HIV infection affects Streptococcus mutans levels, but not genotypes.

Abstract:

:We report a clinical study that examines whether HIV infection affects Streptococcus mutans colonization in the oral cavity. Whole stimulated saliva samples were collected from 46 HIV-seropositive individuals and 69 HIV-seronegative control individuals. The level of S. mutans colonization was determined by conventional culture methods. The genotype of S. mutans was compared between 10 HIV-positive individuals before and after highly active antiretroviral therapy (HAART) and 10 non-HIV-infected control individuals. The results were analyzed against viral load, CD4+ and CD8+ T-cell counts, salivary flow rate, and caries status. We observed that S. mutans levels were higher in HIV-infected individuals than in the non-HIV-infected control individuals (p = 0.013). No significant differences in S. mutans genotypes were found between the two groups over the six-month study period, even after HAART. There was a bivariate linear relationship between S. mutans levels and CD8+ counts (r = 0.412; p = 0.007), but not between S. mutans levels and either CD4+ counts or viral load. Furthermore, compared with non-HIV-infected control individuals, HIV-infected individuals experienced lower salivary secretion (p = 0.009) and a positive trend toward more decayed tooth surfaces (p = 0.027). These findings suggest that HIV infection can have a significant effect on the level of S. mutans, but not genotypes.

journal_name

J Dent Res

authors

Liu G,Saxena D,Chen Z,Norman RG,Phelan JA,Laverty M,Fisch GS,Corby PM,Abrams W,Malamud D,Li Y

doi

10.1177/0022034512454298

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

834-40

issue

9

eissn

0022-0345

issn

1544-0591

pii

0022034512454298

journal_volume

91

pub_type

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