： Doherty NJ

更新日期：1982-05-01 00:00:00

abstract：:Dentin sialoprotein (DSP) and dentin phosphoprotein (DPP) are expressed as a single mRNA transcript coding for a large precursor protein termed dentin sialophosphoprotein (DSPP). DSP, DPP, and DSPP have been considered to be tooth-specific. To test for the expression of the dspp gene in bone, we performed Western immu...

journal_title：Journal of dental research

authors： Qin C,Brunn JC,Cadena E,Ridall A,Tsujigiwa H,Nagatsuka H,Nagai N,Butler WT

更新日期：2002-06-01 00:00:00

abstract：:Previously, we reported that the rate (R) of hydroxyapatite dissolution in acetic, lactic, and phosphoric acid solutions is a function of the degree of saturation with respect to the dissolving mineral, DS (defined as the ratio of the mean ionic activity product for hydroxyapatite [Ca5OH(PO4)3] in solution to its solu...

journal_title：Journal of dental research

authors： Margolis HC,Zhang YP,Lee CY,Kent RL Jr,Moreno EC

更新日期：1999-07-01 00:00:00