The control of morphogenesis in Candida albicans.

Abstract:

:Morphogenesis (germ-tube formation) in Candida albicans was induced gratuitously by N-acetylhexosamine derivatives (N-acetyl-glucosamine covalently linked to agarose, N-acetylmannosamine, hyaluronic acid, colloidal chitin, and mucin). These compounds were not taken up by the yeast cells and did not support growth. 2-Deoxyglucose was a potent inhibitor of germ-tube formation (50 microM), but did not affect the yeast growth yield at a concentration of 2.5 mM. 2-Deoxyglucose covalently linked to agarose did not affect germ-tube formation, and the inhibition by free 2-deoxyglucose was overcome by the addition of glucose to the germ-tube-forming cells. Glucose competitively inhibited 2-deoxyglucose uptake (Ki = 0.14 mM), and these data indicate that 2-deoxyglucose acted intracellularly.

journal_name

J Dent Res

authors

Shepherd MG,Sullivan PA

doi

10.1177/00220345840630031501

subject

Has Abstract

pub_date

1984-03-01 00:00:00

pages

435-40

issue

3

eissn

0022-0345

issn

1544-0591

journal_volume

63

pub_type

杂志文章
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  • Preventing Childhood Caries: A Review of Recent Behavioral Research.

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