Abstract:
:Dentin sialoprotein (DSP) and dentin phosphoprotein (DPP) are expressed as a single mRNA transcript coding for a large precursor protein termed dentin sialophosphoprotein (DSPP). DSP, DPP, and DSPP have been considered to be tooth-specific. To test for the expression of the dspp gene in bone, we performed Western immunoblots and reverse-transcription polymerase chain-reaction (RT-PCR). With Western immunoblots, we detected DSP in the Gdm/EDTA extracts of rat long bone, at a level of about 1/400 of that in dentin. Using RT-PCR, we detected DSPP mRNA in mouse calvaria. Similar to Western immunoblots, the results of RT-PCR indicated that the dspp gene is expressed at a lower level in bone than in dentin and odontoblasts. Analysis of the data shows that DSPP is not a tooth-specific protein, and that dramatically different regulatory mechanisms governing DSPP expression are involved in the bone and dentin.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Qin C,Brunn JC,Cadena E,Ridall A,Tsujigiwa H,Nagatsuka H,Nagai N,Butler WTdoi
10.1177/154405910208100607keywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
392-4issue
6eissn
0022-0345issn
1544-0591journal_volume
81pub_type
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