Synergistic roles of amelogenin and ameloblastin.

Abstract:

:Amelogenin and ameloblastin, the major enamel matrix proteins, are important for enamel mineralization. To identify their synergistic roles in enamel development, we generated Amel X(-/-)/Ambn(-/-) mice. These mice showed additional enamel defects in comparison with Amel X(-/-) or Ambn(-/-) mice. In 7-day-old Amel X(-/-)/Ambn(-/-) mice, not only was the ameloblast layer irregular and detached from the enamel surface, as in Ambn(-/-), but also, the enamel width was significantly reduced in the double-null mice as compared with Amel X(-/-) or Ambn(-/-) mice. Proteomic analysis of the double-null teeth revealed increased levels of RhoGDI (Arhgdia), a Rho-family-specific guanine nucleotide dissociation inhibitor, which is involved in important cellular processes, such as cell attachment. Both Amel X(-/-)/Ambn(-/-) mice and Ambn(-/-) mice displayed positive staining with RhoGDI antibody in the irregularly shaped ameloblasts detached from the matrix. Ameloblastin-regulated expression of RhoGDI suggests that Rho-mediated signaling pathway might play a role in enamel formation.

journal_name

J Dent Res

authors

Hatakeyama J,Fukumoto S,Nakamura T,Haruyama N,Suzuki S,Hatakeyama Y,Shum L,Gibson CW,Yamada Y,Kulkarni AB

doi

10.1177/0022034509334749

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

318-22

issue

4

eissn

0022-0345

issn

1544-0591

pii

88/4/318

journal_volume

88

pub_type

杂志文章
  • Biophysical analyses of sequential bands of enamel related to ruffle-ended and smooth-ended maturation ameloblasts.

    abstract::During amelogenesis in the rat incisor, modulating ruffle-ended (RA) and smooth-ended (SA) ameloblasts are distributed as bands in the enamel organ of the maturation zone. This distribution of the two cell types has been shown to be precisely correlated with a banding of the underlying enamel, as shown by staining and...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345890680020101

    authors: McKee MD,Martin JR,Landis WJ

    更新日期:1989-02-01 00:00:00

  • An investigation into the use of restriction endonuclease analysis for the study of transmission of mutans streptococci.

    abstract::Restriction endonuclease analysis (REA) was performed on the total cellular DNA from each of 396 strains of mutans streptococci (1) to determine its potential usefulness for the study of transmission of the organism and (2) to document the proportions and variety of strains harbored by members of a small group of fami...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345890680070401

    authors: Kulkarni GV,Chan KH,Sandham HJ

    更新日期:1989-07-01 00:00:00

  • Copper-free amalgams: dimensional change after approximately five years at 60, 37, and 23 degrees C.

    abstract::Two copper-free amalgams expanded excessively after storage in air at 60 degrees C for about five yr. One expanded significantly at 37 degrees C and slightly at 23 degrees C. High silver content, absence of copper, and presence of small amounts of zinc, or all three, seemed to promote very high expansions at 60 degree...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345820610063301

    authors: Paffenbarger GC,Rupp NW,Patel PR

    更新日期:1982-06-01 00:00:00

  • Mobilization of intracellular calcium by methacholine and inositol 1,4,5-trisphosphate in rat parotid acinar cells.

    abstract::In the rat parotid acinar cell, methacholine caused an increase in [Ca2+]i as determined by quin-2 fluorescence. The increase in [Ca2+]i was initially independent of, and subsequently dependent on, the presence of extracellular Ca2+, indicating mobilization of intracellular Ca2+, as well as activation of Ca2+ entry. M...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345870660022701

    authors: Aub DL,Putney JW Jr

    更新日期:1987-02-01 00:00:00

  • The Role of Exopolysaccharides in Oral Biofilms.

    abstract::The oral cavity contains a rich consortium of exopolysaccharide-producing microbes. These extracellular polysaccharides comprise a major component of the oral biofilm. Together with extracellular proteins, DNA, and lipids, they form the biofilm matrix, which contributes to bacterial colonization, biofilm formation and...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/0022034519845001

    authors: Cugini C,Shanmugam M,Landge N,Ramasubbu N

    更新日期:2019-07-01 00:00:00

  • Late elongation of the cranial base.

    abstract::A single logistic curve was fitted to serial data for three cranial base lengths (S-N, Ba-N, and Ba-S) in 33 boys and 26 girls. Elongation during pubescence plus adolescence is greater in boys than girls for each length. The maximum rate of pubescent elongation occurs earliest in Ba-N. There are no consistent sex diff...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345770560071501

    authors: Roche AF,Lewis AB,Wainer H,McCartin R

    更新日期:1977-07-01 00:00:00

  • Stimulation of bone formation and bone resorption by fluoride in thyroparathyroidectomized rats.

    abstract::In sham-operated and TPTX animals, F treatment did not affect final body weight, or serum Ca and P. In sham-treated rats, serum iPTH was not affected by F treatment. At the periosteum, F increased bone formation rate and bone and matrix apposition rates. At the endosteum, F treatment decreased forming surface, bone fo...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345770560031601

    authors: Liu CC,Baylink DJ

    更新日期:1977-03-01 00:00:00

  • Relationship between fluoride concentration in enamel, DMFT index, and degree of fluorosis in a community residing in an area with a high level of fluoride.

    abstract::The object of the present study was an attempt to relate fluoride concentration in enamel, caries experience, and the degree of fluorosis in a community residing in an area with a high level of fluoride. A significant difference was found between the male and female samples for the F and D parameters. A positive corre...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345760550012001

    authors: Bischoff JI,van der Merwe EH,Retief DH,Barbakow FH,Cleaton-Jones PE

    更新日期:1976-01-01 00:00:00

  • Anticariogenic effects of tea in rats.

    abstract::Teas varying in fluoride and tannin concentration were evaluated in rats for anticariogenic activity. There was a direct correlation between fluoride in tea and the inhibition of sulcal caries in rats, whereas no relationship was observed between tannin and this type of lesion. Teas also had a significant effect on ca...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345840630051001

    authors: Rosen S,Elvin-Lewis M,Beck FM,Beck EX

    更新日期:1984-05-01 00:00:00

  • Antigens and surface components associated with virulence of Actinomyces viscosus.

    abstract::We have isolated a specific cell wall antigen of high molecular weight which appears to be unique to virulent strains of A viscosus and A naeslundii. The antigen is composed of two parts: a polysaccharide moiety containing 6-DOT as the major sugar and determinant of serologic specificity, and a small peptide bearing s...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/002203457605500111011

    authors: Hammond BF,Steel CF,Peindl KS

    更新日期:1976-01-01 00:00:00

  • PPARγ Maintains Homeostasis through Autophagy Regulation in Dental Pulp.

    abstract::This study investigated the relevance between pulp vitality and autophagy in aged human dental pulp cells (HDPCs) and whether peroxisome proliferator-activated receptor gamma (PPARγ) affects autophagy regulation for homeostasis in the aging progress. In vivo experiments were used in human and Sprague-Dawley rat teeth ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515573833

    authors: Lee YH,Lee HY,Kim TG,Lee NH,Yu MK,Yi HK

    更新日期:2015-05-01 00:00:00

  • Degradation, fatigue, and failure of resin dental composite materials.

    abstract::The intent of this article is to review the numerous factors that affect the mechanical properties of particle- or fiber-filler-containing indirect dental resin composite materials. The focus will be on the effects of degradation due to aging in different media, mainly water and water and ethanol, cyclic loading, and ...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/154405910808700802

    authors: Drummond JL

    更新日期:2008-08-01 00:00:00

  • Transcriptome Reveals Cathepsin K in Periodontal Ligament Differentiation.

    abstract::Periodontal ligaments (PDLs) play an important role in remodeling the alveolar bond and cementum. Characterization of the periodontal tissue transcriptome remains incomplete, and an improved understanding of PDL features could aid in developing new regenerative therapies. Here, we aimed to generate and analyze a large...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034516645796

    authors: Yamada S,Ozaki N,Tsushima K,Yamaba S,Fujihara C,Awata T,Sakashita H,Kajikawa T,Kitagaki J,Yamashita M,Yanagita M,Murakami S

    更新日期:2016-08-01 00:00:00

  • The Evolution of Dental Materials over the Past Century: Silver and Gold to Tooth Color and Beyond.

    abstract::The field of dental materials has undergone more of a revolution than an evolution over the past 100 y. The development of new products, especially in the past half century, has occurred at a staggering pace, and their introduction to the market has been equally impressive. The movement has mostly come in the area of ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034518822808

    authors: Bayne SC,Ferracane JL,Marshall GW,Marshall SJ,van Noort R

    更新日期:2019-03-01 00:00:00

  • Loss of Discoidin Domain Receptor 1 Predisposes Mice to Periodontal Breakdown.

    abstract::The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors and tyrosine kinases. DDRs regulate cell functions, and their extracellular domains affect collagen fibrillogenesis and mineralization. Based on the collagenous nature of dentoalveolar tissues, we hypothesized that DDR1 plays an importan...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034519881136

    authors: Chavez MB,Kolli TN,Tan MH,Zachariadou C,Wang C,Embree MC,Lira Dos Santos EJ,Nociti FH Jr,Wang Y,Tatakis DN,Agarwal G,Foster BL

    更新日期:2019-12-01 00:00:00

  • Different roles of odontoblasts and fibroblasts in immunity.

    abstract::Odontoblasts and fibroblasts are suspected to influence the innate immune response triggered in the dental pulp by micro-organisms that progressively invade the human tooth during the caries process. To determine whether they differ in their responses to oral pathogens, we performed a systematic comparative analysis o...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910808700304

    authors: Staquet MJ,Durand SH,Colomb E,Roméas A,Vincent C,Bleicher F,Lebecque S,Farges JC

    更新日期:2008-03-01 00:00:00

  • Effects of composite restorations on the periodontal membrane in monkeys.

    abstract::We evaluated the histopathological response of the periodontal membrane to intentionally-replanted teeth carrying composite (experimental) and silver amalgam (control) restorations in the middle third of each root. The study revealed that the amalgam produced, in the periodontal tissues, an initial localized inflammat...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345830620011801

    authors: Nasjleti CE,Castelli WA,Caffesse RG

    更新日期:1983-01-01 00:00:00

  • Genes and related proteins involved in amelogenesis imperfecta.

    abstract::Dental enamel formation is a remarkable example of a biomineralization process. The exact mechanisms involved in this process remain partly obscure. Some of the genes encoding specific enamel proteins have been indicated as candidate genes for amelogenesis imperfecta. Mutational analyses within studied families have s...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/154405910508401206

    authors: Stephanopoulos G,Garefalaki ME,Lyroudia K

    更新日期:2005-12-01 00:00:00

  • Saliva and Serum Protein Exchange at the Tooth Enamel Surface.

    abstract::The acquired enamel pellicle is an oral, fluid-derived protein layer that forms on the tooth surface. It is a biologically and clinically important integument that protects teeth against enamel demineralization, and abrasion. Tooth surfaces are exposed to different proteinaceous microenvironments depending on the enam...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034516680771

    authors: Heller D,Helmerhorst EJ,Oppenheim FG

    更新日期:2017-04-01 00:00:00

  • Initial subgingival colonization of 'pristine' pockets.

    abstract::The treatment of periodontitis/peri-implantitis involves the reduction/eradication of periopathogens. After therapy, beneficial and pathogenic species recolonize the subgingival area. The dynamics of recolonization and especially the role of the supragingival environment in this process are still not well-understood. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910508400409

    authors: Quirynen M,Vogels R,Pauwels M,Haffajee AD,Socransky SS,Uzel NG,van Steenberghe D

    更新日期:2005-04-01 00:00:00

  • The chemical composition of tooth enamel in recessive dystrophic epidermolysis bullosa: significance with respect to dental caries.

    abstract::Previous reports have linked the prevalence of tooth abnormalities with high caries experience in the different types of epidermolysis bullosa (EB). However, it is not known to what extent the apparent susceptibility to enamel caries is due to disease-related altered enamel chemistry in these cases. The aim of this st...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345960750090901

    authors: Kirkham J,Robinson C,Strafford SM,Shore RC,Bonass WA,Brookes SJ,Wright JT

    更新日期:1996-09-01 00:00:00

  • Effect of acculturation on objective measures of oral health in Haitian immigrants in New York City.

    abstract::Acculturation is a complex phenomenon that can serve as a proxy for cultural norms and behaviors affecting care-seeking, prevention behaviors, and, ultimately, health outcomes. The purpose of this study was to assess the effect of acculturation on the oral health of Haitian immigrants in New York City. We hypothesized...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910408300219

    authors: Cruz GD,Shore R,Le Geros RZ,Tavares M

    更新日期:2004-02-01 00:00:00

  • Clustering tooth surfaces into biologically informative caries outcomes.

    abstract:UNLABELLED:Dental caries affects most adults worldwide; however, the risk factors for dental caries do not necessarily exert their effects uniformly across all tooth surfaces. Instead, the actions of some risk factors may be limited to a subset of teeth/surfaces. Therefore, we used hierarchical clustering on tooth surf...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034512463241

    authors: Shaffer JR,Feingold E,Wang X,Weeks DE,Weyant RJ,Crout R,McNeil DW,Marazita ML

    更新日期:2013-01-01 00:00:00

  • "Gum bug, leave my heart alone!"--epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis.

    abstract::Evidence from epidemiologic studies suggests that periodontal infections are independently associated with subclinical and clinical atherosclerotic vascular disease. Although the strength of the reported associations is modest, the consistency of the data across diverse populations and a variety of exposure and outcom...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/0022034510375281

    authors: Kebschull M,Demmer RT,Papapanou PN

    更新日期:2010-09-01 00:00:00

  • Use of bacteriophage-resistant mutants to study Actinomyces viscosus cell surface receptors.

    abstract::Spontaneously occurring bacteriophage-resistant mutants of Actinomyces viscosus were isolated. The mutants exhibited altered coaggregation patterns with streptococci. From analysis of the data, it appears that a cell surface structure on A. viscosus may function both as a phage receptor and as a binding site for co-ag...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345830620111801

    authors: Tylenda CA,Kolenbrander PE,Delisle AL

    更新日期:1983-11-01 00:00:00

  • A Comparative Assessment of Implant Site Viability in Humans and Rats.

    abstract::Our long-term objective is to devise methods to improve osteotomy site preparation and, in doing so, facilitate implant osseointegration. As a first step in this process, we developed a standardized oral osteotomy model in ovariectomized rats. There were 2 unique features to this model: first, the rats exhibited an os...

    journal_title:Journal of dental research

    pub_type: 杂志文章,多中心研究

    doi:10.1177/0022034517742631

    authors: Chen CH,Pei X,Tulu US,Aghvami M,Chen CT,Gaudillière D,Arioka M,Maghazeh Moghim M,Bahat O,Kolinski M,Crosby TR,Felderhoff A,Brunski JB,Helms JA

    更新日期:2018-04-01 00:00:00

  • Antibacterial susceptibility of plaque bacteria.

    abstract::Selected anaerobic, capnophilic and facultative bacteria isolated from patients with various forms of periodontal health and disease were tested for their susceptibility to antibiotics and antimicrobial agents. Specific bactericidal and minimum inhibitory concentrations were compared to disc zone diameters, thereby ge...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345790580071401

    authors: Newman MG,Hulem C,Colgate J,Anselmo C

    更新日期:1979-07-01 00:00:00

  • Interaction of glass-ionomer cements with moist dentin.

    abstract::Glass-ionomer cements (GICs) are regarded as aqueous gels made up of polyalkenoic acid salts containing ion-leachable glass fillers. The consequence of water permeation across the GIC-dentin interface is unknown. This study used SEM, field-emission/environmental SEM (FE-ESEM), and TEM to examine the ultrastructure of ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910408300403

    authors: Yiu CK,Tay FR,King NM,Pashley DH,Sidhu SK,Neo JC,Toledano M,Wong SL

    更新日期:2004-04-01 00:00:00

  • Postnatal Identification of Zika Virus Peptides from Saliva.

    abstract::We explored the potential to diagnose Zika virus (ZIKV) infection by analyzing peptides in saliva during a convalescent phase of infection, long after resolution of acute disease. A 25-y-old woman clinically diagnosed with Zika fever in the first trimester was enrolled with her dizygotic twins for a 3-mo postnatal sam...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034517723325

    authors: Zuanazzi D,Arts EJ,Jorge PK,Mulyar Y,Gibson R,Xiao Y,Bringel Dos Santos M,Machado MAAM,Siqueira WL

    更新日期:2017-09-01 00:00:00

  • Ridge alterations post-extraction in the esthetic zone: a 3D analysis with CBCT.

    abstract::Dimensional alterations of the facial bone wall following tooth extractions in the esthetic zone have a profound effect on treatment outcomes. This prospective study in 39 patients is the first to investigate three-dimensional (3D) alterations of facial bone in the esthetic zone during the initial 8 wks following flap...

    journal_title:Journal of dental research

    pub_type: 临床试验,杂志文章

    doi:10.1177/0022034513506713

    authors: Chappuis V,Engel O,Reyes M,Shahim K,Nolte LP,Buser D

    更新日期:2013-12-01 00:00:00