Abstract:
:Odontoblasts and fibroblasts are suspected to influence the innate immune response triggered in the dental pulp by micro-organisms that progressively invade the human tooth during the caries process. To determine whether they differ in their responses to oral pathogens, we performed a systematic comparative analysis of odontoblast-like cell and pulp fibroblast responses to TLR2-, TLR3-, and TLR4-specific agonists (lipoteichoic acid [LTA], double-stranded RNA, and lipopolysaccharide [LPS], respectively). Cells responded to these agonists by differential up-regulation of chemokine gene expression. CXCL2 and CXCL10 were thus increased by LTA only in odontoblast-like cells, while LPS increased CCL7, CCL26, and CXCL11 only in fibroblasts. Supernatants of stimulated cultures increased migration of immature dendritic cells compared with controls, odontoblast-like cells being more potent attractants than fibroblasts. Analysis of these data suggests that odontoblasts and pulp fibroblasts differ in their innate immune responses to oral micro-organisms that invade the pulp tissue.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Staquet MJ,Durand SH,Colomb E,Roméas A,Vincent C,Bleicher F,Lebecque S,Farges JCdoi
10.1177/154405910808700304subject
Has Abstractpub_date
2008-03-01 00:00:00pages
256-61issue
3eissn
0022-0345issn
1544-0591pii
87/3/256journal_volume
87pub_type
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