Abstract:
:We report a clinical study that examines whether HIV infection affects Streptococcus mutans colonization in the oral cavity. Whole stimulated saliva samples were collected from 46 HIV-seropositive individuals and 69 HIV-seronegative control individuals. The level of S. mutans colonization was determined by conventional culture methods. The genotype of S. mutans was compared between 10 HIV-positive individuals before and after highly active antiretroviral therapy (HAART) and 10 non-HIV-infected control individuals. The results were analyzed against viral load, CD4+ and CD8+ T-cell counts, salivary flow rate, and caries status. We observed that S. mutans levels were higher in HIV-infected individuals than in the non-HIV-infected control individuals (p = 0.013). No significant differences in S. mutans genotypes were found between the two groups over the six-month study period, even after HAART. There was a bivariate linear relationship between S. mutans levels and CD8+ counts (r = 0.412; p = 0.007), but not between S. mutans levels and either CD4+ counts or viral load. Furthermore, compared with non-HIV-infected control individuals, HIV-infected individuals experienced lower salivary secretion (p = 0.009) and a positive trend toward more decayed tooth surfaces (p = 0.027). These findings suggest that HIV infection can have a significant effect on the level of S. mutans, but not genotypes.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Liu G,Saxena D,Chen Z,Norman RG,Phelan JA,Laverty M,Fisch GS,Corby PM,Abrams W,Malamud D,Li Ydoi
10.1177/0022034512454298subject
Has Abstractpub_date
2012-09-01 00:00:00pages
834-40issue
9eissn
0022-0345issn
1544-0591pii
0022034512454298journal_volume
91pub_type
杂志文章abstract::Ten dental casting alloys were tested for alloy-element release into cell-culture medium, and this release was related to alloy composition, alloy microstructure, and alloy cytotoxicity (previously determined). Cell-culture medium was analyzed for alloy elements by flame atomic absorption. Concentrations of elements i...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700060301
更新日期:1991-06-01 00:00:00
abstract::An oral radiotelemetric technique was used to determine whether a range of efficient buffers had the capacity to control the levels of hydrogen ions within dental plaque in the presence of sucrose. It was found that the buffers failed to control both the intensity and duration of the acid produced. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550052601
更新日期:1976-09-01 00:00:00
abstract::Various etching methods are examined with respect to their ability to induce the surface nucleation and growth of fluorapatite from solutions of low, sustained supersaturation with respect to hydroxyapatite and fluorapatite. The constant composition kinetics method enables the rates of remineralization to be precisely...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345820610091301
更新日期:1982-09-01 00:00:00
abstract::Blood cortisol levels of oral surgery patients were analyzed to objectively determine the effect of intravenous sedation on surgical stress. Results showed a measure of sedation but did not adequately reflect the stress of oral surgery or the changes produced by intravenous sedation. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345750540053501
更新日期:1975-09-01 00:00:00
abstract::Dental plaque collected from the label aspect of the anterior dentition of children harbored Neisseria that synthesized an extracellular iodophilic polysaccharide (EIP) from sucrose. Gas chromatograms of fully-acetylated EIP derivatives indicated that glucose (97%) and galactose (3%) were the only monosaccharide const...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345820610050101
更新日期:1982-05-01 00:00:00
abstract::Studies have shown that prevention of mutans streptococci (MS) colonization in early childhood can lead to prevention of dental decay. In the microbiological part of the present study in Ylivieska, Finland, with 195 mothers with high salivary MS levels, regular maternal use of xylitol chewing gum resulted in a statist...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/00220345000790111201
更新日期:2000-11-01 00:00:00
abstract::The intent of this article is to review the numerous factors that affect the mechanical properties of particle- or fiber-filler-containing indirect dental resin composite materials. The focus will be on the effects of degradation due to aging in different media, mainly water and water and ethanol, cyclic loading, and ...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/154405910808700802
更新日期:2008-08-01 00:00:00
abstract::Auto-degradation of collagen matrices occurs within hybrid layers created by contemporary dentin bonding systems, by the slow action of host-derived matrix metalloproteinases (MMPs). This study tested the null hypothesis that there are no differences in the activities of MMP-2 and -9 after treatment with different etc...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512467034
更新日期:2013-01-01 00:00:00
abstract::To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) status and dental health data obtained from 1,048 children in a 10-year follow-...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514561657
更新日期:2015-02-01 00:00:00
abstract::Adhesion of epithelium to the extracellular matrix is crucial for the maintenance of systemic and oral health. In the oral cavity, teeth or artificial dental implants penetrate the soft tissue of the gingiva. In this interface, gingival soft tissue needs to be well attached via the epithelial seal to the tooth or impl...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034511402207
更新日期:2011-12-01 00:00:00
abstract::For practical reasons, evaluation of topical fluoride products must depend upon clinical and laboratory assessments. While not always a good predictor of clinical efficacy by itself, fluoride uptake is the most commonly used laboratory test. A consideration of the relationship between possible anticaries mechanisms of...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/00220345900690S149
更新日期:1990-02-01 00:00:00
abstract::Although it has been shown that patients are more satisfied with prostheses supported by implants than with conventional dentures, there have been few direct comparisons of the various designs of implant-supported prostheses. This within-subject crossover clinical trial was designed to compare two forms of removable p...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章
doi:10.1177/00220345970760100901
更新日期:1997-10-01 00:00:00
abstract::Teeth to be extracted for orthodontic reasons were filled in vivo with regular and fine-cut silver amalgams containing 1% and 5% SnF2. The teeth were extracted after 15 or 30 d, and the in vivo fluoride release and uptake by the dental tissues were studied using an electron microprobe analysis technique. The obtained ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600020101
更新日期:1981-02-01 00:00:00
abstract::The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts and cementoblasts. We hypothesized that stem cells may be present in the DF and be capable of differentiating into cells of the periodontium. Stem cells ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808700801
更新日期:2008-08-01 00:00:00
abstract::Selected reference and freshly isolated strains of Streptococcus mitis (mitior) and Streptococcus sanguis were assayed for cell-associated neuraminidase activity by their ability to hydrolyze [3H-] sialyllactitol. A cell-associated neuraminidase was detected with S. mitis and S. sanguis serotype II (reclassified as S....
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630020201
更新日期:1984-02-01 00:00:00
abstract::IL-18 is a pro-inflammatory cytokine that is important in the regulation of T-cells and is elevated in inflammatory disorders such as periodontal disease. Vasoactive intestinal peptide (VIP) modulates immune responses to the periodontal pathogen Porphyromonas gingivalis (Pg). Our objective was to investigate the effec...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708600915
更新日期:2007-09-01 00:00:00
abstract::Selected strains of oral Streptococcus and Actinomyces have been tested for their ability to grow in the presence of mercury. Strains were tested for growth on a semi-defined medium with low mercury-binding characteristics. Sensitivities were initially measured on agar plates, and subsequently, selected strains were g...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720091201
更新日期:1993-09-01 00:00:00
abstract::Defects in the enamelin gene (ENAM) cause amelogenesis imperfecta (AI). Our objective was to identify the genetic etiology of enamel hypoplasia in a Caucasian proband. Our hypothesis was that ENAM was defective. The proband and his father have an AG insertion (g.13185_13186insAG; p.422FsX448) in ENAM previously identi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510365662
更新日期:2010-07-01 00:00:00
abstract::We have previously reported the clinical and radiographic findings of a trial in dogs of a new dental implant system after a functional period of eight months. The present report consists of the corresponding qualitative and quantitative histological data. The implant system was fabricated from Ti-6A1-4V and employed ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670090801
更新日期:1988-09-01 00:00:00
abstract::Dental epithelial progenitor cells differentiate into various cell types during development of tooth germs. To study this mechanism, we produced immortalized dental epithelial progenitor cells derived from the cervical-loop epithelium of a rat lower incisor. The expression patterns of cytokeratin 14, nerve growth fact...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408300209
更新日期:2004-02-01 00:00:00
abstract::The acute effects of smokeless tobacco (ST) on buccal mucosal transport and barrier function were studied by means of in vivo and in vitro techniques. In humans, in vivo exposure to 0.5 g ST transiently increased the transmural electrical potential difference (PD). However, despite continued exposure, PD returned to b...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670111101
更新日期:1988-11-01 00:00:00
abstract::Interfacial bonding and stability of gamma-methacryloxypropyltrimethoxysilane with silica surfaces have been studied by means of infrared spectroscopy. The addition of n-propylamine enhances silanization of gamma-methacryloxypropyltrimethoxysilane to silica surfaces in normal aliphatic hydrocarbons, and cyclohexane yi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345820610121301
更新日期:1982-12-01 00:00:00
abstract::Stable fluoride-resistant mutants of Streptococcus mutans GS-5 were isolated on Todd-Hewitt agar by a step-wise selection procedure. Resistance is defined here as the ability to form colonies in 48 hr. First-step mutants demonstrated six different levels of resistance, ranging from 400 to 1000 micrograms/mL sodium flu...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660101701
更新日期:1987-10-01 00:00:00
abstract::Teeth develop through distinct morphological stages. At the cap stage, a compactly clustered and concentrically arranged cell mass, the enamel knot, appears at the tip of the enamel organ. Cells in this knot express sets of key molecules, and as such have been proposed to act as a signaling center directing tooth morp...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514525784
更新日期:2014-05-01 00:00:00
abstract::The molecular mechanisms that maintain the equilibrium of odontoblast progenitor cells in dental pulp are unknown. Here we tested whether homeostasis in dental pulp is modulated by Twist-1, a nuclear protein that partners with Runx2 during osteoblast differentiation. Our analysis of Twist-1(+/-) mice revealed phenotyp...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708601007
更新日期:2007-10-01 00:00:00
abstract::The Tp63 gene encodes for multiple isoforms of the p63 transcription factor, a member of the p53 family of proteins. Much like its more famous sibling, the biological role of p63 is quite complex, with wide-ranging effects on development, differentiation, and cellular lineage choices. The crucial function of p63 is ep...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034511411302
更新日期:2012-02-01 00:00:00
abstract::During periods of periodontal attachment loss, one of the most significant cellular changes is a decrease in the number of fibroblasts. We previously demonstrated that LPS induces apoptosis of fibroblastic cells in vivo, largely through TNF-alpha. We conducted in vivo experiments by subcutaneous inoculation of LPS in ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408300903
更新日期:2004-09-01 00:00:00
abstract::This study was undertaken in order to correlate the immune status of persons with various types of immune dysfunctions with the incidence of dental caries. Preliminary data on caries experience and the microbial composition of plaque in these individuals are presented. The findings suggest that persons with immunoglob...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560030201
更新日期:1977-03-01 00:00:00
abstract::In the past two decades, accumulated evidence has clearly demonstrated the inhibitory effects of laser irradiation on enamel demineralization, but the exact mechanisms of these effects remain unclear. The purpose of this study was to investigate the effects of low-energy CO2 laser irradiation on demineralization of bo...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345000790091401
更新日期:2000-09-01 00:00:00
abstract::Previous studies of tooth size in twins and their families have suggested a high degree of genetic control, although there have been difficulties separating the various genetic and environmental effects. A genetic analysis of variation in crown size of the permanent incisors of South Australian twins was carried out, ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345950740071101
更新日期:1995-07-01 00:00:00