Abstract:
:Fluorides are present in the environment. Excessive systemic exposure to fluorides can lead to disturbances of bone homeostasis (skeletal fluorosis) and enamel development (dental/enamel fluorosis). The severity of dental fluorosis is also dependent upon fluoride dose and the timing and duration of fluoride exposure. Fluoride's actions on bone cells predominate as anabolic effects both in vitro and in vivo. More recently, fluoride has been shown to induce osteoclastogenesis in mice. Fluorides appear to mediate their actions through the MAPK signaling pathway and can lead to changes in gene expression, cell stress, and cell death. Different strains of inbred mice demonstrate differential physiological responses to ingested fluoride. Genetic studies in mice are capable of identifying and characterizing fluoride-responsive genetic variations. Ultimately, this can lead to the identification of at-risk human populations who are susceptible to the unwanted or potentially adverse effects of fluoride action and to the elucidation of fundamental mechanisms by which fluoride affects biomineralization.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Everett ETdoi
10.1177/0022034510384626subject
Has Abstractpub_date
2011-05-01 00:00:00pages
552-60issue
5eissn
0022-0345issn
1544-0591pii
0022034510384626journal_volume
90pub_type
杂志文章,评审abstract::The hypothesis that periodontal disease is associated with pre-term low birthweight was tested in a prospective follow-up study of rural prima-gravida women (N = 227) who were free of tobacco, alcohol, and drug use. Women with 3rd trimester mean probing pocket depths, plaque, and bleeding scores that were greater than...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910508400313
更新日期:2005-03-01 00:00:00
abstract::The aim of this study was to test effects of preventive regimes using fluoride and chlorhexidine to prevent caries and periodontal diseases in 34 patients with overdentures. The patients, who were treated with immediate overdentures, were distributed at random into three experimental groups. In these groups, different...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/00220345870660101301
更新日期:1987-10-01 00:00:00
abstract::The complexity of the periodontal microbiota resembles that of the gastro-intestinal tract, where infectious diseases are treatable via probiotics. In the oropharyngeal region, probiotic or replacement therapies have shown some benefit in the prevention of dental caries, otitis media, and pharyngitis, but their effect...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708601111
更新日期:2007-11-01 00:00:00
abstract::The solubilities of extracellular polysaccharide fractions produced by 14 oral streptococcal strains were compared in water, aqueous lithium and guanidine salt solutions, dimethyl sulfoxide (DMSO), and a 9:1 DMSO-water mixture. The best results for solubilizing the fractions were obtained with the DMSO-water mixture p...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345750540042601
更新日期:1975-07-01 00:00:00
abstract::Inferior alveolar nerve (IAN) injury induces persistent ectopic pain which spreads to a wide area in the orofacial region. Its exact mechanism remains unclear. We investigated the involvement of nitric oxide (NO) in relation to ectopic orofacial pain caused by IAN transection (IANX). We assessed the changes in mechani...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513509280
更新日期:2013-12-01 00:00:00
abstract::Using a pin-on-disc sliding-wear test apparatus, the wear behavior of a typical composite restorative vs. styli fashioned from human enamel, sintered alumina, and magnesium fluoride was examined. The rates of restorative wear were found to be identical, within the experimental error of the measurements, for tests usin...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630062501
更新日期:1984-06-01 00:00:00
abstract::In previous studies, human dental pulp stem cells (hDPSCs) were mainly isolated from adults. In this present study, we characterized hDPSCs isolated from an earlier developmental stage to evaluate the potential usage of these cells for tissue-regenerative therapy. hDPSCs isolated at the crown-completed stage showed a ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808700716
更新日期:2008-07-01 00:00:00
abstract::Dickkopf-related protein 1 (DKK1) is a potent inhibitor of Wnt/β-catenin signaling. Dkk1-null mutant embryos display severe defects in head induction. Conversely, targeted expression of Dkk1 in dental epithelial cells leads to the formation of dysfunctional enamel knots and subsequent tooth defects during embryonic de...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034511421926
更新日期:2011-11-01 00:00:00
abstract::Ten dental casting alloys were tested for alloy-element release into cell-culture medium, and this release was related to alloy composition, alloy microstructure, and alloy cytotoxicity (previously determined). Cell-culture medium was analyzed for alloy elements by flame atomic absorption. Concentrations of elements i...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700060301
更新日期:1991-06-01 00:00:00
abstract::The aim of this study was to test the hypothesis that the chewing of xylitol- or xylitol/sorbitol-containing chewing gum reduces plaque formation and the acidogenic potential of dental plaque. Thirty healthy volunteers aged from 19 to 28 yrs were randomly allocated to one of three test groups, chewing either xylitol-,...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/00220345980770071001
更新日期:1998-07-01 00:00:00
abstract::The present investigation demonstrates that direct application of a composite resin on an acid-etched, vital dentin surface is hazardous to the pulp in monkey teeth. This indicates that exposed dentin should be protected before treating the tooth with a restorative technique including acid etching. A ca(OH)2-containin...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550022001
更新日期:1976-03-01 00:00:00
abstract::The monomer triethyleneglycoldimethacrylate (TEGDMA) is used as a diluent in many resin-based dental materials. It was previously shown in vitro that TEGDMA was released into the adjacent biophase from such materials during the first days after placement. In this study, the uptake, distribution, and excretion of 14C-T...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345010800050501
更新日期:2001-05-01 00:00:00
abstract::Diabetes mellitus is associated with depression of natural defenses against infection and increases the risk of periodontal disease. However, the effects of diabetes on periradicular tissue, which differs structurally from periodontal tissue, are not known. In this study, we evaluated the effects of type 2 diabetes on...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200416
更新日期:2003-04-01 00:00:00
abstract::Lingual amylase and lingual lipase, two digestive enzymes that are secreted from lingual serous glands (von Ebner's), were simultaneously purified from rat lingual serous glands with hydrophobic chromatography used as the final step. This method, previously developed for the purification of lingual lipase, includes ho...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680020801
更新日期:1989-02-01 00:00:00
abstract::Extracellular microcapsules have been demonstrated on cells of most serotypes of Streptococcus mutans by electron microscopy, using bacterial strains of the various serotypes and peroxidase labeled or unlabeled immune serum. A correlation was noted between the amount of capsular substance on the strains of S mutans ex...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560021101
更新日期:1977-02-01 00:00:00
abstract::Breastfeeding is a powerful health-promoting behavior. A 2016 Lancet global collaboration to review the health implications of breastfeeding was among the first to consider oral health outcomes. While a role was suggested for breastfeeding in preventing malocclusion, caries was the only included disease condition unfa...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034517738925
更新日期:2018-03-01 00:00:00
abstract::Van der Woude syndrome (VWS) is an autosomal-dominant oral facial disorder. To find a gene mutation in a Japanese family using fingernail DNA samples, we performed this study. We hypothesized that a gene mutation in IRF6 might be involved in VWS, and that fingernail DNA samples may be valuable for detecting such mutat...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608501215
更新日期:2006-12-01 00:00:00
abstract::Fibroblast growth factor (FGF) signaling has been implicated in the regulation of osteogenesis in both intramembranous and endochondral ossifications. In the developing palate, the anterior bony palate forms by direct differentiation of cranial neural crest (CNC)-derived mesenchymal cells, but the signals that regulat...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034517750141
更新日期:2018-05-01 00:00:00
abstract::The destabilizing effect of endodontic treatment upon teeth is still controversial. The purpose of this study was to investigate the effects of different steps of endodontic treatments upon the rigidity of teeth. Extracted untreated central maxillary anterior teeth were loaded (3.75 N), and deformations of the root we...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608500416
更新日期:2006-04-01 00:00:00
abstract::The influence of the molecular weight of the poly(acrylic acid) component on some properties of glass-ionomer cement has been investigated. The results can be explained by treatment of glass-ionomer cements as thermoplastic composites. Many of the concepts of polymer science can be applied successfully in a qualitativ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680021401
更新日期:1989-02-01 00:00:00
abstract::The purpose of this study was to determine the surface roughness of enamel-to-enamel contact areas in order to provide a standard for comparison with surface characteristics of commercially available composite restorative materials. In addition, the inherent surface roughness of resin composites was evaluated profilom...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700091301
更新日期:1991-09-01 00:00:00
abstract::Rat parotid atrophy, induced by liquid feeding over 10 days, was manifested as gland weight loss (40%) and histologically as acinar shrinkage. Acinar secretory function was investigated in the same glands using enzymatically dispersed cell preparations and superfused gland slices. Results were normalized for the acina...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345940730060901
更新日期:1994-06-01 00:00:00
abstract::Thermal diffusivity, a property related to the thermal insulative efficiency of a material, was measured in nine glass-ionomer cements and compared with results from a silicate and a polycarboxylate cement. Each cement was mixed at various powder-liquid ratios (P/L) and moulded into a rectangular prism of approximate ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660051001
更新日期:1987-05-01 00:00:00
abstract::PAX9 is a transcription factor expressed in the tooth mesenchyme during tooth morphogenesis. In Pax9-null mice, tooth development is arrested at the bud stage. In humans, heterozygous mutations in PAX9 have been associated with non-syndromic tooth agenesis, predominantly in the molars. Here, we report 2 novel mutation...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513519801
更新日期:2014-03-01 00:00:00
abstract::Auto-degradation of collagen matrices occurs within hybrid layers created by contemporary dentin bonding systems, by the slow action of host-derived matrix metalloproteinases (MMPs). This study tested the null hypothesis that there are no differences in the activities of MMP-2 and -9 after treatment with different etc...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512467034
更新日期:2013-01-01 00:00:00
abstract::The tongue plays an important role in mastication and swallowing by its contact with the hard palate. Using an experimental palatal plate with 7 pressure sensors, and recording jaw movement using mandibular kinesiography, we assessed, in healthy subjects, the coordination of tongue and jaw movements during the entire ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608500214
更新日期:2006-02-01 00:00:00
abstract::In mammals, the periodontal ligament (PDL) is a highly specialized tissue which facilitates tooth eruption and lends mechanical support to the tooth once in occlusion. The PDL extracellular matrix fibers play a major role in such functions. During its development, the spatial arrangement of the PDL extracellular matri...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345920710070201
更新日期:1992-07-01 00:00:00
abstract::The human mandibular condyle has a parasagittal plate-like trabecular structure. We tested the hypothesis that this structure reflects the mechanical loading of the condyle. We developed a finite element model of the condyle to analyze the strains occurring during static compressive loading. The principal strains in t...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910208101010
更新日期:2002-10-01 00:00:00
abstract::A previously reported technique for staining areas of degradation in dental composite restorations was evaluated in 51 removed restorations. The staining reagent was silver nitrate, which penetrated the degraded subsurface as ionic silver and was subsequently developed into colored deposits of metallic silver. Several...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700031201
更新日期:1991-03-01 00:00:00
abstract::Several studies have shown that surgical detachment of marginal gingiva close to the cervical cementum of molar teeth in a rat mandible is a distinct stimulus for alveolar bone resorption. Recently, we found that P2X4, an ATP-receptor, is significantly up-regulated in marginal gingival cells soon after surgery. We hyp...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708600214
更新日期:2007-02-01 00:00:00